mitochondria

  1. haidut

    Intense exercise causes mitochondrial damage even in elite athletes

    Hopefully, this post won't be interpreted as trying to bash exercise. Its goal is to simply draw attention to the fact that intense exercise can be detrimental even for elite athletes. While the damage the study observed was temporary, it is now known that (just like ionizing radiation) the...
  2. haidut

    Damaged mitochondria may cause 90%+ of Parkinson Disease (PD) cases

    More evidence that yet another "incurable" condition is little more than energy deficit (due to mitochondrial dysfunction) in disguise. In this case the mitochondrial dysfunction was caused by accumulation of mitochondrial debris inside the cell, which has been repeatedly shown by other studies...
  3. haidut

    Aging is an energy deficiency problem, taking cardiolipin may reverse it

    Yet another study demonstrating that "aging" is nothing but a phenotype characterizing an organism with declining energy production. Since most of the cellular energy is produced in the mitochondria, another way of stating the same is that aging (and any specific disease for that matter) is a...
  4. haidut

    COVID-19 is an energy deficiency disease

    Yet another seemingly non-metabolic disease turns out to be nothing but energy deficiency in disguise. Apparently, the SARS-CoV-2 virus selectively disables so-called complex I of the electron transport chain (ETC), and as such the overall OXPHOS process. Such inhibition is known to reliably...
  5. haidut

    Loss of mitochondrial function (OXPHOS) induces de-differentiation (cancer)

    The study only focuses on the lymphatic system and its cells, but the principle is general and has been observed in other organ/tissue cells. The most obvious example is cancer - no matter which organ it occurs in, the tumor is composed of de-differentiated cells not unlike the stem cells from...
  6. haidut

    Mitochondrial dysfunction may be the cause of anemia

    Despite anemia being a pretty common condition, I still don't think medicine has a good idea what causes anemia (putting aside the more obvious reasons such as chronic bleeding and dietary iron deficiency). In one of the KMUD interviews Peat opined that in his opinion true iron deficiency...
  7. haidut

    Muscle weakness / wasting linked to poor mitochondrial function

    A study that once again illustrates the central principle of bioenergetics - structure and function cannot be separated. They are interdependent at every level. In this specific case, the "structural" pathology is muscle weakness and wasting (sarcopenia, cachexia, etc). Most doctors, when...
  8. haidut

    Vitamin D deficiency impairs muscles by lowering energy production

    Perhaps this study below will put some of the arguments against vitamin D supplementation to rest. It demonstrated up to 40% reduction of energy production in the muscles of animals deficient in vitamin D, in spite of unchanged number/size/density of mitochondria inside the cells. In addition...
  9. P

    Cool coffee video

    View: https://youtu.be/rNbWDnUMaEk This video talks a lot about the key reasons Peat and others in the bioenergetic community think coffee is so valuable. Well done.
  10. haidut

    Metabolic (energy) deficiency may be the cause of Parkinson Disease (PD)

    The dogma that PD is just a simple dopamine deficiency manifesting in genetically vulnerable individuals is quickly becoming untenable. It is well-known among clinicians that administering dopamine precursors such as L-Dopa, or selective dopamine agonists such as pramipexole has limited...
  11. haidut

    Mitochondrial debris leaking in bloodstream may cause autoimmune disease

    This has been a recurring topic in my posts, and I am glad to see that more and more scientists are starting to take seriously the idea that chronic stress may be the ultimate cause of most/all "autoimmune" conditions. The whole idea of the immune system suddenly starting to attack an...
  12. haidut

    Inhibiting respiration/metabolism reliably causes bipolar disorder

    Just a quick post on a study, which claims to have established a reliable method for inducing bipolar disorder in an animal model. This reliable method consists simply of administering a low-dose of a mitochondrial inhibitor. More specifically, an inhibitor of complex I of the electron transport...
  13. haidut

    Glucose + vitamin B3 combo synergistic for treating mitochondrial disease

    A very interesting study, which demonstrates the unique synergy between glucose and vitamin B3 in treating deficiencies of function in Complex I & II of the electron transport chain (ETC). Deficiencies on those metabolic steps are the most common causes for the wide varieties of debilitating...
  14. haidut

    Keto (low-carb) diet causes heart fibrosis, blocks mitochondrial biogenesis

    The bad news for the low-carb / keto community keep piling on. There are a number of posts on this blog about studies demonstrating insulin resistance, diabetes, obesity and even sarcopenia as a result of low-carb diets or their close mimetic known as intermittent fasting. Now, the study below...
  15. Hans

    Why Omega 3 should be avoided and what to use/do instead

    Since there are so many discussions and confusion on this forum around omega 3s, I thought I do a deep dive and write this article. If there are so many studies showing that it's good and has so many benefits, how can it be bad...
  16. Mauritio

    Dying Organs Restored to Life through mitochondrial transplant

    https://www.nytimes.com/2018/07/10/health/mitochondria-transplant-heart-attack.html
  17. haidut

    Red Light Therapy For Parkinson Disease (PD) Begins Human Trials

    A few weeks ago, I posted about a human study demonstrating reversal of age-related vision decline by staring at a red light for just a few minutes a day. The mechanism of action proposed in that study had to do with improved mitochondrial function and energy production. Now, it seems another...
  18. RealNeat

    Cell Free Mitochondria?

    Researchers Find Cell-Free Mitochondria Floating in Human Blood what do we suppose is the reasoning behind this? Does it in some way expand upon, microvesicles, exosomes, cell to cell communication? Or is it just remnants of the "life cycle" of a blood cell.
  19. S

    Starting Anti Glycolytic Kettlebell Training

    Using Pavel's The Quick and the Dead. Not too sure what to put in log here, so here goes: Age 53 Sex M Weight 248 Height 5'11" Waking temp: 98.2 - 98.8 Health and stats steadily improving over last 8 months of Peating. This type of trainingg is supposed to increase ATP and mitochondrial...
  20. haidut

    Low Metabolism, Cellular Debris May Cause Huntington Disease (HD)

    Yet another study demonstrating the crucial role of oxidative metabolism (OXPHOS) in a chronic degenerative condition considered largely genetic in origin. Just as importantly, the study corroborates findings from other recent reports/experiments demonstrating that the presence of cellular...
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