1. haidut

    Human study - vitamin B6 may relieve anxiety and depression

    Vitamin B6 is perhaps one of the most underrated B vitamins. While it attracted a lot of interest in the 1960s and 1970s as a potential natural treatment to raise dopamine and/or lower prolactin, subsequent "well-controlled" studies claimed that it was not effective. However, the fact remains...
  2. F

    Some Questions About Vitamin B6 (P5P)

    Hi folks, I’d like to supplement P-5-P (the active form of vitamin B6), since I’ve read it could help with brain fog, focus, overall energy and motivation, by boosting dopamine production. I've seen also an interesting theory (TBH can't remember where) according to which P5P could also help...
  3. GutFeeling

    Pyridoxine Is Toxic And Inhibit P5P Function?

    The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. - PubMed - NCBI ↓ Full text The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. Vrolijk MF, et al. Toxicol In...
  4. haidut

    Cardenosine - Liquid Product For R&D

    Our new product is finally here and it is "all about the ATP". I mentioned quite a few times on the forum and over email that we plan on releasing an ATP product and people have been asking me about it for the last few months. It seems a very simple task at first but we thought that we can do a...
  5. M

    P5p Source

    Anyone ever use Pure Bulk as a source for any supplements? Am thinking about purchasing some P5P from them but am not familiar with them. Also, does P5P in powder form taste OK?
  6. ecstatichamster

    Magnesium, P5P And Butt Hurts No More

    I think there is such thing as "bowel tolerance" for Mg. If you take a bunch and you don't get loose stool, it's going into your body. If you take it and it causes loose stool, you've taken too much, the wrong form, OR you need some missing co-factor. I went years with a hurting butt. I first...
  7. haidut

    Vitamin B6 (P5P) Functions As A PPI

    If I am reading this right, P5P acts like a PPI. This would explain some of the protective effects of P5P on stress-induced gastric ulcers in animals and men. http://www.jbc.org/content/263/8/3652.long "...Pig gastric membrane vesicles enriched in (H++K+)-ATPase were covalently modified with...
  8. haidut

    Vitamin B6 (P5P) Is A Glucocorticoid (cortisol) Antagonist

    The studies go back to 1960s and 1970s but when I read them I was surprised to find that the activated form of vitamin B6 called pyridoxal-5-phosphate (what we also use for our Energin supplement) is a glucocorticoid "receptor" antagonist. Some of the in vivo studies referenced in the studies...
  9. J

    P5P (a form of B6) Toxicity

    I found some people on the internet claiming they had neuropathy symptoms from the P5P form of vitamin B6, the one that's supposed to be safer. One used a coated tablet, other sublingual. Maybe some additives caused the problem, not the P5P. One claimed later B12 supplementation cured the...
  10. Bluebell

    Wow Had Great Effect From P5P Active Form Of B6

    I took some P5P, 50mg today and 50mg yesterday, with great effects. I have been struggling with neuropathy and body malaise. After taking the P5P the issues seemed to lift a bit and I felt more myself, more calm but energetic. I'm cautiously optimistic as often supplements are great to start...
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