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aging

  1. haidut

    Aspirin / eugenol can remove lipofuscin from cells

    One of the visible hallmarks of aging is the accumulation of so-called "age pigment" or "aging spots", commonly known in scientific circles as lipofuscin. The latter is a complex mix of peroxidized polyunsaturated fats (PUFA) and various metals (especially iron) that accumulates in cells with...
    • haidut
    • Thread
    • aging aspirin eugenol iron lipofuscin metabolism peroxidation pufa
    • Replies: 48
    • Forum: Scientific Studies
  2. haidut

    Restoring mitochondrial function may be sufficient to reverse aging

    The findings of the study may not sound very novel to my readers, however please keep in mind that the vast majority of anti-aging studies so far have only looked at slowing (not even stopping) aging. Actually reversing aging is the Holy Grail of gerontology, and to date very few studies have...
    • haidut
    • Thread
    • aging energy lifespan metabolism mitochondria oxphos polarization
    • Replies: 6
    • Forum: Scientific Studies
  3. haidut

    The "cancer metabolism" drives aging in humans

    A truly monumental study, as it is perhaps the first one to demonstrate that "aging" in human cells is entirely under metabolic control. What can I say - Ray Peat right again! Unfortunately, the way the actual study has been worded has been, once again, criminally mis-represented by mainstream...
    • haidut
    • Thread
    • aging cancer glycolysis lifespan metabolism mitohondria oxphos
    • Replies: 15
    • Forum: Scientific Studies
  4. C

    Aging Of A 53 YO Male After 25yrs of Dutasteride 35yrs Oral Steroids + No Testosterone Or DHT

    On top of suppressing his natural testosterone production to nothing until age 51 by taking oral steroids, he suppressed his dht to about zero by taking a full dose of dutasteride. He added 125mg of testosterone at age 51 and used to take aromatase inhibitors when he was taking growth hormone...
  5. C

    Hesperetin restores youth in old rats - enhances lifespan ~8% up to ~14% when given late, restores mitochondria & metabolism, reverses heart damage

    Posting this part from a thread i wrote on Hesperidins beneficial effects on toxic metal protection, diabetes, wound healing etc Great study on the life promoting effects of hesperitin (the derivative of hesperidin found in orange juice): *Reverses effects of aging / restores youth...
  6. haidut

    Major depression likely driven by mitochondrial deterioration/dysfunction

    This the latest study demonstrating that not only are various chronic diseases and aging essentially the same process, but that this process is fundamentally bioenergetic in nature. Namely, dysfunctional mitochondria, leading to low OXPHOS, is the direct cause of many physiological and "mental"...
    • haidut
    • Thread
    • aging bioenergetics depression gdf-15 mitochondria oxphos senescence senolytic
    • Replies: 4
    • Forum: Scientific Studies
  7. Limon9

    MTOR Increases With Aging/Sarcopenia, (Partial) Inhibition Restores Muscle Mass

    This was a nice experiment which upsets the naive axis of anabolism and catabolism commonly-associated with the mTOR (mammalian target of rapamycin). Its activation is not sufficient to maintain muscle mass, and partially inhibiting it can unexpectedly restore muscle. Common medical advice is...
  8. haidut

    Higher protein, sugar, and vitamin E consumption beneficial for health/aging

    I would say right from the start that there are obviously a very large number of dietary components that can have beneficial effect on our health. The study below cannot possibly look at all of them, but from the ones it examined those three (3) variables the title mentions gave the most benefit...
    • haidut
    • Thread
    • aging carbs health protein sugar tocopherol vitamin e
    • Replies: 10
    • Forum: Scientific Studies
  9. haidut

    Being Sad and Lonely Accelerates Aging More Than Smoking

    The title is the same as the one of the popular press article. And since feelings of sadness and loneliness are primarily caused by elevated serotonin, we can add premature aging to the list of "benefits" serotonin offers. The findings of this study probably explain a great deal of the premature...
    • haidut
    • Thread
    • aging depression loneliness mental health sadness serotonin smoking ssri
    • Replies: 6
    • Forum: Scientific Studies
  10. haidut

    Negative childhood experiences accelerate aging/disease in humans

    I am posting this study mostly as a counterexample to all the drivel coming out of gerontology research circles. Namely, the dogma is that biological aging is overwhelmingly influenced/determined by genes and cannot really be retarded (pun intended) or accelerated by the environment. This dogma...
    • haidut
    • Thread
    • abuse aging biomarker childhood disease neglect nurture stress
    • Replies: 5
    • Forum: Scientific Studies
  11. haidut

    Lifestyle, not age, rules cognitive function...

    ...whether you are 18 or 80. Yes, I know it is hard to believe this statement but that is the conclusion of the study after examining the link between lifestyle (and environment) and cognitive function in a group of people with ages spanning the 18-89 years interval. The conclusion of the study...
    • haidut
    • Thread
    • aging brain cognition dementia diabetes education lifestyle smoking
    • Replies: 15
    • Forum: Scientific Studies
  12. haidut

    No evidence for rate-of-living theory of aging

    Just a quick post, since this topic dominates anti-aging research - i.e. despite lack of concrete evidence for it, mainstream research (and finding agencies) continue to claim that longevity is tied to metabolism, but in an inverse relationship. The study below is on turtles - one of the longest...
    • haidut
    • Thread
    • aging endotherm lifespan longevity metabolism oxphos turtle
    • Replies: 10
    • Forum: Scientific Studies
  13. haidut

    "Endurance" exercise ages the vascular system of males by more than a decade

    A very interesting study, though I don't really agree with its findings that while "endurance" (in this case running) exercise damages male vascular system it is beneficial for the female one. The majority of intervention studies that looked at both sexes, across all age groups found that...
    • haidut
    • Thread
    • aging calcification cortisol cvd endurance exercise running vascular
    • Replies: 23
    • Forum: Scientific Studies
  14. Sefton10

    Vitamin D supplementation is associated with slower epigenetic aging

    Adverse effects of low vitamin D level on mortality and morbidity are controversially discussed. Especially older people are at risk for vitamin D deficiency and therefore exposed to its potentially harmful consequences. A way of measuring differences in the biological age is through DNA...
    • Sefton10
    • Thread
    • aging anti-aging epigenetic vitamin d
    • Replies: 13
    • Forum: Vitamins
  15. haidut

    Hypogonadism in older males due to low OXPHOS

    I suspect many readers will simply say "duh!", but believe or not the origin of age-related hypogonadism in males is still considered unknown. Most endocrinologists have discovered experimentally that treating their patients with SERM or AI drugs restores androgens to youthful levels, but the...
    • haidut
    • Thread
    • aging co2 hypogonadism male metabolism oxphos precursor testosterone
    • Replies: 9
    • Forum: Scientific Studies
  16. haidut

    Age-related steroid deficiency may be treatable with niacinamide

    The study is actually about eye health, and the effects androgens play in it. However, the findings are not limited to the eyes and are in fact applicable for any other tissue/organ experiencing a decline in steroidogenesis with advancing age, which is basically all of them. As such, I am...
    • haidut
    • Thread
    • aging androgen dry eye eye hypogonadism meibomian nad niacinamide nicotinamide nicotinamide mononucleotide nicotinamide riboside nmn nr steroidogenesis
    • Replies: 12
    • Forum: Scientific Studies
  17. haidut

    Aging and disease are the same process, driven by low metabolism

    I am posting about this mostly due to its "told you so" factor - i.e. more and more professionals in the medical and research fields are starting to realize that the super-specialized approach to treating chronic diseases has not produced any substantial results. In addition, the correlation...
  18. haidut

    Exercise brain-boost may be due simply to increasing brain selenium levels

    Yet another study demonstrating that many of the "mysterious" benefits of exercise most likely have nothing to do with the (insignificant) amount of extra calories burned, but are due to peripheral effects related to metabolism and redox balance. Namely, the study below investigates the...
    • haidut
    • Thread
    • aging brain cognition exercise neurogenesis selenium thyroid
    • Replies: 53
    • Forum: Scientific Studies
  19. Lejeboca

    Ray Peat Interview KMUD - January 21, 2022

    Redwood Community Radio Archive
  20. haidut

    Fasting causes aging by energy depletion, vitamin B2 can stop it

    Well, if this title does not rile up the fasting crowd, I don't know what will:-) Aside from that controversy, it is actually a great study that not only suggests a dirt cheap and widely available option for retarding aging, but once again demonstrates that stress (e.g. fasting) directly causes...
    • haidut
    • Thread
    • aging ampk fad fasting oxphos riboflavin senescence senolytic stress vitamin b2
    • Replies: 38
    • Forum: Scientific Studies
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