inflammation

  1. haidut

    PUFA required for periodontal disease, aspirin may help

    It is common knowledge even among mainstream dentists that periodontal disease is caused by bacteria accumulating under the gums, which over time leads to chronic inflammation and thus destruction of both gum tissue and the alveolar/jaw bone underneath the gums. Another "new" discover is that...
  2. UG Krishnamurti

    Estrogen and inflammation

    If the tissue damage is the cause of the appearance of estrogen in that tissue in order to heal it - what causes that tissue to become so easily damageable? Like in my case for example. I have Crohn's and my intestine is easily damaged with supplements and even cascara sagrada for example. It...
  3. haidut

    Both "long" COVID-19 and CFS are likely caused by hypometabolism

    A good study that examines the remarkable parallels between the so-called "long" COVID-19 (i.e. chronic display of symptoms associated with COVID-19) and the (in)famous chronic fatigue syndrome (CFS). Namely, increases inflammation, excessive glycolysis, suppressed mitochondrial function and...
  4. haidut

    Manufactured citric acid is a powerful inflammatory/allergy agent

    I great study, which goes hand-in-hand with another one I recently posted about in regards to silica (ubiquitous in commercially sold food products/drinks). Namely, just as that other study found silica to be a potent inducer of the endotoxin/LPS receptor TLR4 even in minute amounts, this study...
  5. haidut

    Aspirin reduces symptom severity, COVID-19 mortality by half

    Another great result for aspirin, which I suspect will not see much mainstream media publicity and will probably get censored the moment it hits my Twitter feed:-) Be that as it may, at this point the evidence for available successful/effective treatments for COVID-19 becomes too big to ignore...
  6. RenaissanceMan

    Theanine Ameliorates Neuroinflammation And Protects Against Endotoxin-Induced Inflammation and Acute Liver Injury

    https://pubmed.ncbi.nlm.nih.gov/29969892/ Theanine, a unique bioactive constituent from tea ( Camellia sinensis) leaves, is widely used as a functional ingredient and dietary supplement. To evaluate the anti-inflammatory and hepatoprotective effects of theanine and its molecular mechanism, the...
  7. S

    Dietary type 2 resistant starch improves systemic inflammation and intestinal permeability?

    Abstract Type 2 resistant starch (RS2) is a fermentable dietary fiber conferring health benefits. We investigated the effects of RS2 on host, gut microbiota, and metabolites in aged mice on high-fat diet. In eighteen-month old mice randomly assigned to control, high-fat (HF), or high-fat+20% RS2...
  8. haidut

    Blocking the endotoxin receptor (TLR4) may prevent / treat hearing loss

    I did a post a few months ago on the connection between tinnitus and serotonin - i.e. using anti-serotonin drugs may treat tinnitus. Since tinnitus is almost always a precursor state to hearing loss (and eventually deafness), the two conditions obviously go hand-in-hand and are likely caused by...
  9. haidut

    Air pollution impairs cognition, aspirin is protective

    A new study demonstrating that even short-term (less than a month) exposure to polluted air impaired cognition in humans, and that the mechanism of action was by triggering an inflammatory response. Ergo, anti-inflammatory drugs (NSAID) and especially aspirin, were found to be protective. Since...
  10. haidut

    Inflammation (from PUFA), not telomeres, determines lifespan / healthspan

    The idea of lifespan being entirely determined by limits on cellular division has ruled biology for more than a century and is perhaps best exemplified by the (in)famous (and false) Hayflick limit. Reaching the said limit is postulated to be controlled by telomere length, and as such the...
  11. haidut

    Endotoxin (LPS) may be the cause of fatal lung damage in COVID-19

    Yet another study, which demonstrates that there is virtually no disease (acute of chronic, infections or not) where the infamous LPS does not play a causative role. As it turns out, the often fatal inflammatory reaction (cytokine storm) that usually kills patients with COVID-19 in ICU, is...
  12. haidut

    Silica, present in most supplements/food, activates the endotoxin receptor (TLR4)

    Many of my readers know about the health risks of silica - a substance doctors and pundits call completely "benign, present in virtually all commercially sold dietary supplements and also in most commercially sold food (even organic ones!). The most commonly used form commercially is silicon...
  13. shine

    L. plantarum protects testicles & lowers inflammation/endotoxin

    It is well known that phtalates used in plastics are endocrine disruptors and damage testicular tissue. This study is showing that Lactobacillus plantarum (LP) alleviates testicular damage, increases testosterone back to normal levels, lowers inflammatory mediators like TNF-a, IL-1b and IL-6 and...
  14. haidut

    Androgens (T, DHT) highly protective against the flu

    A gem of a study that throws a wrench in one of medicine's core dogmas - i.e. androgens have detrimental effects on the immune system and males have evolved to live with a trade-off between high androgen levels (and as such high fertility) and higher risk of severe viral episodes that can be...
  15. haidut

    Glucocorticoids may increase inflammation in the long run

    Glucocorticoids (both bioidentical and synthetic) are some of the most widely used drugs in the clinical setting, as well as in outpatient treatment for all sorts of ailments - i.e. autoimmune conditions, joint pain, post-operative inflammation, asthma, and even infectious diseases such as...
  16. haidut

    Blocking PUFA/prostaglandins restores metabolism and reverses brain aging

    The bad news for PUFA has been accumulating for decades, yet public health authorities continue to claim that type of fat is "essential". Whatever indirect admissions of the pathological role of PUFA in both chronic and acute/infectious diseases is given to the public, is usually confined to the...
  17. haidut

    Endotoxin (LPS) as a cause of systemic inflammation seen in obesity

    Yet another study implicating the great villain of systemic health - endotoxin / LPS. It is well-known that most people with obesity have high levels of inflammatory biomarkers both in their tissues and bloodstream. The study below demonstrates that the inflammation seen in adipose tissue of...
  18. F

    My stack for testosterone, anxiety, inflammation and muscle growth: reasonable?

    Hi guys, I've assembled the following stack, in order to address a few goals: - creatine, shilajit, cordyceps, B complex (with niacinamide), vit E, vit K, vit D: testosterone, DHT, anxiety, energy, muscle growth - berberine: gut health, lowering overall inflammation (I have an autoimmune...
  19. Hans

    Cocoa powder for gut health

    I've posted a few studies before that cocoa powder can help to reduce gut inflammation and positively modulate the gut bacteria. Here is another one: https://pubmed.ncbi.nlm.nih.gov/32331673/ "We found that cocoa supplementation up-regulated the levels of the tight junction protein Zonula...
  20. Hans

    Coconut oil for lowering blood sugar, insulin requirements, inflammation and appetite

    This case report showed that coconut oil supplementation reduced this man's insulin requirements (he's a type 2 diabetic by was given insulin as well) dramatically. And when we did use insulin at his normal dose, he often experienced hypoglycemia. The shows that coconut either improves glucose...
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