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Cyproheptadine - A Wonder Drug?

Discussion in 'Scientific Studies' started by haidut, Oct 1, 2013.

  1. haidut

    haidut Member

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    Hi all,

    As you many of you know, Ray Peat has mentioned cyproheptadine as a possible option for correcting certain physiological processes that have been derailed after years of eating PUFA, being exposed to chronic stress, toxins, endotoxin, battling chronic diseases, etc.
    As I mentioned in one of my previous posts, whenever a substance displays a wide variety of protective/curative effects via multiple "pathways", it suggests that the theory behind it is probably correct. In the case of cyproheptadine and Ray Peat, the theory is that histamine, serotonin, cholinergic mechanisms, estrogen, prolactin, growth hormone, cortisol, etc. work in a direction that destabilizes the organism and causes damage. Here are some of the amazing findings I have been compiling on cyproheptadine that add more ammo to Ray's views:

    1. Cyproheptadine may have strong anti-cancer properties:
    http://www.ncbi.nlm.nih.gov/pubmed/23076705
    http://www.ncbi.nlm.nih.gov/pubmed/18502826

    2. Cyproheptadine may treat autism:
    http://www.ncbi.nlm.nih.gov/pubmed/15068403
    http://www.ncbi.nlm.nih.gov/pubmed/12231270

    3. Cyproheptadine may treat schizophrenia. This raises serious questions if schizophrenia is "caused by excessive dopamine" as the current mainstream dogma holds since cyproheptadine would in theory increase dopamine and its effects:
    http://www.ncbi.nlm.nih.gov/pubmed/11728834
    http://www.ncbi.nlm.nih.gov/pubmed/10319907

    4. Cyproheptadine may treat depression and other similar mental issues:
    http://www.ncbi.nlm.nih.gov/pubmed/7667171
    http://www.ncbi.nlm.nih.gov/pubmed/23442031
    http://www.ncbi.nlm.nih.gov/pubmed/9304415

    5. Cyproheptadine may be heart-protective (Ray said that anti-serotonin drugs like ondansetron protect the heart):
    http://www.ncbi.nlm.nih.gov/pubmed/19346455
    http://www.ncbi.nlm.nih.gov/pubmed/7976381

    6. Cyproheptadine may protect the brain from the damage caused by BOTH ischemic and hemorrhagic stroke:
    http://www.ncbi.nlm.nih.gov/pubmed/7976376
    http://www.ncbi.nlm.nih.gov/pubmed/1757225
    http://www.ncbi.nlm.nih.gov/pubmed/3982650

    7. Cyproheptadine may protect the brain in a very generalized way by increasing cholesterol and phospholipids:
    http://www.ncbi.nlm.nih.gov/pubmed/8225552

    8. Cyproheptadine may protect from endotoxin:
    http://www.ncbi.nlm.nih.gov/pubmed/11940385
    http://www.ncbi.nlm.nih.gov/pubmed/1598825
    http://www.ncbi.nlm.nih.gov/pubmed/8368073

    9. Cyproheptadine may stimulate the immune system:
    http://www.ncbi.nlm.nih.gov/pubmed/3567337

    10. Cyproheptadine may have anti-endorphin action similar to naltrexone:
    http://www.ncbi.nlm.nih.gov/pubmed/2995088

    11. Cyproheptadine may suppress prolactin, growth hormone, aldosterone, ACTH, TSH, and cortisol:
    http://www.ncbi.nlm.nih.gov/pubmed/2994332
    http://www.ncbi.nlm.nih.gov/pubmed/6109449
    http://www.ncbi.nlm.nih.gov/pubmed/7017408
    http://www.ncbi.nlm.nih.gov/pubmed/115197
    http://www.ncbi.nlm.nih.gov/pubmed/4600047
    http://www.ncbi.nlm.nih.gov/pubmed/177441
    http://www.ncbi.nlm.nih.gov/pubmed/177112
    http://www.ncbi.nlm.nih.gov/pubmed/1201741
    http://www.ncbi.nlm.nih.gov/pubmed/180050
    http://www.ncbi.nlm.nih.gov/pubmed/401824

    12. Cyproheptadine may suppress prostaglandin synthesis and effects (similar to aspirin):
    http://www.ncbi.nlm.nih.gov/pubmed/412631
    http://www.ncbi.nlm.nih.gov/pubmed/508004

    13. Cyproheptadine may be helpful in the treatment of "alcoholism":
    http://www.ncbi.nlm.nih.gov/pubmed/3797491
    http://www.ncbi.nlm.nih.gov/pubmed/14157085

    14. Cyproheptadine may be helpful in the treatment of "psoriasis":
    http://www.ncbi.nlm.nih.gov/pubmed/6735444

    15. Cyproheptadine may be helpful in the treatment of decompression sickness:
    http://www.ncbi.nlm.nih.gov/pubmed/7233624

    16. Cyproheptadine may be helpful in restoring fertility in old age:
    http://www.ncbi.nlm.nih.gov/pubmed/1204806

    17. Cyproheptadine may be helpful in treating myopathy (muscle weakness):
    http://www.ncbi.nlm.nih.gov/pubmed/4274414

    I am sure there are other studies with similar findings but I just wanted to share my findings so far. In my opinion, this is very strong evidence that Ray's ideas are on a VERY right track.

    Thoughts?
     
  2. John Eels

    John Eels Member

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    This sounds exciting. Have you experimented with the drug? I'd like to. I'm curious. Now, where do I find it online for purchase? If you can help me I assume you better PM me to comply with the forum guidelines.

    Do you think Mirtazapine can be compared with Cyproheptadine? It's probably not as versatile but nevertheless it's anti-histaminergic, an appetite stimulant, and HT3 receptor antagonist like Ondansetron.
     
  3. OP
    haidut

    haidut Member

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    Sure, I've taken it and got some very good results for the issue I had. I saw some studies comparing Mirtazapine and Cyproheptadine on PubMed and the effects were similar. Just search PubMed for both and you'll get some results.
    I will send you a PM in a minute.
     
  4. jag2594

    jag2594 Member

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    Nice work.. I heard weight gain is possible on Cyproheptadine though I think it could be reveal hypothyroidism.

    How did you feel on it ? Did you buy it online or was it prescription ?
     
  5. OP
    haidut

    haidut Member

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    I am originally from Europe, so I get it without prescription when I go there. Weight gain is definitely a known side effect and it is one I experienced myself. I managed to keep it under control by increasing my protein intake and decreasing fats (including saturated fat). Also, dosage is key. Anything over 4mg made me too drowsy and affected the weight too much. Right now, the optimal dosage for me is 1mg before bed.
     
  6. jyb

    jyb Member

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    What do you use it for, haidut?

    I thought that drugs are only useful to solve a particular problem, unlike things like aspirin that have fundamental action and would benefit to many. In particular, drugs have more side effects (weight gain, drowsyness...). Where would you classify Cyproheptadine at low dose?
     
  7. iLoveSugar

    iLoveSugar Member

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    My first nigh on 1mg. Giving it a whirl (I need a wonder drug).
     
  8. charlie

    charlie The Law & Order Admin

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    Keep us updated! You can even start your own Cyproheptadine log if you like.
     
  9. iLoveSugar

    iLoveSugar Member

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    Gave me a bit of an upset stomach last night/this morning and I am also feeling more tired than normal. I took 1mg last night before bed.
     
  10. aquaman

    aquaman Member

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    What issue(s) did you have?
     
  11. SAFarmer

    SAFarmer Member

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    Cyproheptadine is a 1st generation anti-histamine drug. Second generation variants include cetirizine and loratadine with fewer side effects like drowsiness, etc. My son uses the last 2 and have very good response for hayfever and general better feeling when stressed because of the hayfever allergic reactions.

    Ray Peat has said that it is anti estrogenic and thats probably why he responds so well on it.
     
  12. OP
    haidut

    haidut Member

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    I had some stomach inflammation issues, so 4mg of cypro a night for 2 weeks took care of it.
    In addition to being antihistamine, it is also general ani-serotonin (albeit not so much on HT3 in the stomach) and anti-cholinergic (so probably good option of Alzheimer's).
    SAFarmer - which drug is anti-estrogenic? Are you referring to cypro or the second generation drugs?
     
  13. SAFarmer

    SAFarmer Member

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    Both
     
  14. jyb

    jyb Member

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    @haidut: I noticed that you experimented with several (anti-serotonin) drugs. In your experience, during the days you take them, do they fix every hypo symptoms (incl. temperatures), or do they only help with a specific symptom? I don't have much experience with pharma drugs, however my experience with a RP diet and some supplements is that I'm able, on lucky days, to fix the most important symptoms (mental clarity, mood, stress), but the underlying issue (hypothyroidism as evidenced by low temps) is still there and ready to erupt as soon I deviate from those pro-thyroid measures.
     
  15. OP
    haidut

    haidut Member

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    My experience was similar to yours jyb. The anti-serotonin drugs helped with specific problems (gut inflammation) and maybe some soft-tissue calcification. They did not fix the hypo issues but did make them more resilient to them. Before taking cypro, whenever I had an improvement all it would take to get me back to a complete mess was a somewhat stressful day at work. After taking cypro, I could handle a week before starting to succumb. Since I also started working on the thyroid, eventually that resilience period extended to a month and beyond. Once you start recovering, the process is hollistic/continuous and I can't isolate how much each thing helped. Again, the anti-serotonin drugs helped to stop the stress reaction and build resilience of several days that would allow me to both ride out most storms and have time to work on thyroid.
    I did try doing only thyroid before cypro and that did not lead to anything. Granted, I had the dosage not entirely correct but still I did not notice much improvement. Only after taking care of serotonin did things start to get better for me.
    The only advice I have is keep experimenting. A famous baseball player was once asked: "Is there a difference between theory and practice?" He responded: "In theory, there is no difference between theory and practice. In practice there is."
    Ray also said that ideally things should never make sense until suddenly they all make perfect sense.
    So, keep practicing until you figure it out:)
     
  16. superhuman

    superhuman Member

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    lovely haidut.

    Where can i buy cypro?
     
  17. jaa

    jaa Member

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  18. Mittir

    Mittir Member

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    May be 1 mg was too high for you. Here is a RP quote on starting dose

     
  19. charlie

    charlie The Law & Order Admin

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    I started with 1mg and it was too much, got crazy hungry and tired. So I backed down to 16th of a pill which I think might be .25 millgrams. That worked well and have been gradually increasing my dose.
     
  20. superhuman

    superhuman Member

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    what positive effects has it had on your guys that have done it for a little while now?
     
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