Not really, I saw that reference and it does not provide proof of those claims. L-PGA can convert into glutamate but only at higher doses. The liver drug metadoxine mentioned in the Cardenosine thread has been given in doses providing grams of L-PGA per day with no glutamate toxicity issues observed, even in children with ADHD (for whom even higher doses L-PGA are used).
Decrease in those, yes. It should be visible on the next Danny Roddy podcast.
Is it possible this supplement could worsen sleep in people who are not deficient in magnesium? I am asking this because I noticed it takes much longer for me to fall asleep if I take this product about an hour before sleep and my partner noticed the same. You have written in Cardenosine thread that "L-PGA facilitates ATP synthesis bystimulating de novo synthesis of purines." Could it be that stimulating effect of L-PGA outweights the sedating effect of magnessium??
I have been using Magnoil everyday for 4 years now. Most recently I used 3-6 drops every evening on my abdomen or back. I have had insomnia for some time where I would sleep great for 4-5 hours, be awake for 2 and maybe get a little more sleep before having to get up. I wonder if the insomnia is caused by the L-PGA.It is certainly possible, as L-PGA is also dopaminergic and such a chemical would be expected to interfere with sleep.