serotonin

One of the most persistent medical myths can be found in psychiatry. More specifically, in the category of psychotic mental disorders. Schizophrenia is perhaps the most widely studied representative of such conditions and the prevailing dogma/hypothesis about schizophrenia (and other psychotic...

I decided to go over all of the organic acids tests (OAT) I've run in the past on my clients to see if I could find correlations between 5-HIAA and poorer health status at the time of sample collection, and low and behold I saw this: 5-HIAA, the serotonin metabolite is more than 3x higher...

This is one of the studies that Big Pharma will probably spend a lot of money on trying to get retracted. It directly demonstrates that elevated serotonin (5-HT) in the brain drives brain atrophy and depression. Both the rates and severity of these conditions increase with aging and the study...

I've been struggling with this concept in my head given my own experience with dramatically improved mood with antibiotics which lower gut serotonin. The official narrative has been and continues to be that gut serotonin and brain serotonin are completely separate and that serotonin itself does...

I had absolutely debilitating digestive problems for years. I went to all of the “top GI docs'' and they had NO answers. They said we don’t know what’s wrong with you. One even told me it was all in my head. Take pill, drink water, eat fiber, take probiotics, etc. I was furious. I even tried...

In this study they looke at some blood markers in patients with RA. As it turns out they have slighlty higher cortisol and way higher serotonin: their serotonin level was 3 times higher! Their melatonin level was a lot lower than that of the control group, which indicates less downstream...

Unbeknownst to most people, psychiatry has started to make a quiet "paradigm shift" in regards to psychotic conditions such as schizophrenia. Namely, after claiming for decades that psychotic states are caused by excessive dopamine levels/activity, psychiatry has now quietly change the official...

Yet another chronic and debilitating condition may turn out to have a surprisingly cheap, widely available, and safe solution. Namely, vitamin D. In pharma research, a new drug that demonstrates effectiveness for a specific condition of just 20% over a placebo group is considered a very solid...

I did an amino acid test recently and was found to be high in Glutamate. This explains why I used to get excitotoxic symptoms (Panic, OCD, Anger, Migraine, sometimes suicidal thoughts) after eating specific foods like Shitake and Button Mushrooms, any cheese, Potatoes, Bone Broth, All seafood...

https://doi.org/10.1007/bf00497017 "The administration of 14 daily doses of cyproheptadine, BC-105, metergoline and methysergide induced a marked decrease in the number (B max) of 3H-spiroperidol binding sites (5HT2 sites) in frontal cortex, when assayed 48 h after the last dose; the apparent...

A trait of highly successful people is to choose a bigger long-term reward over a smaller short-term reward. The ability control your emotions and impulses. A process known as delayed gratification. The study explains the issue, instant gratification, like this: "...the preference for an...

Can anyone help me understand?

The findings of the study are not surprising, but I wanted to post it on the blog since it is one of the few studies I have seen that examined more than one of the "sickness" mediator levels in a major chronic conditions such as cardiovascular disease (CVD), and found all of them to be elevated...

https://doi.org/10.1016/0014-2999(74)90202-7 Abstract "...Cyproheptadine and LSD, two known antagonists of the peripheral effects of 5-HT, were administered i.v. to conscious rabbits at different times before the intracerebroventricular (i.c.v.) administration of 5-HT, NAD or dopamine...

The role of serotonin in fibrotic conditions is well-known in research circles but is a taboo topic in medicine. Perhaps the best example of this bipolar (and potentially criminal) attitude is the fact that Pfizer sells billions of dollars worth its SSRI drugs Zoloft and Pristiq, yet at the same...

More than a quarter of all military/veteran personnel are estimated to have some form/level of PTSD, regardless of whether those soldiers have seen combat or not (e.g. Coast Guard members also have high rates of PTSD). Despite the obvious link to severe stress, medicine continues to claim that...

We have been discussing surprisingly versatile and, at the same time, strong antiviral properties on this forum for a long time. And now the latest research shows that cyproheptadine is already effective against swine fever. I'm pretty busy so I can't elaborate on that. Maybe @haidut and @Hans...

It seems that consuming pure egg white will indeed make you stupid enough to consume pure egg white. Key Points - Calorie restriction improves mental test performance in mice. - Adding tryptophan into calorie-restricted diet abolished memory benefits. - Giving C.R. mice the serotonergic drug...

In the following thread a girl is talking about her "multiple personality disorder". She is saying basically that she was diagnosed depressive at the age of 8 and then suffered from "malnutrition". Later on, she was diagnosed with multiple personality disorder. And now she is pointing that one...

The rats who ate 50g/kg sucrose for 2 weeks had significantly higher hippocampal serotonin and a more potent response to the serotonergic drug fenfluramine, all compared to rats who ate 50g/kg starch for 2 weeks. The starch group had longer-lasting serotoninergic effects, but the sucrose group...