• Due to excessive bot signups along with nefarious actors we are limiting forum registration. Keep checking back for the register link to appear. Please do not send emails or have someone post to the forum asking for a signup link. Until the current climate changes we do not see a change of this policy. To join the forum you must have a compelling reason. Letting us know what skills/knowledge you will bring to the community along with the intent of your stay here will help in getting you approved.

mitochondria

  1. haidut

    Uncoupling metabolism/OXPHOS may treat inflammatory conditions

    In several of his articles and interviews, Peat mentioned that one of the reliable signs/symptoms of low metabolism is the presence of low-grade chronic inflammation. Basically, the cell is stuck into a constant (and futile) repair process as it cannot complete it properly after discovering the...
  2. haidut

    Restoring oxidative metabolism has curative effects on cancer (leukemia)

    A great study, which directly demonstrates not only the OXPHOS deficiency characteristic of all "cancer" cells, but also proving that restoration of OXPHOS is highly therapeutic (and likely curative) for leukemia. Just as importantly, the study demonstrates that cancer cells have, in fact...
  3. haidut

    Cartilage/bone health depends on oxidative metabolism

    A good study that demonstrates yet another "structural" aspect of health - the strength and growth or our cartilage/bones - is heavily dependent on proper mitochondrial function. As such, even minor disruptions of oxidative metabolism can lead to long-term deformations in bone/cartilage, which...
  4. haidut

    Infrared/red light applied to the skull can treat Alzheimer's/dementia...

    ...and improve cognition even in healthy people! The mechanism of action is the familiar effects of red/infrared light on stimulating mitochondrial function, and especially complex IV, while also decreasing chronic inflammation. The regimen was light exposure for 6min, twice a day, for 4 weeks...
  5. Twohandsondeck

    Science shows that humans are only 6,000 years old (mtDNA)

    View: https://youtu.be/iWshBFUXYNs At the timestamp 8:04 (8 minutes and 4 seconds) the presentation is given that based on the evolutionary rate of the mitochondrial clock of women, the first woman lived about 6,000 years ago, which aligns with the written words of the King James Bible. The...
  6. haidut

    How lipolysis may damage organs such as the heart

    It is well-known in endocrinology, and especially among doctors specializing in diabetes, that excessive lipolysis is highly detrimental not only for the overall progression of metabolic diseases like diabetes, but also for most of the organs of the patient. Lipolysis is known to be elevated in...
  7. haidut

    Cellular "memory" of stress can be passed on for 50+ generations

    There was a study that came out 2-3 years ago showing that when animals were exposed to a toxin, often the negative effects did not even manifest in the directly exposed organism but manifested in their offspring and were passed on for more than 14 generations. The study below now demonstrates...
  8. haidut

    Intense exercise causes mitochondrial damage even in elite athletes

    Hopefully, this post won't be interpreted as trying to bash exercise. Its goal is to simply draw attention to the fact that intense exercise can be detrimental even for elite athletes. While the damage the study observed was temporary, it is now known that (just like ionizing radiation) the...
  9. haidut

    Damaged mitochondria may cause 90%+ of Parkinson Disease (PD) cases

    More evidence that yet another "incurable" condition is little more than energy deficit (due to mitochondrial dysfunction) in disguise. In this case the mitochondrial dysfunction was caused by accumulation of mitochondrial debris inside the cell, which has been repeatedly shown by other studies...
  10. haidut

    Aging is an energy deficiency problem, taking cardiolipin may reverse it

    Yet another study demonstrating that "aging" is nothing but a phenotype characterizing an organism with declining energy production. Since most of the cellular energy is produced in the mitochondria, another way of stating the same is that aging (and any specific disease for that matter) is a...
  11. haidut

    COVID-19 is an energy deficiency disease

    Yet another seemingly non-metabolic disease turns out to be nothing but energy deficiency in disguise. Apparently, the SARS-CoV-2 virus selectively disables so-called complex I of the electron transport chain (ETC), and as such the overall OXPHOS process. Such inhibition is known to reliably...
  12. haidut

    Loss of mitochondrial function (OXPHOS) induces de-differentiation (cancer)

    The study only focuses on the lymphatic system and its cells, but the principle is general and has been observed in other organ/tissue cells. The most obvious example is cancer - no matter which organ it occurs in, the tumor is composed of de-differentiated cells not unlike the stem cells from...
  13. haidut

    Mitochondrial dysfunction may be the cause of anemia

    Despite anemia being a pretty common condition, I still don't think medicine has a good idea what causes anemia (putting aside the more obvious reasons such as chronic bleeding and dietary iron deficiency). In one of the KMUD interviews Peat opined that in his opinion true iron deficiency...
  14. haidut

    Muscle weakness / wasting linked to poor mitochondrial function

    A study that once again illustrates the central principle of bioenergetics - structure and function cannot be separated. They are interdependent at every level. In this specific case, the "structural" pathology is muscle weakness and wasting (sarcopenia, cachexia, etc). Most doctors, when...
  15. haidut

    Vitamin D deficiency impairs muscles by lowering energy production

    Perhaps this study below will put some of the arguments against vitamin D supplementation to rest. It demonstrated up to 40% reduction of energy production in the muscles of animals deficient in vitamin D, in spite of unchanged number/size/density of mitochondria inside the cells. In addition...
  16. P

    Cool coffee video

    View: https://youtu.be/rNbWDnUMaEk This video talks a lot about the key reasons Peat and others in the bioenergetic community think coffee is so valuable. Well done.
  17. haidut

    Metabolic (energy) deficiency may be the cause of Parkinson Disease (PD)

    The dogma that PD is just a simple dopamine deficiency manifesting in genetically vulnerable individuals is quickly becoming untenable. It is well-known among clinicians that administering dopamine precursors such as L-Dopa, or selective dopamine agonists such as pramipexole has limited...
  18. haidut

    Mitochondrial debris leaking in bloodstream may cause autoimmune disease

    This has been a recurring topic in my posts, and I am glad to see that more and more scientists are starting to take seriously the idea that chronic stress may be the ultimate cause of most/all "autoimmune" conditions. The whole idea of the immune system suddenly starting to attack an...
  19. haidut

    Inhibiting respiration/metabolism reliably causes bipolar disorder

    Just a quick post on a study, which claims to have established a reliable method for inducing bipolar disorder in an animal model. This reliable method consists simply of administering a low-dose of a mitochondrial inhibitor. More specifically, an inhibitor of complex I of the electron transport...
  20. haidut

    Glucose + vitamin B3 combo synergistic for treating mitochondrial disease

    A very interesting study, which demonstrates the unique synergy between glucose and vitamin B3 in treating deficiencies of function in Complex I & II of the electron transport chain (ETC). Deficiencies on those metabolic steps are the most common causes for the wide varieties of debilitating...
Top