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cyproheptadine

  1. NewACC

    Study on acute and chronic effects of serotonin (5HT) antagonists on serotonin binding sites

    https://doi.org/10.1007/bf00497017 "The administration of 14 daily doses of cyproheptadine, BC-105, metergoline and methysergide induced a marked decrease in the number (B max) of 3H-spiroperidol binding sites (5HT2 sites) in frontal cortex, when assayed 48 h after the last dose; the apparent...
    • NewACC
    • Thread
    • cyproheptadine metergoline reverse tolerance serotonin serotonin antagonist tolerance
    • Replies: 6
    • Forum: Scientific Studies
  2. NewACC

    Study says: Cyproheptadine is Serotonin Antagonist, Doesn't Block Dopamine and Noradrenaline

    https://doi.org/10.1016/0014-2999(74)90202-7 Abstract "...Cyproheptadine and LSD, two known antagonists of the peripheral effects of 5-HT, were administered i.v. to conscious rabbits at different times before the intracerebroventricular (i.c.v.) administration of 5-HT, NAD or dopamine...
    • NewACC
    • Thread
    • cypro cyproheptadine d-lysergamide dopamine lsd lsd-25 serotonin serotonin antagonist
    • Replies: 4
    • Forum: Scientific Studies
  3. NewACC

    Cyproheptadine May Treat African Swine Fever

    We have been discussing surprisingly versatile and, at the same time, strong antiviral properties on this forum for a long time. And now the latest research shows that cyproheptadine is already effective against swine fever. I'm pretty busy so I can't elaborate on that. Maybe @haidut and @Hans...
    • NewACC
    • Thread
    • antiviral cyproheptadine fever histamine immune system immunity periactin plague serotonin virus
    • Replies: 0
    • Forum: Scientific Studies
  4. NewACC

    Role of Cholinergic and Dopamine Receptors in the Physiology of Caffeine Tolerance

    Dear Forum Members, I found three interesting studies on reversing (or reducing) caffeine tolerance, by adding to chronic (or sub-chronic) caffeine treatment, either the dopamine agonists bromocriptine (a predominantly d2/d3 family agonist) or pergolide (a very potent d1 agonist), or...
    • NewACC
    • Thread
    • acetylcholine agonist antagonist bromocriptine caffeine coffee cyproheptadine dopamine serotonin tolerance
    • Replies: 4
    • Forum: Scientific Studies
  5. Jonathan Estis

    Cyproheptadine + DNP

    What are the effects if you take Cyproheptadine on a DNP cycle? Could a low daily dose (.25 - .5 mg) cyproheptadine safely be used as an antihistamine to mitigate any potential allergic reactions/rash breakouts from DNP? Most DNP users run claritin or benadryl for antihisamtine while on cycle...
  6. C

    Low BP and Blood Sugar with High Cortisol

    Hi All, I'm stumped. My BP recently dropped dramatically and coincided with a big drop in blood sugar. Diet was unchanged. Supplements unchanged (been on Thyroid for about 1 year). I was using about 0.5mg Cyproheptadine alongside the thyroid but came off. I've since reintroduced and...
  7. A

    Hyperthermia and Serotonin: The Quest for a "Better Cyproheptadine"

    https://ncbi.nlm.nih.gov/pmc/articles/PMC8952796 Abstract Fine temperature control is essential in homeothermic animals. Both hyper- and hypothermia can have deleterious effects. Multiple, efficient and partly redundant mechanisms of adjusting the body temperature to the value set by the...
  8. haidut

    Cyproheptadine (12mg daily) cures patient's metastatic liver cancer in just 2 weeks

    A truly shocking case study, which demonstrates once again how even terminal disease are often curable with cheap, safe, and widely available compounds that have long ago been written off as "obsolete" by mainstream medicine. More importantly, the case study highlights the core role metabolism...
    • haidut
    • Thread
    • 5-ht cure cyproheptadine hcc histamine liver cancer metastatic serotonin
    • Replies: 20
    • Forum: Scientific Studies
  9. Brandin

    Creating a therapeutic systematic health boosting combo

    I am experimenting with creating a combination of supps that would compliment eachothers effect and hopefully even inhibiting eachothers bad effects. Question 1: Anybody knows if taking a dopamine d2 agonist with higher affinity for the receptors than cypro would lead to cypro not binding to...
  10. P

    Question about how cypro induces weight gain

    I'm seeing how Cypro induced weight gain on the majority of subjects in every study I've come across. The issue is I can't see whether this weight gain is induced by the increase in appetite or by some other mechanism. I really like Cypro and would like to take 0.5-1mg a day for a month with two...
    • PointOutside
    • Thread
    • cypro cyproheptadine
    • Replies: 61
    • Forum: Metabolism
  11. FitnessMike

    Your Cyproheptadine experience?

    there are plenty of anti-stress/serotonin substances that we know of over here, but they do vary in strength and how quickly we build a tolerance to them. I wonder how good did it work for you and if you build a tolerance to it.
  12. Orome

    Efficacy of Cyproheptadine Monotherapy in Hepatocellular Carcinoma With Bone Metastasis

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563693/ Abstract Background Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related deaths worldwide. Particularly, cases of bone metastasis have poorer prognoses. Case Presentation A 62-year-old woman with suspected...
  13. InChristAlone

    Kid with ADHD got MORE hyper on cypro

    My 9 yr old son has the hyperactive type of ADHD and we decided to try cypro because he also struggles with anxiety and poor appetite. We got up to 2 mg and I literally didn't see ANY signs of drowsiness other than when it was time to go to sleep. I can only take 0.5mg and the drowsiness never...
  14. P

    Avoiding cypro fogginess?

    I just recently ordered @haidut's cyproheptadine (mainly for digestive issues), and it seems like many people who have taken it seem to get extremely foggy and tired, even if it helps their other symptoms. To anyone who has experience with cypro, how did you overcome this? I also hear some...
  15. ecstatichamster

    I felt really sick - cyproheptadine is like magic

    I knew I didn't have a bug but it felt like it. From allergies and probably an endotoxin reaction. I couldn't even summon the desire to go out of my house. Nothing helped. Then I took half a cyproheptadine before bedtime. Next morning, good as new. I feel absolutely fine. Magical. I suppose...
  16. C

    Feverfew/Silk Tree as Replacement for Cypro/Meter

    What are your guys's thoughts about this? I can't use metergoline as an anti-serotonin supp because when I stop I get horrific symptroms of DAWS. Cypro is okay, but I don't like the dopamine receptor antagonizing effects and I am also finding it very hard to stop. Any time I stop the cypro, I...
  17. Mr Joe

    Combo High Dose (B1 + Cypro + B3) + T3 for recovery

    2 Years ago Symptoms : All day Anxiety, Depression Emergency state. Any bad thought would cause belly contraction and a cycle of stress diffucult to calm. Sleepness, GERD intense headaches when doing mental effort. I am understanding now that all of these could be symptoms of very low metabolism...
    • Mr Joe
    • Thread
    • anxiety cortisol cyproheptadine high-dose metabolic disorder ptsd serotonin stress thiamine vitamin b1
    • Replies: 12
    • Forum: Mental Issues
  18. deliciousfruit

    cyproheptadine increasing serotonin?

    I love cyproheptadine, I usually take 1mg in the afternoon. It significantly cools down my body temperature, makes me feel relaxed, increases my libido, lessens my nerve pain, and gives temporarily relief for all my gut symptoms. Today I took 2mg for the first time, and now I'm very hot...
  19. Lokzo

    Cyproheptadine Prevents High Altitude-Induced Testicular Disturbances

    Male rats were exposed to 4,340 m altitude for 4 days. At this time histological alteration in the testes were observed. There were tubules with pyknotic primary spermatocytes and spermatids, necrosis of numerous cells, and sloughing of primary spermatocytes. The damaged areas were limited by...
  20. mujuro

    Replacing Decade-long Quetiapine With Cyproheptadine (bipolar Sufferer)

    Hi folks, Just placing this thread here, more or less as a placeholder for developments in this journey as they arise. Not much to disclose so far, as I'm less than a week into this "experiment", for lack of a better word. The reason I have begun this now and not any time prior is because I've...
    • mujuro
    • Thread
    • bipolar cortisol cyproheptadine quetiapine
    • Replies: 5
    • Forum: Cyproheptadine
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