atp

  1. haidut

    Niacinamide may treat ALS by improving energetic state

    Another study sent to me by the Austrian collaborator. Once again, the energetic origin of "incurable" diseases like amyotrophic lateral sclerosis (ALS) is on full display. The study elucidates that ALL types of ALS are characterized by metabolic/energetic abnormalities and the metabolic...
  2. haidut

    Niacinamide may treat depression by improving energetic state

    A very interesting study, sent to me by a collaborator who lives in Austria. It demonstrated that depression is accompanied by increased SIRT1 activity (i.e. increased fatty acid oxidation), lower ATP levels and redox balance shifted towards reduction. The study demonstrated that animals without...
  3. S

    Starting Anti Glycolytic Kettlebell Training

    Using Pavel's The Quick and the Dead. Not too sure what to put in log here, so here goes: Age 53 Sex M Weight 248 Height 5'11" Waking temp: 98.2 - 98.8 Health and stats steadily improving over last 8 months of Peating. This type of trainingg is supposed to increase ATP and mitochondrial...
  4. haidut

    Restoring Metabolism Prevents / Reverses "permanent" Nerve Damage

    Yet another study demonstrating the crucial role cellular metabolism plays in pathological processes. While most of my posts deal with beneficial effects of improving OXPHOS on various chronic diseases, the study below demonstrates that the same may be true in acute pathologies such as traumatic...
  5. haidut

    Glucose Is Anabolic For Thymus, Opposes Catabolic Effects Of Cortisol

    As most of my readers know, cortisol is a highly catabolic steroid and one of the main agents (estrogen being another) responsible for thymus atrophy with age. These catabolic effects of cortisol can be blocked by progesterone, DHEA, pregnenolone, and even DHT (but not by testosterone). The...
  6. haidut

    Niacinamide May Restore Female Fertility In Old Age

    The mainstream medical dogma is that after the onset of menopause, female reproductive potential is essentially zero. I posted a thread recently that challenged that dogma and demonstrated that infertility is essentially an energetic dysfunction process and can be reversed with exposure to red...
  7. haidut

    Mitochondria (energy) As The Main Driver Of Health, Intelligence, And Aging

    We are finally starting to see Peat enter the mainstream and article like the one below are calling for a complete review of what we know about health and aging and how intelligence is tied to them. As the authors says, or actually borrows from Peat, there is solid evidence that mitochondrial...
  8. haidut

    Fertility Depends On Metabollism (ATP), Not Age

    As many of you know, there are 2 fundamental dogmas in reproductive medicine. One is that every woman is born with a fixed number of eggs and those cannot be replenished. The second one is that there is a biological fertility clock in every woman that inexorably ticks, and if the female does not...
  9. haidut

    Chronic Stress / Defeat Causes Mental Illness By Damaging Mitochondria

    Yet another study demonstrating that mental illness has little to do with genetics, and is likely entirely due to energetic deficiency caused by environmental stress. This energetic deficiency is caused by mitochondrial damage caused by said stress. Keeping lipolysis and/or PUFA intake low can...
  10. M

    Serotonin Injection Induces A Dramatic Fall In Brain ATP Levels

    This is a study from 1994 by Koren-Schwartzer et al. that is often cited often by Ray Peat. It shows that intraperitoneal serotonin injection (40 mg/kg) causes a dramatic fall in brain ATP levels (24% of normal level). What I don't understand is how the injected serotonin in the peritoneum can...
  11. haidut

    Liver Disease Is Caused By Low ATP Driven By Fat (PUFA) Oxidation

    I posted a study several months ago on the ability of inosine to prevent/reverse liver disease, and how liver damage caused by various toxins was due to lower ATP levels in the liver. Inosine, being both a metabolite and precursor of ATP, is able to restore ATP levels and as such to...
  12. haidut

    Morphostasis Theory Of Immunity Confirmed - Body Treats Heart Attack Like Viral Infection

    Peat has touched upon his views of the immune system in several articles, mostly related to autoimmune disease. In his view, the role of the immune system is not so much to "attack" foreign pathogens that threaten the organism, but is more akin to sanitation workers who clean up trash and other...
  13. haidut

    Simple Body Stretching Reduces Tumor Size By More Than 50%

    As many of you know, stretching is known to increase ATP levels in muscle. The effects is the reverse of the one caused by contracting, which breaks down ATP. User @Such_Saturation posted a study about that and Peat has mentioned it many times as well. Stretch Creates ATP In the Cardenosine...
  14. haidut

    Cardenosine - Liquid Product For R&D

    Our new product is finally here and it is "all about the ATP". I mentioned quite a few times on the forum and over email that we plan on releasing an ATP product and people have been asking me about it for the last few months. It seems a very simple task at first but we thought that we can do a...
  15. haidut

    Inosine Powerfully Stimulates Mitochondriogenesis, Oxidative Metabolism & Cell Differentiation

    Yet another absolutely great study on inosine. It shows that not only can inosine replenish ATP (as shown in the previous studies I posted) but it can inhibit excessive glycolysis, lower lactate, and dramatically improve oxidative metabolism - effects which are key driver of cell differentiation...
  16. haidut

    Inosine Increases ATP And Reverses NAFLD (and Likely Other Liver Disease)

    As I mentioned in another recent thread on inosine and serotonin/cortisol, many pathologies are simply signs/symptoms of inefficient ATP synthesis and restoring proper synthesis or replenishing ATP levels through precursors often reverses the pathology. These two studies below show that fatty...
  17. haidut

    In Defense Of Gilbert Ling - Ion Pumps Not Needed To Explain Cell Physiology

    The purported existence of pumps is the official reason why Gilbert Ling's AI hypothesis was removed from Wikipedia. I posted a few days ago about the "newly" discovered role of ATP as a protein hydrotrope and co-solvent - something Ling postulated back in the 1950s. Gilbert Ling's Theory...
  18. haidut

    Gilbert Ling's Theory Confirmed - ATP Required For Protein Solubility & Aggregation Control

    As some of you know, the Wikipedia article on Gilbert Ling's AI hypothesis was removed due to being too "alternative" and not accepted as valid by the scientific "consensus". In the mainstream biochemical view, ATP is nothing but an energy currency for cells and has no role in maintaining...
  19. haidut

    More Dietary Salt Increases Urea Synthesis And Energy Requirements

    The salt recommendations mentioned by Peat in some of his articles have been the source of much controversy. He has given accounts of people with various conditions recovering when they increased their salt intake to 1-2 tablespoons daily. I also posted studies showing that when sodium intake is...
  20. haidut

    CFS/ME Once Again Confirmed As A Metabolic Disorder

    I posted previously about recent research indicating that CFS/ME is likely due to hypometabolism caused by environmental stress. https://raypeatforum.com/community/threads/confirmed-cfs-is-hypometabolism-triggered-by-environmental-stress.12405/ The earlier studies found lower activity of the...
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