Adrenaline
Member
- Joined
- Sep 9, 2019
- Messages
- 96
As you know catecholamines (adrenaline/noradrenaline) play important role for cancer growth.
But interesting part is Propranolol lowers expression like COX, VEGF, HIF-1, NO which Peat mentions.
I think not only catecholamines but also beta receptors plays important role for cancer. Because Propranolol doesn't lower adrenaline, it just blocks beta receptors and lower adrenaline's effects.
# Propranolol induces regression of hemangioma cells through HIF-1α-mediated inhibition of VEGF-A. - PubMed - NCBI
# Anti-tumor effects of propranolol: Adjuvant activity on a transplanted murine breast cancer model. - PubMed - NCBI
# Propranolol induces regression of hemangioma cells via the down-regulation of the PI3K/Akt/eNOS/VEGF pathway. - PubMed - NCBI
# Propranolol Suppresses Cobalt Chloride-Induced Hypoxic Proliferation in Human Umbilical Vein Endothelial Cells in vitro. - PubMed - NCBI
# Propranolol suppresses HUVEC viability, migration, VEGF expression, and promotes apoptosis by downregulation of miR-4295. - PubMed - NCBI
# Propranolol represses infantile hemangioma cell growth through the β2-adrenergic receptor in a HIF-1α-dependent manner. - PubMed - NCBI
# β-Adrenergic receptor antagonists inhibit vasculogenesis of embryonic stem cells by downregulation of nitric oxide generation and interference with V... - PubMed - NCBI
# Clinical efficacy of propranolol in the treatment of hemangioma and changes in serum VEGF, bFGF and MMP-9. - PubMed - NCBI
# The role of propranolol as a radiosensitizer in gastric cancer treatment. - PubMed - NCBI
# https://www.ncbi.nlm.nih.gov/m/pubmed/19946348
# https://www.ncbi.nlm.nih.gov/m/pubmed/19724861
# https://www.ncbi.nlm.nih.gov/m/pubmed/21042766
But interesting part is Propranolol lowers expression like COX, VEGF, HIF-1, NO which Peat mentions.
I think not only catecholamines but also beta receptors plays important role for cancer. Because Propranolol doesn't lower adrenaline, it just blocks beta receptors and lower adrenaline's effects.
# Propranolol induces regression of hemangioma cells through HIF-1α-mediated inhibition of VEGF-A. - PubMed - NCBI
# Anti-tumor effects of propranolol: Adjuvant activity on a transplanted murine breast cancer model. - PubMed - NCBI
# Propranolol induces regression of hemangioma cells via the down-regulation of the PI3K/Akt/eNOS/VEGF pathway. - PubMed - NCBI
# Propranolol Suppresses Cobalt Chloride-Induced Hypoxic Proliferation in Human Umbilical Vein Endothelial Cells in vitro. - PubMed - NCBI
# Propranolol suppresses HUVEC viability, migration, VEGF expression, and promotes apoptosis by downregulation of miR-4295. - PubMed - NCBI
# Propranolol represses infantile hemangioma cell growth through the β2-adrenergic receptor in a HIF-1α-dependent manner. - PubMed - NCBI
# β-Adrenergic receptor antagonists inhibit vasculogenesis of embryonic stem cells by downregulation of nitric oxide generation and interference with V... - PubMed - NCBI
# Clinical efficacy of propranolol in the treatment of hemangioma and changes in serum VEGF, bFGF and MMP-9. - PubMed - NCBI
# The role of propranolol as a radiosensitizer in gastric cancer treatment. - PubMed - NCBI
# https://www.ncbi.nlm.nih.gov/m/pubmed/19946348
# https://www.ncbi.nlm.nih.gov/m/pubmed/19724861
# https://www.ncbi.nlm.nih.gov/m/pubmed/21042766