Janelle525 said:post 102175 Did you use caffeine with it? Coffee helps that mood issue as well.
Oh yeah, but caffeine, especially coffee, konks me out more often than it actually stimulates me.
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Janelle525 said:post 102175 Did you use caffeine with it? Coffee helps that mood issue as well.
haidut said:post 102170 Dean wrote:
Source of the post Just as a follow up to my experience before. I tried 1 mg before bed the other night and the next day fell into a deep despair within a few hours of waking that lasted for several hours. Perhaps I was flooded with serotonin after the dosage wore off?
I tried it again because on hindsight I felt that my taking of cypro had helped me with motivation(via lessening learned helplessness, I presume) for even a few weeks after I stopped (due to how much it depressed me.) Thought maybe I could get that benefit without the depressiveness with the small dose at night. So much for that.
It's great to hear that cypro helps some people, but I guess it's important to keep in mind there is some risk involved and the negative side effects, for some, can be dangerous. Hurtling into the mood abyss, but with increased motivation...for example.
Perhaps I will come around to trying cypro again in combo with lisuride at some point, but for now it's on to trying other things.
Cyproheptadine is known to lower dopamine in some people even though its primary effects are on serotonin. That's why for those people it may be worth it to try with a combination of a dopaminergic drug like bromocriptine, cabergoline, lisuride, pramipexole, methysergide, etc.
Fetch said:post 102214haidut said:post 102170 Dean wrote:
Source of the post Just as a follow up to my experience before. I tried 1 mg before bed the other night and the next day fell into a deep despair within a few hours of waking that lasted for several hours. Perhaps I was flooded with serotonin after the dosage wore off?
I tried it again because on hindsight I felt that my taking of cypro had helped me with motivation(via lessening learned helplessness, I presume) for even a few weeks after I stopped (due to how much it depressed me.) Thought maybe I could get that benefit without the depressiveness with the small dose at night. So much for that.
It's great to hear that cypro helps some people, but I guess it's important to keep in mind there is some risk involved and the negative side effects, for some, can be dangerous. Hurtling into the mood abyss, but with increased motivation...for example.
Perhaps I will come around to trying cypro again in combo with lisuride at some point, but for now it's on to trying other things.
Cyproheptadine is known to lower dopamine in some people even though its primary effects are on serotonin. That's why for those people it may be worth it to try with a combination of a dopaminergic drug like bromocriptine, cabergoline, lisuride, pramipexole, methysergide, etc.
When I first started Cypro earlier this year (at a does of 1mg at night) it gave me the same effects depressed, irritable etc. I wanted to stop but I knew I had bad allergies coming and so I stuck with it. At first every time I increased my dose by 1mg the depression came back but once I got up to about 4mg (2mg at night 1mg morning and afternoon) the increases stop giving me trouble. I continued increasing my does till I got to 4mg three times a day and sometimes an extra 2mg if my allergies acted up. I was drinking coffee at the time also and it didn't seem to help in the short term but possibly it did in the long term.
Anyway after taking it for like 4 months I tapered off. I think Cypro may have been the best thing so far to get my stress hormones down. Over the time I was taking it I began to be able to sleep in on weekends( lowered cortisol?), I also kinda just started to careless about things that probably don't matter. I was less prone to micromanage myself and my environment, I became less interested in distraction. Overtime I believe it drove me to become re-inspired to take action in my life again. I had put a lot of my passions on the back burner in order to work a lot to make money so I could purchase land to live on without a mortgage. During that time of doing something I have no interest in (making money and working "for the man") was and still is pretty soul crushing for me.
The cypro I believe removed some of the "learned helplessness" and forced me to find ways to be more fulfilled NOW rather than wait for my situation to change. I believe I was using these distractions (diet, excessive exercise, TV and movies, pornography and taking on excess burdens of others, and generally retreating into myself) in order to not have to face what I was losing( a strong connection to nature, development of a craft, connection to community, a daily connection with animals, plants and soil, and most importantly a feeling of place and worth within and through these things) It also forced me to push the issue with friends and family that I can't carry the whole load economically and needed more significant help. Luckily this was already in the process of happening and now we are very close. So in my opinion the hard time of Cypro was very worth it to be in the place I am now. I am sure there are other things at work here but I do believe Cypro was a major factor.
I have a few very unscientific ideas/questions regarding why it was so hard at first.
1.Could it be like stopping SSRI drugs? Maybe whatever causes the body to become dependent on SSRI's resulting in the well know withdrawal symptoms could be at work in someone with non drug induced high serotonin. I am sure it would be nothing compared to actual SSRI withdrawal. But possibly make you a little depressed and irritable? It could be a completely different mechanism and I would not know where to begin looking to find this out.
2. Could it be associated with raising allopregnanolone and pregnanolone. Haidut mentioned that a small raise in either of these has been associated with irritability in some people. I had a lot of the same symptoms when I tried pregnanolone. I am not sure if Cypro has an effect on these hormones but it's doesn't seem to far fetched. Maybe it just allowed them to be better utilized by a less burdened system. I seem to be able to handle pregnanolone fine now.
3. Maybe it's just revealing a low metabolism. If this is the case my metabolism was able to compensate without thyroid over the course of about a month.
Makrosky said:post 102218 Might I ask you how is it now that you don't take cypro anymore ? Did you have withdrawal symptoms ? You say you tappered off. But what about now that you don't take it ? Did the learned helplessness symptoms come back ? I hope not.
Fetch said:post 102243Makrosky said:post 102218 Might I ask you how is it now that you don't take cypro anymore ? Did you have withdrawal symptoms ? You say you tappered off. But what about now that you don't take it ? Did the learned helplessness symptoms come back ? I hope not.
I have been off it now for about a month as I came off it I added cabergoline in .5mg twice a week(I know this is maybe the most dangerous of the LSD based drugs) I did this because as I was lowering my Cypro dose I was feeling great drive. But my feeling of excitement and creativity didn't seem like my old self my desire to take chances or make sacrifices to learn new things seemed low. In someways it felt good not to care but at the same time the passion wasn't there. Caber has seemed to solve these issues I love music again dancing and sing in my house while I cook and clean, the desire to start drawing both artistically and design and architecturally. I am learning black smithing and studying building techniques I don't know (stone masonry) and have a become re-interested in the building techniques I do know or have some experience with Timber frame, Cob and general carpentry (I've been a carpenter professionally for like 13 years or something) and fine woodworking.
I also started trying out Pansterone around this time because I thought maybe that Cypro would help me handle pregnanolone and DHEA better. Haidut does not recommend this but because 1.you can't tell whats doing what and 2.because the effects of DMSO on other medications is unknown. I am sometimes not a very cautious person( I use to hop freight trains, I have been to jail more then a few times, I will do the dangerous stuff at work if others are scared) and this is a case of that. I had no issues doing this and everything has been really positive but I may have just got lucky or it just hasn't hit me yet. Also I recently found out my initial bad experience with Preg may have been just a matter of to low a dose. In which case I probably didn't need to be using the Cypro as a buffer.
I guess what I am saying is no I haven't yet seen sings of learn helplessness returning but it is still early and there are other factors at play. As far as withdrawal I didn't feel anything just some lingering allergies because we had a house full of 4 foster kittens and I am mildly allergic to cats. I started cutting down my dose in august and it took about 3 weeks after about 2 weeks is when I added in the cabergoline and I just started at the full dose. With the caber I didn't start to fell much until about the 3rd dose and the effects for me came on without any sides. Now I am coming off of caber and adding in things like small doses of B6, taurine and have been really happy with Magnesium Bicarbonate and I think most importantly Pansterone. So we will see what the future holds.
Are you still taking amitryptaline? I started taking by splitting the 10mg of amitryptaline into small pieces. Perhaps It was 3mg I took. My doc prescribed me for my depression and ocd. I also like cypro a lot, lets see how amitryp will work for me.answersfound said:post 101046khan said:Medicine which I have tried so far are lisuride, cyproheptadine, mirtazapine. Cyproheptadine suits me very well, haven't got any sedation on 4 mg. Cypro clearly reduces my ocd symptoms and depression. Next I would like to try is amitryptaline. Which is better option between cypro and amitryptaline in terms of safety?
I've taken amitriptyline and I think it increased adrenaline but it reduced serotonin. I think cypro is better.
I'm wondering why can you get visuals as dreaming seems to occur with high acetylcholine/melatonin and Cyproheptadine is an acetycholine/serotonin antagonist?Such_Saturation said:I suggest going off slowly if you've been on a long cycle! I was in class and I started getting visuals like lysergic acid.
Parsifal said:post 103342I'm wondering why can you get visuals as dreaming seems to occur with high acetylcholine/melatonin and Cyproheptadine is an acetycholine/serotonin antagonist?Such_Saturation said:I suggest going off slowly if you've been on a long cycle! I was in class and I started getting visuals like lysergic acid.
Such_Saturation said:Mucuna Pruriens has L-Dopa.
HDD said:post 103728 How long have you been taking .5 grain grain of NDT and 35 mg t3? What is your resting pulse and temperature throughout the day? You can find the following under thyroid hormone in the link to the Peatarian email exchanges wiki page.
"If you are eating enough protein, about 100 grams, and salt and thyroid, then I would consider the steroids--something might be interfering with your production of pregnenolone and DHEA. Things that could do that would be very low cholesterol, or a deficiency of vitamin A (retinol), or possibly other deficiencies.
If your cholesterol is above 200, and the thyroid supplements didn't warm you up, it's possible that something is interfering with your steroid synthesis, which might be a deficiency of something like vitamin A, or interference from something like iron or carotene. Have you tried a supplement of pregnenolone or DHEA? Were any other hormones, such as prolactin, measured? If you are taking the aspirin regularly, you should make sure to get vitamin K, from kale, liver, or a supplement. Anemia, like cold feet, is a common sign of low thyroid function."
docall18 said:I have tried cypro on and off over the last couple of weeks. I will occasionally take 1mg at night if i know i wont be doing much the next day.It makes me sleep like a log, sleeping for up to 10+ hours instead of my usual 7.
Coldhandsandfeet said:post 103756 i started by taking about 2-3 doses of 8 mg each dose. this how much i needed initially to bring down stress hormones. now I'm scaling back to 3 doses of 4 mg each dose.
Brian said:post 103760Coldhandsandfeet said:post 103756 i started by taking about 2-3 doses of 8 mg each dose. this how much i needed initially to bring down stress hormones. now I'm scaling back to 3 doses of 4 mg each dose.
With doses that big you must be decreasing dopamine too. Are you doing anything to increase it?