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mitochondria
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Chronic pain due to mitochondrial dysfunction, niacinamide can treat it
As many of my readers know, there is an epidemic of chronic pain disorders in Western countries, which has subsequently led to over-prescription and (ab)use of opioid medication, which has then acted as a gateway drug and fueled a massive and deadly opioid epidemic in those countries. In order...- haidut
- Thread
- inflammation mitochondria niacinamide nicotinamide nicotinamide riboside pain vitamin b3
- Replies: 0
- Forum: Scientific Studies
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A single 15min exposure to red light boosts mitochondria and lowers blood glucose
A human study, which makes it that much more important. While the findings are not very surprising, what is important to take from the study is that 1) elevated blood glucose is likely a good biomarker of poor mitochondrial function, 2) exposure to just 15min of red light daily can lower blood...- haidut
- Thread
- atp diabetes glucose glycogen mitochondria oxphos red light
- Replies: 8
- Forum: Scientific Studies
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Obesity linked to mitochondrial dysfunction in GI tract, treatable by fat restriction
I think the claim that obesity can be caused by lower metabolism is not something contentious, even though mainstream medicine will claim that it only happens in clinical hypothyroidism. The so-called idiopathic obesity in the general population (now affecting 40%+ of people) is claimed to be...- haidut
- Thread
- chylomicrons diabetes enterocytes fat gi lipids mitochondria obesity
- Replies: 6
- Forum: Scientific Studies
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Adolescent stress causes mental illness, cognitive issues by lowering metabolism
It has long been known that pre-natal stress (e.g. stressed of the mother during pregnancy), as well as chronic stress after birth are associated with high risk of mental illness, criminal behavior, substance abuse, reduced cognitive function, chronic illness, and even early death. However, the...- haidut
- Thread
- cognition energy mental illness mitochondria oxphos respiration stress
- Replies: 3
- Forum: Scientific Studies
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LipOdd - Liquid Product With Odd-Chain Saturated Fats (SFA)
More than a decade ago, when I was just beginning my exploration of bioenergetics, one of the first indications that Ray's writings were onto something when it came to SFA vs. PUFA was the fact that while mainstream medicine ruthlessly bashed SFA in general and promoted PUFA, virtually very... -
Mammals can generate ATP from sunlight like plants , if they eat chlorophyll (interesting)
Light-harvesting chlorophyll pigments enable mammalian mitochondria to capture photonic energy and produce ATP Light-harvesting chlorophyll pigments enable mammalian mitochondria to capture photonic energy and produce ATP Effect is enhanced by (dependant on?) chlorophyll substances...- cs3000
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- atp chlorophyll chlorophyll a green peas light mitochondria photosynthesis plants sunlight
- Replies: 9
- Forum: Articles & Scientific Studies
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Iron is essential for ability of thyroid hormone to function
Study highlighting the importance of having good iron levels for peat approach to health. in the peat realm sometimes there's a tilted view against iron as if it's on the same level as a PUFA or something to be avoided, so can be overlooked. (overload toxicity isn't good + trying to fix...- cs3000
- Thread
- atp bioenergetics iron mitochondria t3 thyroid
- Replies: 2
- Forum: Scientific Studies
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Reduced availability/oxidation of glucose sufficient to cause heart failure (HF)
Yet another "mysterious" idiopathic condition turns out to be nothing but metabolic dysregulation in disguise. Also, unlike many other studies implicating metabolism in disease, this one actually manages to demonstrate that reduction of oxidative glucose metabolism is sufficient to cause severe...- haidut
- Thread
- glucose heart failure lactate ldh mitochondria oxphos pyruvate
- Replies: 1
- Forum: Scientific Studies
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Inhibiting oxidative metabolism can cause inflammation, aggressive cancer
Despite medicine's rabid defense of the "cancerous mutation" origin theory of cancer, it looks like evidence for the metabolic origins of cancer has always been around and hiding in "plain sight". The study below cites the apparently well-known causal link between accumulation of fumarate (a...- haidut
- Thread
- autoimmune cancer citric fumarate inflammation krebs mitochondria oxphos
- Replies: 0
- Forum: Scientific Studies
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Parkinson Disease (PD) akin to infectious disease - driven by endotoxin, damaged mitochondria
Yet another study demonstrating that there is no need for genes or any other hereditary mechanism to explain the cause and development of PD. The study below demonstrated that the presence of damaged mitochondrial DNA in the bloodstream is sufficient to cause all symptoms of PD, and the effects...- haidut
- Thread
- endotoxin lps mitochondria mtdna parkinson prion tlr4 tlr9
- Replies: 3
- Forum: Scientific Studies
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Restoring mitochondrial function reverses aging in blood/immune cells
The number of studies focusing on bioenergetics as a reliable method for delaying (or even reversing) aging continues to rapidly grow. A few years ago, an in-vivo study with humans demonstrated that human immune system aging can be reversed by a combination of DHEA and a few other, less...- haidut
- Thread
- aging bioenergetics immune mitochondria mitophagy oxphos
- Replies: 2
- Forum: Scientific Studies
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Stress/Injury (mitochondrial dysfunction) sufficient to cause de-differentiation, even cancer
One of the most pernicious myths in medicine is the "irreversibility" of several cellular processes related to aging, diabetes, fibrosis and, of course, cancer. Perhaps the most fundamental of those processes is cellular differentiation. To this day, the dominant opinion in medicine is that once...- haidut
- Thread
- cancer differentiation electron flow etc mitochondria oxphos reactive oxygen species ros
- Replies: 2
- Forum: Scientific Studies
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The performance enhancing effects of erythromycin
This study looked at the performance enhancing effects of erythromycin and other anti-biotics in mice, with some pretty interesting results. Erythromycin was very effective at increasing the swimming time in mice. "After intragastric administration for 3consecutive days, erythromycin showed a...- Mauritio
- Thread
- athletic performance atp erythromycin glycogen mitochondria performance swimming
- Replies: 21
- Forum: Scientific Studies
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Video with visuals: Taurine - a supplement for longevity? -- The Sheekey Science Show
Here is a video on youtube by The Sheeky Science Show. Going over some results of some studies, showing graphs and other data, explaining potential benefits and some mechanisms. Taurine - a supplement for longevity Some timestamps and extracts from the video: 1:02 taurine...- TruffleGnocchi
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- bone density cytotoxicity gaba longevity mitochondria protein folding senescence taurine tudca white blood cells
- Replies: 3
- Forum: Taurine
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Sodium Copper Chlorophyllin (liquid chlorophyll) benefits
Chlorophyllin is a derivative of chlorophyll, aka water soluble chlorophyll Increases White blood count, Red blood count, Hemoglobin slightly, by 14 and 28 days , (from normal baselines, in rats with oxidative stress induced lowering of these i bet would be big effect)...- cs3000
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- blood count chlorophyllin colitis copper h2o2 liquid chlorophyll mitochondria mitochondria dysfunction oxidative stress wound healing
- Replies: 3
- Forum: Supplements, Pharmaceutical Drugs
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Fasting/exercise/lowcarb/keto may promote cancer (melanoma) metastasis
Quite the title for this post, but I think the evidence from the study below is clear. Namely, chronic activation of the so-called "master metabolic sensor" AMPK is a key mechanism through which melanoma cells rewire their metabolism from higher into lower OXPHOS, change their physical structure...- haidut
- Thread
- ampk cancer exercise fao fasting fission lowcarb melanoma mitochondria oxphos paleo
- Replies: 29
- Forum: Scientific Studies
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Metabolic rate may determine personality type and disease risk
Very interesting study that links mitochondrial density/number (and as such, the metabolic rate) with personality types. Namely, people with fewer mitochondrial (i.e. hypometabolic) tend to have high levels of neuroticism, with the latter causally linked to a higher risk of a number of serious...- haidut
- Thread
- atp bioenergetics mitochondria neuroticism oxphos personality
- Replies: 4
- Forum: Scientific Studies
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CoQ10 (Ubiquinone) reduces exercise induced lactate increase
Effects of oral coenzyme Q10 on preventing the accumulation of lactic acid developing during the exercise performances of endurance skiing athletes CoQ10 levels are often reduced in people who do a lot of exercise, people who take statins. 300mg+ may interfere with exercise adaptation. but...- cs3000
- Thread
- coq10 exercise lactate lactic acid mitochondria oxidative phosphorylation oxidative stress ubiquinone
- Replies: 1
- Forum: Scientific Studies
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Restoring mitochondrial function may be sufficient to reverse aging
The findings of the study may not sound very novel to my readers, however please keep in mind that the vast majority of anti-aging studies so far have only looked at slowing (not even stopping) aging. Actually reversing aging is the Holy Grail of gerontology, and to date very few studies have...- haidut
- Thread
- aging energy lifespan mitochondria oxphos polarization
- Replies: 6
- Forum: Scientific Studies
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Hesperetin restores youth in old rats - enhances lifespan ~8% up to ~14% when given late, restores mitochondria & metabolism, reverses heart damage
Posting this part from a thread i wrote on Hesperidins beneficial effects on toxic metal protection, diabetes, wound healing etc Great study on the life promoting effects of hesperitin (the derivative of hesperidin found in orange juice): *Reverses effects of aging / restores youth...- cs3000
- Thread
- aging flavonoid heart hesperetin hesperidin life extension lifespan mitochondria mitochondrial dysfunction
- Replies: 19
- Forum: Supplements, Pharmaceutical Drugs