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  1. haidut

    Another "paradox" - glucocorticoids cause inflammation, insulin blocks it

    As many of my readers know, I am not a fan of the ubiquitous usage of both bioidentical and synthetic glucocorticoids (GC) in medicine. Once used only in the most severe cases, some form of GC therapy awaits virtually all patients in a hospital (regardless of condition), and doctors are now...
  2. haidut

    Endotoxin (LPS) causes Alzheimer Disease (AD)

    I have made posts on this topic in the past, but it seems this most recent study directly states that endotoxin/LPS is a major cause of AD. All other studies have been either animal models or did not directly implicate LPS. The study below claims to be the first that integrates all available...
  3. Mauritio

    Sodium Butyrate leads to weight loss and less inflammation/endotoxin

    Very interesting study on Sodium Butyrate and weight loss/inflammation. The researchers fed mice a high fat diet(HFD) and gave some of them Sodium butyrate (I think it was 5% of the diet) as a supplement. Not only did the butyrate +HFD-mice weigh less (~20%) than the HFD-mice, they weighed...
  4. E

    Bag breathing curiosity

    Greetings All, I have an interesting situation that I’m wanting to run by you fine folks who have frequently helped me on my path to wellness. As some may know, I had dermatitis for about ten years before curing it in the last year or so with activated charcoal. Since doing so I’ve been...
  5. NewACC

    Agmatine Is Wonder Drug (Endotoxins, Endorphins, Adrenaline, NO)

    As you can know agmatine is very interesting peaty chemical, but steel I want to show you some interesting and maybe less known articles Anti-endotoxin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923203/ "...agmatine treatment inhibited LPS-induced production of nitrates dose dependently. As...
  6. Hans

    Should “inflammatory” testosterone-boosting saturated fat be avoided since it increases endotoxin

    https://men-elite.com/2022/05/17/should-inflammatory-testosterone-boosting-saturated-fat-be-avoided-since-it-increases-endotoxin/ If saturated fat is good for testosterone but endotoxin bad, how can saturated fat be good if it enhances the absorption of endotoxin and causes inflammation?
  7. Green Dot

    HFCS Can Cause Obesity and Gut Microbial Changes

    Effects of HFCS on intestinal microbiota structure and obesity in mice In this study, the long-term intake of drinking water containing 30% HFCS caused significant increases in body weight, perirenal fat, epididymal fat (P = 0.001, P = 0.0009, P = 0.007, respectively), and liver fat percentage...
  8. haidut

    Blocking endotoxin may reverse cognitive decline of aging

    Another study implicating endotoxin (LPS) and its associated receptor (TLR4) in a phenotype of aging considered "normal" by mainstream medicine, though it almost universally progresses into dementia territory with advancing age, to the point where 90%+ of people over 85 have at least moderate...
  9. haidut

    Endotoxin (LPS) drives obesity, diabetes and CVD in young people

    It looks like medicine is starting to change course on its attitude to endotoxin (LPS). After claiming that LPS is not an issue at all for any human with a functioning liver, a number of high profile studies have come out recently demonstrating chronic endotoxemia (even low-grade) is a causal...
  10. miquelangeles

    Baked carrot salad more effective than raw?

  11. haidut

    Cancer cells deprive immune cells of energy by devouring their mitochondria

    In a description that could be a good plot for a horror-movie, the study below demonstrates that the immune failure often seen in cancer is, again, bioenergetic in origin. More specifically, the immune system cells are getting literally the energy (i.e. mitochondria) sucked out of them by cancer...
  12. Kvothe

    Anti-Peat Compared to soybean oil and olive oil coconut oil results in endotoxemia and fatty liver

    Consumption of soybean or olive oil at recommended concentrations increased the intestinal microbiota diversity and insulin sensitivity and prevented fatty liver compared to the effects of coconut oil Author links open overlay panelValeriaLópez-Salazarab1 Mónica...
  13. A

    The homeoviscous adaptation to dietary lipids (HADL) model explains controversies over saturated fat, cholesterol, and cardiovascular disease risk

    SFAs play the leading role in 1 of the greatest controversies in nutrition science. Relative to PUFAs, SFAs generally increase circulating concentrations of LDL cholesterol, a risk factor for atherosclerotic cardiovascular disease (ASCVD). However, the purpose of regulatory mechanisms that...
  14. haidut

    Endotoxin (LPS) may directly cause cancerization of normal cells

    A very interesting new study, which confirms the direct causal role LPS has in chronic inflammatory diseases, and especially in cancer. In addition, the study may answer one of the long-standing critiques the medical establishment has always had against the hypothesis that LPS causes cancer (and...
  15. Mauritio

    1 dose of endotoxin causes endothelial dysfunction for up to 1 week

    In this study they injected endotoxin into the hand of healthy volunteers. As it turned out, one dose of endotoxin lead to persistent constriction of the blood vessel that took up to 1 week to recover! There's molecules like nitric oxide, serotonin , bradikinin ,arachidonic acid or CO2 that...
  16. haidut

    PUFA required for periodontal disease, aspirin may help

    It is common knowledge even among mainstream dentists that periodontal disease is caused by bacteria accumulating under the gums, which over time leads to chronic inflammation and thus destruction of both gum tissue and the alveolar/jaw bone underneath the gums. Another "new" discover is that...
  17. haidut

    Endotoxin (LPS) causes rheumatoid arthritis...and COVID-19

    A great new study, which is perhaps the first to directly point the finger at endotoxin as perhaps the main cause of rheumatoid arthritis (RA). RA is an "autoimmune" condition and not only shares symptoms with other similar conditions such as Lupus, psoriasis, MS, etc, but now all of them are...
  18. RenaissanceMan

    Oral spore-based probiotic supplementation was associated with 42% reduction of post-meal dietary endotoxin

    https://pubmed.ncbi.nlm.nih.gov/28868181/ AIM To determine if 30-d of oral spore-based probiotic supplementation could reduce dietary endotoxemia. METHODS Apparently healthy men and women (n = 75) were screened for post-prandial dietary endotoxemia. Subjects whose serum endotoxin concentration...
  19. 'peataphysique

    Childhood dementia claiming young lives | A Current Affair

  20. RenaissanceMan

    Theanine Ameliorates Neuroinflammation And Protects Against Endotoxin-Induced Inflammation and Acute Liver Injury

    https://pubmed.ncbi.nlm.nih.gov/29969892/ Theanine, a unique bioactive constituent from tea ( Camellia sinensis) leaves, is widely used as a functional ingredient and dietary supplement. To evaluate the anti-inflammatory and hepatoprotective effects of theanine and its molecular mechanism, the...