obesity

  1. haidut

    Replacing starch with sucrose increases metabolism, prevent obesity

    A study that will certainly generate controversy in the low-carb blogosphere, but the findings are hard to dispute. Namely, feeding a diet for 15 weeks, in which 74.3% of the calories come from carbs in the form of starch was clearly obesogenic, caused insulin resistance and elevated blood...
  2. haidut

    Fasting ineffective for shrinking belly fat, may actually increase it

    Hopefully, this study will give some serious food for thought to people who use (intermittent) fasting (IF) with the goal of losing excess weight. A recent post of mine discussed that IF is ineffective for fat loss and actually leads to loss of lean mass. The lead author of that study, himself...
  3. haidut

    DHT better (and safer) than testosterone for improving blood pressure, insulin levels

    A great human study on the beneficial effects of androgens for a variety of metabolic biomarkers associated with insulin resistance and diabetes II. The only gripe I have with this study is that they claim it was conducted with "healthy" men when in reality all men had low plasma total...
  4. haidut

    Even mainstream medicine admits many claims about sugar are myths

    It is always nice to see when a outpost of mainstream medicine tries to set the record straight on something as controversial as refined sugar. My personal favorites are the myths on sugar and causal links to diabetes / cancer. Apparently, there is solid evidence those links are myths. Yet...
  5. charlie

    Thiamin Deficiency in People with Obesity

    Abstract Although obesity has been viewed traditionally as a disease of excess nutrition, evidence suggests that it may also be a disease of malnutrition. Specifically, thiamin deficiency was found in 15.5–29% of obese patients seeking bariatric surgery. It can present with vague signs and...
  6. haidut

    Stress (cortisol) as the driver of hyperglycemia in type II diabetes

    To most of my readers, the title of the post may seem like something completely obvious and not deserving explanation of clarification. However, according to mainstream medicine (until now, at least) cortisol does not really have a causative role either in the development of diabetes type II or...
  7. haidut

    Endotoxin (LPS) as a cause of systemic inflammation seen in obesity

    Yet another study implicating the great villain of systemic health - endotoxin / LPS. It is well-known that most people with obesity have high levels of inflammatory biomarkers both in their tissues and bloodstream. The study below demonstrates that the inflammation seen in adipose tissue of...
  8. Mauritio

    Low Dopamine D2 receptor density leads to obesity and insulin resistance , D2 agonism may treat

    These studies show that the Dopmine D2 receptors are strongly involved in obesity and insulin resistance . 1. (Brain dopamine and obesity - PubMed) "Striatal dopamine D2 receptor availability was significantly lower in the ten obese individuals (2.47 [SD 0.36]) than in controls (2.99 [0.41]...
  9. Hans

    The high sugar model did not prove to be a good model of obesity

    Excess sugar consumption doesn't necessarily make you fat, if you have sufficient nutrients to use the carbs. "but the daily caloric intake was higher in the HS group in relation to the C and HFHS groups (HS: 92 ± 2.0 vs. C: 79.2 ± 2.6 and HFHS: 77.3 ± 1.7 kcal/day, p < 0.05)." And yet...
  10. haidut

    Glycine (and leucine) can treat fatty liver (NAFLD and NASH)

    A great new study that demonstrates the strong protective effects of glycine, alone or in combination with leucine, on preventing/treating various forms of fatty liver disease, as well as the obesity that often accompanies these conditions. One of the strong points of the study is that it also...
  11. Tristan Loscha

    (EU) Committee for Medicinal Products for Human Use (CHMP) Assessment report: EnCyzix (Enclomifene)

    Treatment of hypogonadotropic hypogonadism (secondary hypogonadism) in adult men aged ≤60 years with a body mass index (BMI) ≥25 kg/m2 which has been confirmed by clinical features and biochemical tests in patients which have not responded to diet and exercise
  12. haidut

    Obesity "paradox" Strikes Again - Protection Against COVID-19

    I suspect this one will not go down will with the "lean is always good" crowd, which consists predominantly of members of the medical profession. Aside from all the health risks of obesity for pretty much any chronic disease, the news over the last 6 months have been replete with warning from...
  13. Hans

    The One Gut Bacterium You Have To Boost (and Here’s How)

    There is so much controversy over gut bacteria and if we should lower it or boost it or try to modulate it. Well, we have a gut microbiota whether we like it not, so we have to make the best of it. Lowering gut bacteria with antibiotics can be very helpful, but is rarely a long term solution...
  14. Drareg

    Obesity And COVID 19 Increased Risk Of Adverse Outcomes

    Most of the deaths from covid19 outside vulnerable groups were obese patients. This study is pretty damning, it seems this politically correct body positive PR campaign needs to stop, I’m not saying we need to shame people but we sure don’t need to glorify obesity. If governments genuinely...
  15. lvysaur

    Thymus Function: Higher In The Young/fat/female/Asian

    Population Distributions of Thymic Function in Adults: Variation by Sociodemographic Characteristics and Health Status http://www.self.gutenberg.org/articles/eng/mongoloid
  16. haidut

    Levothyroxine (T4) Monotherapy Often Ineffective For Hypothyroidism

    As most of my readers know, the currently approved therapy for hypothyroidism is levothyroxine (T4). While technically T3 and combined T4/T3 therapy are also approved by FDA, the former is only used in severe cases of myxedema and the latter is considered obsolete and a remnant of the days when...
  17. haidut

    PUFA Makes Girls Fat / Lazy / Diabetic And Exercise Futile

    Just a few minutes ago I made a post about PUFA (from nuts) increasing risk of diabetes. I just came across another very similar study below. It found that PUFA consumption, in both mice and humans, makes them fat and highly sedentary while also increasing their diabetes risk. MUFA and SFA had...
  18. haidut

    PUFA May Drive Obesity, Insulin Resistance, Liver Issues In Diabetes II Patients

    Yet another study where the message is clear - there is nothing "essential" about the PUFA we are bombarded with from all directions be that diet, medical interventions, household products, etc. What makes this study particularly relevant is that PUFA ingestion actually is promoted as one of the...
  19. Mauritio

    Serotonin Causes Obesity, Diabetes, Fibrosis,liver Damage ,increases Endotoxin And NO

    Inspired by this thread Serotonin/endotoxin/PUFA As Primary Causes Of Depression And Diabetes; Can Be Easily Blocked I was reading a few more recent studies on the detrimental effect of serotonin on ones health. It seems clear that by now it is known in medicine, that blocking it is highly...
  20. haidut

    Vitamin D Reduces Blood Sugar And Body Fat In Obese Women

    A neat study, albeit lasting much longer (about 1.5 years) than most other intervention studied with vitamin D. What makes this study particularly interesting is that it only used high doses vitamin D (60,000 IU once weekly) initially until blood levels rose into the normal range. It did not...
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