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dopamine

  1. Lokzo

    Vitamin C ESSENTIAL To Lower Prolactin?

    We have demonstrated that dopamine rapidly downregulates dopamine Ds receptors and that the physiological concentration of ascorbic acid prevents the D2 receptor downregulation. The ascorbic acid not only protects dopamine from oxidation (17, 22) but also potentiates the inhibitory action of...
  2. Hans

    Why TRT isn't working for you and what to do about it

    Although there might be a variety of reasons, this one should be part of the foundation to optimize any TRT protocol. https://men-elite.com/2021/12/06/why-trt-isnt-working-for-you/
  3. Brandin

    High dht and dopamine but low gaba?

    Hi I have succesfully increased my dht and lowered my estrogen alot. My stress is also ridicously low but for some reason I cant seem to increase gabaergic effects and feel huge difference when trying for example phenibut once. I think maybe my gaba receptors are very poor from inflammation...
  4. I

    MOTIVATION AND FOCUS

    I want to hear anything you guys have to say in regards to sustaining motivation/willpower and focus over long periods of time. I am very much a 'doer' and I am most happy when I am working furiously towards a goal. I feel absolutely euphoric when I am in this state, and I want to maximise it...
  5. Hans

    Shedding light on the 1 thing an Alpha Energy Male needs to do more of

    This is really one thing most men can benefit more from. https://men-elite.com/2021/10/11/shedding-light-on-the-1-thing-an-alpha-energy-male-needs-to-do-more-of/
  6. JamesGatz

    Traveling at HIGH speed/SPEEDING BOOSTS Dopamine

    Why do dogs like sticking their head out the window of a car so much ? Speed-related activation in the mesolimbic dopamine system during the observation of driver-view videos It seems like now we know: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768705/ I notice when I'm riding...
  7. Epik

    How to mitigate vomiting/nausea/emesis from D2 agonism?

    I've tried metergoline and it gives me this effect where food quite literally spills out of my stomach, especially when I'm asleep. I also get constipation. I recently tried a large dose of cat's claw, which is an MAOB inhibitor, which increases dopamine. I got the same effect that night. I was...
  8. haidut

    Serotonin puts the brakes on libido, by lowering dopamine

    Nothing really surprising, as far as Peatarians are concerned, in the findings of this study. I am only posting it here as it is one of the few that officially acknowledge that serotonergic drugs cause sexual dysfunction - i.e. something mainstream medicine has vehemently denied for decades. As...
    • haidut
    • Thread
    • dopamine fertility infertility libido pssd serotonin ssri stress
    • Replies: 2
    • Forum: Scientific Studies
  9. Hans

    Milk: pro-dopamine or pro-serotonin?

    View: https://youtu.be/WfTj7ugSaEc What's your experience with milk (if you digest it well)? I always feel good after some milk. Great stuff imo!
    • Hans
    • Thread
    • calcium dopamine milk pth serotonin tryptophan tyrosine
    • Replies: 83
    • Forum: Scientific Studies
  10. Lokzo

    Dopamine Reuptake Inhibitor That Lasts 30 Days

    DBL-583 is a selective dopamine reuptake inhibitor of the piperazine chemical class.[1] It is the decanoate ester of a hydroxy vanoxerine.[1] DBL-583 breaks down very slowly in the body, lasting for up to a month after a single injection.[1] Preclinical Evaluation of GBR12909 Decanoate as a...
  11. Mauritio

    Bromantane reduces liver fibrosis by 60%, kidney fibrosis by 50%

    This study shows that Bromantane significantly and impressively reduced liver fibrosis by up to 60% in a mouse model and is now in stage 2 clinical trials for treating NASH and chronic kidney fibrosis. I've repeatedly seen stated that those dosages aren't used in humans ,but that's actually not...
    • Mauritio
    • Thread
    • bromantane dopamine fibrosis kidney fibrosis ladasten liver fibrosis nafld nash np-160
    • Replies: 17
    • Forum: Scientific Studies
  12. Hans

    Perfect health trilogy for reducing stress, lowering cortisol and improving health

    Hi guys, I haven't been writing a lot of articles lately since I've got a lot on my plate atm. Soon I'll start writing more again, but in the meanwhile, I'm relatively active on my YT channel. I thought I'd share this vid about stress management since keeping stress at bay is one of the most...
    • Hans
    • Thread
    • breathing carbon dioxide cortisol dopamine earthing grounding red light stress sunlight thyroid
    • Replies: 13
    • Forum: Articles & Scientific Studies
  13. maillol

    T3, Methylene Blue and Prolactin

    Peat city https://www.researchgate.net/publication/12338364_The_regulation_of_adenohypophyseal_prolactin_secretion_Effect_of_triiodothyronine_and_methylene_blue_on_estrogenized_rat_adenohypophysis
  14. maillol

    Progesterone, Progesterone Receptors and Prolactin

    This is an interesting paper I came across from 2019 with new research on progesterone's effects on prolactin. Some highlights: Does progesterone need a certain level of E2 to be beneficial? If you look at the study referenced here (27) it says So it seems this is only an acute effect...
  15. Mauritio

    Low Dopamine D2 receptor density leads to obesity and insulin resistance , D2 agonism may treat

    These studies show that the Dopmine D2 receptors are strongly involved in obesity and insulin resistance . 1. (Brain dopamine and obesity - PubMed) "Striatal dopamine D2 receptor availability was significantly lower in the ten obese individuals (2.47 [SD 0.36]) than in controls (2.99 [0.41]...
  16. Charger

    Peating, Politics, and Passivity

    I've noticed since focusing on maximizing a high dopamine, low serotonin, low cortisol state that I've become much more passive regarding topics that I was much more fired up about a few years ago. I've spoken of having much more (far) right leaning views during the most stressful periods of my...
  17. Lokzo

    Systemic inflammation enhances stimulant-induced dopamine levels [2017]

    Systemic inflammation enhances stimulant-induced striatal dopamine elevation [2017] This is a human study with 8 participants to test the effects of inflammation on the dopamine increase produced by Methylphenidate (MP = Ritalin/Concerta), a dopamine reuptake inhibitor. Inflammation was...
  18. Mauritio

    Parkinsons Disease is not just a dopamine deficieny - mainstream admits

    This study goes along the lines of what haidut has been posting the last years . Namely that parkinsons disease (PD) is not just caused by a dopamin deficiency, but a serotonin excess . I think this is what the study is pointing to , in a very twisted indirect way ... I guess they dont want to...
  19. Mauritio

    Autism caused by low allopregnenolone , chinese herb can treat

    This study shows that the chinese herbal formula Kami-shoyo-san, also known as Jia Wei Xiao Yao Pian, can treat autism / reverse autistic behaviors in mice . First they show that autistic behaviour was caused by a decrease in allopregnenolone. Then they gave mice the herbal formula and...
    • Mauritio
    • Thread
    • allopregnanolone autism dopamine gaba herbs kami shoyo san tcm
    • Replies: 62
    • Forum: Autism
  20. Hans

    8 uncommon herbs that lower prolactin and restore dopaminergic neurotransmission

    Boosting dopamine is the first plan of action when it comes to lowering prolactin. But few herbs/supplements/drugs actually restore the dopaminergic system. In this article, I discuss 8 uncommon such herbs/supplements...
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