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acrylic

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Haidut - Can you provide a little more info on the safety of this substance? Especially in the doses in lapodin, potentiated by the DMSO?

Here's "title-ified" versions of the links.

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haidut

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Haidut - Can you provide a little more info on the safety of this substance? Especially in the doses in lapodin, potentiated by the DMSO?

Well, chemically it is very similar to lapachol which was tried as a cancer drug in the 1960s and 1970s and it ad great success but also showed some toxicity. Beta-lapachone was the result of a search for a derivative with the same benefits but no systemic toxicity. The only "toxicity" I know of is that it may thin the blood when used in very high doses, similar to aspirin and vitamin E. Other than that, it is supposed to be pretty safe. One of the studies I posted in the original thread showed reversal of aging in rats by increasing NAD levels and lower cortisol. The human trials with very high dose beta-lapachone for pancreatic cancer so far have found no systemic toxicity other than some mild GI upset.
 

burtlancast

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Here it says it's teratogenic in rats: Toxicological assessment of beta-lapachone on organs from pregnant and non-pregnant rats. - PubMed - NCBI

Naphthoquinones have been studied extensively due to their activity as topoisomerase inhibitors. These enzymes are critical to DNA replication in cells. beta-Lapachone (beta-lap) is an o-naphthoquinone chemically obtained from lapachol. This work results in a toxicological evaluation of beta-lap in Wistar rats observing the following parameters: teratology, histology, hematology and serum biochemistry. The data demonstrate teratogenic action at the doses used, as well as hematological alterations in the total leukocytes, monocytes and segmented. The biochemical data demonstrated an increase in gamma glutamyl transferase, alkaline phosphatase and glutamate pyruvate transaminase levels. Histological study showed significant alterations in the spleen, however, the liver and kidney did not present significant alterations.
 

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