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depression

  1. C

    High Acetylcholine = learned helplessness, depression - What are good ways to lower acetylcholine or increase acetylcholinesterase activity?

    Ray peat has spoken about the negatives of acetylcholine relating to stress and learning Acetylcholine is an excitotoxic neurotransmitter Acetylcholine likely raises serotonin in the brain (preferentially inhibits MAO-A in the brain) https://pubmed.ncbi.nlm.nih.gov/19025057/ AChE inhibitors...
    • cs3000
    • Thread
    • acetylcholine acetylcholinesterase depression inhibit learned helplessness lower acetylcholine reduce
    • Replies: 2
    • Forum: Ask For Help or Advice
  2. haidut

    Chronic stress causes depression by depleting allopregnanolone

    This is perhaps one of the very few articles that directly makes the claim that stress can, by itself, cause mental illness. All official information "sources" on mental disease etiology claim that stress by itself is neither a necessary nor a sufficient cause. If stress has any role, the...
    • haidut
    • Thread
    • allopregnanolone chronic stress cums depression dht mental illness neurosteroid stress
    • Replies: 1
    • Forum: Scientific Studies
  3. haidut

    Vitamin D supplementation may lower suicide risk by 50%

    Suicide rates have been rising for the last 20+ years and have truly gotten out of control since the pandemic started. As usual, the mainstream version is that this is not an environmentally-driven issue but a "complex" interplay of genetic factors and poor lifestyle choices. As such, medicine...
    • haidut
    • Thread
    • cholecalciferol depression suicide vitamin d vitamin d3
    • Replies: 2
    • Forum: Scientific Studies
  4. haidut

    Major depression likely driven by mitochondrial deterioration/dysfunction

    This the latest study demonstrating that not only are various chronic diseases and aging essentially the same process, but that this process is fundamentally bioenergetic in nature. Namely, dysfunctional mitochondria, leading to low OXPHOS, is the direct cause of many physiological and "mental"...
    • haidut
    • Thread
    • aging bioenergetics depression gdf-15 mitochondria oxphos senescence senolytic
    • Replies: 4
    • Forum: Scientific Studies
  5. Mauritio

    CO2 therapy can cure neurological diseases

    This is what this old school report found. They tested CO2 therpay for a variety of neurological issues from anxiety and depression to psychopathy and even alcoholism . They also talk about a boy with symptoms that sound like tourette's who was completely changed and could live a normal life...
    • Mauritio
    • Thread
    • alcoholism anxiety co2 co2 therpay depression neurological disease
    • Replies: 14
    • Forum: CO2, Bag Breathing
  6. haidut

    Human study - vitamin B6 may relieve anxiety and depression

    Vitamin B6 is perhaps one of the most underrated B vitamins. While it attracted a lot of interest in the 1960s and 1970s as a potential natural treatment to raise dopamine and/or lower prolactin, subsequent "well-controlled" studies claimed that it was not effective. However, the fact remains...
    • haidut
    • Thread
    • anxiety depression gaba glutamate p5p pyridoxal pyridoxine vitamin b6
    • Replies: 11
    • Forum: Scientific Studies
  7. C

    Naringin - impact on behavioral measures in mice (nitrate/nitric oxide, anti-depressant, anti-anxiety, activity, cognition, antioxidant)

    https://www.sciencedirect.com/science/article/pii/S0753332218347668 - Repeated treatment with naringin produced increased locomotor activity, - Demonstrated antidepressant-like effects evidenced by decreased immobility time in forced swim test and increased % social preference in the social...
    • cs3000
    • Thread
    • aldehyde aluminium anxiety depression flavanoid iron naringin nitrate nitric oxide superoxide
    • Replies: 6
    • Forum: Scientific Studies
  8. haidut

    Being Sad and Lonely Accelerates Aging More Than Smoking

    The title is the same as the one of the popular press article. And since feelings of sadness and loneliness are primarily caused by elevated serotonin, we can add premature aging to the list of "benefits" serotonin offers. The findings of this study probably explain a great deal of the premature...
    • haidut
    • Thread
    • aging depression loneliness mental health sadness serotonin smoking ssri
    • Replies: 6
    • Forum: Scientific Studies
  9. IPlayDart

    Incels: A Result of Technology?

    Incels wouldn’t exist in a world where technology and the internet weren’t there. I don’t see any Incels in hunter- gatherer and primitive tribes. It seems to be a modern problem caused by modern things. The internet and technology waste a lot of time and most people have zero social...
  10. haidut

    Dietary sugar can treat chronic depression

    Not much to comment on here, except to point out that the sugar "addiction" in depressed people has been recognized by medicine for at least 50 years and has always been treated as a co-morbidity of the depressed state, also in need of treatment. Doctors have been advising depressed patients to...
    • haidut
    • Thread
    • depression dopamine mental health mood reward sucrose sugar
    • Replies: 16
    • Forum: Scientific Studies
  11. haidut

    Vitamin D likely effective as an antidepressant

    That is the simple conclusion of the largest meta-study to date. Namely, vitamin D in doses above 2,000 IU daily has antidepressant effect when used as monotherapy. The antidepressant effects of vitamin D when used in combination with pharma antidepressant drugs is already well-established, so...
    • haidut
    • Thread
    • antidepressant cholecalciferol depression mental illness monotherapy mood vitamin d
    • Replies: 2
    • Forum: Scientific Studies
  12. BestSinceDAYONE

    Carbs and ZeroCarbs Depression

    So, like many of us on this forum, I have tried many diets, low carb, high carb, vegan, IF etc. So my question is as it relates to mental health, anecdotally (and it sounds like others have the same experience) a low carb diet feels GREAT for a few days almost euphoric and then I slip into a...
  13. NewACC

    Agmatine Is Wonder Drug (Endotoxins, Endorphins, Adrenaline, NO)

    As you can know agmatine is very interesting peaty chemical, but steel I want to show you some interesting and maybe less known articles Anti-endotoxin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923203/ "...agmatine treatment inhibited LPS-induced production of nitrates dose dependently. As...
    • NewACC
    • Thread
    • addiction agmatine alcohol addiction depression endorphins endotoxin lithium nitric oxide opioids
    • Replies: 3
    • Forum: Scientific Studies
  14. haidut

    Progesterone may help quitting smoking

    A very interesting article, on a topic that has been studied for decades but has not seen much mainstream media exposure mostly because it does not fit the narrative. Namely, that "addictions", including smoking, are mostly genetically determined and not much can be done about them except manage...
    • haidut
    • Thread
    • addiction cholinergic depression estrogen nicotine progesterone smoking
    • Replies: 5
    • Forum: Scientific Studies
  15. haidut

    Even very low-dose endocrine disruptors induce learned helplessness, anhedonia

    Not much to comment on this study, considering the mountains of literature already available on the topic of endocrine disruptors such as BPA/BPA/DEHP, except to point out that the results were obtained even with very low-dose exposure to the harmful chemicals. Another interesting finding was...
    • haidut
    • Thread
    • anhedonia bpa bps dehp depression dopamine endocrine disruptor feminization learned helplessness
    • Replies: 4
    • Forum: Scientific Studies
  16. haidut

    BOMBSHELL: Serotonin High in Depression, Not a "Happy" Chemical, Lowers Energy, Depression Self-Resolves

    When I first saw the article pop up in my feed, I could hardly believe my eyes that a mainstream mouthpiece of Big Pharma will publish such frank admission of psychiatry's utter failure - i.e. the claims in regards to serotonin (5-HT), its role in mental illness, and even its social "label". In...
    • haidut
    • Thread
    • 5-ht depression energy metabolism oxphos serotonin ssri suicide
    • Replies: 32
    • Forum: Scientific Studies
  17. haidut

    Just a week-long break from social media alleviates anxiety and depression

    I don't think this study will come as a surprise to my readers, but it still helps to have some peer-reviewed evidence confirming what many people intuitively sense, yet are afraid to verbalize due to FOMO or being ostracized - i.e. social media, and digitization in general, is a bane on human...
    • haidut
    • Thread
    • abstinence anxiety depression fomo mental health routine serotonin social media
    • Replies: 19
    • Forum: Scientific Studies
  18. haidut

    Higher PUFA intake correlated with mental disease

    An epidemiological study, yet still useful IMO since the correlation was maintained across the various levels of PUFA intake - i.e. the higher the PUFA intake the higher the prevalence of a mental disorder such as depression, which suggests a causal link. The link was the strongest in males and...
    • haidut
    • Thread
    • cox depression fat inflammation leukotriene linoleic lox mental disease prostaglandin pufa
    • Replies: 6
    • Forum: Scientific Studies
  19. haidut

    Dopamine agonists can treat anhedonia

    The title may sound obvious to many, but this study is one of the few to bring up the taboo topic of serotonin's role in symptoms of depression. The current dogma still holds that raising serotonin levels (or activating its receptors) is the most beneficial mechanism to treating depression and...
  20. haidut

    Young people are lonelier than ever

    The actual title of the article, covering recent studies about loneliness rates in Western populations. It dispels the convenient excuse that the "pandemic" is what caused this true epidemic of loneliness by showing those rates were high years before any talk about virus/lockdown entered the...
    • haidut
    • Thread
    • anxiety depression epidemic loneliness mental health young youth
    • Replies: 102
    • Forum: Society
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