nitric oxide

I want to add methylene blue to my daily stack, currently at about 300 mcg. It is bearable right now, but I think the nitric oxide lowering effects are increasing my blood pressure. -I want to up the dose, but scared of too high BP then. -I also want to up the dose, but everything above 400 mcg...

Hi, despite being a fit and active 39-year-old, I've had a few issues that have plagued much of my adult life, namely: -erectile dysfunction (I've tested my NO levels, using strips and they are constantly low, despite taking L-arginine/Citrulline, which I've come to realise is unlikely to help...

Inspired by this thread Serotonin/endotoxin/PUFA As Primary Causes Of Depression And Diabetes; Can Be Easily Blocked I was reading a few more recent studies on the detrimental effect of serotonin on ones health. It seems clear that by now it is known in medicine, that blocking it is highly...

Yet another study demonstrating that many of the so-called chronic, degenerative and above all "mysterious" conditions often have quite a simple cause and, potentially, treatment. There is no need for mutated genes or complex interactions of genes with environment that nobody can decipher...

As my readers have noticed, I started putting quotes around the "effect" part of the infamous observation made by Otto Warburg himself. Over the last 3-4 years, even mainstream medicine has started to publish studies acknowledging that the "effect" is very much a cause as well. In other words...

Despite the billions of dollars poured into advertising by municipal water authorities trying to convince people, the evidence for the negative effects of drinking such water just keeps piling on. Fluoride has been added for decades, despite the constant stream of research demonstrating its ill...

Let’s repeat the mantra one more time – structure and function cannot be separated, they are mutually dependent at every level of reality/life. As such, it is little surprise (to us) that a structural disorder like osteoporosis may be caused by a deficiency in energy production. Yet, despite...

A few years ago I posted a study showing that 1.2g aspirin daily greatly ameliorated fatigue in MS patients and was considered safe enough even at that high dose to be recommended for daily use. Sunlight And Aspirin Can Treat Multiple Sclerosis (MS) However, those studies did not look at...

“NO” to Autophagy: Fat Does the Trick for Diabetes During the progression from obesity to diabetes, a critical attribute is inability to maintain metabolic homeostasis under excessive energy and nutrient exposure, which triggers insulin resistance. Intensive research efforts have linked chronic...

I highlighted some parts but other parts are interesting too https://www.sciencedirect.com/science/article/pii/S0735109714071782 Consequently, a large amount of Na+ is bound to GAGs, creating a microenvironment of hypertonic Na+concentration (19). However, the dense network exhibits a low...

As horrifying as it sounds, prescribing NO-boosting drugs to pregnant women is apparently perfectly acceptable in the search of more profit. The doctors probably got misled by the common practice in NICU of giving babies with pulmonary hypertension (or other breathing problems) an inhalation...

As many forum users already know dietary nitrates are an effective precursor to nitric oxide (NO). NO has been reliably linked to mania in humans, and mania is a known side effect of drugslike Viagra or nitroglycerin, but so far the official claim is that dietary nitrate intake does not cause...

If you have any conflicting or supporting studies or information perhaps you could contribute! Aspirin (lowers ALL - eNOS, iNOS, nNOS conflicting - possibly raises eNOS) Arginine (raises eNOS, nNOS, iNOS) Agmatine (raises eNOS lowers nNOS, iNOS) Caffeine (lowers eNOS iNOS? nNOS?) Iodine...

Not very Peaty after all... Here's some studies: "taurine caused elevated concentration of 3-NT and NOx" Effects of taurine on nitric oxide and 3-nitrotyrosine levels in spleen during endotoxemia. - PubMed - NCBI "The results showed that taurine increasedserum levels of nitric oxide and...

I posted a number of studies on Ceylon cinnamon and its metabolite sodium benzoate, showing their benefit in Parkinson disease, depression and anxiety. While all of those studies were on animal models, the toxicity of ammonia in the brain is undisputed and its role in all of these disease has...

Some bold statements in this study, which combined both in vitro and in vivo models. The HED for methylene blue (MB) was just 0.15mg/kg, which is in the range of 10mg-15mg doses that showed great effectiveness in treating mental disorders like depression and psychosis. As you can see from the...

Many people on the forum are familiar with the beneficial properties of adamantane and its derivatives. However, most of the research conducted on the beneficial effects of these chemicals has been with adamantane derivatives such as amantadine, memantine, rimantadine, bromantane, etc. When we...

The study looked at carriers of a specific variant of the gene CPS1 and the control this gene exerts over specific metabolites. Carriers of this gene variant had significantly increased glycine levels in the blood and lower levels of urea cycle metabolites, especially citrulline (which is a...

Ray had a separate newsletter and a radio show on the dangers of NO precursors like dietary nitrates / nitrites and supplements like arginine. It is a bit ironic that quite a few bodybuilders out there pay a lot of money for the so-called NO boosters and in reality get the exact opposite effect...

Didn't see this posted and is a fairly new study. Also, does anyone any ideas how this relates to endotoxin? I am quite new at looking at studies. Caffeine prevents LPS-induced inflammatory responses in RAW264.7 cells and zebrafish. - PubMed - NCBI " Caffeine decreased the LPS-induced...