Propranolol As Anti-Cancer Agent

[Adrenaline]

As you know catecholamines (adrenaline/noradrenaline) play important role for cancer growth.

But interesting part is Propranolol lowers expression like COX, VEGF, HIF-1, NO which Peat mentions.

I think not only catecholamines but also beta receptors plays important role for cancer. Because Propranolol doesn't lower adrenaline, it just blocks beta receptors and lower adrenaline's effects.

# Propranolol induces regression of hemangioma cells through HIF-1α-mediated inhibition of VEGF-A. - PubMed - NCBI

# Anti-tumor effects of propranolol: Adjuvant activity on a transplanted murine breast cancer model. - PubMed - NCBI

# Propranolol induces regression of hemangioma cells via the down-regulation of the PI3K/Akt/eNOS/VEGF pathway. - PubMed - NCBI

# Propranolol Suppresses Cobalt Chloride-Induced Hypoxic Proliferation in Human Umbilical Vein Endothelial Cells in vitro. - PubMed - NCBI

# Propranolol suppresses HUVEC viability, migration, VEGF expression, and promotes apoptosis by downregulation of miR-4295. - PubMed - NCBI

# Propranolol represses infantile hemangioma cell growth through the β2-adrenergic receptor in a HIF-1α-dependent manner. - PubMed - NCBI

# β-Adrenergic receptor antagonists inhibit vasculogenesis of embryonic stem cells by downregulation of nitric oxide generation and interference with V... - PubMed - NCBI

# Clinical efficacy of propranolol in the treatment of hemangioma and changes in serum VEGF, bFGF and MMP-9. - PubMed - NCBI

# The role of propranolol as a radiosensitizer in gastric cancer treatment. - PubMed - NCBI

# https://www.ncbi.nlm.nih.gov/m/pubmed/19946348

# https://www.ncbi.nlm.nih.gov/m/pubmed/19724861

# https://www.ncbi.nlm.nih.gov/m/pubmed/21042766

 

[SOMO]

Beta Receptors are involved in weight loss, fat oxidation and thermoregulation as well.

Like all things, we need to balance.

I’ve vaguely remember a mouse study where the researchers blocked Beta Receptors and the mice became intolerant to cold and were also slightly overweight.


The strongest natural stimulator of Beta Receptors is...Exercise.
And caffeine.

 

[Adrenaline]

Beta Receptors are involved in weight loss, fat oxidation and thermoregulation as well.

Like all things, we need to balance.

I’ve vaguely remember a mouse study where the researchers blocked Beta Receptors and the mice became intolerant to cold and were also slightly overweight.


The strongest natural stimulator of Beta Receptors is...Exercise.
And caffeine.

I think all these functions come with stress.

 

[cedric]

Natural beta antagonist is… vagus nerve and ACh. Supplementation of B5 (panthetine) and choline would be a natural way.
https://www.sott.net/article/311586-Cho ... ic-illness
Cardiac Autonomic Nerve Stimulation in the Treatment of Heart Failure
https://fourfoldhealing.com/blogs/news/ ... rt-attacks
Milner Acetylcholine Protocol (FebMarch 2013) Townsend Letter for Doctors & Patients

 

[aguilaroja]

Natural beta antagonist is… vagus nerve and ACh. Supplementation of B5 (panthetine) and choline would be a natural way.
https://www.sott.net/article/311586-Cho ... ic-illness ... Cardiac Autonomic Nerve Stimulation in the Treatment of Heart Failure...https://fourfoldhealing.com/blogs/news/ ... rt-attacks...Milner Acetylcholine Protocol (FebMarch 2013) Townsend Letter for Doctors & Patients

Autonomic systems
"On the level of the whole cell, organ, and organism, the parasympathetic function limits oxygen consumption in a variety of ways, including the reduction of blood flow. Acetylcholine, like histamine and serotonin, activates glycolysis, the conversion of glucose to lactic acid, which provides energy in the absence of oxygen."

"Too much serotonin, histamine, acetylcholine, and polyunsaturated fatty acids, like too much adrenalin, can cause spasms of the coronary arteries, along with disturbances of mitochondrial respiration. In stress, these substances are almost sure to be present in excess. (Anti-serotonin drugs are effective for a variety of heart problems, and other degenerative diseases.)
By increasing the production of lactic acid and the loss of carbon dioxide, exaggerated nervous stimulation (especially the excess of acetylcholine, histamine, and serotonin) can cause a variety of problems, including generalized vasoconstriction and systemic alkalosis, as well as increased intracellular alkalinity. This metabolic pattern is characteristic of many kinds of stress, including cancer. (Elsewhere, I have referred to this pattern as “relative hyperventilation.”) The metabolic effects probably account for some of the “paradoxical” effects of the autonomic agents.
When nutrition and thyroid function, light, atmospheric pressure, and other conditions are favorable, the autonomic transmitters (e.g., acetylcholine, histamine, serotonin, adrenalin) and pituitary hormones and other “signal substances” are kept within safe limits."

http://raypeat.com/articles/articles/dark-side-of-stress-learned-helplessness.shtml
"Studying their brains, they found that the enzyme cholinesterase, which destroys the neurotransmitter, acetylcholine, was increased. They later found that the offspring of these rats were better learners than their parents, and their brains contained more cholinesterase. Their brains were also larger, with a considerable thickening of the cortex, which is considered to be the part mainly responsible for complex behavior, learning and intelligence."

"The increase of cholinesterase by enriched living serves to protect tissues against an accumulation of acetylcholine. The activation of nitric oxide synthesis by acetylcholine tends to block energy production, and to activate autolytic or catabolic processes, which are probably involved in the development of a thinner cerebral cortex in isolated or stressed animals. Breaking down acetylcholine rapidly, the tissue renewal processes are able to predominate in the enriched animals."