1. cs3000

    Naringin inhibition of adenosine deaminase (ADA) + Ghrelin activation This enzyme breaks down adenosine to inosine, Naringin was shown to moderately inhibit this enzyme, but would high intakes of OJ lead to increased adenosine levels / decreased inosine levels? (they used cordycepin as it mimicks adenosine...
  2. Bruna

    Difference between inositol vs inosine?

    Hello everyone, I want to start using inosine, but I can't find a mixture that doesn't have some harmful excipient. I found inositol, which looks clean, but I'm not sure inositol is a good choice. So my question is: what is the difference between inositol and inosine?
  3. Hans

    How to protect yourself against exercise-induced endotoxin absorption

    Endotoxin can significantly negatively affect your health, from chronic low-grade inflammation, joint degeneration, organ inflammation and dysfunction, brain degeneration, insulin resistance, etc. Most people know that gut dysbiosis can increase endotoxin production and absorption into the body...
  4. haidut

    Inosine For The Treatment Of COVID-19

    Just posting this one as an additional option for people who cannot tolerate methylene blue, anti-serotonin chemicals or large doses vitamin C. The drug used is available in Europe but plain inosine has been shown to work just as well so that would be the option for people in the US and other...
  5. haidut

    Glucose Is Anabolic For Thymus, Opposes Catabolic Effects Of Cortisol

    As most of my readers know, cortisol is a highly catabolic steroid and one of the main agents (estrogen being another) responsible for thymus atrophy with age. These catabolic effects of cortisol can be blocked by progesterone, DHEA, pregnenolone, and even DHT (but not by testosterone). The...
  6. haidut

    Cardenosine - Liquid Product For R&D

    Our new product is finally here and it is "all about the ATP". I mentioned quite a few times on the forum and over email that we plan on releasing an ATP product and people have been asking me about it for the last few months. It seems a very simple task at first but we thought that we can do a...
  7. haidut

    Inosine Increases NAD/NADH Ratio And Reduces Systemic Inflammation

    Yet another great study on inosine. It shows that a HED of just 8mg/kg administered just twice daily increased the NAD/NADH ratio by a whopping factor of 15 (see attached screenshot). While inosine itself is neither a precursor to NAD (like niacinamide) nor is it an oxidizing agent, I think its...
  8. haidut

    Inosine Powerfully Stimulates Mitochondriogenesis, Oxidative Metabolism & Cell Differentiation

    Yet another absolutely great study on inosine. It shows that not only can inosine replenish ATP (as shown in the previous studies I posted) but it can inhibit excessive glycolysis, lower lactate, and dramatically improve oxidative metabolism - effects which are key driver of cell differentiation...
  9. haidut

    Inosine Increases ATP And Reverses NAFLD (and Likely Other Liver Disease)

    As I mentioned in another recent thread on inosine and serotonin/cortisol, many pathologies are simply signs/symptoms of inefficient ATP synthesis and restoring proper synthesis or replenishing ATP levels through precursors often reverses the pathology. These two studies below show that fatty...
  10. haidut

    Inosine As A Powerful Inhibitor Of Serotonin And Cortisol Synthesis

    As many of you know, I have been reading older Russian studies on many of the substances Peat talks about. He mentioned inosine in one of is articles, but only in relation to improving immunity and preventing dementia. The problem of Alzheimer's disease as a clue to immortality Part 1...