estrogen

  1. shine

    Social isolation stimulates hippocampal estradiol synthesis

    "17β-Estradiol is synthesized de novo in the rat hippocampus. However, the regulatory mechanism of hippocampal estradiol synthesis has remained unclear. We investigated the effects of social isolation on rat hippocampal estradiol synthesis. Rats were divided into two groups: social isolation and...
  2. Charger

    Blunted Emotions from Vitamin K2?

    Has anyone else experienced a blunted mood when dosing K2 (MK4) higher than 5mg? I pretty much become emotionless and careless, have less empathy. It took me awhile to figure it out as I tend to take several supplements. I do notice a reduction in anxiety from K2, but too much throws me to the...
  3. haidut

    Fasting ups estrogen & cortisol, decimates vitamin D, may cause diabetes

    A really interesting study, which will likely generate more than a few hateful emails for my Inbox :): Anyways, as the study demonstrates, fasting achieves these negative effects due to the elevated fatty acids working through PPAR activator PGC-1α, to activate both the estrogen receptor (ER)...
  4. Lokzo

    Elevated Serum Estradiol Levels May Impair Erectile Function

    Erectile dysfunction attributable to testosterone deficiency is less common in young males, and the effect of estradiol on erectile function in eugonadal young males is unclear. We analyzed data from 195 male participants, including 143 eugonadal patients with erectile dysfunction and 52...
  5. T

    Each Hormone Deficiency Is Associated With A Distinct Kind Of Fatigue. I Had Them All

    Hello, I am a medical student in my last year. For a few years I have been replacing all of my major hormones (see here) and I have been both high and low in many different constellations. From all this I learned 2 things. Each hormone deficiency can cause chronic fatigue. Each hormone...
  6. Harryedgar

    Methionine In A Modern Context - Needed?

    Hey guys - just so y’all know from the start I won’t be posting studies etc as here with kiddies and little time - just checking for thoughts and opinions - would be especially interested in what @haidut might think so - methionine - definitely inflammation promoting, aging etc etc etc - not...
  7. haidut

    Lowering Estrogen Prevents Memory Decline In Menopausal Females

    As many of my readers know, the WHI studies were highly detrimental to the profits of the estrogen industry. Every since the results of those studies came out, the estrogen industry has been trying to undermine the findings and re-introduce estrogen HRT for women with the claims that estrogen is...
  8. haidut

    Estrogen Can Both Cause And Exacerbate Lupus

    A quick post as a response to a recent argument I had over email with an endocrinologist who follows me on Twitter. His claim was that the causes of Lupus are currently unknown but are likely "multifactorial" and me ascribing such causes to "isolated peculiarities" such as endotoxin (LPS) or...
  9. haidut

    Estrogen May Be The Cause Of "estrogen-negative" Breast Cancer

    IMO, one of the biggest medical frauds so far is the idea that androgens (especially DHT) cause and promote prostate cancer. We now have an abundance of evidence (posted on this blog) that it is instead deficiency of androgens and/or excess of estrogens that initiates and drives the progression...
  10. haidut

    Androgens Boost, Estrogen Inhibits, Anti-aging Gene Klotho

    This post has two main messages, based on the studies below. Namely, androgens (and especially DHT) potently increase the expression of the anti-aging gene Klotho while estrogens strikingly decrease its expression. Moreover, the more potent the androgen, in terms of androgen receptor (AR)...
  11. haidut

    Estrogen Lowers T, DHT, And Fertility; Inhibits 5α-Reductase (5-AR)

    I am posting this study below as a response to numerous angry emails I have been getting over the years. People sending me those emails just cannot accept the idea that estrogen can be detrimental for males (and females as well), and that estrogen levels are directly antagonistic to the male...
  12. haidut

    Irritable Bowel Syndrome (IBS) Caused By Histamine And Serotonin

    I did not expect to see this statement in a mainstream science news outlet, but here it is below. I am starting to see a change in attitude towards serotonin but mainstream medicine is careful about its game. Somehow, the message about serotonin has now split into two separate, nonsensical ones...
  13. B

    Phytoestrogens Administered At Auschwitz Tanked The IQs Of Children Born Several Years Later

    Jean Jofen tested the IQs of children born to jewish women who had been in Auschwitz during the holocaust and found that they tended to be twenty points lower than the jewish average of 115. She then discovered documents showing that the Nazis attempted to sterilize jews in Auschwitz by feeding...
  14. rzero

    Breast Cancer Survivors Who Use Estrogenic Botanical Supplements Have Lower Serum Estrogen Levels

    Breast cancer survivors who use estrogenic botanical supplements have lower serum estrogen levels than non users The authors seem to agree that lower serum estrogen is correlated to lower breast cancer risk, but the part I found interesting is the ambiguity surrounding whether particular...
  15. T

    Estrone Sulfate: I Finally Tested It. Question About The Range

    I finally tested Estrone Sulfate to check my estrogenic load. The results are in the lower range. Does anyone else have experience testing for this? My prolactin was also tested and is below 6. Does anyone know how low the Estrone Sulfate should be?
  16. haidut

    Aromatase Inhibitor (AI) + DHT Combo May Reverse Kidney Disease (CKD)

    A truly great study for a number of reasons. First, it cites extensive evidence that male patients with diabetes (both types) have low androgens and high estrogen (estradiol). The association between this endocrine abnormality and the severity of diabetes is apparently quite strong, yet it is...
  17. haidut

    Lipolysis / FFA Drive Breast Cancer By Promoting Estrogen Signalling

    The evidence for the fat-loving nature of cancer just keeps on accumulating. During the last podcast with Danny and Ray, I mentioned that in cancer cells the enzyme fatty acid synthase (FAS) is actually part of the estrogen receptor (ER) complex. As such, anything that increases the...
  18. ScurveDream

    Muscles & Health: Overview, Theories, Development, Etc

    So it seems some here have attacked Peat's general ideologies in respect to "muscle gainz" in a way -- i.e. some here discredit him because "his diet" doesn't necessarily encourage significant muscle growth in all (although I'd say here that almost no "diet" per se does this magically for...
  19. S

    Preventing Letrozole Rebounds

    Backstory: Took letrozole to remove gynecomastia. 85% of the gynecomastia disappeared within a month Problem: Whenever I tried tapering off letrozole, I would get a rebound, even when tapering slowly while taking Proviron, and adding Aromasin. Result: Couldn't stop rebound. Gynecomastia is...
  20. Harryedgar

    Fat Loss, PUFA, Estrogen Detox And Increased Metabolism

    So dear all - questions questions questions....theories theories theories....don't we all just love em!!! Would really appreciate any help and input here from any and all who find the topics around Peat, Fat gain, and metabolism interesting. A bit of background. I come from a varied past of...
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