depression

Some of us might know that serotonin is involved in mental and emotional suppression and lowering it or increasing the dopamine to serotonin ratio can be very helpful for re-igniting motivation, drive, enjoyment, etc. Feeling meh? Do this to get rid of apathy! Towards the end of the article, I...

Hello everyone, I decided to start a personal log, where I can hold record of my diet, lifestyle and supplementation, because I don‘t want to start so many new threads for just small questions or informational posts. This could become my legacy log, that I leave behind, so that my...

Just a quick post on a study, which claims to have established a reliable method for inducing bipolar disorder in an animal model. This reliable method consists simply of administering a low-dose of a mitochondrial inhibitor. More specifically, an inhibitor of complex I of the electron transport...

This is just a heads up to everyone strugglin with depression by itself and especially depression caused by social isolation and a hopeless situation, that many people find them selves in . Social isolation does have an effect on the human body and especially brain ! There's a few studies...

I will probably post some questions about this again in the future as I am extremely tired, anhedonic, depressed, and feel like I am always on the cusp of a panic attack (though I never actually have one), so I don't know if I can't really flesh this out. I am a male of 29 years. 5'10". 185lb...

Social touch is important for interpersonal interaction. Gentle touch and slow brushing are typically perceived as pleasant, the degree of pleasantness is linked to the activity of the C-tactile (CT) fibers, a class of unmyelinated nerves in the skin. The inability to experience pleasure in...

A very interesting study, sent to me by a collaborator who lives in Austria. It demonstrated that depression is accompanied by increased SIRT1 activity (i.e. increased fatty acid oxidation), lower ATP levels and redox balance shifted towards reduction. The study demonstrated that animals without...

A great study for a number of reasons. First, it discussed openly that in animal research circles cortisol administration is considered an official and reliable method of causing major depression. As the article states, for some reason human medical circles have been unwilling to accept the...

I know Japan is not the best comparison to the West due to their unique cultural attitude/tolerance towards suicides, especially in regards to people perceived to be "dishonored" due to falling on hard luck. However, it is still a stark reminded of what the lockdowns lead to and I suspect we may...

In one of Peat's recent newsletters he mentioned that there is an epidemic of mental disease in the population because the evil system these people live is preventing them from living their lives "meaningfully, creatively". A recent study corroborated Peat's writings on the truly abysmal state...

hello all I am currently 8 months pregnant, and I am not doing so well. I feel constantly distressed and extremely depressed. These high levels of hormones are making me crazy. I’m having emotional flashbacks to things that happened to me in my early childhood to early twenties that I thought...

Another good study, which not only corroborates the causative role of elevated serotonin in a number of behavioral disorders in children (which extend into adulthood) but demonstrates the key role of endotoxin (LPS) in that process. Namely, the pregnant animals exposed to stress who had sterile...

Last week I hit a wall... Burn out... Such a horrible feeling. It was so bad that I went to see my Doc and he prescribed me with something to slow my heart rate down (stop the fight or flight response), some Valium and something to stop nausea (I was literally dry reaching). I am upset with...

I wrote an article on acetylcholine which describes symptoms of high and low acetylcholine. I also discuss what can cause it to be high or low and what supplements can be used to block or boost it. The high acetylcholine syndrome » MenElite

The news about deteriorating health of the population just keep piling on. The latest one below shows that at least a third of the US population shows signs of clinical anxiety and/or depression. The reason I put clinical in bold is that it means the pathology is severe enough to require...

As many of my readers know, FDA recently approved the party drug ketamine (known as Special-K on the street) as a rapidly-acting antidepressant. The rapid antidepressant effects of ketamine have been known since the 1960s but FDA denied that those effects are relevant in humans and refused to...

Yet another medical myth gets busted today. A common dogma in psychiatry is that one of the core symptoms of patients with major depressive disorder (MDD) is lack of empathy. In other words, while such patients are perfectly in tune with their own suffering and negative emotions, they are...

I have had discussions with numerous psychiatrists about the concept of "learned helplessness" (LH) and its relation to chronic stress. All of those doctors flatly denied that LH is a concept relevant to humans and argued that it is nothing more than a useful model of depression in animal...

As many of my readers know, anhedonia is one of the most pernicious symptoms of most mental disorders, and is perhaps the most resistant to therapy. It also happens to be one of the main triggers of attempted suicide, based on interviews with suicide survivors. I posted some threads in the past...

The evidence for the role of chronic stress in virtually every health condition doctors have a name for just keeps on accumulating. Unfortunately, even in this latest study the scientists keep insisting that there is some mysterious and unquantifiable difference between chronic stress...