Blocking serotonin, promoting dopamine may reverse cardiovascular disease (CVD)

[haidut]

The claim in the title stems from the fact that bromocriptine - the drug used in the study below - is an approximate 5-HT antagonist while also being full agonist on several dopamine receptors. IMO, the study is a monumental success since CVD is largely considered a progressive condition, for which neither a cure nor disease-modifying therapy exists, according to mainstream medicine. Yet, this study shows actual reversal of CVD biomarkers after just a month of therapy. Interestingly enough, bromocriptine is already approved by the FDA for treating type II diabetes. Importantly, the proposed mechanism of action of bromocriptine used for its diabetes II approval is inhibition of lipolysis and gluconeogenesis. This implies that the CVD risk in patients with type I diabetes are probably driven by the same mechanisms - i.e. excessive lipolysis and gluconeogenesis. Aspirin and niacinamide are also excellent anti-lipolytic chemicals and the former is also known to inhibit gluconeogenesis. As such, those OTC remedies may be able to serve as alternatives to bromocriptine for people who do not have access to that medication or have a doctor unwilling to prescribe it.
https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.122.19547
Parkinson’s medication improved blood pressure in teens with Type 1 diabetes

"...Research Highlights:

• Teens with Type 1 diabetes who took bromocriptine, a medication usually prescribed to treat Parkinson’s disease, had lower blood pressure after one month of treatment compared to those who did not take the medicine.
• Participants taking the medication for one month also experienced significant improvements in aortic stiffness, a measure of vascular health.
• Larger, longer-term studies are needed to determine if bromocriptine may be recommended to adolescents with Type 1 diabetes.

..."

 

[Blaze]

The claim in the title stems from the fact that bromocriptine - the drug used in the study below - is an approximate 5-HT antagonist while also being full agonist on several dopamine receptors. IMO, the study is a monumental success since CVD is largely considered a progressive condition, for which neither a cure nor disease-modifying therapy exists, according to mainstream medicine. Yet, this study shows actual reversal of CVD biomarkers after just a month of therapy. Interestingly enough, bromocriptine is already approved by the FDA for treating type II diabetes. Importantly, the proposed mechanism of action of bromocriptine used for its diabetes II approval is inhibition of lipolysis and gluconeogenesis. This implies that the CVD risk in patients with type I diabetes are probably driven by the same mechanisms - i.e. excessive lipolysis and gluconeogenesis. Aspirin and niacinamide are also excellent anti-lipolytic chemicals and the former is also known to inhibit gluconeogenesis. As such, those OTC remedies may be able to serve as alternatives to bromocriptine for people who do not have access to that medication or have a doctor unwilling to prescribe it.
https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.122.19547
Parkinson’s medication improved blood pressure in teens with Type 1 diabetes

"...Research Highlights:

• Teens with Type 1 diabetes who took bromocriptine, a medication usually prescribed to treat Parkinson’s disease, had lower blood pressure after one month of treatment compared to those who did not take the medicine.
• Participants taking the medication for one month also experienced significant improvements in aortic stiffness, a measure of vascular health.
• Larger, longer-term studies are needed to determine if bromocriptine may be recommended to adolescents with Type 1 diabetes.

..."

Interesting info, thank you. Good stuff on what to use to reduce seratonin and lypolysis. But, what substances would you use to promote dopamine production?

 

[DennisX]

The claim in the title stems from the fact that bromocriptine - the drug used in the study below - is an approximate 5-HT antagonist while also being full agonist on several dopamine receptors. IMO, the study is a monumental success since CVD is largely considered a progressive condition, for which neither a cure nor disease-modifying therapy exists, according to mainstream medicine. Yet, this study shows actual reversal of CVD biomarkers after just a month of therapy. Interestingly enough, bromocriptine is already approved by the FDA for treating type II diabetes. Importantly, the proposed mechanism of action of bromocriptine used for its diabetes II approval is inhibition of lipolysis and gluconeogenesis. This implies that the CVD risk in patients with type I diabetes are probably driven by the same mechanisms - i.e. excessive lipolysis and gluconeogenesis. Aspirin and niacinamide are also excellent anti-lipolytic chemicals and the former is also known to inhibit gluconeogenesis. As such, those OTC remedies may be able to serve as alternatives to bromocriptine for people who do not have access to that medication or have a doctor unwilling to prescribe it.
https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.122.19547
Parkinson’s medication improved blood pressure in teens with Type 1 diabetes

"...Research Highlights:

• Teens with Type 1 diabetes who took bromocriptine, a medication usually prescribed to treat Parkinson’s disease, had lower blood pressure after one month of treatment compared to those who did not take the medicine.
• Participants taking the medication for one month also experienced significant improvements in aortic stiffness, a measure of vascular health.
• Larger, longer-term studies are needed to determine if bromocriptine may be recommended to adolescents with Type 1 diabetes.

..."

Bromocriptine along with cabergoline are 5HT2b agonists which cause left heart valve fibrosis with extended years of use.

 

[Jessie]

Interesting find. Though unsurprising for us. Lipolysis is a driving factor for both CHD, CKD, and diabetes. Adding some vitamin E with aspirin would likely have synergistic protection as well (as noted in past studies). Interestingly, I would be willing to bet adding cyproheptadine to the mix would provide additional support with it's ability to block 5ht2b receptors and reverse fibrosis. Would love to see a large-scale study of cypro in CHD patients.

Also just eating a low fat diet will provide basic protection as well. It's astonishing that no one has caught onto walter kempner's work with the rice diet. Some of his patients had significant improvements in kidney function and "irreversible" heart diseases (like cardiomegaly) just from eating a diet that was 5% fat.

 

[Mauritio]

The claim in the title stems from the fact that bromocriptine - the drug used in the study below - is an approximate 5-HT antagonist while also being full agonist on several dopamine receptors. IMO, the study is a monumental success since CVD is largely considered a progressive condition, for which neither a cure nor disease-modifying therapy exists, according to mainstream medicine. Yet, this study shows actual reversal of CVD biomarkers after just a month of therapy. Interestingly enough, bromocriptine is already approved by the FDA for treating type II diabetes. Importantly, the proposed mechanism of action of bromocriptine used for its diabetes II approval is inhibition of lipolysis and gluconeogenesis. This implies that the CVD risk in patients with type I diabetes are probably driven by the same mechanisms - i.e. excessive lipolysis and gluconeogenesis. Aspirin and niacinamide are also excellent anti-lipolytic chemicals and the former is also known to inhibit gluconeogenesis. As such, those OTC remedies may be able to serve as alternatives to bromocriptine for people who do not have access to that medication or have a doctor unwilling to prescribe it.
https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.122.19547
Parkinson’s medication improved blood pressure in teens with Type 1 diabetes

"...Research Highlights:

• Teens with Type 1 diabetes who took bromocriptine, a medication usually prescribed to treat Parkinson’s disease, had lower blood pressure after one month of treatment compared to those who did not take the medicine.
• Participants taking the medication for one month also experienced significant improvements in aortic stiffness, a measure of vascular health.
• Larger, longer-term studies are needed to determine if bromocriptine may be recommended to adolescents with Type 1 diabetes.

..."

Bromocriptine is a TLR4 Inhibitor.

Actually it has a pretty strong affinity for the receptor!

That might be another reason it has many benefits .

FDA Approved Drugs Repurposing of Toll-Like Receptor4 (TLR4) Candidate for Neuropathy

Accumulating evidence indicates that toll-like receptor 4 (TLR4) plays a critical role in promoting adaptive immune responses and are definitively involved ...

brieflands.com