metabolism

  1. haidut

    Loss of mitochondrial function (OXPHOS) induces de-differentiation (cancer)

    The study only focuses on the lymphatic system and its cells, but the principle is general and has been observed in other organ/tissue cells. The most obvious example is cancer - no matter which organ it occurs in, the tumor is composed of de-differentiated cells not unlike the stem cells from...
  2. haidut

    Muscle weakness / wasting linked to poor mitochondrial function

    A study that once again illustrates the central principle of bioenergetics - structure and function cannot be separated. They are interdependent at every level. In this specific case, the "structural" pathology is muscle weakness and wasting (sarcopenia, cachexia, etc). Most doctors, when...
  3. haidut

    DHEA causes fat-loss and improved glucose metabolism in humans

    Another study corroborating the role of DHEA as one of the "youth" hormones. A recent study already demonstrated that DHEA can reverse aging of the human immune system, which usually goes hand in hand with lower cortisol and improved metabolism. The proven anti-cortisol effects of DHEA are...
  4. haidut

    Almost half of obese adults are (metabolically) healthy

    A seemingly contradictory title, but only to people who are not aware of the so-called "obesity paradox". As I have mentioned in the past, usage of the word "paradox" usually implies a very inconvenient truth that threatens the profits of one or more branches of mainstream medicine. In this case...
  5. A

    Yet another "Is it hypothyroidism?" thread

    Hi everyone, im quite new to this forum, but already found a some great knowledge here. Althought im not convinced to go full peaty-style, i think i can use some of this wisdom to better my life. To the point. I recently did a hormone blood tests and found out that i have high prolactin (could...
  6. haidut

    Metabolic (energy) deficiency may be the cause of Parkinson Disease (PD)

    The dogma that PD is just a simple dopamine deficiency manifesting in genetically vulnerable individuals is quickly becoming untenable. It is well-known among clinicians that administering dopamine precursors such as L-Dopa, or selective dopamine agonists such as pramipexole has limited...
  7. haidut

    Inhibiting respiration/metabolism reliably causes bipolar disorder

    Just a quick post on a study, which claims to have established a reliable method for inducing bipolar disorder in an animal model. This reliable method consists simply of administering a low-dose of a mitochondrial inhibitor. More specifically, an inhibitor of complex I of the electron transport...
  8. haidut

    Glucose + vitamin B3 combo synergistic for treating mitochondrial disease

    A very interesting study, which demonstrates the unique synergy between glucose and vitamin B3 in treating deficiencies of function in Complex I & II of the electron transport chain (ETC). Deficiencies on those metabolic steps are the most common causes for the wide varieties of debilitating...
  9. BearWithMe

    Boosting metabolism causes huge stress reaction in very well fed body

    I'm eating 400-500g of sugar and 200-250g of protein every day. Around 3000 kcal daily. All good quality, Peaty foods. Oranges, raisins, milk, cheese, organ meats. I'm eating every hour or so. Yet I can't handle even the slightest metabolic boost. 100mg of caffeine, 50mg of niacinamide, 150mg...
  10. haidut

    PUFA promote torpor / hibernation, decrease lifespan

    Not many studies on this topic, but here is one that will hopefully satisfy my critics who keep complaining that there is no evidence for the anti-metabolic, pro-hibernation effects of PUFA. Apparently, PUFA is sought after by hibernating animals (but even they consume it within very tightly...
  11. haidut

    Blocking PUFA/prostaglandins restores metabolism and reverses brain aging

    The bad news for PUFA has been accumulating for decades, yet public health authorities continue to claim that type of fat is "essential". Whatever indirect admissions of the pathological role of PUFA in both chronic and acute/infectious diseases is given to the public, is usually confined to the...
  12. ScurveDream

    Should friendship be forced? How exactly does "friendship" or "having friends" work across different parameters?

    I have noticed some people just always have friends, and they don't do anything special or specific to make or keep them. Sometimes it's just neighborhood kids, workplace, schools, etc. -- and often it just naturally happens. I find it disheartening that some say that "making" or "finding"...
  13. K

    Rat smarter with pullover / rat hats

    Hello friends of metabolic health Georgi @haidut mentions a study in a danny roddy podcast (iirc) that rats with beanies or a sweater are more intelligent/ solve a rat labyrinth faster. I am now searching this for like a week, and i can not find it. IF PLEASE SOMEONE CAN TELL ME WHERE I CAN...
  14. rothko

    Recommendations for Books on Evolution of Metabolism

    Hello! Im interested in the evolution of metabolic processes. I have found academic books which are focused on the very minute, but nothing that would be useful to me. Does anyone have any recommendations? I was looking at Nick Lane's vital question. Mae-Won Ho? Gerald Pollack? Ling? I am...
  15. haidut

    Reduced pyruvate and/or increased lactate drive heart failure

    I just did a post on the role of reduced glucose metabolism, lower pyruvate/NAM/NAD and elevated lactate in the pathogenesis of glaucoma. Just minutes later, another study popped up in my newsfeed. Namely, a study that demonstrates the exact same metabolic disturbances as the main drivers of...
  16. haidut

    Low energy production (glucose metabolism) may cause andropause

    As many of my readers know, aging men can also experience the equivalent of menopause and doctors informally call that state "andropause". Its official name is age-related hypogonadism and most of that hypogonadism is of the "secondary" type - i.e. the gonads appears to be in fine shape but for...
  17. haidut

    The Cure For Aging Might Be The Cure For Alzheimer’s

    Almost 25 years ago, Dr. Peat himself wrote a 2-article series in which he outlined arguments in favor of the hypothesis that aging and Alzheimer Disease (AD) are just examples of a more and less systemic sign respectively of declining energy production, and that curing one would lead to a cure...
  18. haidut

    Low, Not High, Metabolism Creates Oxidative Stress

    A hugely popular tenet of the "rate of living" theory is that the higher the metabolic rate the more reactive oxygen species (ROS) an organism produces. ROS elevation has already been implicated in a host of chronic disease including diabetes, CVD, cancer, neurological conditions and even mental...
  19. haidut

    Red Light Therapy For Parkinson Disease (PD) Begins Human Trials

    A few weeks ago, I posted about a human study demonstrating reversal of age-related vision decline by staring at a red light for just a few minutes a day. The mechanism of action proposed in that study had to do with improved mitochondrial function and energy production. Now, it seems another...
  20. J

    Eating Liver Makes Me Feel Cold More Often And Faster, Why?

    On a low A diet I have less energy, can't sleep, have oily and worse skin, but my temps are higher between meals. I found I have to eat liver daily. I get great energy from it, sleep perfectly and have much better skin. But I always find it makes my temps drop faster between meals. Is this...
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