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  1. EnergeticLeo

    Why is Progest-E trusted but there is no consensus on a good pregnenolone?

    From what I understand Peat had stopped recommending pregnenolone because of poor reactions he was hearing, and suspected the quality of pregnenolone had declined. But progest-E's progesterone is USP and AFAIK he was still recommending and using progest-E in recent years. Does anyone know where...
  2. haidut

    Cells preferentially accumulate Pregnenolone (P5), Progesterone (P4), and DHEA

    A study not directly dealing with disease, though its findings are probably relevant for all diseases. It demonstrates that in addition to the so-called "active transport", which we have been told is the dominant mechanism in steroid absorption and intracellular relevance, there also exists a...
  3. haidut

    Pregnenolone (P5) blocks stress-induced anxiety, hypertension and cocaine cravings

    A great new study, and with humans too! As the study aptly demonstrates, the primary driver of cocaine cravings is likely stress and the anxiety it causes. This finding is another corroboration of the findings of the great Rat Park experiment/study on "addiction". In the study below, the...
  4. miquelangeles

    Pregnenolone acetate in treatment of mycetoma

    THE PURPOSES of this presentation are (1) to report a case of mycetoma (nocardiosis) in a child who had failed to respond to all the standard forms of therapy and who apparently has been cured by treatment with pregnenolone acetate and (2) to call attention to pregnenolone acetate as an agent...
  5. miquelangeles

    Metabolism of DHEA, pregnenolone, progesterone and other steroids by plant tissues

    Some raw vegetables and fruits in the diet can generate different metabolites from oral DHEA/pregnenolone/progesterone. Excerpts:
  6. miquelangeles

    Androgen Biosynthesis in the Stomach

    For the last ~6 months I've been experimenting with pregnenolone in different dosages, frequencies, schedule and routes of administration. There are already numerous threads about it's effects (they are very different depending on all those factors), but I want to mention two things that I...
  7. haidut

    Pregnenolone/aspirin can block cellular estrogen uptake, PUFA promotes it

    I have posted in the past about the "obscure" estrogen estrone sulfate (E1S) and its role as a biomarker of both onset and progression of breast, colon, prostate, endometrial, and many other cancers. Despite its major role in cancer development, E1S remains known to mainstream medicine as simply...
  8. C

    Low cholesterol is dangerous (cancer, suicide) + artichoke extract

    Ray peat posted before about this: Cholesterol, longevity, intelligence, and health. "In the last 20 years, there have been many studies showing that lowering cholesterol increases mortality, especially from cancer and suicide, and that people with naturally low cholesterol are more likely to...
  9. miquelangeles

    Intranasal pregnenolone

    Anyone else tried this? Just a small pinch gives me such profound and immediate effects like no other supplement. Not just limited to brain/mood but also increased proprioception, body coordination, strength and endurance. @Makrosky @shine @Arnold Grape a few years ago you wrote "I've been...
  10. NewACC

    Anti-Peat Why do children have so good health if their androgens low?

    After thinking about peating, I wondered: why are children so metabolically ideal that they even overtake elite athletes by this factor, if their androgenic level is very low? Is it strange that everyone on the forum is talking about the rejuvenating effect of androgens, if children are the...
  11. haidut

    Pregnenolone (P5) improves recovery from stroke

    One of the few direct studies with P5 in-vivo, though that may be changing as I noticed the rate of articles on P5 has been rising over the last 5-6 years. This study used four (4) administrations of P5, at a HED of just 0.3mg/kg, 1, 6, 12, and 18 hours after the (ischemic) stroke was caused...
  12. T

    DHEA, pregnenolone oral vs topical conversion

    What is the topical equivalent of 50mg of DHEA? How many mg topically would I have to apply to my scrotum to get the same benefits of a a sustained release 25-50mg? Same question for Pregnenolone. How much topical pregnenolone is equivalent to 100mg of oral pregnenolone?
  13. tastyfood

    Is 39 ng/dL too low for a pregnenolone blood test result? 34 year old male

    I decided to test pregnenolone to get a good sense before I hop back on to supplementing it. The result seems very low? The range from Labcorp is <151. Checking online I've seen the lower range being 33 ng/DL. The other tests I got, in case they help understand my pregnenolone result were...
  14. M

    How to get hair/skin effect from preg without preg?

    Preg makes my face younger and my hair thicker but it also makes me shed. Overnight the hairs themselves are thicker even if I’m shedding more. I wish to have my face look like it does on preg without having to take it, could someone point me in the right direction of what would be the best...
  15. T

    High dose pregnenolone

    here for some pregnenolone conversation. I’ve posted a handful of times on my situation here and gotten plenty of what would seem to be good help. But what has fixed me big time and FAST is high dose pregnenolone. Quick background. I’m 25 year old male physically look healthy 6’3 215 lean...
  16. TheGoogler

    Negative effects from dosing too much Androsterone+Pansterone?

    I usually use 2-3 drops androsterone+4-5 drops pansterone once a day, or slightly less of each 2x a day, and the effects over the course of several months were quite noticeable. Improved energy, motivation, self-discipline, fat loss and muscle gain, decreased depressive symptoms. I wanted to...
  17. C

    Help, High cholesterol and triglycerides

    Hi guys, i have recently done blood work and it turned out with: total cholesterol = 279 mg/dl HDL = 34 mg/dl Trig = 311 mg/dl Magnesium = 1.80 mg/dl Total Ca = 9.90 mg/dl Vitamin D = 92 nmol/L Im 24yo male, my diet is peaty low pufa, high carbs and protein, high fruits. Last year i had...
  18. Soren

    Pregnenolone vs Progesterone for Back Pain, Endotoxin, Parkinsons Disease

    As some on this forum might know my mother suffers from Parkinson's disease which I have been attempting to treat with a number of serotonin blocking substances. Circumstances of the Pandemic and her own disposition have made it very difficult to get her into consistently good habits and...
  19. S

    Pregnenolone vs Progesterone for under developed cognitive function

    I am 23, male. My cognitive function (verbal IQ) is underdeveloped due to my mom being vegan and undereating during pregnancy. I also under eat whilst growing up, was mainly vegetarian. Therefore, I was was wondering if taking for short term either pregnenolone or progesterone would help restore...
  20. Hans

    One of the best TRT alternatives (natural potent stack)

    Going on TRT can be a challenging decision. How long are you going to be on? How are you going to get off? Do you want to get off? What about fertility, risks, success rate, etc? I'm not trying to say TRT shouldn't be an option, but want to give an alternative. Fixing hypogonadism naturally is...