• Due to excessive bot signups along with nefarious actors we are limiting forum registration. Keep checking back for the register link to appear. Please do not send emails or have someone post to the forum asking for a signup link. Until the current climate changes we do not see a change of this policy. To join the forum you must have a compelling reason. Letting us know what skills/knowledge you will bring to the community along with the intent of your stay here will help in getting you approved.

cortisol

  1. haidut

    Another "paradox" - glucocorticoids cause inflammation, insulin blocks it

    As many of my readers know, I am not a fan of the ubiquitous usage of both bioidentical and synthetic glucocorticoids (GC) in medicine. Once used only in the most severe cases, some form of GC therapy awaits virtually all patients in a hospital (regardless of condition), and doctors are now...
  2. haidut

    Progesterone, bromocriptine may treat autism

    A great new study, which, while genomic in character, inadvertently points the finger directly at estrogen and/or serotonin as causes of autism. After all progesterone's main role in the human organism is as an estrogen (and cortisol!) antagonist, while bromocriptine is one of the oldest...
  3. C

    11b-HSD1 inhibitors don't lower cortisol levels? increased ACTH response

    a lot of people try to lower cortisol this way. But these studies with a 11b-hsd1 inhibitor given to humans shows plasma cortisol levels stay the same regardless and ACTH levels rise. (ACTH rises in response to the lower conversion of cortisone -> cortisol from the enzyme inhibition, so with...
  4. haidut

    Niacinamide increases ATP/NAD, lower glucose/cortisol in humans

    A great new study demonstrating for the first time in a human experiment what hundreds of animal studies had suggested in the past. Namely, that niacinamide can serve as a reliable precursor to NAD+ and by raising the NAD/NADH ratio results in improved glucose metabolism and higher ATP levels...
  5. haidut

    "Endurance" exercise ages the vascular system of males by more than a decade

    A very interesting study, though I don't really agree with its findings that while "endurance" (in this case running) exercise damages male vascular system it is beneficial for the female one. The majority of intervention studies that looked at both sexes, across all age groups found that...
  6. czgr

    Confusion about T use

    In this recent talk Georgi is endorsing very high dose Testosterone use (100 mg a day), saying (according to the study) even 50 mg per day wasn't good enough. I'm very confused now, since I saw him recommend a physiological dose of about 5 mg per day. I use a few milligrams of T transscrotally...
  7. Epik

    How high to go on Emodin

    Hi all, I was just wondering if there are any down sides in taking maybe 1g of Emodin a day to force cortisol down. Any side effects or possible issues coming off Emodin? If so, what should be my max dose a day? Thanks!
  8. tastyfood

    How much do you pee per day?

    Serious question. Urine output is a good indicator for cortisol levels. It can be used to gauge the state of metabolism as well. I just took a 24 hour sample to Labcorp. The amount this time was 2.1L. I have struggled with large urine daily outputs for years. Frequent urination is really...
  9. haidut

    Stress (cortisol) makes even altruistic people selfish

    A great new study, which may explain a good deal of the general perception and several studies from the last decade claiming that societies in Western countries are becoming more selfish, combative/polarized, and even psychopathic. The more shocking finding of the study was that cortisol was...
  10. haidut

    Fasting / stress decimate gonadal steroidogenesis, with no effect on blood cortisol

    A very interesting and very "controversial" (read: inconvenient truth) study, since it shows beyond reasonable doubt that even brief (4 days) fasting is a form of severe stress, at least when it comes to endocrine health. The study may also provide answers to various endocrine "mysteries"...
  11. haidut

    DHT as anti-inflammatory as cortisol, but without the side effects

    As most of my readers know, glucocorticoids (synthetic or bioidentical) are widely used clinically and there is hardly a chronic conditions for which they are not prescribed even if only for managing brief "acute exacerbations". Despite mainstream medicine doing everything it can to conceal the...
  12. haidut

    Scoliosis (even in females) may be driven by low androgen levels, DHT may treat it

    I am posting about this condition as it seems recently its numbers have absolutely exploded in the general population. Scoliosis used to be a relatively uncommon condition, usually present in adults over the age of 50. Mainstream medicine has no explanation for its possible causes, but suspects...
  13. tastyfood

    Can lower blood cortisol make you excrete more through the urine?

    I've been taking Lisuride and Gonadin for three weeks with the idea of lowering Cortisol levels. I did the 24 urine test again, and my results were higher than the last time. My result this time was 59 ug/24 hours, versus 50 the last time. The top of the lab range is 62. I think that after 50...
  14. JamesGatz

    Can earplugs or sound-resistant rooms have a positive effect on metabolism in certain environments ? Examining the cortisol increase for loud noises

    I notice that since Peating - I notice "stressors" a lot more - I cannot stand being around a construction site - hearing the sound of a jackhammer or a drill sends me to disarray or someone hammering really stresses me out I also notice that if I'm in a party-like environment - where the...
  15. haidut

    Vitamin D3 anabolic, calcitriol catabolic for muscle/thymus

    Several great studies, which will probably do little to calm down the controversy that seems to be brewing lately in the blogosphere over whether supplementing with vitamin D3 is beneficial or not. Namely, the last study below demonstrated direct muscle-anabolic effects from supplementation with...
  16. Hans

    When keto diets backfire and cause health problems

    Chronically doing a very low-carb diet can lead to problems. Obviously, not everyone suffers from them, but a relatively large percentage do. Here I talk about a few of the side effects of doing a very low carb diet...
  17. haidut

    Exercise causes (and worsens) arterial calcification

    A great new study sent to me by one of my readers. It will more than likely cause a lot of controversy, despite its findings having a very simple explanation. Namely, chronic exercise increases baseline cortisol and over time, cortisol (acting through the aldosterone/mineralocorticoid receptor)...
  18. P

    Progesterone feminizing effects?

    I want to start trying progesterone to address some high cortisol/estrogen symptoms I am experiencing (sleep interruptions, digestive issues, low energy/brain fog etc.) but I have read that it may not be a good supplement for men. I have even seen some forum users say it started to physically...
  19. U

    Is TSH supposed to be higher or lower during pregnancy?

    I have heard according to Peat that tsh should be less than 1. Tsh was 2.3 at 13 weeks pregnant and was 1.8 while not pregnant.
  20. shine

    Effects of dietary fatty acids on the social life of male Guinea pigs from adolescence to adulthood

    https://pubmed.ncbi.nlm.nih.gov/32504693/ "Dietary intake of polyunsaturated fatty acids (PUFAs) or saturated fatty acids (SFAs) differently modulates neurophysiological and behavioral functions in response to altered hypothalamic-pituitary-adrenal (HPA)-axis...
Top