Amazing Medicinal Properties Of Emodin

[ddjd]

As another forum member noted, it sounds like serotonin symptoms. Never heard or seen studies of emodin/cascara producing such effects. But of course it is good to always be mindful of side effects.

The role of constitutive and inducible nitric oxide synthase in senna- and cascara-induced diarrhoea in the rat - PubMed

The role of constitutive and inducible nitric oxide (NO) synthase in rats treated with senna and cascara was studied. Senna (60 mg/kg p.o.) and cascara (800 mg/kg p.o.) ex vivo significantly increased Ca(2+)-dependent constitutive NO synthase activity in the rat colon. Induction of NO synthase...

pubmed.ncbi.nlm.nih.gov

 

[ddjd]

No, I have not seen anything indicating that the lapachones would have the same effect on colon. Also, if you take it topically cascara won't have the colon-darkening effects it exhibits when taken orally.

How do you take cascara topically?

 

[haidut]

The role of constitutive and inducible nitric oxide synthase in senna- and cascara-induced diarrhoea in the rat - PubMed

The role of constitutive and inducible nitric oxide (NO) synthase in rats treated with senna and cascara was studied. Senna (60 mg/kg p.o.) and cascara (800 mg/kg p.o.) ex vivo significantly increased Ca(2+)-dependent constitutive NO synthase activity in the rat colon. Induction of NO synthase...

pubmed.ncbi.nlm.nih.gov

The study did not use emodin, it used cascara bark, which contains numerous other substances in addition to emodin. Emodin itself has been shown to inhibit iNOS.

Emodin inhibits inducible nitric oxide synthase in a rat model of craniocerebral explosive injury - PubMed

To investigate the effects of emodin on blast-induced traumatic brain injury (bTBI) in a rat model. Eighty rats were randomly divided into 2 groups (the control group and the emodin-treated group; N = 40 per group) and were used to establish the model of blast-induced traumatic brain injury. Ten...

pubmed.ncbi.nlm.nih.gov

Also, the study says the used dexamethasone as a NO inhibitor, which is quite strange since even if that steroid inhibits NO synthesis/release it has a number of other pro-constipation properties (e.g. activation of GR receptor and raising prolactin) so the claim that its usage demonstrates the role of NO in cascara's effects cannot be taken seriously. There is a highly selective NO inhibitor known as L-NAME and it is the drug of choice for most studies trying to study/manipulate the NO pathway. Why they chose to not use L-NAME but went for a steroid with a myriad of other effects is beyond me...

 

[ddjd]

The study did not use emodin, it used cascara bark, which contains numerous other substances in addition to emodin. Emodin itself has been shown to inhibit iNOS.

Emodin inhibits inducible nitric oxide synthase in a rat model of craniocerebral explosive injury - PubMed

To investigate the effects of emodin on blast-induced traumatic brain injury (bTBI) in a rat model. Eighty rats were randomly divided into 2 groups (the control group and the emodin-treated group; N = 40 per group) and were used to establish the model of blast-induced traumatic brain injury. Ten...

pubmed.ncbi.nlm.nih.gov

Also, the study says the used dexamethasone as a NO inhibitor, which is quite strange since even if that steroid inhibits NO synthesis/release it has a number of other pro-constipation properties (e.g. activation of GR receptor and raising prolactin) so the claim that its usage demonstrates the role of NO in cascara's effects cannot be taken seriously. There is a highly selective NO inhibitor known as L-NAME and it is the drug of choice for most studies trying to study/manipulate the NO pathway. Why they chose to not use L-NAME but went for a steroid with a myriad of other effects is beyond me...

Appreciate this reply, many thanks!

 

[Mauritio]

Emodin's effect seem to rely on activating the FXR (Farnesoid X Receptor) because "...it did not improve lipid accumulation, insulin sensitivity, or glucose tolerance in HFD-fed FXR knockout mice."
- Emodin palliates high-fat diet-induced nonalcoholic fatty liver disease in mice via activating the farnesoid X receptor pathway - PubMed

The "X"-receptor type family is quite interesting, including FXR, PXR and RXR. They have numerous benefits as seen in the study above: emodin was basically useless, witout it beeing able to activate the FXR.

Here is some more info on the FXR:

- Activating FXR decreases PUFA in the liver

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