transdermal

Can you make steroids topically bio available (cream/oil/dmso)? Talking about things like Masteron/EQ/Tren etc? Do they have to be no ester? Whats their bioavailability compared to injectables like this? I know they are unhealthy, just wanna know.

I have seen posts here of people saying aspirin does their stomach bad and thus they can't take it, even though in some cases/contexts it could be beneficial I suppose for almost anyone. If you can not "stomach" straight aspirin then here are several other methods to use it for those willing to...

One of the most common questions I get from my readers is "What is the topical absorption rate of your products?" There are a number of studies demonstrating that a solvent mixture of DMSO/ethanol achieves close to 100% absorption no matter where on the skin it is applied. However, we stopped...

So much for the safety of sunscreen. Of course, the article immediately goes on the defensive and warns against stopping sunscreen. It even includes gems like "The sun is the real enemy here" and keeps repeating the mantra that it is all about risk-benefits analysis. Yet, even MSM is forced to...

As many forum users know, magnesium (Mg) is one of the most important minerals for proper metabolic function. It is a required cofactor for hundreds of metabolic enzymes, including the crucial mitochondrial enzyme pyruvate dehydrogenase (PDH), ATP synthesis, and ATP transport in the bloodstream...

This seems like a very interesting study, but is in French and not available from PubMed. So, I am hoping @burtlancast would be able to obtain it and maybe translate the relevant fractions. The study shows that dietary stearic acid is both incorporated into cell lipids and metabolized further...

I wanted to post this as it allows people who cannot tolerate coconut oil or other saturated fat orally to still inflluence their systemic SFA : PUFA balance. This study looked at the transdermal absorption of PUFA (safflower oil) and SFA (coconut oil) and found both to be rather well absorbed...

I posted some studies before showing that ALS is a disease of mitochondrial origin and delivering copper directly to the motor neurons may be a viable treatment. Here are some of the previous posts on that: Copper May Treat Als | Ray Peat Forum More evidence that diseases like ALS are...

For those asking about my steroid supplements, and why use DMSO as a carrier (questions mostly coming from the Facebook RP groups). The studies below show that transdermal application of steroids (including progesterone, estrogen, and testosterone) dissolved in DMSO achieved the same...