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  1. haidut

    COVID-19 is a serotonin-dependent disease

    As the COVID-19 pandemic spread all over the world in early 2020, some of the earliest studies identified serotonin (5-HT) as a culprit in the severity of the disease and proposed using 5-HT antagonists such as cyproheptadine as treatment. Other studies found by accident that the anti-acid drug...
  2. haidut

    Progesterone, bromocriptine may treat autism

    A great new study, which, while genomic in character, inadvertently points the finger directly at estrogen and/or serotonin as causes of autism. After all progesterone's main role in the human organism is as an estrogen (and cortisol!) antagonist, while bromocriptine is one of the oldest...
  3. haidut

    Serotonin enhances learning from punishment, reduces learning from reward

    Research as early as the 1960s firmly established that there is nothing "happy" when it comes to serotonin (5-HT). Namely, elevated 5-HT levels were found in many chronic diseases and especially clinical depression. It took more than 7 decades for medicine to finally start admitting that 5-HT is...
  4. NewACC

    Platelet Serotonin Uptake Sites Increased in Drinkers of Ayahuasca

    https://pubmed.ncbi.nlm.nih.gov/7892432/ "An increased number of binding sites (Bmax) in the platelets of ayahuasca drinkers was found, while the dissociation constant (Kd) remained the same for both group."
  5. C

    Does Theanine actually agonize GABA receptors / increase GABA? +Serotonin

    I've seen some people concerned with GABA rebound effects from l-theanine due to effects on increasing GABA. Theanine is commonly mentioned as a gaba agonist. 1. Does it actually have significant effects on GABA that would lead to rebound? 2. Would a daily gram amounts be safe for potential...
  6. haidut

    SSRI use during pregnancy increase risk of neonatal seizures/epilepsy

    So much for "safe and effective during pregnancy"...I shudder at the thought of how many women get talked into using SSRI during pregnancy without even having depression. You know, just in case they MIGHT get postpartum depression. https://n.neurology.org/content/neurology/98/23/e2329.full.pdf...
  7. NewACC

    Aspirin Cause Antiserotonine Effect Only At Low Doses (My Vision of the Non-Linear Dose-Dependent Antiserotonin Effect of Aspirin)

    Dear peats! As you all know, serotonin has a direct aggregative coagulant effect through the 5-ht2 family of receptors. And so, aspirin has the strongest antiplatelet effect at doses below 325 mg. We also know that aspirin has the most potent beneficial effect on tyrosine hydroxylase at a...
  8. NewACC

    My Vision of the Non-Linear Dose-Dependent Antiserotonin Effect of Aspirin

    Dear peats! As you all know, serotonin has a direct aggregative coagulant effect through the 5-ht2 family of receptors. And so, aspirin has the strongest antiplatelet effect at doses below 325 mg. We also know that aspirin has the most potent beneficial effect on tyrosine hydroxylase at a...
  9. haidut

    BOMBSHELL: Serotonin High in Depression, Not a "Happy" Chemical, Lowers Energy, Depression Self-Resolves

    When I first saw the article pop up in my feed, I could hardly believe my eyes that a mainstream mouthpiece of Big Pharma will publish such frank admission of psychiatry's utter failure - i.e. the claims in regards to serotonin (5-HT), its role in mental illness, and even its social "label". In...
  10. haidut

    Just a week-long break from social media alleviates anxiety and depression

    I don't think this study will come as a surprise to my readers, but it still helps to have some peer-reviewed evidence confirming what many people intuitively sense, yet are afraid to verbalize due to FOMO or being ostracized - i.e. social media, and digitization in general, is a bane on human...
  11. Hans

    Shilajit on testosterone, dopamine and sexual function

    https://men-elite.com/2022/05/13/shilajit-on-testosterone-dopamine-and-sexual-function/ What has been your experience with shilajit?
  12. haidut

    Dopamine agonists can treat anhedonia

    The title may sound obvious to many, but this study is one of the few to bring up the taboo topic of serotonin's role in symptoms of depression. The current dogma still holds that raising serotonin levels (or activating its receptors) is the most beneficial mechanism to treating depression and...
  13. tastyfood

    What number do you aim for when you test blood serotonin?

    I've been testing blood serotonin occasionally. Six months ago I was at 199 ng/mL. The lab range is 21-321. Two weeks ago I tested 148. The main differences I introduced were taking fewer oral supplements, and eating 1/3 a cup of oat bran every morning which has been really helpful for bowel...
  14. haidut

    Quinine - liquid product for R&D

    Just a placeholder thread for now, until I organize all the references I think would be interesting/relevant to post here. For now, a quote from Peat on a recent interview about quinine and inflammation/ACE2, a very long thread/discussion in regards to quinine's anti-serotonin effects, and some...
  15. haidut

    Cyproheptadine (12mg daily) cures patient's metastatic liver cancer in just 2 weeks

    A truly shocking case study, which demonstrates once again how even terminal disease are often curable with cheap, safe, and widely available compounds that have long ago been written off as "obsolete" by mainstream medicine. More importantly, the case study highlights the core role metabolism...
  16. Grouptose

    Serotonin causes autism

    I really don't know what it is, but every single serotonergic substance or medication I have ever tried turned me into either an aspie, or a complete autist. It all started back in 2017 when I had insomnia, I was a pretty normal person but had trouble sleeping, a doctor prescribed melatonin...
  17. haidut

    Blocking serotonin may treat leukemia and other blood cancers

    Yet another cancer is revealed to be metabolic of origin and potentially treatable with cheap and widely available anti-serotonin chemicals (e.g. Benadryl, cyproheptadine, the ergot derivatives, etc). Conversely, the study raises serious questions in regards to whether the explosion in blood...
  18. C

    Need some help with SSRI/Faverin Withdrawal

    So my friend's younger sister has been prescribed faverin and other SSRIs for her BPD, and after 4 months and increasingly depressive behaviour and suicidal ideation(she was tired all the time, felt like she "needed" to kill herself jumping off a roof, amongst other deeply concerning symptons)...
  19. A

    Charles Darwin’s Mitochondrial Disorder: Possible Neuroendocrine Involvement

    Abstract Charles Darwin, the famous naturalist, suffered relapsing, debilitating illness for most of his adult life with a plethora of symptoms. The diagnosis favoured here for this illness is that of an adult-onset mitochondrial disorder due to a maternally inherited, pathological mitochondrial...
  20. JamesGatz

    Is low serotonin always associated with higher social status ? Throughout the animal kingdom there seems to be conflicting ideas

    I was reading through an older thread on the forum and saw a user say something along the lines of serotonergic chimpanzees being the leaders of their group ? I am not sure what to think because from what I notice in people - low-serotonin attitudes seems to always imply higher social status...