endotoxin

  1. Mauritio

    Nicotine, pro- or anti-inflammatory ?

    Nicotine seems to have pro- and anti-inflammatory effects. Its increase in COX2 would be pro inflammatory. On the other hand nicotine has some interesting anti-endotoxin effects, with endotoxin beeing one the biggest promoters of inflammation in the body. This study suggests 2 mechanisms of...
  2. Limon9

    Endotoxin (LPS) suppresses "anti-aging protein" Klotho

    Molecular cloning of rat klotho cDNA: markedly decreased expression of klotho by acute inflammatory stress Biochem Biophys Res Commun. 1998 Oct 29;251(3):920-5. Ohyama Y et al. "We have recently identified a novel gene, termed klotho, that is involved in the suppression of several aging...
  3. NewACC

    Serotonin antagonists fail to prevent endotoxin lethality in healthy mice

    https://www.karger.com/Article/Abstract/162500 Very scary article. I'd be glad if @haidut and @Hans commented it
  4. haidut

    Endotoxin (LPS) - a reliable biomarker of cardiovascular disease (CVD)

    It looks like more and more medical groups are waking up to the important role LPS plays in many chronic diseases. In the body, LPS is transported back to the liver for processing/excretion by the so-called lipopolysaccharide binding protein (LBP) and by measuring serum levels of LBP, one can...
  5. haidut

    Endotoxin (LPS) may drive kidney damage in diabetes type II

    Not much of a news, but I like adding to the, already big, pile of evidence that endotoxin/LPS is a major causal factor in virtually all chronic conditions that continue to mystify medicine. Since the study below mentions the compromised intestinal barrier in diabetes patients, interventions...
    • haidut
    • Thread
    • ckd diabetes endotoxin gut barrier kidney damage lps microalbumineria tlr4
    • Replies: 3
    • Forum: Scientific Studies
  6. cs3000

    TDCA bile acid protects gut against lipopolysaccharide (LPS) endotoxin from bacteria

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904360/ "Dietary TDCA supplementation alleviates mucosal damage and improves survival after LPS-induced intestinal injury. Taurodeoxycholic acid is protective of the intestinal mucosa by increasing resistance to injury-induced apoptosis...
    • cs3000
    • Thread
    • bacteria bile acid endotoxin gut lps tdca
    • Replies: 1
    • Forum: Digestion
  7. haidut

    Another "paradox" - glucocorticoids cause inflammation, insulin blocks it

    As many of my readers know, I am not a fan of the ubiquitous usage of both bioidentical and synthetic glucocorticoids (GC) in medicine. Once used only in the most severe cases, some form of GC therapy awaits virtually all patients in a hospital (regardless of condition), and doctors are now...
    • haidut
    • Thread
    • cortisol endotoxin glucocorticoid inflammation insulin lps tlr tlr4
    • Replies: 4
    • Forum: Scientific Studies
  8. haidut

    Endotoxin (LPS) causes Alzheimer Disease (AD)

    I have made posts on this topic in the past, but it seems this most recent study directly states that endotoxin/LPS is a major cause of AD. All other studies have been either animal models or did not directly implicate LPS. The study below claims to be the first that integrates all available...
    • haidut
    • Thread
    • alzheimer dementia endotoxin fiber inflammation lps tlr4
    • Replies: 6
    • Forum: Scientific Studies
  9. Mauritio

    Sodium Butyrate leads to weight loss and less inflammation/endotoxin

    Very interesting study on Sodium Butyrate and weight loss/inflammation. The researchers fed mice a high fat diet(HFD) and gave some of them Sodium butyrate (I think it was 5% of the diet) as a supplement. Not only did the butyrate +HFD-mice weigh less (~20%) than the HFD-mice, they weighed...
  10. E

    Bag breathing curiosity

    Greetings All, I have an interesting situation that I’m wanting to run by you fine folks who have frequently helped me on my path to wellness. As some may know, I had dermatitis for about ten years before curing it in the last year or so with activated charcoal. Since doing so I’ve been...
  11. NewACC

    Agmatine Is Wonder Drug (Endotoxins, Endorphins, Adrenaline, NO)

    As you can know agmatine is very interesting peaty chemical, but steel I want to show you some interesting and maybe less known articles Anti-endotoxin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923203/ "...agmatine treatment inhibited LPS-induced production of nitrates dose dependently. As...
    • NewACC
    • Thread
    • addiction agmatine alcohol addiction depression endorphins endotoxin lithium nitric oxide opioids
    • Replies: 3
    • Forum: Scientific Studies
  12. Green Dot

    HFCS Can Cause Obesity and Gut Microbial Changes

    Effects of HFCS on intestinal microbiota structure and obesity in mice In this study, the long-term intake of drinking water containing 30% HFCS caused significant increases in body weight, perirenal fat, epididymal fat (P = 0.001, P = 0.0009, P = 0.007, respectively), and liver fat percentage...
  13. haidut

    Blocking endotoxin may reverse cognitive decline of aging

    Another study implicating endotoxin (LPS) and its associated receptor (TLR4) in a phenotype of aging considered "normal" by mainstream medicine, though it almost universally progresses into dementia territory with advancing age, to the point where 90%+ of people over 85 have at least moderate...
    • haidut
    • Thread
    • brain cognitive dementia endotoxin inflammation lps memory tlr4
    • Replies: 5
    • Forum: Scientific Studies
  14. haidut

    Endotoxin (LPS) drives obesity, diabetes and CVD in young people

    It looks like medicine is starting to change course on its attitude to endotoxin (LPS). After claiming that LPS is not an issue at all for any human with a functioning liver, a number of high profile studies have come out recently demonstrating chronic endotoxemia (even low-grade) is a causal...
  15. miquelangeles

    Baked carrot salad more effective than raw?

    SORPTION OF BILE ACIDS AND CHOLESTEROL BY DIETARY FIBER OF CARROTS, CABBAGE AND APPLES http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.459.4177&rep=rep1&type=pdf
  16. haidut

    Cancer cells deprive immune cells of energy by devouring their mitochondria

    In a description that could be a good plot for a horror-movie, the study below demonstrates that the immune failure often seen in cancer is, again, bioenergetic in origin. More specifically, the immune system cells are getting literally the energy (i.e. mitochondria) sucked out of them by cancer...
    • haidut
    • Thread
    • cancer cell endotoxin estrogen immune invadopodia lps mitochondria oxphos phagocytosis
    • Replies: 1
    • Forum: Scientific Studies
  17. Kvothe

    Compared to soybean oil and olive oil coconut oil results in endotoxemia and fatty liver

    Consumption of soybean or olive oil at recommended concentrations increased the intestinal microbiota diversity and insulin sensitivity and prevented fatty liver compared to the effects of coconut oil Author links open overlay panelValeriaLópez-Salazarab1 Mónica...
    • Kvothe
    • Thread
    • coconut oil endotoxin soybean oil tlr4
    • Replies: 23
    • Forum: Debate
  18. A

    The homeoviscous adaptation to dietary lipids (HADL) model explains controversies over saturated fat, cholesterol, and cardiovascular disease risk

    SFAs play the leading role in 1 of the greatest controversies in nutrition science. Relative to PUFAs, SFAs generally increase circulating concentrations of LDL cholesterol, a risk factor for atherosclerotic cardiovascular disease (ASCVD). However, the purpose of regulatory mechanisms that...
  19. haidut

    Endotoxin (LPS) may directly cause cancerization of normal cells

    A very interesting new study, which confirms the direct causal role LPS has in chronic inflammatory diseases, and especially in cancer. In addition, the study may answer one of the long-standing critiques the medical establishment has always had against the hypothesis that LPS causes cancer (and...
    • haidut
    • Thread
    • cancer cancerization chronic endotoxin inflammation low-grade lps tlr4
    • Replies: 2
    • Forum: Scientific Studies
  20. Mauritio

    1 dose of endotoxin causes endothelial dysfunction for up to 1 week

    In this study they injected endotoxin into the hand of healthy volunteers. As it turned out, one dose of endotoxin lead to persistent constriction of the blood vessel that took up to 1 week to recover! There's molecules like nitric oxide, serotonin , bradikinin ,arachidonic acid or CO2 that...
    • Mauritio
    • Thread
    • blood vessels endothelial dysfunction endotoxin nitric oxide no
    • Replies: 8
    • Forum: Scientific Studies
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