haidut

Member
Joined
Mar 18, 2013
Messages
18,034
Location
USA / Europe
Hi all,

As you many of you know, Ray Peat has mentioned cyproheptadine as a possible option for correcting certain physiological processes that have been derailed after years of eating PUFA, being exposed to chronic stress, toxins, endotoxin, battling chronic diseases, etc.
As I mentioned in one of my previous posts, whenever a substance displays a wide variety of protective/curative effects via multiple "pathways", it suggests that the theory behind it is probably correct. In the case of cyproheptadine and Ray Peat, the theory is that histamine, serotonin, cholinergic mechanisms, estrogen, prolactin, growth hormone, cortisol, etc. work in a direction that destabilizes the organism and causes damage. Here are some of the amazing findings I have been compiling on cyproheptadine that add more ammo to Ray's views:

1. Cyproheptadine may have strong anti-cancer properties:
http://www.ncbi.nlm.nih.gov/pubmed/23076705
http://www.ncbi.nlm.nih.gov/pubmed/18502826

2. Cyproheptadine may treat autism:
http://www.ncbi.nlm.nih.gov/pubmed/15068403
http://www.ncbi.nlm.nih.gov/pubmed/12231270

3. Cyproheptadine may treat schizophrenia. This raises serious questions if schizophrenia is "caused by excessive dopamine" as the current mainstream dogma holds since cyproheptadine would in theory increase dopamine and its effects:
http://www.ncbi.nlm.nih.gov/pubmed/11728834
http://www.ncbi.nlm.nih.gov/pubmed/10319907

4. Cyproheptadine may treat depression and other similar mental issues:
http://www.ncbi.nlm.nih.gov/pubmed/7667171
http://www.ncbi.nlm.nih.gov/pubmed/23442031
http://www.ncbi.nlm.nih.gov/pubmed/9304415

5. Cyproheptadine may be heart-protective (Ray said that anti-serotonin drugs like ondansetron protect the heart):
http://www.ncbi.nlm.nih.gov/pubmed/19346455
http://www.ncbi.nlm.nih.gov/pubmed/7976381

6. Cyproheptadine may protect the brain from the damage caused by BOTH ischemic and hemorrhagic stroke:
http://www.ncbi.nlm.nih.gov/pubmed/7976376
http://www.ncbi.nlm.nih.gov/pubmed/1757225
http://www.ncbi.nlm.nih.gov/pubmed/3982650

7. Cyproheptadine may protect the brain in a very generalized way by increasing cholesterol and phospholipids:
http://www.ncbi.nlm.nih.gov/pubmed/8225552

8. Cyproheptadine may protect from endotoxin:
http://www.ncbi.nlm.nih.gov/pubmed/11940385
http://www.ncbi.nlm.nih.gov/pubmed/1598825
http://www.ncbi.nlm.nih.gov/pubmed/8368073

9. Cyproheptadine may stimulate the immune system:
http://www.ncbi.nlm.nih.gov/pubmed/3567337

10. Cyproheptadine may have anti-endorphin action similar to naltrexone:
http://www.ncbi.nlm.nih.gov/pubmed/2995088

11. Cyproheptadine may suppress prolactin, growth hormone, aldosterone, ACTH, TSH, and cortisol:
http://www.ncbi.nlm.nih.gov/pubmed/2994332
http://www.ncbi.nlm.nih.gov/pubmed/6109449
http://www.ncbi.nlm.nih.gov/pubmed/7017408
http://www.ncbi.nlm.nih.gov/pubmed/115197
http://www.ncbi.nlm.nih.gov/pubmed/4600047
http://www.ncbi.nlm.nih.gov/pubmed/177441
http://www.ncbi.nlm.nih.gov/pubmed/177112
http://www.ncbi.nlm.nih.gov/pubmed/1201741
http://www.ncbi.nlm.nih.gov/pubmed/180050
http://www.ncbi.nlm.nih.gov/pubmed/401824

12. Cyproheptadine may suppress prostaglandin synthesis and effects (similar to aspirin):
http://www.ncbi.nlm.nih.gov/pubmed/412631
http://www.ncbi.nlm.nih.gov/pubmed/508004

13. Cyproheptadine may be helpful in the treatment of "alcoholism":
http://www.ncbi.nlm.nih.gov/pubmed/3797491
http://www.ncbi.nlm.nih.gov/pubmed/14157085

14. Cyproheptadine may be helpful in the treatment of "psoriasis":
http://www.ncbi.nlm.nih.gov/pubmed/6735444

15. Cyproheptadine may be helpful in the treatment of decompression sickness:
http://www.ncbi.nlm.nih.gov/pubmed/7233624

16. Cyproheptadine may be helpful in restoring fertility in old age:
http://www.ncbi.nlm.nih.gov/pubmed/1204806

17. Cyproheptadine may be helpful in treating myopathy (muscle weakness):
http://www.ncbi.nlm.nih.gov/pubmed/4274414

I am sure there are other studies with similar findings but I just wanted to share my findings so far. In my opinion, this is very strong evidence that Ray's ideas are on a VERY right track.

Thoughts?
 

John Eels

Member
Joined
Dec 26, 2012
Messages
151
This sounds exciting. Have you experimented with the drug? I'd like to. I'm curious. Now, where do I find it online for purchase? If you can help me I assume you better PM me to comply with the forum guidelines.

Do you think Mirtazapine can be compared with Cyproheptadine? It's probably not as versatile but nevertheless it's anti-histaminergic, an appetite stimulant, and HT3 receptor antagonist like Ondansetron.
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
18,034
Location
USA / Europe
John Eels said:
This sounds exciting. Have you experimented with the drug? I'd like to. I'm curious. Now, where do I find it online for purchase? If you can help me I assume you better PM me to comply with the forum guidelines.

Do you think Mirtazapine can be compared with Cyproheptadine? It's probably not as versatile but nevertheless it's anti-histaminergic, an appetite stimulant, and HT3 receptor antagonist like Ondansetron.

Sure, I've taken it and got some very good results for the issue I had. I saw some studies comparing Mirtazapine and Cyproheptadine on PubMed and the effects were similar. Just search PubMed for both and you'll get some results.
I will send you a PM in a minute.
 

jaguar43

Member
Joined
Oct 10, 2012
Messages
1,310
haidut said:
Hi all,

As you many of you know, Ray Peat has mentioned cyproheptadine as a possible option for correcting certain physiological processes that have been derailed after years of eating PUFA, being exposed to chronic stress, toxins, endotoxin, battling chronic diseases, etc.
As I mentioned in one of my previous posts, whenever a substance displays a wide variety of protective/curative effects via multiple "pathways", it suggests that the theory behind it is probably correct. In the case of cyproheptadine and Ray Peat, the theory is that histamine, serotonin, cholinergic mechanisms, estrogen, prolactin, growth hormone, cortisol, etc. work in a direction that destabilizes the organism and causes damage. Here are some of the amazing findings I have been compiling on cyproheptadine that add more ammo to Ray's views:

1. Cyproheptadine may have strong anti-cancer properties:
http://www.ncbi.nlm.nih.gov/pubmed/23076705
http://www.ncbi.nlm.nih.gov/pubmed/18502826

2. Cyproheptadine may treat autism:
http://www.ncbi.nlm.nih.gov/pubmed/15068403
http://www.ncbi.nlm.nih.gov/pubmed/12231270

3. Cyproheptadine may treat schizophrenia. This raises serious questions if schizophrenia is "caused by excessive dopamine" as the current mainstream dogma holds since cyproheptadine would in theory increase dopamine and its effects:
http://www.ncbi.nlm.nih.gov/pubmed/11728834
http://www.ncbi.nlm.nih.gov/pubmed/10319907

4. Cyproheptadine may treat depression and other similar mental issues:
http://www.ncbi.nlm.nih.gov/pubmed/7667171
http://www.ncbi.nlm.nih.gov/pubmed/23442031
http://www.ncbi.nlm.nih.gov/pubmed/9304415

5. Cyproheptadine may be heart-protective (Ray said that anti-serotonin drugs like ondansetron protect the heart):
http://www.ncbi.nlm.nih.gov/pubmed/19346455
http://www.ncbi.nlm.nih.gov/pubmed/7976381

6. Cyproheptadine may protect the brain from the damage caused by BOTH ischemic and hemorrhagic stroke:
http://www.ncbi.nlm.nih.gov/pubmed/7976376
http://www.ncbi.nlm.nih.gov/pubmed/1757225
http://www.ncbi.nlm.nih.gov/pubmed/3982650

7. Cyproheptadine may protect the brain in a very generalized way by increasing cholesterol and phospholipids:
http://www.ncbi.nlm.nih.gov/pubmed/8225552

8. Cyproheptadine may protect from endotoxin:
http://www.ncbi.nlm.nih.gov/pubmed/11940385
http://www.ncbi.nlm.nih.gov/pubmed/1598825
http://www.ncbi.nlm.nih.gov/pubmed/8368073

9. Cyproheptadine may stimulate the immune system:
http://www.ncbi.nlm.nih.gov/pubmed/3567337

10. Cyproheptadine may have anti-endorphin action similar to naltrexone:
http://www.ncbi.nlm.nih.gov/pubmed/2995088

11. Cyproheptadine may suppress prolactin, growth hormone, aldosterone, ACTH, TSH, and cortisol:
http://www.ncbi.nlm.nih.gov/pubmed/2994332
http://www.ncbi.nlm.nih.gov/pubmed/6109449
http://www.ncbi.nlm.nih.gov/pubmed/7017408
http://www.ncbi.nlm.nih.gov/pubmed/115197
http://www.ncbi.nlm.nih.gov/pubmed/4600047
http://www.ncbi.nlm.nih.gov/pubmed/177441
http://www.ncbi.nlm.nih.gov/pubmed/177112
http://www.ncbi.nlm.nih.gov/pubmed/1201741
http://www.ncbi.nlm.nih.gov/pubmed/180050
http://www.ncbi.nlm.nih.gov/pubmed/401824

12. Cyproheptadine may suppress prostaglandin synthesis and effects (similar to aspirin):
http://www.ncbi.nlm.nih.gov/pubmed/412631
http://www.ncbi.nlm.nih.gov/pubmed/508004

13. Cyproheptadine may be helpful in the treatment of "alcoholism":
http://www.ncbi.nlm.nih.gov/pubmed/3797491
http://www.ncbi.nlm.nih.gov/pubmed/14157085

14. Cyproheptadine may be helpful in the treatment of "psoriasis":
http://www.ncbi.nlm.nih.gov/pubmed/6735444

15. Cyproheptadine may be helpful in the treatment of decompression sickness:
http://www.ncbi.nlm.nih.gov/pubmed/7233624

16. Cyproheptadine may be helpful in restoring fertility in old age:
http://www.ncbi.nlm.nih.gov/pubmed/1204806

17. Cyproheptadine may be helpful in treating myopathy (muscle weakness):
http://www.ncbi.nlm.nih.gov/pubmed/4274414

I am sure there are other studies with similar findings but I just wanted to share my findings so far. In my opinion, this is very strong evidence that Ray's ideas are on a VERY right track.

Thoughts?

Nice work.. I heard weight gain is possible on Cyproheptadine though I think it could be reveal hypothyroidism.

How did you feel on it ? Did you buy it online or was it prescription ?
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
18,034
Location
USA / Europe
jag2594 said:
haidut said:
Hi all,

As you many of you know, Ray Peat has mentioned cyproheptadine as a possible option for correcting certain physiological processes that have been derailed after years of eating PUFA, being exposed to chronic stress, toxins, endotoxin, battling chronic diseases, etc.
As I mentioned in one of my previous posts, whenever a substance displays a wide variety of protective/curative effects via multiple "pathways", it suggests that the theory behind it is probably correct. In the case of cyproheptadine and Ray Peat, the theory is that histamine, serotonin, cholinergic mechanisms, estrogen, prolactin, growth hormone, cortisol, etc. work in a direction that destabilizes the organism and causes damage. Here are some of the amazing findings I have been compiling on cyproheptadine that add more ammo to Ray's views:

1. Cyproheptadine may have strong anti-cancer properties:
http://www.ncbi.nlm.nih.gov/pubmed/23076705
http://www.ncbi.nlm.nih.gov/pubmed/18502826

2. Cyproheptadine may treat autism:
http://www.ncbi.nlm.nih.gov/pubmed/15068403
http://www.ncbi.nlm.nih.gov/pubmed/12231270

3. Cyproheptadine may treat schizophrenia. This raises serious questions if schizophrenia is "caused by excessive dopamine" as the current mainstream dogma holds since cyproheptadine would in theory increase dopamine and its effects:
http://www.ncbi.nlm.nih.gov/pubmed/11728834
http://www.ncbi.nlm.nih.gov/pubmed/10319907

4. Cyproheptadine may treat depression and other similar mental issues:
http://www.ncbi.nlm.nih.gov/pubmed/7667171
http://www.ncbi.nlm.nih.gov/pubmed/23442031
http://www.ncbi.nlm.nih.gov/pubmed/9304415

5. Cyproheptadine may be heart-protective (Ray said that anti-serotonin drugs like ondansetron protect the heart):
http://www.ncbi.nlm.nih.gov/pubmed/19346455
http://www.ncbi.nlm.nih.gov/pubmed/7976381

6. Cyproheptadine may protect the brain from the damage caused by BOTH ischemic and hemorrhagic stroke:
http://www.ncbi.nlm.nih.gov/pubmed/7976376
http://www.ncbi.nlm.nih.gov/pubmed/1757225
http://www.ncbi.nlm.nih.gov/pubmed/3982650

7. Cyproheptadine may protect the brain in a very generalized way by increasing cholesterol and phospholipids:
http://www.ncbi.nlm.nih.gov/pubmed/8225552

8. Cyproheptadine may protect from endotoxin:
http://www.ncbi.nlm.nih.gov/pubmed/11940385
http://www.ncbi.nlm.nih.gov/pubmed/1598825
http://www.ncbi.nlm.nih.gov/pubmed/8368073

9. Cyproheptadine may stimulate the immune system:
http://www.ncbi.nlm.nih.gov/pubmed/3567337

10. Cyproheptadine may have anti-endorphin action similar to naltrexone:
http://www.ncbi.nlm.nih.gov/pubmed/2995088

11. Cyproheptadine may suppress prolactin, growth hormone, aldosterone, ACTH, TSH, and cortisol:
http://www.ncbi.nlm.nih.gov/pubmed/2994332
http://www.ncbi.nlm.nih.gov/pubmed/6109449
http://www.ncbi.nlm.nih.gov/pubmed/7017408
http://www.ncbi.nlm.nih.gov/pubmed/115197
http://www.ncbi.nlm.nih.gov/pubmed/4600047
http://www.ncbi.nlm.nih.gov/pubmed/177441
http://www.ncbi.nlm.nih.gov/pubmed/177112
http://www.ncbi.nlm.nih.gov/pubmed/1201741
http://www.ncbi.nlm.nih.gov/pubmed/180050
http://www.ncbi.nlm.nih.gov/pubmed/401824

12. Cyproheptadine may suppress prostaglandin synthesis and effects (similar to aspirin):
http://www.ncbi.nlm.nih.gov/pubmed/412631
http://www.ncbi.nlm.nih.gov/pubmed/508004

13. Cyproheptadine may be helpful in the treatment of "alcoholism":
http://www.ncbi.nlm.nih.gov/pubmed/3797491
http://www.ncbi.nlm.nih.gov/pubmed/14157085

14. Cyproheptadine may be helpful in the treatment of "psoriasis":
http://www.ncbi.nlm.nih.gov/pubmed/6735444

15. Cyproheptadine may be helpful in the treatment of decompression sickness:
http://www.ncbi.nlm.nih.gov/pubmed/7233624

16. Cyproheptadine may be helpful in restoring fertility in old age:
http://www.ncbi.nlm.nih.gov/pubmed/1204806

17. Cyproheptadine may be helpful in treating myopathy (muscle weakness):
http://www.ncbi.nlm.nih.gov/pubmed/4274414

I am sure there are other studies with similar findings but I just wanted to share my findings so far. In my opinion, this is very strong evidence that Ray's ideas are on a VERY right track.

Thoughts?

Nice work.. I heard weight gain is possible on Cyproheptadine though I think it could be reveal hypothyroidism.

How did you feel on it ? Did you buy it online or was it prescription ?


I am originally from Europe, so I get it without prescription when I go there. Weight gain is definitely a known side effect and it is one I experienced myself. I managed to keep it under control by increasing my protein intake and decreasing fats (including saturated fat). Also, dosage is key. Anything over 4mg made me too drowsy and affected the weight too much. Right now, the optimal dosage for me is 1mg before bed.
 

jyb

Member
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Nov 9, 2012
Messages
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Location
UK
What do you use it for, haidut?

I thought that drugs are only useful to solve a particular problem, unlike things like aspirin that have fundamental action and would benefit to many. In particular, drugs have more side effects (weight gain, drowsyness...). Where would you classify Cyproheptadine at low dose?
 

charlie

The Law & Order Admin
Joined
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Messages
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Location
USA
iLoveSugar said:
My first nigh on 1mg. Giving it a whirl (I need a wonder drug).

Keep us updated! You can even start your own Cyproheptadine log if you like.
 

iLoveSugar

Member
Joined
Sep 19, 2013
Messages
980
Gave me a bit of an upset stomach last night/this morning and I am also feeling more tired than normal. I took 1mg last night before bed.
 

SAFarmer

Member
Joined
Jul 31, 2013
Messages
182
Cyproheptadine is a 1st generation anti-histamine drug. Second generation variants include cetirizine and loratadine with fewer side effects like drowsiness, etc. My son uses the last 2 and have very good response for hayfever and general better feeling when stressed because of the hayfever allergic reactions.

Ray Peat has said that it is anti estrogenic and thats probably why he responds so well on it.
 

haidut

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Messages
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I had some stomach inflammation issues, so 4mg of cypro a night for 2 weeks took care of it.
In addition to being antihistamine, it is also general ani-serotonin (albeit not so much on HT3 in the stomach) and anti-cholinergic (so probably good option of Alzheimer's).
SAFarmer - which drug is anti-estrogenic? Are you referring to cypro or the second generation drugs?
 

jyb

Member
Joined
Nov 9, 2012
Messages
2,777
Location
UK
@haidut: I noticed that you experimented with several (anti-serotonin) drugs. In your experience, during the days you take them, do they fix every hypo symptoms (incl. temperatures), or do they only help with a specific symptom? I don't have much experience with pharma drugs, however my experience with a RP diet and some supplements is that I'm able, on lucky days, to fix the most important symptoms (mental clarity, mood, stress), but the underlying issue (hypothyroidism as evidenced by low temps) is still there and ready to erupt as soon I deviate from those pro-thyroid measures.
 

haidut

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Thread starter
Joined
Mar 18, 2013
Messages
18,034
Location
USA / Europe
jyb said:
@haidut: I noticed that you experimented with several (anti-serotonin) drugs. In your experience, during the days you take them, do they fix every hypo symptoms (incl. temperatures), or do they only help with a specific symptom? I don't have much experience with pharma drugs, however my experience with a RP diet and some supplements is that I'm able, on lucky days, to fix the most important symptoms (mental clarity, mood, stress), but the underlying issue (hypothyroidism as evidenced by low temps) is still there and ready to erupt as soon I deviate from those pro-thyroid measures.

My experience was similar to yours jyb. The anti-serotonin drugs helped with specific problems (gut inflammation) and maybe some soft-tissue calcification. They did not fix the hypo issues but did make them more resilient to them. Before taking cypro, whenever I had an improvement all it would take to get me back to a complete mess was a somewhat stressful day at work. After taking cypro, I could handle a week before starting to succumb. Since I also started working on the thyroid, eventually that resilience period extended to a month and beyond. Once you start recovering, the process is hollistic/continuous and I can't isolate how much each thing helped. Again, the anti-serotonin drugs helped to stop the stress reaction and build resilience of several days that would allow me to both ride out most storms and have time to work on thyroid.
I did try doing only thyroid before cypro and that did not lead to anything. Granted, I had the dosage not entirely correct but still I did not notice much improvement. Only after taking care of serotonin did things start to get better for me.
The only advice I have is keep experimenting. A famous baseball player was once asked: "Is there a difference between theory and practice?" He responded: "In theory, there is no difference between theory and practice. In practice there is."
Ray also said that ideally things should never make sense until suddenly they all make perfect sense.
So, keep practicing until you figure it out:):
 

Mittir

Member
Joined
Feb 20, 2013
Messages
2,034
iLoveSugar said:
Gave me a bit of an upset stomach last night/this morning and I am also feeling more tired than normal. I took 1mg last night before bed.

May be 1 mg was too high for you. Here is a RP quote on starting dose

Ray Peat said:
It's good to start with about half a milligram, at bedtime, to judge its
effects when sedation isn't risky.
http://peatarian.com/peatexchanges#cyproheptadine
 

charlie

The Law & Order Admin
Joined
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Messages
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Location
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Mittir said:
iLoveSugar said:
Gave me a bit of an upset stomach last night/this morning and I am also feeling more tired than normal. I took 1mg last night before bed.

May be 1 mg was too high for you. Here is a RP quote on starting dose

Ray Peat said:
It's good to start with about half a milligram, at bedtime, to judge its
effects when sedation isn't risky.
http://peatarian.com/peatexchanges#cyproheptadine
I started with 1mg and it was too much, got crazy hungry and tired. So I backed down to 16th of a pill which I think might be .25 millgrams. That worked well and have been gradually increasing my dose.
 
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