Kuinone - Liquid Vitamin K2 (MK-4)

[Fllora]

@haidut hope this is not redundant - are you aware of the study cited here? Very confusing figuring out what to take (ingest) when. Thanks!

A 2015 study (12) looked at absorption in mice to see whether consuming more than one fat soluble vitamin at a time increased or decrease the absorption of the others. The study showed “significant competitive interactions for uptake” between Vitamin D, E, A and K. It seems that the only fat soluble vitamin that did not lose out was Vitamin A when taken with vitamin E.

The recommendation on Consumer Lab is that if you want to benefit from maximum absorption on your Vitamin K that you take it at least 3 hours apart from other fat soluble Vitamins (D, E and A). To learn more about this listen to my interview with ConsumerLab’s CEO, Dr. Tod Cooperman on Calcium Supplements for Osteoporosis.

(12) van Ballegooijen A.J., et al. The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review, Int J Endocrinol. 2017; 2017: 7454376, Published online 2017 Sep 12
LInk: Vitamin K2 Dosage for Osteoporosis Treatment

 

[Mauritio]

@haidut hope this is not redundant - are you aware of the study cited here? Very confusing figuring out what to take (ingest) when. Thanks!

A 2015 study (12) looked at absorption in mice to see whether consuming more than one fat soluble vitamin at a time increased or decrease the absorption of the others. The study showed “significant competitive interactions for uptake” between Vitamin D, E, A and K. It seems that the only fat soluble vitamin that did not lose out was Vitamin A when taken with vitamin E.

The recommendation on Consumer Lab is that if you want to benefit from maximum absorption on your Vitamin K that you take it at least 3 hours apart from other fat soluble Vitamins (D, E and A). To learn more about this listen to my interview with ConsumerLab’s CEO, Dr. Tod Cooperman on Calcium Supplements for Osteoporosis.

(12) van Ballegooijen A.J., et al. The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review, Int J Endocrinol. 2017; 2017: 7454376, Published online 2017 Sep 12
LInk: Vitamin K2 Dosage for Osteoporosis Treatment

Ray talks about it here as well .

View: https://youtu.be/48lV_SEuXqE

 

[Fllora]

Ray talks about it here as well .

View: https://youtu.be/48lV_SEuXqE

Right, knew about that, thanks. That's E and K. If the study above has any merit, even K and D should not be combined. How very ironic, too, that fortified milk has A,D, and E, as others have mentioned.

 

[Fllora]

I wonder how others deal with this - I drink 2% milk through the day, so it's got A,D,E in it. And take my Kuinone in the morning with my cafe au lait, so I am in fact combining K2 with all the other fat solubles, including E. There is no time through the day that I'm not within two or three hours of having drunk milk, so how to not combine at least K2 and E?

 

[cremes]

I wonder how others deal with this - I drink 2% milk through the day, so it's got A,D,E in it. And take my Kuinone in the morning with my cafe au lait, so I am in fact combining K2 with all the other fat solubles, including E. There is no time through the day that I'm not within two or three hours of having drunk milk, so how to not combine at least K2 and E?

From what I can tell, the vitamin E in milk products is all-rac-alpha-tocopheryl acetate which is the synthetic form. It's also just the alpha tocopherol and doesn't include any of the other 4 tocopherols or any of the 4 tocotrienols. And it goes without saying that it contains none of the policosanols that a natural vitamin E from wheat germ oil would likely contain.

As such, I wouldn't worry about that E blocking your K2 absorption. It's also a quite small amount in the milk. If you do a few drops of Kuinone, I believe they are 2mg per drop. If doing it topically, it will be absorbed via a different mechanism than the E you drink.

I should point out that these are educated guesses. I don't actually know that the absorption will be unaffected.

 

[Fllora]

From what I can tell, the vitamin E in milk products is all-rac-alpha-tocopheryl acetate which is the synthetic form. It's also just the alpha tocopherol and doesn't include any of the other 4 tocopherols or any of the 4 tocotrienols. And it goes without saying that it contains none of the policosanols that a natural vitamin E from wheat germ oil would likely contain.

As such, I wouldn't worry about that E blocking your K2 absorption. It's also a quite small amount in the milk. If you do a few drops of Kuinone, I believe they are 2mg per drop. If doing it topically, it will be absorbed via a different mechanism than the E you drink.

I should point out that these are educated guesses. I don't actually know that the absorption will be unaffected.

Thanks, good to know. . I use it on teeth and gums. I am certainly not looking to their d-mned added ADE for anything beneficial.

 

[Waynish]

Is the synthesis process for this public information? I realize most K on the market is created via bacteria - and then some form of purification process... Trying to find the relevant details. Thanks :)

 

[PopSocket]

.

 

[wtf]

Did I miss this somewhere.. Are the SFA esters in Kuinone known? Are these methyl esters?

 

[gabys225]

Any idea when this will be back in stock?