synthesis

  1. haidut

    Upregulated serotonin synthesis may be a biomarker for breast cancer

    Once again, the available evidence contradicts the popular myth promoted by public health agencies that serotonin is the "happiness hormone". One only needs to talk to a person on serotonergic (SSRI) drugs for a few minutes to realize just how "happy" those people are as a result of their...
  2. haidut

    PUFA Inhibit Progesterone Production And Thus Drive/cause Menopause

    Peat wrote in a few of his articles that menopause is largely driven by a deficiency of progesterone and mentioned several anecdotes of women in their 50s and 60s getting their periods back after supplementing with large doses progesterone. In one of his articles he said that PUFA and estrogen...
  3. haidut

    Inosine As A Powerful Inhibitor Of Serotonin And Cortisol Synthesis

    As many of you know, I have been reading older Russian studies on many of the substances Peat talks about. He mentioned inosine in one of is articles, but only in relation to improving immunity and preventing dementia. The problem of Alzheimer's disease as a clue to immortality Part 1...
  4. haidut

    Plain (unmodified) Adamantane Is A Powerful Inhibitor Of NO Synthesis

    Many people on the forum are familiar with the beneficial properties of adamantane and its derivatives. However, most of the research conducted on the beneficial effects of these chemicals has been with adamantane derivatives such as amantadine, memantine, rimantadine, bromantane, etc. When we...
  5. haidut

    Progesterone Is As Anabolic For Muscle As Testosterone (in Women)

    I am posting this in support of the recent thread on what constitutes an anabolic supplement steroid and how to properly combine various steroids to help prevent/limit catabolism and enhance anabolism in both men and women. Quest For The Perfect Anticatabolic / Anabolic Supplement This study...
  6. haidut

    Palmitic Acid Is Androgen Agonist, Increases Androgen Synthesis, Decreases Cortisol

    Palmitic acid has a bad reputation in mainstream medicine and the blogosphere. It is claimed to directly cause insulin resistance, obesity and even hypogonadism. Well, these studies found the exact opposite. The first one found that methyl-palmitate (MP) is an actual androgen receptor agonist...
  7. haidut

    Gonadin - Liquid Steroid Optimizer For Lab/R&D

    As I mentioned in a few threads before, I have always been interested in the so-called "reproductive aging", both in males and females. There is solid evidence that gonadal function declines with age and as such the synthesis and circulating levels of protective steroids like testosterone (T)...
  8. haidut

    Just One (1) Tablespoon Of Gelatin Daily Is Enough To Improve Joint Health

    A human study, and as such very relevant. The current "kind" of joint supplements on mainstream TV is undoubtedly glucosamine. Very little evidence is available to support the claims behind this heavily advertised supplement. On the other hand, gelatin (and glycine) have over 100 years of...
  9. haidut

    Optimal Dose Of Pregnenolone For Androgen Synthesis

    There was a recent discussion about high dose pregnenolone on the forum and some people sent Peat my comments that high dose pregnenolone can inhibit androgen synthesis. Peat replied that he has not seen such effects, but did not directly speak against the idea. Privately, I got quite a few...
  10. haidut

    Palmitic Acid Inhibits Cortisol Synthesis

    Palmitic acid has a bad reputation in mainstream medical circles. It is being blamed for insulin resistance, obesity, and even triggering diabetes II. Ray has written a few times about palmitic acid, and has explained that it is one of the few known exogenous factors that can activate the enzyme...
  11. haidut

    Raising Serum Androgens Using DHEA, Pregnenolone, And Vitamin K

    User testimony (4/26/2021): My Experiences With Raising Androgens Log (Pansterone, k2, magnoil) Many people use supplements like DHEA, pregnenolone, and progesterone with the goal of raising their androgens and lowering estrogen. While this approach works for raising tissue levels of steroids...
  12. haidut

    Hypothyroidism Dramatically Increases Estrogen Synthesis

    I posted a study some time ago showing the effects of thyroid hormone on synthesis/metabolism of various steroids. Hyperthyroidism increased androgen production several-fold, but the effects on estrogen synthesis were less clear. This study shows that hypothyroidism increases estrogen...
  13. haidut

    Prolactin Increases Cortisol Secretion

    I think this is a pretty important study as it provides further evidence of the close relationship between various biomarkers of stress such as prolactin, estrogen, and cortisol. As Ray said, estrogen is really not a female hormone but rather the stress hormone. Prolactin is pretty similar, and...
  14. haidut

    DHEA, In Low Doses, Directly Inhibits Cortisol Synthesis

    The synthesis of cortisol is controlled by the enzyme 11b-HSD1. The enzyme 11b-HSD2 is what converts cortisol into the inactive cortisone. Agents that inhibit 11b-HSD1 and/or enhance 11b-HSD2 are the holly grail of endocrinology as they are thought to be able to reverse diabetes and a host of...
  15. haidut

    Dhea Inhibits Serotonin Synthesis Due To Stress Exposure

    DHEA seems to be an inhibitor of the enzyme TPH, which as we know synthesizes serotonin from tryptophan. It seems that, as per Peat's ideas, the serotonin increases from stress is due to cortisol. DHEA being a cortisol antagonist was able to block this effect. DHEA only had an effect when rats...
  16. haidut

    TSH upregulates cholesterol synthesis

    After years (maybe decades) of denial by official medicine that thyroid status affects cholesterol levels, this study is lighting up the blogosphere. It looks like the connection between high TSH and high cholesterol is re-established and it validates some of the ideas and methods of Broda...
  17. haidut

    Resveratrol Stimulates Cortisol Synthesis

    Yet another reason to avoid resveratrol. The mechanism of action is suppression of cytochrome P450, which is known as the "master detox" enzyme. I wonder if other estrogenic substances, including estrogen itself stimulate cortisol synthesis through the same mechanism. If yes, substances that...
  18. haidut

    Taurine Increases Dopamine Synthesis In The Brain

    Taurine is a close analog to GABA and is thought to function through the same "receptors". Ray has mentioned that it would be beneficial. There are multiple studies on oral taurine increasing testosterone in rats by 200% and I have experienced that effects myself, confirmed by saliva hormone...
  19. haidut

    Cyproheptadine - A Wonder Drug?

    Hi all, As you many of you know, Ray Peat has mentioned cyproheptadine as a possible option for correcting certain physiological processes that have been derailed after years of eating PUFA, being exposed to chronic stress, toxins, endotoxin, battling chronic diseases, etc. As I mentioned in...
Top