Mauritio
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- Joined
- Feb 26, 2018
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This study looked at the performance enhancing effects of erythromycin and other anti-biotics in mice, with some pretty interesting results.
Erythromycin was very effective at increasing the swimming time in mice.
"After intragastric administration for 3consecutive days, erythromycin showed a steady dose-effect relationship in forced-swimming time, with a significant increase at a lower
dose of 5 mg/kg/d and nearly 4 folds elevation at dose of 30 mg/kg/d (Fig. 1A). Other macrolide antibiotics tested, i.e. clarithromycin at 30mg/kg/d (Fig. 1B), roxithromycin at 30 mg/kg/d (Fig. 1C) and acetylspiramycin at 100 mg/kg/d (Fig. 1D) also showed a significant improvement in this fatigue model."
Even at the lowest does the swimming time of the mice almost doubled and at the higest dose it more than quadrupled.
The lowest dose was a HED of 30mg and the highest about 180mg. Erythromycin often comes in 250mg tablets, so this is absoultely achievebale. And even a microdose had great effects on swimming endurance.
Interestingly other macrolides didn't perform as well, so there must be something special to erythromycin.
This is one of the most impressive performance enhancing effects I've seen so far, allthimaine was even more effective: Allithiamine increases physical performance 7-fold, increases glycogen storage and glucose utilization)
Part of the mechanism was an increase in size and number of mitochondira. It also seems to evolve around a protein called orosomucoid (ORM),which has been shown to increase performance before.
Next they looked at glyocgen and ATP levels.
Erythromycin was able to significantly increase muscle and liver glycogen levels. Muscle glyocen was increased about 60%.
Even more impressive was the incerase of ATP in the muscle: it increased more than 500% !
- Erythromycin has therapeutic efficacy on muscle fatigue acting specifically on orosomucoid to increase muscle bioenergetics and physiological parameters of endurance
Erythromycin was very effective at increasing the swimming time in mice.
"After intragastric administration for 3consecutive days, erythromycin showed a steady dose-effect relationship in forced-swimming time, with a significant increase at a lower
dose of 5 mg/kg/d and nearly 4 folds elevation at dose of 30 mg/kg/d (Fig. 1A). Other macrolide antibiotics tested, i.e. clarithromycin at 30mg/kg/d (Fig. 1B), roxithromycin at 30 mg/kg/d (Fig. 1C) and acetylspiramycin at 100 mg/kg/d (Fig. 1D) also showed a significant improvement in this fatigue model."
Even at the lowest does the swimming time of the mice almost doubled and at the higest dose it more than quadrupled.
The lowest dose was a HED of 30mg and the highest about 180mg. Erythromycin often comes in 250mg tablets, so this is absoultely achievebale. And even a microdose had great effects on swimming endurance.
Interestingly other macrolides didn't perform as well, so there must be something special to erythromycin.
This is one of the most impressive performance enhancing effects I've seen so far, allthimaine was even more effective: Allithiamine increases physical performance 7-fold, increases glycogen storage and glucose utilization)
Part of the mechanism was an increase in size and number of mitochondira. It also seems to evolve around a protein called orosomucoid (ORM),which has been shown to increase performance before.
Next they looked at glyocgen and ATP levels.
Erythromycin was able to significantly increase muscle and liver glycogen levels. Muscle glyocen was increased about 60%.
Even more impressive was the incerase of ATP in the muscle: it increased more than 500% !
- Erythromycin has therapeutic efficacy on muscle fatigue acting specifically on orosomucoid to increase muscle bioenergetics and physiological parameters of endurance
