serotonin

  1. haidut

    Serotonin (5-HT) drives diabetes and liver disease, blocking it is therapeutic

    After more than a decade of doing research in bioenergetics, I have come to the conclusion that there is hardly a disease (both acute and chronic) where 5-HT is not involved as a causal factor. Out of all those conditions, the ones with the biggest public health impacts are probably obesity...
    • haidut
    • Thread
    • 5-ht diabetes fibrosis inflammation nafld nash obesity serotonin
    • Replies: 5
    • Forum: Scientific Studies
  2. haidut

    Vitamin D deficiency and low, not high, dopamine drive schizophrenia

    One of the most persistent medical myths can be found in psychiatry. More specifically, in the category of psychotic mental disorders. Schizophrenia is perhaps the most widely studied representative of such conditions and the prevailing dogma/hypothesis about schizophrenia (and other psychotic...
    • haidut
    • Thread
    • cholecalciferol dopamine psychosis schizophrenia serotonin tryptophan hydroxylase vitamin d
    • Replies: 11
    • Forum: Scientific Studies
  3. chrstn4o

    You may be onto something with this "High Serotonin Bad" thing... (Organic acids test result with very elevated 5-HIAA)

    I decided to go over all of the organic acids tests (OAT) I've run in the past on my clients to see if I could find correlations between 5-HIAA and poorer health status at the time of sample collection, and low and behold I saw this: 5-HIAA, the serotonin metabolite is more than 3x higher...
  4. haidut

    High serotonin linked to poor aging trajectory (brain atrophy and depression)

    This is one of the studies that Big Pharma will probably spend a lot of money on trying to get retracted. It directly demonstrates that elevated serotonin (5-HT) in the brain drives brain atrophy and depression. Both the rates and severity of these conditions increase with aging and the study...
    • haidut
    • Thread
    • 5-ht alzheimer atrophy brain cognition dementia depression serotonin
    • Replies: 7
    • Forum: Scientific Studies
  5. Outdoctrination

    Serotonin does in fact cross the blood brain barrier.

    I've been struggling with this concept in my head given my own experience with dramatically improved mood with antibiotics which lower gut serotonin. The official narrative has been and continues to be that gut serotonin and brain serotonin are completely separate and that serotonin itself does...
  6. Outdoctrination

    How serotonin is the primary driver of digestive problems (and how to address it)

    I had absolutely debilitating digestive problems for years. I went to all of the “top GI docs'' and they had NO answers. They said we don’t know what’s wrong with you. One even told me it was all in my head. Take pill, drink water, eat fiber, take probiotics, etc. I was furious. I even tried...
    • Outdoctrination
    • Thread
    • bacteria cyproheotadine digestion digestion issues endotoxin experience ibs ondansetron serotonin
    • Replies: 36
    • Forum: Digestion
  7. Mauritio

    Rheumatoid Arthritis patients have higher serotonin and cortisol levels

    In this study they looke at some blood markers in patients with RA. As it turns out they have slighlty higher cortisol and way higher serotonin: their serotonin level was 3 times higher! Their melatonin level was a lot lower than that of the control group, which indicates less downstream...
    • Mauritio
    • Thread
    • arthritis cortisol endotoxin melatonin rheumatoid arthritis serotonin
    • Replies: 2
    • Forum: Scientific Studies
  8. haidut

    Serotonin (5-HT) may drive both schizophrenia and Alzheimer Disease (AD)

    Unbeknownst to most people, psychiatry has started to make a quiet "paradigm shift" in regards to psychotic conditions such as schizophrenia. Namely, after claiming for decades that psychotic states are caused by excessive dopamine levels/activity, psychiatry has now quietly change the official...
    • haidut
    • Thread
    • 5-ht 5-ht7 alzheimer dementia psychosis schizophrenia serotonin sulpiride
    • Replies: 4
    • Forum: Scientific Studies
  9. haidut

    Vitamin D may prevent/treat migraine in humans

    Yet another chronic and debilitating condition may turn out to have a surprisingly cheap, widely available, and safe solution. Namely, vitamin D. In pharma research, a new drug that demonstrates effectiveness for a specific condition of just 20% over a placebo group is considered a very solid...
    • haidut
    • Thread
    • cholecalciferol headache migraine serotonin topiramate vitamin d vitamin d3
    • Replies: 0
    • Forum: Scientific Studies
  10. A

    Glutamate and Mental Problems - Any Hacks to overcome??

    I did an amino acid test recently and was found to be high in Glutamate. This explains why I used to get excitotoxic symptoms (Panic, OCD, Anger, Migraine, sometimes suicidal thoughts) after eating specific foods like Shitake and Button Mushrooms, any cheese, Potatoes, Bone Broth, All seafood...
  11. NewACC

    Study on acute and chronic effects of serotonin (5HT) antagonists on serotonin binding sites

    https://doi.org/10.1007/bf00497017 "The administration of 14 daily doses of cyproheptadine, BC-105, metergoline and methysergide induced a marked decrease in the number (B max) of 3H-spiroperidol binding sites (5HT2 sites) in frontal cortex, when assayed 48 h after the last dose; the apparent...
    • NewACC
    • Thread
    • cyproheptadine metergoline reverse tolerance serotonin serotonin antagonist tolerance
    • Replies: 6
    • Forum: Scientific Studies
  12. Mauritio

    Lisuride facilitates delayed gratification by 5HT-2a antagonism; may be helpful for addiction

    A trait of highly successful people is to choose a bigger long-term reward over a smaller short-term reward. The ability control your emotions and impulses. A process known as delayed gratification. The study explains the issue, instant gratification, like this: "...the preference for an...
    • Mauritio
    • Thread
    • 5ht2a 5ht2ar addiction delayed gratification impulsivity lisuride serotonin
    • Replies: 16
    • Forum: Scientific Studies
  13. Sapien

    Lsd is referred to as “anti-serotonergic” by peat and others, yet is an agonist at a large number of serotonin receptors whilst an antagonist at none?

    Can anyone help me understand?
  14. haidut

    Atherosclerosis linked to high estrogen/cortisol/serotonin, low androgens

    The findings of the study are not surprising, but I wanted to post it on the blog since it is one of the few studies I have seen that examined more than one of the "sickness" mediator levels in a major chronic conditions such as cardiovascular disease (CVD), and found all of them to be elevated...
    • haidut
    • Thread
    • 5-ht atherosclerosis cortisol cvd estrogen hypogonadism pulmonary disease serotonin
    • Replies: 0
    • Forum: Scientific Studies
  15. NewACC

    Study says: Cyproheptadine is Serotonin Antagonist, Doesn't Block Dopamine and Noradrenaline

    https://doi.org/10.1016/0014-2999(74)90202-7 Abstract "...Cyproheptadine and LSD, two known antagonists of the peripheral effects of 5-HT, were administered i.v. to conscious rabbits at different times before the intracerebroventricular (i.c.v.) administration of 5-HT, NAD or dopamine...
    • NewACC
    • Thread
    • cypro cyproheptadine d-lysergamide dopamine lsd lsd-25 serotonin serotonin antagonist
    • Replies: 4
    • Forum: Scientific Studies
  16. haidut

    SSRI/serotonin cause heart damage/failure

    The role of serotonin in fibrotic conditions is well-known in research circles but is a taboo topic in medicine. Perhaps the best example of this bipolar (and potentially criminal) attitude is the fact that Pfizer sells billions of dollars worth its SSRI drugs Zoloft and Pristiq, yet at the same...
    • haidut
    • Thread
    • 5-ht fibrosis heart damage heart failure mitral valve serotonin ssri
    • Replies: 9
    • Forum: Scientific Studies
  17. haidut

    Elevated serotonin (5-HT) and norepinephrine (NE) drive nightmares in PTSD

    More than a quarter of all military/veteran personnel are estimated to have some form/level of PTSD, regardless of whether those soldiers have seen combat or not (e.g. Coast Guard members also have high rates of PTSD). Despite the obvious link to severe stress, medicine continues to claim that...
    • haidut
    • Thread
    • 5-ht nightmares norepinephrine ptsd serotonin sleep ssri stress
    • Replies: 3
    • Forum: Scientific Studies
  18. NewACC

    Cyproheptadine May Treat African Swine Fever

    We have been discussing surprisingly versatile and, at the same time, strong antiviral properties on this forum for a long time. And now the latest research shows that cyproheptadine is already effective against swine fever. I'm pretty busy so I can't elaborate on that. Maybe @haidut and @Hans...
    • NewACC
    • Thread
    • antiviral cyproheptadine fever histamine immune system immunity periactin plague serotonin virus
    • Replies: 0
    • Forum: Scientific Studies
  19. Limon9

    Cognitive Benefits Of Caloric Restriction Are Due To Reduced Tryptophan/Serotonin/mTOR Signalling

    It seems that consuming pure egg white will indeed make you stupid enough to consume pure egg white. Key Points - Calorie restriction improves mental test performance in mice. - Adding tryptophan into calorie-restricted diet abolished memory benefits. - Giving C.R. mice the serotonergic drug...
    • Limon9
    • Thread
    • caloric restriction cognition mtor rapamycin serotonin study tryptophan
    • Replies: 1
    • Forum: Scientific Studies
  20. Mr Joe

    Famous young influencer announce assisted suicide (DID)

    In the following thread a girl is talking about her "multiple personality disorder". She is saying basically that she was diagnosed depressive at the age of 8 and then suffered from "malnutrition". Later on, she was diagnosed with multiple personality disorder. And now she is pointing that one...
    • Mr Joe
    • Thread
    • brain cortisol metabolic stress serotonin ssri suicide thyroid
    • Replies: 10
    • Forum: Mental Issues
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