metabolism

  1. haidut

    Human study - vitamin B1 safe & effective for preventing & treating Alzheimer Disease (AD)

    A remarkable study, that for some reason is not being covered by mainstream media. Considering 99% of the clinical trials for AD since 2000 have completely failed, this study should be front-page news for most mainstream outlets. I suspect mainstream media, being literally owned by the same...
  2. haidut

    Metabolically, children are different species compared to adults

    A great study, which once again puts metabolism in the spotlight. Many studies have tried to discover the main biological differences between children and adults and so far none of them have discovered a "smoking gun". At the same time, multiple studies have demonstrated that children are much...
  3. R

    Mice treated with TSLP cytokine lose weight by ‘sweating’ fat

    Another nail in CICO coffin: https://www.sciencedaily.com/releases/2021/07/210729143412.htm Treating obese mice with the cytokine known as TSLP led to significant abdominal fat and weight loss compared to controls, according to new research published Thursday in Science from researchers in the...
  4. R

    Endotoxin antagonists appear to slow metabolism.

    Through a ton of self experimentation I've found out that in order to increase metabolism on a high calorie diet all TLR4(endotoxin) inhibitors should be greatly reduced. And it does not really matter which ones exactly are currently saturating endotoxin receptors as antagonists, whether its...
  5. B

    Does Coffee Make Your Heart Flutter?

    3 1/2 minutes. A little Peaty! :thumbsup:
  6. haidut

    Damaged mitochondria may cause 90%+ of Parkinson Disease (PD) cases

    More evidence that yet another "incurable" condition is little more than energy deficit (due to mitochondrial dysfunction) in disguise. In this case the mitochondrial dysfunction was caused by accumulation of mitochondrial debris inside the cell, which has been repeatedly shown by other studies...
  7. haidut

    Aging is an energy deficiency problem, taking cardiolipin may reverse it

    Yet another study demonstrating that "aging" is nothing but a phenotype characterizing an organism with declining energy production. Since most of the cellular energy is produced in the mitochondria, another way of stating the same is that aging (and any specific disease for that matter) is a...
  8. haidut

    Loss of mitochondrial function (OXPHOS) induces de-differentiation (cancer)

    The study only focuses on the lymphatic system and its cells, but the principle is general and has been observed in other organ/tissue cells. The most obvious example is cancer - no matter which organ it occurs in, the tumor is composed of de-differentiated cells not unlike the stem cells from...
  9. haidut

    Muscle weakness / wasting linked to poor mitochondrial function

    A study that once again illustrates the central principle of bioenergetics - structure and function cannot be separated. They are interdependent at every level. In this specific case, the "structural" pathology is muscle weakness and wasting (sarcopenia, cachexia, etc). Most doctors, when...
  10. haidut

    DHEA causes fat-loss and improved glucose metabolism in humans

    Another study corroborating the role of DHEA as one of the "youth" hormones. A recent study already demonstrated that DHEA can reverse aging of the human immune system, which usually goes hand in hand with lower cortisol and improved metabolism. The proven anti-cortisol effects of DHEA are...
  11. haidut

    Almost half of obese adults are (metabolically) healthy

    A seemingly contradictory title, but only to people who are not aware of the so-called "obesity paradox". As I have mentioned in the past, usage of the word "paradox" usually implies a very inconvenient truth that threatens the profits of one or more branches of mainstream medicine. In this case...
  12. A

    Yet another "Is it hypothyroidism?" thread

    Hi everyone, im quite new to this forum, but already found a some great knowledge here. Althought im not convinced to go full peaty-style, i think i can use some of this wisdom to better my life. To the point. I recently did a hormone blood tests and found out that i have high prolactin (could...
  13. haidut

    Metabolic (energy) deficiency may be the cause of Parkinson Disease (PD)

    The dogma that PD is just a simple dopamine deficiency manifesting in genetically vulnerable individuals is quickly becoming untenable. It is well-known among clinicians that administering dopamine precursors such as L-Dopa, or selective dopamine agonists such as pramipexole has limited...
  14. haidut

    Inhibiting respiration/metabolism reliably causes bipolar disorder

    Just a quick post on a study, which claims to have established a reliable method for inducing bipolar disorder in an animal model. This reliable method consists simply of administering a low-dose of a mitochondrial inhibitor. More specifically, an inhibitor of complex I of the electron transport...
  15. haidut

    Glucose + vitamin B3 combo synergistic for treating mitochondrial disease

    A very interesting study, which demonstrates the unique synergy between glucose and vitamin B3 in treating deficiencies of function in Complex I & II of the electron transport chain (ETC). Deficiencies on those metabolic steps are the most common causes for the wide varieties of debilitating...
  16. BearWithMe

    Boosting metabolism causes huge stress reaction in very well fed body

    I'm eating 400-500g of sugar and 200-250g of protein every day. Around 3000 kcal daily. All good quality, Peaty foods. Oranges, raisins, milk, cheese, organ meats. I'm eating every hour or so. Yet I can't handle even the slightest metabolic boost. 100mg of caffeine, 50mg of niacinamide, 150mg...
  17. haidut

    PUFA promote torpor / hibernation, decrease lifespan

    Not many studies on this topic, but here is one that will hopefully satisfy my critics who keep complaining that there is no evidence for the anti-metabolic, pro-hibernation effects of PUFA. Apparently, PUFA is sought after by hibernating animals (but even they consume it within very tightly...
  18. haidut

    Blocking PUFA/prostaglandins restores metabolism and reverses brain aging

    The bad news for PUFA has been accumulating for decades, yet public health authorities continue to claim that type of fat is "essential". Whatever indirect admissions of the pathological role of PUFA in both chronic and acute/infectious diseases is given to the public, is usually confined to the...
  19. ScurveDream

    Should friendship be forced? How exactly does "friendship" or "having friends" work across different parameters?

    I have noticed some people just always have friends, and they don't do anything special or specific to make or keep them. Sometimes it's just neighborhood kids, workplace, schools, etc. -- and often it just naturally happens. I find it disheartening that some say that "making" or "finding"...
  20. K

    Rat smarter with pullover / rat hats

    Hello friends of metabolic health Georgi @haidut mentions a study in a danny roddy podcast (iirc) that rats with beanies or a sweater are more intelligent/ solve a rat labyrinth faster. I am now searching this for like a week, and i can not find it. IF PLEASE SOMEONE CAN TELL ME WHERE I CAN...
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