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  1. haidut

    "Endurance" exercise ages the vascular system of males by more than a decade

    A very interesting study, though I don't really agree with its findings that while "endurance" (in this case running) exercise damages male vascular system it is beneficial for the female one. The majority of intervention studies that looked at both sexes, across all age groups found that...
  2. Sefton10

    Vitamin D supplementation is associated with slower epigenetic aging

    Adverse effects of low vitamin D level on mortality and morbidity are controversially discussed. Especially older people are at risk for vitamin D deficiency and therefore exposed to its potentially harmful consequences. A way of measuring differences in the biological age is through DNA...
  3. haidut

    Hypogonadism in older males due to low OXPHOS

    I suspect many readers will simply say "duh!", but believe or not the origin of age-related hypogonadism in males is still considered unknown. Most endocrinologists have discovered experimentally that treating their patients with SERM or AI drugs restores androgens to youthful levels, but the...
  4. haidut

    Age-related steroid deficiency may be treatable with niacinamide

    The study is actually about eye health, and the effects androgens play in it. However, the findings are not limited to the eyes and are in fact applicable for any other tissue/organ experiencing a decline in steroidogenesis with advancing age, which is basically all of them. As such, I am...
  5. haidut

    Aging and disease are the same process, driven by low metabolism

    I am posting about this mostly due to its "told you so" factor - i.e. more and more professionals in the medical and research fields are starting to realize that the super-specialized approach to treating chronic diseases has not produced any substantial results. In addition, the correlation...
  6. haidut

    Exercise brain-boost may be due simply to increasing brain selenium levels

    Yet another study demonstrating that many of the "mysterious" benefits of exercise most likely have nothing to do with the (insignificant) amount of extra calories burned, but are due to peripheral effects related to metabolism and redox balance. Namely, the study below investigates the...
  7. Lejeboca

    Ray Peat Interview KMUD - January 21, 2022

    Redwood Community Radio Archive
  8. haidut

    Fasting causes aging by energy depletion, vitamin B2 can stop it

    Well, if this title does not rile up the fasting crowd, I don't know what will:-) Aside from that controversy, it is actually a great study that not only suggests a dirt cheap and widely available option for retarding aging, but once again demonstrates that stress (e.g. fasting) directly causes...
  9. haidut

    DHT can stop aging of the pancreatic beta-cells (insulin-producing)

    Another great study, which demonstrates that far from being a "villain" (in both males and females) DHT is in fact a crucial and positive factor in health. In this specific study below, it was demonstrated that DHT dose-dependently inhibited the aging/dysfunction of the pancreatic beta-cells...
  10. A

    Hypercapnia-inducible factor: a hypothesis | Aging and longevity

    Abstract Cells and tissues sense and respond to hypercapnia by global activation or down-regulation of hundreds of genes and switching on/off a number of signaling and metabolic pathways. We hypothesize for the first time that such complex rearrangements are hardly possible without subtle...
  11. LLight

    Selecting your food might make you (flies) age faster

    https://elifesciences.org/articles/59399 We might be f*cked. Or, establish a good diet that is available all year long and do not deviate from it one bit?
  12. haidut

    Aging is an energy deficiency problem, taking cardiolipin may reverse it

    Yet another study demonstrating that "aging" is nothing but a phenotype characterizing an organism with declining energy production. Since most of the cellular energy is produced in the mitochondria, another way of stating the same is that aging (and any specific disease for that matter) is a...
  13. haidut

    Inflammation (from PUFA), not telomeres, determines lifespan / healthspan

    The idea of lifespan being entirely determined by limits on cellular division has ruled biology for more than a century and is perhaps best exemplified by the (in)famous (and false) Hayflick limit. Reaching the said limit is postulated to be controlled by telomere length, and as such the...
  14. haidut

    Low DHT can cause hypogonadism symptoms even in eugonadal men

    Seemingly contradictory title, but the study findings are pretty clear. Namely, even in males with normal testosterone levels there is a direct inverse relationship between DHT levels and symptoms of hypogonadism such as sexual dysfunction and "aging male" syndrome. For every 10% increase in DHT...
  15. A

    Aging seems to progress in discrete steps - at 34, 60, 78 years

    According to this study which analysed proteins in blood: Stanford scientists reliably predict people’s age by measuring proteins in blood This would strongly point at programmed aging, rather than driven strictly by metabolism, no? As much as I appreciate Ray's work and agree with his methods...
  16. BestSinceDAYONE

    Low carb dieters look so much older

    Is it me or do the low carb gurus look significantly older? Peter Attia, Joe Rogan, Mark Sisson, Gary Taubes, Shawn Baker They all have one thing in common, their faces (and hairlines) look so much worse but they have shredded physiques.
  17. haidut

    Blocking PUFA/prostaglandins restores metabolism and reverses brain aging

    The bad news for PUFA has been accumulating for decades, yet public health authorities continue to claim that type of fat is "essential". Whatever indirect admissions of the pathological role of PUFA in both chronic and acute/infectious diseases is given to the public, is usually confined to the...
  18. cupofcoffee

    Caffeine promotes the expression of telomerase reverse transcriptase to regulate cellular senescence and aging

  19. P

    55 year-old looks like 25

    Interesting video about a 55 year-old photographer who looks like an elite 25 year-old fitness model. He's 55 Years Old But Looks 25... Reacting To Chuando Tan Reveal His Secrets Summary: He looks the same as he did in the late 1980s, in his 20s. He doesn't drink or smoke, doesn't drink coffee...
  20. llian

    Reverse aging

    Hi! Fairly new to this forum Can somebody correct/add anything else to my guide that i made and infos that i gathered for a while?? This is it: • Lifestyle: ⚠️no stres, smoking, drinking, drugs, too much sun⚠️ 》Wim Hof breathing / Buteyko Method 》Meditation 》3x/week sprint. 3x/week running...