1. A

    Thyroid dosing during bike tour

    Hi smart people on the internet. Looking for some advice here. I am about to embark on a 25 day bike tour. Not for the purpose of exercise (I know this will negatively affect my metabolism) but for the thrill of adventure. I was taking 25mg of Thyrovanz over the winter/spring and then stopped...
  2. haidut

    Aspirin reduces risk of developing diabetes

    Not sure if my readers have noticed it, but Big Pharma has drastically increased their bashing of aspirin since the pandemic started. Those attacks began when a few studies published back in 2020 demonstrated that aspirin users had a much lower risk of both contracting and dying from COVID-19...
  3. haidut

    Low mitochondrial function is akin to immunosuppression

    While most people intuitively link metabolic rate with things like weight and exercise/athletic performance, few people realize that since everything in the body (including its structure) is dependent on energy production, our immune system function and response to infections is also largely...
  4. Sapien

    How does caffine boost metabolism ? (Mechanism of action)

    I have heard from Peat as well as the mainstream that caffine boosts metabolic rate/glucose oxidation, however I have never heard the means by which it does this; I did some brief searching on the internet and could not find any info Does anyone know?
  5. haidut

    Media: Endotoxin (LPS) drives obesity/diabetes

    I did not think we will ever see such a headline in a major news outlet, but here is is. And in The Guardian of all places, which is a newspaper that rarely deviates from the official medical narrative on any condition, especially obesity and diabetes. The official narrative for those conditions...
  6. youngsinatra

    The Emergence Diet : Get Out of Torpor! „ In this video I ask how mammals get out of torpor. Grizzly bears are the most appropriate model organism: monogastric, large-bodied, omnivorous hibernators. We also happen to have very detailed knowledge about their diet and it...
  7. haidut

    Regaining weight post diet/exercise due to lowered metabolism by increased PUFA in cardiolipin

    This is by far the most significant study I have seen come out in the last 2-3 years, simply because of the impact it has on virtually every person out there who has tried to lose excess weight (and who hasn't?). Virtually every person considering (or having done) dieting/exercise to lose excess...
  8. haidut

    Century-long metabolic decline, not less exercise and/or more eating, causing the obesity epidemic

    I did a few posts years ago on the alarming findings that the youngest generations are among the most physically active, consume the least amount of calories, yet are the most obese (on average) compared to previous generations going back to at least the 1950s. Those studies did not look at...
  9. mantq

    The Metabolic Effects of Dietary Salt Intake: High Salt intake Leads to Cardiovascular and Metabolic Changes

    Hey everyone! Found an interesting illustration regarding salt, thought many of you would find this rather interesting and perhaps useful :)
  10. haidut

    Aspirin / eugenol can remove lipofuscin from cells

    One of the visible hallmarks of aging is the accumulation of so-called "age pigment" or "aging spots", commonly known in scientific circles as lipofuscin. The latter is a complex mix of peroxidized polyunsaturated fats (PUFA) and various metals (especially iron) that accumulates in cells with...
  11. haidut

    Metabolic rate may determine personality type and disease risk

    Very interesting study that links mitochondrial density/number (and as such, the metabolic rate) with personality types. Namely, people with fewer mitochondrial (i.e. hypometabolic) tend to have high levels of neuroticism, with the latter causally linked to a higher risk of a number of serious...
  12. haidut

    Restoring mitochondrial function may be sufficient to reverse aging

    The findings of the study may not sound very novel to my readers, however please keep in mind that the vast majority of anti-aging studies so far have only looked at slowing (not even stopping) aging. Actually reversing aging is the Holy Grail of gerontology, and to date very few studies have...
  13. Limon9

    The Mitochondrial Progesterone Receptor (PR-M) In Human Sperm

    Haidut has written threads elsewhere about the necessity of the CatSper for male fertility, a calcium channel activated by progestogens: Male Fertility Depends On Intensity Of (sperm) Metabolism ... but did you know it expresses the "mitochondrial progesterone receptor" Dr. Peat talked about...
  14. haidut

    The "cancer metabolism" drives aging in humans

    A truly monumental study, as it is perhaps the first one to demonstrate that "aging" in human cells is entirely under metabolic control. What can I say - Ray Peat right again! Unfortunately, the way the actual study has been worded has been, once again, criminally mis-represented by mainstream...
  15. haidut

    Gel manicures lead to cell death, mitochondrial dysfunction and cancer

    Yet another common and "benign" cosmetic procedures has now been demonstrated to be actually quite dangerous. Prior studies have already demonstrated that hair dyes, makeup, botox, nail polish, and even essential oil therapy all have toxic side effects that in the long run can cause serious...
  16. cs3000

    Hesperetin restores youth in old rats - enhances lifespan ~8% up to ~14% when given late, restores mitochondria & metabolism, reverses heart damage

    Posting this part from a thread i wrote on Hesperidins beneficial effects on toxic metal protection, diabetes, wound healing etc Great study on the life promoting effects of hesperitin (the derivative of hesperidin found in orange juice): *Reverses effects of aging / restores youth...
  17. haidut

    Mitochondrial dysfunction is a major cause of cardiovascular disease (CVD)

    At a first glance, mitochondrial dysfunction (a "functional" problem) has little in common with the build-up of plaque on arterial walls (a "structural" problem). However, as my readers know quite well, structure and function cannot be separated and a functional pathology is perfectly capable...
  18. haidut

    Neuron/brain growth depends on metabolism (OXPHOS)

    As many of my readers know, the mainstream medical dogma is that the number of neurons in the human grain increases until early adulthood, after which it stops completely. Thus, medicine views the adult human brain as having a fixed number of neurons and any damage to them or complete loss of...
  19. A

    DHT + T3 + Creatine combo

    + pyrucet Explosive.
  20. Mr Joe

    Fraud Case Report : Hydrocortisone + Acetazolamide

    I am trying to dig Dr. Peat mention of Acetazolamide to help retain CO2. I've found a recent article : "We report a novel presentation of deficit in anterior pituitary function with variable immune deficiency (DAVID) syndrome in a healthy young girl presenting in Addisonian crisis with raised...