Amazing Medicinal Properties Of Emodin

Discussion in 'Cascara Sagrada' started by haidut, Jan 29, 2016.

  1. haidut

    haidut Member

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    This thread is similar to the one I created for beta-lapachone and in support of the Lapodin supplement I released.

    Lapodin: https://raypeatforum.com/community/...pplement-with-beta-lapachone-and-emodin.9423/

    Beta-lapachone: https://raypeatforum.com/community/...roperties-of-beta-lapachone-v-lapachone.9422/

    I know Ray has written about some of the positive effects of emodin - an anthraquinone from Cascara, rhubarb, burdock, etc. However, there is no condensed list of the studies on its effects. Today, I released the supplement Lapodin and it contains emodin.

    In the past, people have complained that the thread on my supplements is daunting to read when I dump there a few dozen studies. So, I thought that instead of overwhelming the Lapodin thread with studies I'd better post them separately and then simply refer people to this thread.
    So here is the avalanche of positive studies for emodin. I sincerely doubt that any pharmaceutical drug (besides possibly aspirin and cyproheptadine) has been the subject of so many independent (read: unsponsored / untainted) studies, over so many years, for so many different issues. If my prediction of systemic effect magnitude being predictive of benefit is true then emodin easily beats any pharma drug sold in the last 30 years. Being a potent quinone, most (if not all) of the emodin benefits are due to its stimulation of respiration and especially raising NAD levels.
    I did my best to separate the studies in sections by topic but I may have misplaced a few studies, so if you find such a case please let me know so that I can put it in the right section/topic.



    Miscellaneous
    http://www.ncbi.nlm.nih.gov/pubmed/24428231
    http://www.ncbi.nlm.nih.gov/pubmed/23962559
    http://www.ncbi.nlm.nih.gov/pubmed/23864887 (anti-estrogen)
    http://www.ncbi.nlm.nih.gov/pubmed/23696164
    http://www.ncbi.nlm.nih.gov/pubmed/21442678
    http://www.ncbi.nlm.nih.gov/pubmed/17540366



    Cancer/Hypoxia
    http://www.ncbi.nlm.nih.gov/pubmed/26813281
    http://www.ncbi.nlm.nih.gov/pubmed/26782786
    http://www.ncbi.nlm.nih.gov/pubmed/26722474
    http://www.ncbi.nlm.nih.gov/pubmed/26722264
    http://www.ncbi.nlm.nih.gov/pubmed/26683360
    http://www.ncbi.nlm.nih.gov/pubmed/26682731
    http://www.ncbi.nlm.nih.gov/pubmed/26629030
    http://www.ncbi.nlm.nih.gov/pubmed/26628989
    http://www.ncbi.nlm.nih.gov/pubmed/26524020
    http://www.ncbi.nlm.nih.gov/pubmed/26238071
    http://www.ncbi.nlm.nih.gov/pubmed/26162964
    http://www.ncbi.nlm.nih.gov/pubmed/26081222
    http://www.ncbi.nlm.nih.gov/pubmed/26018259
    http://www.ncbi.nlm.nih.gov/pubmed/25987055
    http://www.ncbi.nlm.nih.gov/pubmed/25948190
    http://www.ncbi.nlm.nih.gov/pubmed/25891176
    http://www.ncbi.nlm.nih.gov/pubmed/25834536
    http://www.ncbi.nlm.nih.gov/pubmed/25744842
    http://www.ncbi.nlm.nih.gov/pubmed/25673059
    http://www.ncbi.nlm.nih.gov/pubmed/25607726
    http://www.ncbi.nlm.nih.gov/pubmed/25580427
    http://www.ncbi.nlm.nih.gov/pubmed/25370743
    http://www.ncbi.nlm.nih.gov/pubmed/25318952
    http://www.ncbi.nlm.nih.gov/pubmed/25311112
    http://www.ncbi.nlm.nih.gov/pubmed/25272825
    http://www.ncbi.nlm.nih.gov/pubmed/25187829
    http://www.ncbi.nlm.nih.gov/pubmed/25174432
    http://www.ncbi.nlm.nih.gov/pubmed/25124606
    http://www.ncbi.nlm.nih.gov/pubmed/25081669
    http://www.ncbi.nlm.nih.gov/pubmed/25040975
    http://www.ncbi.nlm.nih.gov/pubmed/24707862
    http://www.ncbi.nlm.nih.gov/pubmed/24620697
    http://www.ncbi.nlm.nih.gov/pubmed/24157255
    http://www.ncbi.nlm.nih.gov/pubmed/24115089
    http://www.ncbi.nlm.nih.gov/pubmed/24065213
    http://www.ncbi.nlm.nih.gov/pubmed/23975033
    http://www.ncbi.nlm.nih.gov/pubmed/23866157
    http://www.ncbi.nlm.nih.gov/pubmed/23848338
    http://www.ncbi.nlm.nih.gov/pubmed/23763280
    http://www.ncbi.nlm.nih.gov/pubmed/23700228
    http://www.ncbi.nlm.nih.gov/pubmed/23524196
    http://www.ncbi.nlm.nih.gov/pubmed/23484691
    http://www.ncbi.nlm.nih.gov/pubmed/23480347
    http://www.ncbi.nlm.nih.gov/pubmed/23472074
    http://www.ncbi.nlm.nih.gov/pubmed/23440366
    http://www.ncbi.nlm.nih.gov/pubmed/26555969
    http://www.ncbi.nlm.nih.gov/pubmed/23046742
    http://www.ncbi.nlm.nih.gov/pubmed/22992976
    http://www.ncbi.nlm.nih.gov/pubmed/22974371
    http://www.ncbi.nlm.nih.gov/pubmed/22876305
    http://www.ncbi.nlm.nih.gov/pubmed/22799356
    http://www.ncbi.nlm.nih.gov/pubmed/22679728
    http://www.ncbi.nlm.nih.gov/pubmed/22565822
    http://www.ncbi.nlm.nih.gov/pubmed/22532249
    http://www.ncbi.nlm.nih.gov/pubmed/22378302
    http://www.ncbi.nlm.nih.gov/pubmed/22375400
    http://www.ncbi.nlm.nih.gov/pubmed/22343391
    http://www.ncbi.nlm.nih.gov/pubmed/22321733
    http://www.ncbi.nlm.nih.gov/pubmed/22299827
    http://www.ncbi.nlm.nih.gov/pubmed/22159556
    http://www.ncbi.nlm.nih.gov/pubmed/22137788
    http://www.ncbi.nlm.nih.gov/pubmed/22040955
    http://www.ncbi.nlm.nih.gov/pubmed/22038303
    http://www.ncbi.nlm.nih.gov/pubmed/21861846
    http://www.ncbi.nlm.nih.gov/pubmed/21805032
    http://www.ncbi.nlm.nih.gov/pubmed/21769433
    http://www.ncbi.nlm.nih.gov/pubmed/21743963
    http://www.ncbi.nlm.nih.gov/pubmed/21660305
    http://www.ncbi.nlm.nih.gov/pubmed/21608232
    http://www.ncbi.nlm.nih.gov/pubmed/21542284
    http://www.ncbi.nlm.nih.gov/pubmed/21491088
    http://www.ncbi.nlm.nih.gov/pubmed/21468555
    http://www.ncbi.nlm.nih.gov/pubmed/21438405
    http://www.ncbi.nlm.nih.gov/pubmed/21382473



    Cortisol/Diabetes/Obesity
    http://www.ncbi.nlm.nih.gov/pubmed/26759701
    http://www.ncbi.nlm.nih.gov/pubmed/26626587
    http://www.ncbi.nlm.nih.gov/pubmed/26299942
    http://www.ncbi.nlm.nih.gov/pubmed/25232702
    http://www.ncbi.nlm.nih.gov/pubmed/24981886
    http://www.ncbi.nlm.nih.gov/pubmed/24691542
    http://www.ncbi.nlm.nih.gov/pubmed/24140264
    http://www.ncbi.nlm.nih.gov/pubmed/23303186
    http://www.ncbi.nlm.nih.gov/pubmed/22922341
    http://www.ncbi.nlm.nih.gov/pubmed/22673833
    http://www.ncbi.nlm.nih.gov/pubmed/22649478
    http://www.ncbi.nlm.nih.gov/pubmed/22645054
    http://www.ncbi.nlm.nih.gov/pubmed/22408453
    http://www.ncbi.nlm.nih.gov/pubmed/20718744
    http://www.ncbi.nlm.nih.gov/pubmed/19699280
    http://www.ncbi.nlm.nih.gov/pubmed/18785977
    http://www.ncbi.nlm.nih.gov/pubmed/17511151
    http://www.ncbi.nlm.nih.gov/pubmed/12150738


    Inflammation/CVD
    http://www.ncbi.nlm.nih.gov/pubmed/26159184
    http://www.ncbi.nlm.nih.gov/pubmed/26139382
    http://www.ncbi.nlm.nih.gov/pubmed/26131983
    http://www.ncbi.nlm.nih.gov/pubmed/26113441
    http://www.ncbi.nlm.nih.gov/pubmed/26001677
    http://www.ncbi.nlm.nih.gov/pubmed/25867480
    http://www.ncbi.nlm.nih.gov/pubmed/25634255
    http://www.ncbi.nlm.nih.gov/pubmed/24964845
    http://www.ncbi.nlm.nih.gov/pubmed/24855831
    http://www.ncbi.nlm.nih.gov/pubmed/24837536
    http://www.ncbi.nlm.nih.gov/pubmed/24751713
    http://www.ncbi.nlm.nih.gov/pubmed/24114447
    http://www.ncbi.nlm.nih.gov/pubmed/22791134
    http://www.ncbi.nlm.nih.gov/pubmed/22667136
    http://www.ncbi.nlm.nih.gov/pubmed/22426603
    http://www.ncbi.nlm.nih.gov/pubmed/22271272
    http://www.ncbi.nlm.nih.gov/pubmed/21881229
    http://www.ncbi.nlm.nih.gov/pubmed/21767904
    http://www.ncbi.nlm.nih.gov/pubmed/17939930
    http://www.ncbi.nlm.nih.gov/pubmed/16494030



    Bones/Dental
    http://www.ncbi.nlm.nih.gov/pubmed/25832436
    http://www.ncbi.nlm.nih.gov/pubmed/25187845
    http://www.ncbi.nlm.nih.gov/pubmed/24594415
    http://www.ncbi.nlm.nih.gov/pubmed/24565373
    http://www.ncbi.nlm.nih.gov/pubmed/23729279
    http://www.ncbi.nlm.nih.gov/pubmed/23685361
    http://www.ncbi.nlm.nih.gov/pubmed/21245807
    http://www.ncbi.nlm.nih.gov/pubmed/20368118
    http://www.ncbi.nlm.nih.gov/pubmed/18387517



    Neurological/Mental/Mood
    http://www.ncbi.nlm.nih.gov/pubmed/25590369
    http://www.ncbi.nlm.nih.gov/pubmed/25562207
    http://www.ncbi.nlm.nih.gov/pubmed/25064046
    http://www.ncbi.nlm.nih.gov/pubmed/25206430
    http://www.ncbi.nlm.nih.gov/pubmed/21303687
    http://www.ncbi.nlm.nih.gov/pubmed/21275776
    http://www.ncbi.nlm.nih.gov/pubmed/21137369
    http://www.ncbi.nlm.nih.gov/pubmed/24932776
    http://www.ncbi.nlm.nih.gov/pubmed/20863847
    http://www.ncbi.nlm.nih.gov/pubmed/20573598
    http://www.ncbi.nlm.nih.gov/pubmed/18301953
    http://www.ncbi.nlm.nih.gov/pubmed/17897641



    Endotoxin/Gastrointestinal/Liver/Pancreas/Kidney
    http://www.ncbi.nlm.nih.gov/pubmed/26742314
    http://www.ncbi.nlm.nih.gov/pubmed/26550148
    http://www.ncbi.nlm.nih.gov/pubmed/26308161
    http://www.ncbi.nlm.nih.gov/pubmed/26084177
    http://www.ncbi.nlm.nih.gov/pubmed/26031413
    http://www.ncbi.nlm.nih.gov/pubmed/25957424
    http://www.ncbi.nlm.nih.gov/pubmed/25792514
    http://www.ncbi.nlm.nih.gov/pubmed/25565015
    http://www.ncbi.nlm.nih.gov/pubmed/25351888
    http://www.ncbi.nlm.nih.gov/pubmed/25347274
    http://www.ncbi.nlm.nih.gov/pubmed/25228362
    http://www.ncbi.nlm.nih.gov/pubmed/25173984
    http://www.ncbi.nlm.nih.gov/pubmed/24912640
    http://www.ncbi.nlm.nih.gov/pubmed/24874440
    http://www.ncbi.nlm.nih.gov/pubmed/24750844
    http://www.ncbi.nlm.nih.gov/pubmed/24741989
    http://www.ncbi.nlm.nih.gov/pubmed/24740873
    http://www.ncbi.nlm.nih.gov/pubmed/24727085
    http://www.ncbi.nlm.nih.gov/pubmed/24649070
    http://www.ncbi.nlm.nih.gov/pubmed/24190079
    http://www.ncbi.nlm.nih.gov/pubmed/24189982
    http://www.ncbi.nlm.nih.gov/pubmed/24028150
    http://www.ncbi.nlm.nih.gov/pubmed/23605470
    http://www.ncbi.nlm.nih.gov/pubmed/23551520
    http://www.ncbi.nlm.nih.gov/pubmed/23499696
    http://www.ncbi.nlm.nih.gov/pubmed/22735924
    http://www.ncbi.nlm.nih.gov/pubmed/22563203
    http://www.ncbi.nlm.nih.gov/pubmed/22452333
    http://www.ncbi.nlm.nih.gov/pubmed/22103790
    http://www.ncbi.nlm.nih.gov/pubmed/22044459
    http://www.ncbi.nlm.nih.gov/pubmed/22020806
    http://www.ncbi.nlm.nih.gov/pubmed/21912566
    http://www.ncbi.nlm.nih.gov/pubmed/21308995
    http://www.ncbi.nlm.nih.gov/pubmed/21265105
    http://www.ncbi.nlm.nih.gov/pubmed/20575398
    http://www.ncbi.nlm.nih.gov/pubmed/19968079
    http://www.ncbi.nlm.nih.gov/pubmed/19067753
    http://www.ncbi.nlm.nih.gov/pubmed/18706249
    http://www.ncbi.nlm.nih.gov/pubmed/15918207
    http://www.ncbi.nlm.nih.gov/pubmed/11776026



    Anti-viral/Anti-bacterial/Anti-parasitic/Anti-fungal
    http://www.ncbi.nlm.nih.gov/pubmed/26670446
    http://www.ncbi.nlm.nih.gov/pubmed/26621875
    http://www.ncbi.nlm.nih.gov/pubmed/26446827
    http://www.ncbi.nlm.nih.gov/pubmed/26151018
    http://www.ncbi.nlm.nih.gov/pubmed/25998658
    http://www.ncbi.nlm.nih.gov/pubmed/25966789
    http://www.ncbi.nlm.nih.gov/pubmed/25892872
    http://www.ncbi.nlm.nih.gov/pubmed/24670452
    http://www.ncbi.nlm.nih.gov/pubmed/24448066
    http://www.ncbi.nlm.nih.gov/pubmed/21356245
    http://www.ncbi.nlm.nih.gov/pubmed/21050882
    http://www.ncbi.nlm.nih.gov/pubmed/20925591
    http://www.ncbi.nlm.nih.gov/pubmed/19960563
    http://www.ncbi.nlm.nih.gov/pubmed/18552872
    http://www.ncbi.nlm.nih.gov/pubmed/16940925
    http://www.ncbi.nlm.nih.gov/pubmed/16338070
    http://www.ncbi.nlm.nih.gov/pubmed/15242821
    http://www.ncbi.nlm.nih.gov/pubmed/9462956
    http://www.ncbi.nlm.nih.gov/pubmed/8133650



    Allergy/Respiratory
    http://www.ncbi.nlm.nih.gov/pubmed/25519442
    http://www.ncbi.nlm.nih.gov/pubmed/24239713
    http://www.ncbi.nlm.nih.gov/pubmed/23238477
    http://www.ncbi.nlm.nih.gov/pubmed/22484343
    http://www.ncbi.nlm.nih.gov/pubmed/21907188
    http://www.ncbi.nlm.nih.gov/pubmed/18785980
     
  2. jyb

    jyb Member

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  3. OP
    haidut

    haidut Member

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    As another forum member noted, it sounds like serotonin symptoms. Never heard or seen studies of emodin/cascara producing such effects. But of course it is good to always be mindful of side effects.
     
  4. jyb

    jyb Member

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    The thread does link to studies. Although they don't refer to an obvious symptom. I myself also have trouble imagining any immediate and obvious symptom from cascara after years of use.
     
  5. OP
    haidut

    haidut Member

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    That one study says emodin is an antagonist on P2X7 receptor. Another one is P5P. Both substances are anti-inflammatory but to describe them as immunosuppressive is unwarranted IMO. Blocking P2X7 is used for treating HIV, and the last thing these people need is an immunosuppressant. So, no, blocking P2X7 is not immunosuppressive (assuming this is the mechanism of action of emodin in that study).
    http://www.jimmunol.org/content/early/2012/03/26/jimmunol.1102482.full.pdf
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659914/
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340214/
     
  6. Dan Wich

    Dan Wich Member

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    Here's "title-ified" versions of the links, I think this should help people that search for keywords related to their conditions.

    Miscellaneous


    Cancer/Hypoxia


    Cortisol/Diabetes/Obesity

    Inflammation/CVD


    Bones/Dental


    Neurological/Mental/Mood


    Endotoxin/Gastrointestinal/Liver/Pancreas/Kidney


    Anti-viral/Anti-bacterial/Anti-parasitic/Anti-fungal


    Allergy/Respiratory
     
  7. Nighteyes

    Nighteyes Member

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    Interestingly, when I tried cascara for constipation I immediately had a sinus infection along with a general feeling of the flu. This happened two independent times of use. Of course it might have been serotonin, but I read a few studies back then that put me off emodin for the time being:


    Emodin induces human T cell apoptosis in vitro by ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction.

    http://www.ncbi.nlm.nih.gov/pubmed/23811723

    Immunosuppressive effects of emodin: an in vivo and in vitro study.

    http://www.ncbi.nlm.nih.gov/pubmed/19545739

    Immunosuppressive effect of emodin, a free radical generator.

    http://www.ncbi.nlm.nih.gov/pubmed/1535596


    Not trying so put down the product here or anything, just trying to understand emodin better as I am tempted to try it again from a purer source (which you Haidut has just brought to us! yay).

    Any thought on the quality / content of studies above?
     
  8. Spondive

    Spondive Member

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  9. Spondive

    Spondive Member

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    I think my above post mainly applies to taking specifically Senna but not totally sure
     
  10. ejalrp

    ejalrp Member

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    I'd also like to hear some feedback on the above studies putting emodim in a less flattering light.
     
  11. OP
    haidut

    haidut Member

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    I think we already discussed this in another thread. Emodin is used for immunocompromised conditions like HIV, and leukemia, and is in clinical trials right now. If it was indeed immunosuppressive, that would have been a show-stopper for such conditions. The flu-like symptoms are most likely gut irritation, but there is no way to tell for sure without doing a more controlled experiment with some blood tests.
     
  12. OP
    haidut

    haidut Member

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    Peat is against using Senna and like you said the blackening of the colon is mostly seen with Senna products OR with very high dose Cascara (up to 1tbsp) used chronically. I think the effects is due not to emodin but to one of the other anthraquinones in Cascara. Actually the plain anthraquinone molecule has some toxicity (unlike emodin) and this is why it was used to develop some of the early anthracyclin therapies - i.e. to kill "cancer" cells. Hopefully, nobody here is ingesting tablespoons of cascara on a regular basis.
     
  13. SQu

    SQu Member

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    "Hopefully, nobody here is ingesting tablespoons of cascara on a regular basis."

    1/8 to 1/4 tsp cascara but more - 1 heaped tsp - pau d arco daily. Enough for concern? Or is beta lapachone not a problem in this way?
     
  14. OP
    haidut

    haidut Member

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    Not even close to a tablespoon, which is usually 3-4 tsp:)
     
  15. superhuman

    superhuman Member

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    For me that struggle with endotoxin that results in to high estrogen and cortisol. I use carrot salad daily and i use cascara before bed.
    So far it has not helped much so i want to increase it. Is taking some cascara 3 times a day a good way as a "therapy" for lowering endotoxin?
     
  16. OP
    haidut

    haidut Member

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    I don't know that cascara helps directly with endotoxin. What it does is speed up food transit through colon so less endotoxin is formed, and also once endotoxi is formes the emodin in cascara helps negate some of the effects of endotoxin on NO and serotonin. If you suspect you have high endotoxin, maybe some antibiotics won't hurt.
     
  17. superhuman

    superhuman Member

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    @haidut yeah i try to get my hands on antibiotics but i need prescription in my country, so that sux big time
     
  18. mujuro

    mujuro Member

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    haidut, have you found anything in your readings that indicates that the anthraquinones in Pau D'arco would inflict similar damages on the colon as high dose Cascara?
     
  19. OP
    haidut

    haidut Member

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    No, I have not seen anything indicating that the lapachones would have the same effect on colon. Also, if you take it topically cascara won't have the colon-darkening effects it exhibits when taken orally.
     
  20. mujuro

    mujuro Member

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    Good to know. I just got my order of cascara and PDA capsules, but in light of this thread, I instead ordered some of your Lapodin. I'll keep the cascara for its laxative benefits and use sparingly.
     
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