metabolism

Hi smart people on the internet. Looking for some advice here. I am about to embark on a 25 day bike tour. Not for the purpose of exercise (I know this will negatively affect my metabolism) but for the thrill of adventure. I was taking 25mg of Thyrovanz over the winter/spring and then stopped...

Not sure if my readers have noticed it, but Big Pharma has drastically increased their bashing of aspirin since the pandemic started. Those attacks began when a few studies published back in 2020 demonstrated that aspirin users had a much lower risk of both contracting and dying from COVID-19...

While most people intuitively link metabolic rate with things like weight and exercise/athletic performance, few people realize that since everything in the body (including its structure) is dependent on energy production, our immune system function and response to infections is also largely...

I have heard from Peat as well as the mainstream that caffine boosts metabolic rate/glucose oxidation, however I have never heard the means by which it does this; I did some brief searching on the internet and could not find any info Does anyone know?

I did not think we will ever see such a headline in a major news outlet, but here is is. And in The Guardian of all places, which is a newspaper that rarely deviates from the official medical narrative on any condition, especially obesity and diabetes. The official narrative for those conditions...

https://fireinabottle.net/the-emergence-diet-get-out-of-torpor/ „ In this video I ask how mammals get out of torpor. Grizzly bears are the most appropriate model organism: monogastric, large-bodied, omnivorous hibernators. We also happen to have very detailed knowledge about their diet and it...

This is by far the most significant study I have seen come out in the last 2-3 years, simply because of the impact it has on virtually every person out there who has tried to lose excess weight (and who hasn't?). Virtually every person considering (or having done) dieting/exercise to lose excess...

I did a few posts years ago on the alarming findings that the youngest generations are among the most physically active, consume the least amount of calories, yet are the most obese (on average) compared to previous generations going back to at least the 1950s. Those studies did not look at...

Hey everyone! Found an interesting illustration regarding salt, thought many of you would find this rather interesting and perhaps useful :)

One of the visible hallmarks of aging is the accumulation of so-called "age pigment" or "aging spots", commonly known in scientific circles as lipofuscin. The latter is a complex mix of peroxidized polyunsaturated fats (PUFA) and various metals (especially iron) that accumulates in cells with...

Very interesting study that links mitochondrial density/number (and as such, the metabolic rate) with personality types. Namely, people with fewer mitochondrial (i.e. hypometabolic) tend to have high levels of neuroticism, with the latter causally linked to a higher risk of a number of serious...

The findings of the study may not sound very novel to my readers, however please keep in mind that the vast majority of anti-aging studies so far have only looked at slowing (not even stopping) aging. Actually reversing aging is the Holy Grail of gerontology, and to date very few studies have...

Haidut has written threads elsewhere about the necessity of the CatSper for male fertility, a calcium channel activated by progestogens: Male Fertility Depends On Intensity Of (sperm) Metabolism ... but did you know it expresses the "mitochondrial progesterone receptor" Dr. Peat talked about...

A truly monumental study, as it is perhaps the first one to demonstrate that "aging" in human cells is entirely under metabolic control. What can I say - Ray Peat right again! Unfortunately, the way the actual study has been worded has been, once again, criminally mis-represented by mainstream...

Yet another common and "benign" cosmetic procedures has now been demonstrated to be actually quite dangerous. Prior studies have already demonstrated that hair dyes, makeup, botox, nail polish, and even essential oil therapy all have toxic side effects that in the long run can cause serious...

Posting this part from a thread i wrote on Hesperidins beneficial effects on toxic metal protection, diabetes, wound healing etc Great study on the life promoting effects of hesperitin (the derivative of hesperidin found in orange juice): *Reverses effects of aging / restores youth...

At a first glance, mitochondrial dysfunction (a "functional" problem) has little in common with the build-up of plaque on arterial walls (a "structural" problem). However, as my readers know quite well, structure and function cannot be separated and a functional pathology is perfectly capable...

As many of my readers know, the mainstream medical dogma is that the number of neurons in the human grain increases until early adulthood, after which it stops completely. Thus, medicine views the adult human brain as having a fixed number of neurons and any damage to them or complete loss of...

+ pyrucet Explosive.

I am trying to dig Dr. Peat mention of Acetazolamide to help retain CO2. I've found a recent article : "We report a novel presentation of deficit in anterior pituitary function with variable immune deficiency (DAVID) syndrome in a healthy young girl presenting in Addisonian crisis with raised...