cyproheptadine

  1. Guille Yacante

    This may be the reason why cyproheptadine is the "wonder drug" for so many.

    Because it antagonizes some acetylcholine receptors, not so much because of antiserotonergic or antihistaminic properties. I mean, everything should be held in consideration. Why would one "need a drug" in the first place? Or a supplement? One may have come getting used to be poisoned little...
  2. NatachaRose

    Cyproheptadine is making me nervous the next day

    I have been taking 1mg of cyproheptadine before bed for 3 days in a row, and I definitely sleep better and have no bad dreams, which used to be the case. However, the next day, around 5 pm, I start to feel extremely nervous and very aggressive. Also, every morning, I notice dark circles around...
  3. P

    Cypro made me hallucinate

    So i've been taking cypro past the last 5 days. I was tooking 2mg on lunch and 2mg on dinner. It was being amazingly therapeutic for me (i was happier, seeing colors more vibrant, enjoying more life, recovering from the learned helplessness i was stuck in, etc). Today i decided to take 2mg on...
  4. Candeias

    Renoprotective effects of Cyproheptadine

    Cyproheptadine, a SET7/9 inhibitor, reduces hyperglycaemia-induced ER stress alleviating inflammation and fibrosis in renal tubular epithelial cells "Results: SET7/9 and H3K4Me1 expression significantly increased with ER stress, inflammation, apoptosis, and fibrosis, in-vivo and in-vitro under...
  5. Candeias

    Searching best supps/pharma for soft tissue calcification

    Cyproheptadine Cyproheptadine Prevents / Reverses Soft Tissue Calcification "Human equivalent dose was about 12mg daily, duration was just 4 days. Cyproheptadine prevented AND reversed soft tissue calcification by acting as an anti-heparin agent, which is similar to what vitamin K2 does...
  6. O

    Are you selling your Cyproheptadine?

    Hi, I'm looking for anyone who is selling their Cyproheptadine, ideally the one by idealabs! I'm based in England, UK. (As an aside...i'm also interested in Copper(1) aka cuprus nicotinic acid aka mitosynergy)
  7. Lynne

    Cypro useby?

    Hi all, just wondering if anyone can tell me how long Periactin/Cyproheptadine is still effective beyond the use by date? Pharmacists have not been helpful, covering their arses by telling me to go by the date on the box. Cheers.
  8. Outdoctrination

    Serotonin does in fact cross the blood brain barrier.

    I've been struggling with this concept in my head given my own experience with dramatically improved mood with antibiotics which lower gut serotonin. The official narrative has been and continues to be that gut serotonin and brain serotonin are completely separate and that serotonin itself does...
  9. NewACC

    Study on acute and chronic effects of serotonin (5HT) antagonists on serotonin binding sites

    https://doi.org/10.1007/bf00497017 "The administration of 14 daily doses of cyproheptadine, BC-105, metergoline and methysergide induced a marked decrease in the number (B max) of 3H-spiroperidol binding sites (5HT2 sites) in frontal cortex, when assayed 48 h after the last dose; the apparent...
  10. NewACC

    Study says: Cyproheptadine is Serotonin Antagonist, Doesn't Block Dopamine and Noradrenaline

    https://doi.org/10.1016/0014-2999(74)90202-7 Abstract "...Cyproheptadine and LSD, two known antagonists of the peripheral effects of 5-HT, were administered i.v. to conscious rabbits at different times before the intracerebroventricular (i.c.v.) administration of 5-HT, NAD or dopamine...
  11. NewACC

    Cyproheptadine May Treat African Swine Fever

    We have been discussing surprisingly versatile and, at the same time, strong antiviral properties on this forum for a long time. And now the latest research shows that cyproheptadine is already effective against swine fever. I'm pretty busy so I can't elaborate on that. Maybe @haidut and @Hans...
  12. NewACC

    Role of Cholinergic and Dopamine Receptors in the Physiology of Caffeine Tolerance

    Dear Forum Members, I found three interesting studies on reversing (or reducing) caffeine tolerance, by adding to chronic (or sub-chronic) caffeine treatment, either the dopamine agonists bromocriptine (a predominantly d2/d3 family agonist) or pergolide (a very potent d1 agonist), or...
  13. Jonathan Estis

    Cyproheptadine + DNP

    What are the effects if you take Cyproheptadine on a DNP cycle? Could a low daily dose (.25 - .5 mg) cyproheptadine safely be used as an antihistamine to mitigate any potential allergic reactions/rash breakouts from DNP? Most DNP users run claritin or benadryl for antihisamtine while on cycle...
  14. C

    Low BP and Blood Sugar with High Cortisol

    Hi All, I'm stumped. My BP recently dropped dramatically and coincided with a big drop in blood sugar. Diet was unchanged. Supplements unchanged (been on Thyroid for about 1 year). I was using about 0.5mg Cyproheptadine alongside the thyroid but came off. I've since reintroduced and...
  15. A

    Hyperthermia and Serotonin: The Quest for a "Better Cyproheptadine"

    https://ncbi.nlm.nih.gov/pmc/articles/PMC8952796 Abstract Fine temperature control is essential in homeothermic animals. Both hyper- and hypothermia can have deleterious effects. Multiple, efficient and partly redundant mechanisms of adjusting the body temperature to the value set by the...
  16. haidut

    Cyproheptadine (12mg daily) cures patient's metastatic liver cancer in just 2 weeks

    A truly shocking case study, which demonstrates once again how even terminal disease are often curable with cheap, safe, and widely available compounds that have long ago been written off as "obsolete" by mainstream medicine. More importantly, the case study highlights the core role metabolism...
  17. Brandin

    Creating a therapeutic systematic health boosting combo

    I am experimenting with creating a combination of supps that would compliment eachothers effect and hopefully even inhibiting eachothers bad effects. Question 1: Anybody knows if taking a dopamine d2 agonist with higher affinity for the receptors than cypro would lead to cypro not binding to...
  18. P

    Question about how cypro induces weight gain

    I'm seeing how Cypro induced weight gain on the majority of subjects in every study I've come across. The issue is I can't see whether this weight gain is induced by the increase in appetite or by some other mechanism. I really like Cypro and would like to take 0.5-1mg a day for a month with two...
  19. FitnessMike

    Your Cyproheptadine experience?

    there are plenty of anti-stress/serotonin substances that we know of over here, but they do vary in strength and how quickly we build a tolerance to them. I wonder how good did it work for you and if you build a tolerance to it.
  20. Orome

    Efficacy of Cyproheptadine Monotherapy in Hepatocellular Carcinoma With Bone Metastasis

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563693/ Abstract Background Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related deaths worldwide. Particularly, cases of bone metastasis have poorer prognoses. Case Presentation A 62-year-old woman with suspected...
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