depression

  1. Greg says

    Erethism. Mad Hatter’s Syndrome. Help!

    my girlfriend’s health has declined rapidly over the last few months, particularly her cognition. Her symptoms match Erethism to a tee, from suicidal ideation to shyness to a ‘locked in her own mind’ sensation. She’s done a toe nail test which indeed did show high mercury. I’ve read the Mercury...
  2. Mauritio

    Serotonin transporter gene variant linked to anxiety hostility and depression

    There is a suprsing amount of studies linking a specific variant of the serotonin transporter to higher neuroticism. Neuroticism, one of the big five traits in psychology, is defined as the proclivity to feel negative emotions like anxiety and depression. Women are higher in trait neuroticism...
  3. haidut

    LipOdd - Liquid Product With Odd-Chain Saturated Fats (SFA)

    More than a decade ago, when I was just beginning my exploration of bioenergetics, one of the first indications that Ray's writings were onto something when it came to SFA vs. PUFA was the fact that while mainstream medicine ruthlessly bashed SFA in general and promoted PUFA, virtually very...
    • haidut
    • Thread
    • aging anemia antibacterial autoimmune cancer cvd depression diabetes fibrosis heptadecanoic inflammation lifespan lipodd metabolism mitochondria neurodegeneration obesity oxphos pentadecanoic sfa
    • Replies: 93
    • Forum: IdeaLabs
  4. haidut

    SSRI drugs cause depression/anxiety, blocking serotonin rapidly reverses the latter

    It is hard to come up with a more controversial statement in psychiatry than to say that the blockbuster "antidepressant" drugs not only actually cause depression - the very condition they are supposed to treat- but also anxiety (a separate mental disorder, according to DSM V) on top of that...
    • haidut
    • Thread
    • 5-ht 5-ht7 anxiety depression fluoxetine prozac serotonin
    • Replies: 10
    • Forum: Scientific Studies
  5. haidut

    Blocking serotonin (5-HT) stops withdrawal symptoms in addicts

    The role of 5-HT and other stress mediators such as cortisol, adrenaline, estrogen, prolactin, histamine, etc has long been suspected in both "addiction" and the withdrawal symptoms seen in virtually all "addicts" upon abstinence. The anti-adrenaline (and anti-cortisol) drug clonidine has been...
    • haidut
    • Thread
    • 5-ht addiction anxiety clonidine depression mianserin mirtazapine serotonin stress withdrawal
    • Replies: 2
    • Forum: Scientific Studies
  6. haidut

    High serotonin linked to poor aging trajectory (brain atrophy and depression)

    This is one of the studies that Big Pharma will probably spend a lot of money on trying to get retracted. It directly demonstrates that elevated serotonin (5-HT) in the brain drives brain atrophy and depression. Both the rates and severity of these conditions increase with aging and the study...
    • haidut
    • Thread
    • 5-ht alzheimer atrophy brain cognition dementia depression serotonin
    • Replies: 7
    • Forum: Scientific Studies
  7. haidut

    STUDY: Glycine may treat depression; MEDIA: Glycine may cause depression

    The level of misreporting in mainstream media is reaching criminal levels. For example, there have been many studies discovering that an increase in the activity of the serotonin transporter (SERT), which results in lower levels of extracellular serotonin, results in alleviation of depression or...
    • haidut
    • Thread
    • anxiety cancer cortisol depression glycine gpr158 stress taurine
    • Replies: 13
    • Forum: Scientific Studies
  8. A

    Was it mold illness all along?

    - Lifelong low energy and fatigue. - Mood issues. Depression and anxiety. - Neurological issues. Memory loss. So much difficulty learning anything new that I began to despair over ever doing anything with my life, ever. Feeling like my brain had turned into a brick. - Intense brain fog...
    • animalcule
    • Thread
    • brain fog chronic fatigue depression frequent urination metallic taste mold mold illness mold toxicity mycotoxin weight gain
    • Replies: 28
    • Forum: Testimonials
  9. cs3000

    High Acetylcholine = learned helplessness, depression - What are good ways to lower acetylcholine or increase acetylcholinesterase activity?

    Ray peat has spoken about the negatives of acetylcholine relating to stress and learning Acetylcholine is an excitotoxic neurotransmitter Acetylcholine likely raises serotonin in the brain (preferentially inhibits MAO-A in the brain) https://pubmed.ncbi.nlm.nih.gov/19025057/ AChE inhibitors...
    • cs3000
    • Thread
    • acetylcholine acetylcholinesterase depression inhibit learned helplessness lower acetylcholine reduce
    • Replies: 13
    • Forum: Ask For Help or Advice
  10. haidut

    Chronic stress causes depression by depleting allopregnanolone

    This is perhaps one of the very few articles that directly makes the claim that stress can, by itself, cause mental illness. All official information "sources" on mental disease etiology claim that stress by itself is neither a necessary nor a sufficient cause. If stress has any role, the...
    • haidut
    • Thread
    • allopregnanolone chronic stress cums depression dht mental illness neurosteroid stress
    • Replies: 2
    • Forum: Scientific Studies
  11. haidut

    Vitamin D supplementation may lower suicide risk by 50%

    Suicide rates have been rising for the last 20+ years and have truly gotten out of control since the pandemic started. As usual, the mainstream version is that this is not an environmentally-driven issue but a "complex" interplay of genetic factors and poor lifestyle choices. As such, medicine...
    • haidut
    • Thread
    • cholecalciferol depression suicide vitamin d vitamin d3
    • Replies: 2
    • Forum: Scientific Studies
  12. haidut

    Major depression likely driven by mitochondrial deterioration/dysfunction

    This the latest study demonstrating that not only are various chronic diseases and aging essentially the same process, but that this process is fundamentally bioenergetic in nature. Namely, dysfunctional mitochondria, leading to low OXPHOS, is the direct cause of many physiological and "mental"...
    • haidut
    • Thread
    • aging bioenergetics depression gdf-15 mitochondria oxphos senescence senolytic
    • Replies: 4
    • Forum: Scientific Studies
  13. Mauritio

    CO2 therapy can cure neurological diseases

    This is what this old school report found. They tested CO2 therpay for a variety of neurological issues from anxiety and depression to psychopathy and even alcoholism . They also talk about a boy with symptoms that sound like tourette's who was completely changed and could live a normal life...
    • Mauritio
    • Thread
    • alcoholism anxiety co2 co2 therpay depression neurological disease
    • Replies: 14
    • Forum: CO2, Bag Breathing
  14. haidut

    Human study - vitamin B6 may relieve anxiety and depression

    Vitamin B6 is perhaps one of the most underrated B vitamins. While it attracted a lot of interest in the 1960s and 1970s as a potential natural treatment to raise dopamine and/or lower prolactin, subsequent "well-controlled" studies claimed that it was not effective. However, the fact remains...
    • haidut
    • Thread
    • anxiety depression gaba glutamate p5p pyridoxal pyridoxine vitamin b6
    • Replies: 18
    • Forum: Scientific Studies
  15. cs3000

    Naringin - impact on behavioral measures in mice (nitrate/nitric oxide, anti-depressant, anti-anxiety, activity, cognition, antioxidant)

    https://www.sciencedirect.com/science/article/pii/S0753332218347668 - Repeated treatment with naringin produced increased locomotor activity, - Demonstrated antidepressant-like effects evidenced by decreased immobility time in forced swim test and increased % social preference in the social...
    • cs3000
    • Thread
    • aldehyde aluminium anxiety depression flavanoid iron naringin nitrate nitric oxide superoxide
    • Replies: 6
    • Forum: Scientific Studies
  16. haidut

    Being Sad and Lonely Accelerates Aging More Than Smoking

    The title is the same as the one of the popular press article. And since feelings of sadness and loneliness are primarily caused by elevated serotonin, we can add premature aging to the list of "benefits" serotonin offers. The findings of this study probably explain a great deal of the premature...
    • haidut
    • Thread
    • aging depression loneliness mental health sadness serotonin smoking ssri
    • Replies: 6
    • Forum: Scientific Studies
  17. IPlayDart

    Incels: A Result of Technology?

    Incels wouldn’t exist in a world where technology and the internet weren’t there. I don’t see any Incels in hunter- gatherer and primitive tribes. It seems to be a modern problem caused by modern things. The internet and technology waste a lot of time and most people have zero social...
  18. haidut

    Dietary sugar can treat chronic depression

    Not much to comment on here, except to point out that the sugar "addiction" in depressed people has been recognized by medicine for at least 50 years and has always been treated as a co-morbidity of the depressed state, also in need of treatment. Doctors have been advising depressed patients to...
    • haidut
    • Thread
    • depression dopamine mental health mood reward sucrose sugar
    • Replies: 16
    • Forum: Scientific Studies
  19. haidut

    Vitamin D likely effective as an antidepressant

    That is the simple conclusion of the largest meta-study to date. Namely, vitamin D in doses above 2,000 IU daily has antidepressant effect when used as monotherapy. The antidepressant effects of vitamin D when used in combination with pharma antidepressant drugs is already well-established, so...
    • haidut
    • Thread
    • antidepressant cholecalciferol depression mental illness monotherapy mood vitamin d
    • Replies: 2
    • Forum: Scientific Studies
  20. BestSinceDAYONE

    Carbs and ZeroCarbs Depression

    So, like many of us on this forum, I have tried many diets, low carb, high carb, vegan, IF etc. So my question is as it relates to mental health, anecdotally (and it sounds like others have the same experience) a low carb diet feels GREAT for a few days almost euphoric and then I slip into a...
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