How much pregnenolone? Isn't pregnenolone already an AI? Wasn't it shown that pregnenolone mostly increased just pregnenolone and progesterone? Or does resulting testosterone get converted to estrogen and cleared out? But then again isn't pregnenolone already an AI preventing such conversions? Would a "natural" AI work as well? That is, would serum estradiol be primarily/all that matters or are there other effects?
I think they used 50mg-100mg daily together with an AI. Not sure why they got better effects by combining with an AI. Maybe estrogen needs to be suppressed beyound a certain level in order to allow the gonads to use the pregnenolone for T synthesis. There has been no comparison so far between pregnenolone and an AI in terms of aromatase inhibition potency.