nad

  1. haidut

    Alcohol Causes Liver (and Other Organ) Damage By Lowering NAD/NADH Ratio

    A neat little study, which demonstrates once again the crucial role of energy and optimal redox status in a public health issue that has now reached catastrophic proportions. Namely, alcohol-related morbidity and mortality. Those have always been an issue in any developed country but since the...
  2. Lokzo

    5-Amino-1MQ Increases Energy, Fat Loss & Strength

    What is 5-AMINO-1MQ This compound is a small, selective membrane permeable molecule that blocks the NNMT enzyme. As fat cells grow larger, they begin to overproduce an enzyme called NNMT. NNMT = Nicotinamide N-methyltransferase. This enzyme acts to slow down fat cell metabolism (fat burning)...
  3. haidut

    Vitamin B3 May Treat "incurable" Muscle Disease

    Over the last 2-3 years I have seen a dramatic increase in the number of studies and popular press articles using the keywords "controversial", "paradox", "paradigm shift", "ameliorates an incurable condition X", etc. This is just a thinly veiled attempt to mask the collapse of the corrupt dogma...
  4. haidut

    Raising NAD Levels May Be Therapeutic For COVID-19

    A rather timely study, which demonstrates once again the crucial role energy plays even in "non-metabolic" diseases such as viral infections. At this point, even mainstream medicine admits that every function of the organism requires energy, so it would be plausible to expect an organism with...
  5. haidut

    Low-dose (but Not High) Niacinamide Reverses Reproductive Decline In Old Females

    A great new study, which once again confirms the importance of metabolism in "aging" disorders such as infertility (both female and male) and menopause. More specifically, it was the increase in NAD/NADH ratio that was the main mechanism of action behind the beneficial effects of nicotinamide...
  6. haidut

    Increased Fatty Acid Synthesis (FAS) Is Simply A Sign Of Oxygen Deficiency / Low Metabolism

    Just a quick post on a study that provides insight as to how increased fatty acid oxidation (FAO) can "paradoxically" result in increased FAS as well, thus leading to a vicious cycle most commonly seen in diabetes and cancer. One of my recent posts discussed a much more recent study that...
  7. haidut

    Dietary Niacinamide (B3) Deficiency May Be A Cause Of Schizophrenia

    As many of my readers know, the link between niacinamide and schizophrenia dates back at least the 1950s and possibly much earlier. The late Abram Hoffer, one of the founders of the orthomolecular approach, was convinced that stress was a huge factor in mental illness and ran several successful...
  8. haidut

    Niacinamide May Restore Female Fertility In Old Age

    The mainstream medical dogma is that after the onset of menopause, female reproductive potential is essentially zero. I posted a thread recently that challenged that dogma and demonstrated that infertility is essentially an energetic dysfunction process and can be reversed with exposure to red...
  9. haidut

    Niacinamide May Help Treat/reverse Heart Disease

    Yet another study showing the beneficial effects of improving mitochondrial function. This time, the study looked at heart health and found that NAD precursors like niacinamide and nicotinamide riboside (NR) can help prevent the decline in mitochondrial function and oxygen consumption driven by...
  10. haidut

    Giving Niacinamide To Pregnant Females Greatly Benefits The Offspring

    A few very interesting studies came out in 2018 showing that niacinamide may be very helpful for (pre)-eclampsia, as well as prevent miscarriages and birth defects. Keep in mind that according to mainstream medicine, eclampsia is untreatable and the approach is to have the baby delivered ASAP...
  11. haidut

    Niacinamide And Methylene Blue Increase Estrogen Deactivation (by Liver)

    There is an old study often cited by Peat in regards to liver health and estrogen. That study found that vitamins B1 (thiamine) and B2 (riboflavin) are crucial for the deactivation/metabolism of estrogen by the liver. Vitamins B1 & B2 Are Required For Estrogen Inactivation By Liver The study...
  12. haidut

    Niacinamide Can Treat Alcoholic Liver Disease

    As many forum users have probably heard on the news, alcohol abuse is now a leading cause of death in young people under 35. It is projected to soon surpass drug overdose as a cause of death in this demographic. Millennials are dying of alcohol-related liver disease at increasing rates The...
  13. haidut

    Niacinamide May Treat (acute) Kidney Failure (AKI) - Human Study

    It seems modern medicine is slowly starting to recognize the role of energy in organ health, and more specifically the role of NAD/NADH ratio in variety of diseases long thought to be mostly mechanism in origin. A few months ago, I posted a study on raising NAD levels with nicotinamide riboside...
  14. haidut

    Niacinamide May Be A Viable Treatment For Parkinson Disease (PD)

    It looks like the pharma industry is experiencing a resurgence in the search for metabolic therapies with patented chemicals. There must have been at least 50 different studies in 2017 alone with the NAD precursor nicotinamide riboside (NR) for conditions ranging from cancer, to glaucoma, to...
  15. haidut

    New Human Trial With An NAD Precursor

    I just wanted to post this here, as it seems interest in raising NAD is high among pharma companies. While nicotinamide riboside is the most popular precursor used in the Western world, nicotinamide mononucleotide (NMN) is another one that has been used clinically. This clinical trial below...
  16. P

    Nothing Boring About Boron

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712861/ The trace mineral boron is a micronutrient with diverse and vitally important roles in metabolism that render it necessary for plant, animal, and human health, and as recent research suggests, possibly for the evolution of life on Earth. As...
  17. haidut

    Inosine Increases NAD/NADH Ratio And Reduces Systemic Inflammation

    Yet another great study on inosine. It shows that a HED of just 8mg/kg administered just twice daily increased the NAD/NADH ratio by a whopping factor of 15 (see attached screenshot). While inosine itself is neither a precursor to NAD (like niacinamide) nor is it an oxidizing agent, I think its...
  18. haidut

    Niacinamide Retards/Reverses Aging And Physiological Decline

    Yet another study on the beneficial effects of raising NAD levels, and unlike other recent studies this one is not sponsored by ChromaDex. This study used nicotinamide mononucleotide (NMN), and human studies have shown that niacinamide is equally effective as NMN in raising NAD levels. Also, as...
  19. haidut

    Niacinamide And Doxycycline May Treat Alzheimer Disease (AD)

    This study is yet another one that shows benefit of raising NAD levels for treating neurodegenerative conditions like AD. There were a few older studies around 2003, which were also done on mice and as a result of those studies a human clinical trial with 3g niacinamide daily (a dose that...
  20. haidut

    Niacinamide May Treat ALS (and Stroke)

    I posted a few studies in the past demonstrating that ALS is a mitochondrial/metabolic disease and as such can be treated with pro-metabolic therapies like thyroid or copper (currently in clinical trials). This new study shows that raising NAD levels with the NAD precursor nicotinamide...
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