- Apr 30, 2015
Thank you!So, pyroglutamic acid actually has several names including 5-oxo-proline / 5-keto-proline. In other words, it is proline with an extra oxygen atom and Peat has written about the beneficial effects of proline along with those of glycine. I think the choice of name "pyroglutamic" is unfortunate as it confuses people. In reality, L-PGA seems to act like an antagonist to glutamate and seems to increase GABA signalling (where it is needed). The Wiki link in regards 5-HT2B antagonism mentions that. Another glutamate analog is the amino acid theanine and it is also known to antagonize glutamate and promote GABA.
Theanine - Wikipedia
Inosine may raise uric acid but human studies showed that only chronic daily doses of 3g or more led to elevations of uric acid beyond the acceptable range.
The only side effects I had when testing this was overstimulation and trouble sleeping, which is a known side effect of ATP administered through infusion. Hence, the design of the product to be used every other day instead of daily like the other products we have.