mitochondria

  1. haidut

    Metabolic (energy) deficiency may be the cause of Parkinson Disease (PD)

    The dogma that PD is just a simple dopamine deficiency manifesting in genetically vulnerable individuals is quickly becoming untenable. It is well-known among clinicians that administering dopamine precursors such as L-Dopa, or selective dopamine agonists such as pramipexole has limited...
  2. haidut

    Mitochondrial debris leaking in bloodstream may cause autoimmune disease

    This has been a recurring topic in my posts, and I am glad to see that more and more scientists are starting to take seriously the idea that chronic stress may be the ultimate cause of most/all "autoimmune" conditions. The whole idea of the immune system suddenly starting to attack an...
  3. haidut

    Inhibiting respiration/metabolism reliably causes bipolar disorder

    Just a quick post on a study, which claims to have established a reliable method for inducing bipolar disorder in an animal model. This reliable method consists simply of administering a low-dose of a mitochondrial inhibitor. More specifically, an inhibitor of complex I of the electron transport...
  4. haidut

    Glucose + vitamin B3 combo synergistic for treating mitochondrial disease

    A very interesting study, which demonstrates the unique synergy between glucose and vitamin B3 in treating deficiencies of function in Complex I & II of the electron transport chain (ETC). Deficiencies on those metabolic steps are the most common causes for the wide varieties of debilitating...
  5. haidut

    Keto (low-carb) diet causes heart fibrosis, blocks mitochondrial biogenesis

    The bad news for the low-carb / keto community keep piling on. There are a number of posts on this blog about studies demonstrating insulin resistance, diabetes, obesity and even sarcopenia as a result of low-carb diets or their close mimetic known as intermittent fasting. Now, the study below...
  6. Hans

    Why Omega 3 should be avoided and what to use/do instead

    Since there are so many discussions and confusion on this forum around omega 3s, I thought I do a deep dive and write this article. If there are so many studies showing that it's good and has so many benefits, how can it be bad...
  7. Mauritio

    Dying Organs Restored to Life through mitochondrial transplant

    https://www.nytimes.com/2018/07/10/health/mitochondria-transplant-heart-attack.html
  8. haidut

    Red Light Therapy For Parkinson Disease (PD) Begins Human Trials

    A few weeks ago, I posted about a human study demonstrating reversal of age-related vision decline by staring at a red light for just a few minutes a day. The mechanism of action proposed in that study had to do with improved mitochondrial function and energy production. Now, it seems another...
  9. RealNeat

    Cell Free Mitochondria?

    Researchers Find Cell-Free Mitochondria Floating in Human Blood what do we suppose is the reasoning behind this? Does it in some way expand upon, microvesicles, exosomes, cell to cell communication? Or is it just remnants of the "life cycle" of a blood cell.
  10. S

    Starting Anti Glycolytic Kettlebell Training

    Using Pavel's The Quick and the Dead. Not too sure what to put in log here, so here goes: Age 53 Sex M Weight 248 Height 5'11" Waking temp: 98.2 - 98.8 Health and stats steadily improving over last 8 months of Peating. This type of trainingg is supposed to increase ATP and mitochondrial...
  11. haidut

    Low Metabolism, Cellular Debris May Cause Huntington Disease (HD)

    Yet another study demonstrating the crucial role of oxidative metabolism (OXPHOS) in a chronic degenerative condition considered largely genetic in origin. Just as importantly, the study corroborates findings from other recent reports/experiments demonstrating that the presence of cellular...
  12. noqcks

    Neurometabolic Mechanisms For Memory Enhancement And Neuroprotection Of Methylene Blue

    Posting some interesting information from this paper. Read the full paper if you are interested in the hypothesized reason MB is helpful for memory. ---- Mechanism of Action "MB not only has great affinity for nervous tissue, it has also been recognized as one of the most potent...
  13. Tristan Loscha

    Monocyte Mitochondrial Function In Calcium Oxalate Stone Formers

    Monocyte Mitochondrial Function in Calcium Oxalate Stone Formers Urology. Author manuscript; available in PMC 2017 Jul 1. Published in final edited form as: Urology. 2016 Jul; 93: 224.e1–224.e6. Published online 2016 Mar 10. doi: 10.1016/j.urology.2016.03.004 PMCID: PMC4914421 NIHMSID...
  14. haidut

    Cardiolipin Supplementation May Reverse Signs Of Aging

    One of the key features of aging is the decline in mitochondrial function (metabolism), and that fact is widely recognized even by mainstream medicine. However, doctors still claim that the relationship between metabolic decline and aging has not be elucidated and a causative link cannot be...
  15. haidut

    Mad Cow Disease May Be A Mitochondrial/metabolic Issue

    Peat has mentioned the Creutzfeldt-Jacob disease (CJD) / BSE in several of his articles and interviews and has explained how environmental stress, estrogen, PUFA, ionizing radiation, etc can cause metabolic derangements resulting in the same brain damage so characteristic of this pathology. The...
  16. haidut

    Aspirin Protects Mitochondria From Inflammation And Aging

    The good news about aspirin just never seem to stop. While the anti-inflammatory effects of aspirin are well-known, mainstream medicine like to explain them away with the limited (and frankly primitive) mechanism of COX inhibition alone. If aspirin happens to achieve some other beneficial health...
  17. haidut

    Restoring Metabolism Prevents / Reverses "permanent" Nerve Damage

    Yet another study demonstrating the crucial role cellular metabolism plays in pathological processes. While most of my posts deal with beneficial effects of improving OXPHOS on various chronic diseases, the study below demonstrates that the same may be true in acute pathologies such as traumatic...
  18. haidut

    Restoring Energy Production In Immune Cells Is Therapeutic In Cancer

    The title of the popular press article is kind of the reverse of mine - i.e. cancer cells evade treatment by blocking energy production in immune cells (T-cells). However, my title still holds since the actual study did show that restoring energy production in T-cells restores the effectiveness...
  19. haidut

    Exposure To Fluoride Actually Damages Teeth, Even At Low Concentrations

    Most adults are familiar with the much-publicized (and advertised) claims of public health authorities about the purported benefits of fluoride exposure for dental health. The official story is that by adding fluoride to tap water, people's teeth are exposed to "low" concentration of fluoride...
  20. haidut

    Some ALS Cases May Be Cured By Vitamin B2 (riboflavin)

    A rather fascinating case study/report, which, despite its misleading and convoluted description, suggests yet again that motor neuron diseases such as Amyotropic Lateral Sclerosis (ALS) are nothing but severe mitochondrial/energetic dysfunction that can often be remediated quite easily. This is...
Top