serotonin

  1. JCastro

    Sucrose raises brain serotonin significantly more than starch in rat study

    The rats who ate 50g/kg sucrose for 2 weeks had significantly higher hippocampal serotonin and a more potent response to the serotonergic drug fenfluramine, all compared to rats who ate 50g/kg starch for 2 weeks. The starch group had longer-lasting serotoninergic effects, but the sucrose group...
    • JCastro
    • Thread
    • carbohydrate scientific study serotonin starch study sugar
    • Replies: 3
    • Forum: Debate
  2. haidut

    SSRI drug use during pregnancy linked (again) to autism

    I don't think the topic needs much of an introduction. At this point, the only people who deny the causal link between SSRI use by pregnant or soon-to-become pregnant women and autism in their children are either pharma employees...or doctors who receive so much money from pharma companies to...
    • haidut
    • Thread
    • 5-ht autism autoimmunity inflammation prozac serotonin sert ssri
    • Replies: 2
    • Forum: Scientific Studies
  3. haidut

    Ubiquitous food dye causes inflammatory bowel disease (IBD)...by increasing serotonin

    It is rare these days to get a so-called "one-two punch" study. Namely, a study that not only discovers that instead of a genetic (medicine's favorite) there is a purely environmental (and man-made at that) cause of yet another chronic, degenerative conditions medicine considers incurable, but...
    • haidut
    • Thread
    • 5-ht colitis crohn’s diet dye ibd inflammation serotonin ulcerative
    • Replies: 16
    • Forum: Scientific Studies
  4. haidut

    Finasteride causes gut inflammation, high serotonin, low dopamine; allopregnanolone may treat

    A great new study, which goes a long way towards explaining the dreaded post-finasteride syndrome (PFS). Currently, medicine does not recognize PFS as a formal disease and in fact attempts to gaslight the patients with PFS into believing they are simply mentally ill and in need of SSRI drugs...
    • haidut
    • Thread
    • allopregnanolone colon dopamine finasteride gut inflammation pfs serotonin
    • Replies: 1
    • Forum: Scientific Studies
  5. haidut

    Serotonin (5-HT) drives fear and conditions such as anxiety/PTSD

    Conversely, blocking 5-HT or lowering its synthesis can probably cure most fear-based conditions such as generalized anxiety disorder (GAD), PTSD, psychotic conditions (e.g. schizophrenia), etc. At least, those are the findings of the study below, which demonstrated that animals completely...
  6. haidut

    Blocking serotonin, promoting dopamine may reverse cardiovascular disease (CVD)

    The claim in the title stems from the fact that bromocriptine - the drug used in the study below - is an approximate 5-HT antagonist while also being full agonist on several dopamine receptors. IMO, the study is a monumental success since CVD is largely considered a progressive condition, for...
    • haidut
    • Thread
    • blood pressure bromocriptine calcification cvd diabetes dopamine serotonin stiffness
    • Replies: 4
    • Forum: Scientific Studies
  7. Hans

    Testosterone and impulsivity; what's really the culprit

    https://men-elite.com/2022/12/06/testosterone-and-impulsivity-whats-really-the-culprit/ Surprise surprise, it's estrogen and serotonin.
  8. tastyfood

    LabCorp lowers Serotonin upper limit from 321 ng/mL to 207 ng/mL

    LabCorp lowered the upper limit for blood serotonin, which I find surprising, knowing the trend is to make the ranges bigger. Proof of the change from a recent test: @haidut is this a rare case of a lab like LabCorp lowering the upper limit for one of the harmful hormones by so much?
  9. Sapien

    How to decrease systemic serotonin induced by weightlifting?

    Young male seeking to build muscle not only for aesthetic purposes but also it’s ability to increase metabolism :) After a hard, likley “catabolic” workout (from the eccentric stuff), is there a way to lower serotonin that is released in the blood stream? Peat article- Tryptophan, Serotonin...
  10. NewACC

    Serotonin antagonists fail to prevent endotoxin lethality in healthy mice

    https://www.karger.com/Article/Abstract/162500 Very scary article. I'd be glad if @haidut and @Hans commented it
  11. tastyfood

    What's the short term (next week or two) impact of covid on stress blood markers?

    I am dealing with what seems like covid (at least according to the test). I have mild flu symptoms, and resting at home. I was scheduled to test for some stress hormones that I'm monitoring after making some changes to my daily protocol. I am thinking about postponing the test, worried that the...
  12. haidut

    Being Sad and Lonely Accelerates Aging More Than Smoking

    The title is the same as the one of the popular press article. And since feelings of sadness and loneliness are primarily caused by elevated serotonin, we can add premature aging to the list of "benefits" serotonin offers. The findings of this study probably explain a great deal of the premature...
    • haidut
    • Thread
    • aging depression loneliness mental health sadness serotonin smoking ssri
    • Replies: 6
    • Forum: Scientific Studies
  13. A

    Identification of Androsterone and Pizotifen as Anti-Metastasis Compounds

    Abstract Few models exist that allow for rapid and effective screening of anti-metastasis drugs. Here, we present a drug screening protocol utilizing gastrulation of zebrafish embryos for identification of anti-metastasis drugs. Based on the evidence that metastasis proceeds through utilizing...
  14. NewACC

    Role of Cholinergic and Dopamine Receptors in the Physiology of Caffeine Tolerance

    Dear Forum Members, I found three interesting studies on reversing (or reducing) caffeine tolerance, by adding to chronic (or sub-chronic) caffeine treatment, either the dopamine agonists bromocriptine (a predominantly d2/d3 family agonist) or pergolide (a very potent d1 agonist), or...
    • NewACC
    • Thread
    • acetylcholine agonist antagonist bromocriptine caffeine coffee cyproheptadine dopamine serotonin tolerance
    • Replies: 4
    • Forum: Scientific Studies
  15. haidut

    COVID-19 is a serotonin-dependent disease

    As the COVID-19 pandemic spread all over the world in early 2020, some of the earliest studies identified serotonin (5-HT) as a culprit in the severity of the disease and proposed using 5-HT antagonists such as cyproheptadine as treatment. Other studies found by accident that the anti-acid drug...
    • haidut
    • Thread
    • 5-ht covid-19 gut infection inflammation sars-cov-2 serotonin
    • Replies: 33
    • Forum: Scientific Studies
  16. haidut

    Progesterone, bromocriptine may treat autism

    A great new study, which, while genomic in character, inadvertently points the finger directly at estrogen and/or serotonin as causes of autism. After all progesterone's main role in the human organism is as an estrogen (and cortisol!) antagonist, while bromocriptine is one of the oldest...
    • haidut
    • Thread
    • allopregnanolone autism bromocriptine cortisol dopamine estrogen progesterone serotonin
    • Replies: 6
    • Forum: Scientific Studies
  17. haidut

    Serotonin enhances learning from punishment, reduces learning from reward

    Research as early as the 1960s firmly established that there is nothing "happy" when it comes to serotonin (5-HT). Namely, elevated 5-HT levels were found in many chronic diseases and especially clinical depression. It took more than 7 decades for medicine to finally start admitting that 5-HT is...
    • haidut
    • Thread
    • 5-ht behavior fear learning lsd punishment serotonin servility
    • Replies: 5
    • Forum: Scientific Studies
  18. NewACC

    Platelet Serotonin Uptake Sites Increased in Drinkers of Ayahuasca

    https://pubmed.ncbi.nlm.nih.gov/7892432/ "An increased number of binding sites (Bmax) in the platelets of ayahuasca drinkers was found, while the dissociation constant (Kd) remained the same for both group."
    • NewACC
    • Thread
    • ayahuasca dmt psychedelic psychedelics serotonin serotonin antagonist serotonin transporter sert
    • Replies: 0
    • Forum: Scientific Studies
  19. cs3000

    Does Theanine actually agonize GABA receptors / increase GABA? +Serotonin

    I've seen some people concerned with GABA rebound effects from l-theanine due to effects on increasing GABA. Theanine is commonly mentioned as a gaba agonist. 1. Does it actually have significant effects on GABA that would lead to rebound? 2. Would a daily gram amounts be safe for potential...
    • cs3000
    • Thread
    • agonist downregulation gaba l-theanine rebound serotonin theanine withdrawal
    • Replies: 2
    • Forum: Supplements
  20. haidut

    SSRI use during pregnancy increase risk of neonatal seizures/epilepsy

    So much for "safe and effective during pregnancy"...I shudder at the thought of how many women get talked into using SSRI during pregnancy without even having depression. You know, just in case they MIGHT get postpartum depression. https://n.neurology.org/content/neurology/98/23/e2329.full.pdf...
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