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  1. haidut

    PUFA metabolite (prostaglandin) promotes lipolysis / fibrosis, causes obesity / diabetes

    Just in case there are still doubts out there about just how detrimental PUFA is to our health, here is a study showing that just one of PUFA's "normal" metabolites (i.e. enzymatically derived, instead of through peroxidation) is sufficient to elevate lipolysis, and that effect alone is enough...
  2. EnergeticLeo

    Can anyone help me find this study that Ray references?

    Ray talks about a group of women trying to lose weight who were found to be able to gain weight on even 700 calories a day, where the food was controlled in metabolic wards. He mentions it here, for example: View: https://youtu.be/yylOTFJFxko?t=1203 Does anyone know what study he's referring...
  3. haidut

    Low-dose niacinamide has striking anti-obesity effects

    It looks like the medical world has firmly set its sights on the bioenergetic wave/target, as the number of scientific papers focusing on niacinamide, NAD/NADH ratio and OXPHOS in general has been steadily climbing since 2010. That would be good news, despite the attempts of companies such as...
  4. JCastro

    Anti-Peat Fructose augments synthesis and release of free fatty acids and lactate

    Metabolic fate of fructose in human adipocytes: a targeted 13C tracer fate association study ”This study demonstrated that fructose stimulates anabolic processes in adipocytes robustly, including glutamate and de novo fatty acid synthesis. Furthermore, fructose also augments the release of free...
  5. D

    Im losing hope..

    I've been somewhat peating for a year now, now ill admit i don't go 100% but Ive drank a lot of milk and probably more OJ then ever, I've drank a lot of coffee, and its not working. I'm still fat as ****, I have a massive belly and it just never seems to go down. I feel like I need to either go...
  6. Green Dot

    HFCS Can Cause Obesity and Gut Microbial Changes

    Effects of HFCS on intestinal microbiota structure and obesity in mice In this study, the long-term intake of drinking water containing 30% HFCS caused significant increases in body weight, perirenal fat, epididymal fat (P = 0.001, P = 0.0009, P = 0.007, respectively), and liver fat percentage...
  7. :M :B.

    Ray Peat Interview Dr. Ray Peat, Brad Marshall on the History of PUFA and Obesity (Part 1). Show-Title: A Neighbor's Choice.

    View: https://rumble.com/v14myc7-dr.-ray-peat-brad-marshall-on-the-history-of-pufa-and-obesity-part-1.html
  8. haidut

    Endotoxin (LPS) drives obesity, diabetes and CVD in young people

    It looks like medicine is starting to change course on its attitude to endotoxin (LPS). After claiming that LPS is not an issue at all for any human with a functioning liver, a number of high profile studies have come out recently demonstrating chronic endotoxemia (even low-grade) is a causal...
  9. Sefton10

    Ray Peat Interview Ray Peat in panel discussion on obesity and PUFAs

    David Gornoski sits down with Dr. Cate Shanahan, Dr. Ray Peat, Tucker Goodrich, Brad Marshall, and Dr. Petro Dobromylskyj. The conversation revolves around the question of what causes obesity. What explains the correlation between seed oil consumption and rising obesity in America? If obesity is...
  10. haidut

    Lactate is a key driver of diabetes/obesity, by promoting inflammation

    A great study, demonstrating that in diabetes (just as in cancer) the so-called Warburg Effect (aerobic glycolysis) is as much a cause of those degenerative conditions as it is an effect of. The study below demonstrated that increased intracellular lactate results in robust increase in systemic...
  11. haidut

    Inhibiting lipolysis may treat diabetes

    Probably nothing surprising to my readers, but I think the study below is still important as it is one of the very few that openly state that diabetes is driven not by genetics but by excessive free fatty acids in the blood. While it does not mention it directly, the study is a great...
  12. 3

    An Econ Blog on Sugar and Obesity

    No big surprise for anyone here (except maybe the corn syrup aspect), but eating sugar is not closely correlated with obesity... https://marginalrevolution.com/marginalrevolution/2021/11/sugar-consumption.html
  13. haidut

    Endotoxin (LPS) as a cause of liver disease, obesity and diabetes

    The first article below is actually about praising fermented foods, which I don't really agree with. So, I am posting it mostly because of the quote on endotoxin/LPS, which is a very rare finding in published medical literature since medicine does not recognize chronic, low-grade endotoxemia as...
  14. haidut

    Cortisol causes fatty liver (as well as obesity, diabetes, etc)

    Not really a surprise for most of my readers, but it is always nice to see more evidence establishing various disorders attributed to "gluttony", "weak will", "addiction", etc as actual endocrine disturbances. And since the current study implicates cortisol, we can point the finger once again at...
  15. haidut

    DHEA causes fat-loss and improved glucose metabolism in humans

    Another study corroborating the role of DHEA as one of the "youth" hormones. A recent study already demonstrated that DHEA can reverse aging of the human immune system, which usually goes hand in hand with lower cortisol and improved metabolism. The proven anti-cortisol effects of DHEA are...
  16. haidut

    Almost half of obese adults are (metabolically) healthy

    A seemingly contradictory title, but only to people who are not aware of the so-called "obesity paradox". As I have mentioned in the past, usage of the word "paradox" usually implies a very inconvenient truth that threatens the profits of one or more branches of mainstream medicine. In this case...
  17. haidut

    Estrogens cause obesity / PCOS in women, DHT is protective

    Female obesity and the closely related condition PCOS are perhaps the female equivalent of the so-called "androgen hypothesis" for balding and prostate cancer in men, as the female version of this hypothesis not only blames androgens for these conditions but specifically singles out DHT as the...
  18. haidut

    Replacing starch with sucrose increases metabolism, prevent obesity

    A study that will certainly generate controversy in the low-carb blogosphere, but the findings are hard to dispute. Namely, feeding a diet for 15 weeks, in which 74.3% of the calories come from carbs in the form of starch was clearly obesogenic, caused insulin resistance and elevated blood...
  19. haidut

    Fasting ineffective for shrinking belly fat, may actually increase it

    Hopefully, this study will give some serious food for thought to people who use (intermittent) fasting (IF) with the goal of losing excess weight. A recent post of mine discussed that IF is ineffective for fat loss and actually leads to loss of lean mass. The lead author of that study, himself...
  20. haidut

    DHT better (and safer) than testosterone for improving blood pressure, insulin levels

    A great human study on the beneficial effects of androgens for a variety of metabolic biomarkers associated with insulin resistance and diabetes II. The only gripe I have with this study is that they claim it was conducted with "healthy" men when in reality all men had low plasma total...