1. haidut

    Parkinson Disease (PD) akin to infectious disease - driven by endotoxin, damaged mitochondria

    Yet another study demonstrating that there is no need for genes or any other hereditary mechanism to explain the cause and development of PD. The study below demonstrated that the presence of damaged mitochondrial DNA in the bloodstream is sufficient to cause all symptoms of PD, and the effects...
  2. haidut

    Parkinson Disease (PD) is metabolic, of gut origin, progesterone to the rescue

    One of the most famous sayings in medicine since antiquity has been Hippocrates' quip that "all disease begins in the gut". Despite millennia that passed since that phrase was first uttered and countless "advances" in our knowledge of diseases, evidence continues to accumulate that the ancients...
  3. haidut

    Blocking endotoxin (TLR4) may prevent death from viral infections (COVID-19/ARDS)

    Almost a decade ago I posted about a "rogue" study which had the audacity to suggest that most of so-called viral infections (including HIV) produce most of their most severe symptoms not through the virus or its direct effects, but through synergism with the bacterial endotoxin (LPS) that we...
  4. haidut

    Dietary PUFA (linoleic acid) causes inflammatory bowel disease (IBD)

    The rates of IBD have truly skyrocketed over the last 10-15 years, significantly surpassing the general increase seen in most chronic conditions, especially in people younger than 40. Over the last couple of years, I posted about studies showing artificial colors (e.g. Red 40), silicon dioxide...
  5. Outdoctrination

    How serotonin is the primary driver of digestive problems (and how to address it)

    I had absolutely debilitating digestive problems for years. I went to all of the “top GI docs'' and they had NO answers. They said we don’t know what’s wrong with you. One even told me it was all in my head. Take pill, drink water, eat fiber, take probiotics, etc. I was furious. I even tried...
  6. J


    Can anyone tell me if lipopolysaccharide (LPS) is simply a biofilm? If we destroy the biofilm, does that take care of the LPS toxin?
  7. Mauritio

    Rheumatoid Arthritis patients have higher serotonin and cortisol levels

    In this study they looke at some blood markers in patients with RA. As it turns out they have slighlty higher cortisol and way higher serotonin: their serotonin level was 3 times higher! Their melatonin level was a lot lower than that of the control group, which indicates less downstream...
  8. haidut

    Media: Endotoxin (LPS) drives obesity/diabetes

    I did not think we will ever see such a headline in a major news outlet, but here is is. And in The Guardian of all places, which is a newspaper that rarely deviates from the official medical narrative on any condition, especially obesity and diabetes. The official narrative for those conditions...
  9. haidut

    Vitamin E may prevent, treat rheumatoid arthritis (RA) by restoring the gut barrier

    This is one of those studies where the most important finding is not directly stated, but implied. Namely, if healing the gut barrier, as the study says, may prevent/treat RA then the condition is most likely tied to the microbiome in our GI tract. More specifically, to the byproducts of the...
  10. haidut

    Endotoxin, cold, flue increase risk of dementia

    I am posting this study not so much because of the link between chronic low-grade inflammation and neurological conditions it demonstrates. That link is by now well-known even in mainstream medical circles. The main reason this study/article caught by eye is that the experiment mimicked the...
  11. Limon9

    Falcarinol (Carrot) Is Protective Against Endotoxin (LPS)

    Anyone familiar with Dr. Peat's writings about carbon monoxide should stop and consider the effect on heme-oxygenase here. By acting as cytotoxins, plant compounds have numerous and ostensibly conflicting effects, even if the net effect is beneficial. The results of this study are positive, and...
  12. B

    Aspirin in the context of Endotoxin Tolerance

    Summary of studies: Endotoxin tolerance (ET) is a reduced responsiveness to a LPS challenge following a first encounter with endotoxin. Chronically, this may lead to local or systemic immunosuppression. Despite ongoing low-grade tissue irritation, only a blunted immune response is mounted. On...
  13. haidut

    Serum endotoxin level is a reliable biomarker of liver disease

    It looks like the interest in gut-derived pathogenic substances is steadily increasing in the medical field. After claiming for decades (and still doing so) that liver disease is either genetic in origin or driven mostly by sugar (especially fructose) consumption, now studies like the one below...
  14. haidut

    Niacinamide fully reverses endotoxemia and leaky gut (from ethanol)

    The study below is a true gem due to both its broadness of impact, as well as the ease and low-cost of the therapeutic intervention it studied. Chronic endotoxemia, a cause and a result of increased gut permeability (aka "leaky gut") is now known to be a major cause of virtually all chronic...
  15. T

    Activated Charcoal With Probiotic Encapsulation

    Many probiotics today are formulated with specific capsules or coating designed to make it into the colon unscathed. Being that one of the major downsides from consistent activated charcoal use is that it will also bind to "good" nutrients in our small intestine, could we negate these downsides...
  16. Limon9

    MTOR Activates Warburg Effect From Endotoxin

    As Dr. Peat referred to in his newsletters, it's no surprise that a cell-proliferative enzyme activates aerobic glycolysis. Oxidative energy production is halted so the cells may regress to a primitive growth-state. Inhibiting either mTOR or the glycolytic enzyme it upregulated was sufficient to...
  17. Mauritio

    Nicotine, pro- or anti-inflammatory ?

    Nicotine seems to have pro- and anti-inflammatory effects. Its increase in COX2 would be pro inflammatory. On the other hand nicotine has some interesting anti-endotoxin effects, with endotoxin beeing one the biggest promoters of inflammation in the body. This study suggests 2 mechanisms of...
  18. Limon9

    Endotoxin (LPS) suppresses "anti-aging protein" Klotho

    Molecular cloning of rat klotho cDNA: markedly decreased expression of klotho by acute inflammatory stress Biochem Biophys Res Commun. 1998 Oct 29;251(3):920-5. Ohyama Y et al. "We have recently identified a novel gene, termed klotho, that is involved in the suppression of several aging...
  19. NewACC

    Serotonin antagonists fail to prevent endotoxin lethality in healthy mice

    https://www.karger.com/Article/Abstract/162500 Very scary article. I'd be glad if @haidut and @Hans commented it
  20. haidut

    Endotoxin (LPS) - a reliable biomarker of cardiovascular disease (CVD)

    It looks like more and more medical groups are waking up to the important role LPS plays in many chronic diseases. In the body, LPS is transported back to the liver for processing/excretion by the so-called lipopolysaccharide binding protein (LBP) and by measuring serum levels of LBP, one can...