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  1. haidut

    Progesterone, bromocriptine may treat autism

    A great new study, which, while genomic in character, inadvertently points the finger directly at estrogen and/or serotonin as causes of autism. After all progesterone's main role in the human organism is as an estrogen (and cortisol!) antagonist, while bromocriptine is one of the oldest...
  2. ivy

    The SARS-CoV-2 spike protein binds and modulates estrogen receptors - study

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9164441/ Robert Malone (I know, I know) posted this and stressed: "Spike, no matter if it is from virus or vaccine". Then he asked the question: "Is the Sars-Cov-2 a toxin?"
  3. Daft

    Call for information: Trying to determine extent of estrogenic substances still in food supply.

    I would like for anyone to help contribute some knowledge, speculation and studies, and open a discussion on the extent to which, despite supposedly getting rid of BPA containing plastics, there are still estrogenic substances in all the plastics we store much of our food in, and used during the...
  4. j2mugs

    Reluctant to follow midfie's PUFA advice

    Hey all. My wife has had a VERY successfully pregnancy after 17 years of infertility and 7 years of peating! She has been having a pretty eventless pregnancy (first bio kid at 38 and has no GD, no preeclampsia, etc). The baby is huge too, also thanks to Ray Peat's advice! I continue to be amazed...
  5. haidut

    Progesterone may help quitting smoking

    A very interesting article, on a topic that has been studied for decades but has not seen much mainstream media exposure mostly because it does not fit the narrative. Namely, that "addictions", including smoking, are mostly genetically determined and not much can be done about them except manage...
  6. A

    Are White Button Mushrooms Estrogenic or Anti-Estrogenic?

    Inhibiting aromatase activity make it seem like they are anti-estrogenic but they also compete with estrogen for binding to estrogen receptors. Is their agonist efficacy lower than estrogen or in fact higher?
  7. haidut

    An estrogen antagonist treats many cancers, including triple-negative breast cancer

    Just a portion of the title is already paradoxical, according to mainstream medical dogma. Namely, how can an estrogen antagonist treat triple-negative breast cancer that is supposedly fully immune to any hormonal effects!? Well, maybe the whole idea of hormonal "receptors" as the only mechanism...
  8. haidut

    Higher progesterone, lower estrogen makes women more generous

    It looks like the beneficial effects if progesterone and harmful effects of estrogen are not limited to health. The study below found a women become much more generous in terms of buying drinks or gifts for their peers during the luteal phase, when progesterone is elevated and estrogen is low...
  9. haidut

    DHT blocks, androgen antagonists promote breast cancer

    The first claim of the title is already well-known to my readers and to clinical practice. DHT was clinically used back in the middle of the 20th century as a treatment for breast cancer, and the synthetic androgen Drostanolone (Masteron), which still retains its approval by FDA for breast...
  10. Gûs80

    Could aromatase inhibitors be useful in autoimmune diseases?

    Dr Ray Peat mentions in some articles that the cause of autoimmune diseases is high estrogen. Considering this, has anyone seen benefits from using a pharmaceutical aromatase inhibitor? I have a positive ANA marker for Lupus/Sjogren's, and even though it's low, I have several of the symptoms of...
  11. haidut

    Stearic acid (SA) is an estrogen receptor antagonist

    Over the last year or so I stumbled upon a few studies claiming both SA (C18:0) and its methyl ester are capable of binding the estrogen receptors (ER) and modulate their transcription effects. However, those studies did not evaluate if SA acted as an agonist or antagonist on those receptors...
  12. mantq

    Do aromatase inhibitors cause hair loss?

    Do aromatase inhibitors cause hair loss?
  13. ScurveDream

    Muscle & Growth Overall = (mostly) Unsaturated; Estrogenic? Is this why some people have bigger muscles or bigger bones; others smaller/less mass?

    Obviously it's more complicated than that to a degree, but I got to reading this old thread by @haidut on saturatedness or unsaturedness: https://raypeatforum.com/community/threads/unsaturation-estrogenic-saturation-androgenic.13162/#post-180467 Here is the study he referenced: Oestrogenic...
  14. tastyfood

    Which daily habits that you consider estrogenic go unnoticed?

    I am trying to keep my estrogen lower by paying more attention to things that I do on a daily basis that could have an estrogenic effect. Two examples I can share: - Using toilet paper for cleaning the buttocks as well as blowing the nose. - Washing the skin with soap excessively. These...
  15. haidut

    Estrogen may cause/exacerbate reflux disease (GERD)

    A very interesting study, which once again corroborates the hypothesis that there is no chronic condition, which is not either caused or heavily influenced by steroids. Among the conditions medicine considers not to be linked to hormone imbalances is the extremely common "reflux disease"...
  16. haidut

    Alzheimer's Severity Tied to Longer Estrogen Exposure in Women

    A neat study, which somehow managed to slip through my "radar" when it was first published the middle of last (2021) year. The study is pretty straighforward in its claim that longer exposure to endogenous estrogen was associated with exacerbated/higher biomarkers of Alzheimer disease (AD), as...
  17. haidut

    Estrogen promotes, progesterone inhibits drug (cocaine) abuse

    An interesting study, which not only exposes yet another negative side of estrogen but also demonstrates the opposing actions estrogen and progesterone have on the brain. The former is excitatory (by activating the glutamate system and inhibiting the GABA system) while the latter does the exact...
  18. A

    How fingers could point to a link between low testosterone and COVID hospitalizations

    https://www.swansea.ac.uk/press-office/news-events/news/2022/03/how-fingers-could-point-to-a-link-between-low-testosterone-and-covid-hospitalizations.php Could the length of a person’s fingers provide a clue to how ill they might get after contracting Covid-19? It is widely recognised that a...
  19. Drareg

    Glow Fish: A New Biosensor to Detect How Environmental Estrogens Affect Tissues

    Interesting study, this a genetically engineered organism, you can buy them, its used to subtly introduce the public to genetic engineering. PMC3404679 Chemicals that mimic natural estrogens have well-documented effects on the reproductive systems of vertebrates, typically acting as endocrine...
  20. tastyfood

    What benefits have you seen from just using water instead of toiler paper after bowel movements?

    I started experimenting with just using water to wash after bowel movements. After some of the threads shared on this forum about the presence of possibly estrogenic substances in toilet paper, I decided to stop using it for a while. Unfortunately, I don't experience ghost-like stools, and I...