study

COVID‐19 pneumonia causes lower testosterone levels To evaluate the testicular damage caused by COVID‐19, we prospectively evaluated 44 patients who applied to the COVID‐19 outpatient clinic between March 2020 and July 2020. Patients' ages, COVID‐19 PCR results, presence of pneumonia, total...

Several months ago, I did a post on just how stressful the IP administration method is for lab animals. That method is considered the de-facto standard for steroid studies, yet it appears it is so stressful that it can easily produce invalid results due to the its strong effects on the HPA axis...

Has anyone read/looked over this article? I've never heard of/knew this was possible until recently. Tetracyclines function as dual-action light-activated antibiotics (in vitro/incubated cells) I'll bold/quote some of the parts I thought were interesting, assuming this hasn't been...

In trying to get a better understanding of varicocele, I somehow missed this study from 1980 which specifically implicates elevated serotonin in both varicocele and impaired fertility (albeit this was observed in canines, not humans). I was surprised and pleased to find the following bold...

This study was conducted to investigate the effects of caffeine on lipid and mineral content in the serum of rats given a caffeine free diet(FC), a low caffeine diet(LC), a medium caffeine diet(MC), a high caffeine diet(HC) or a super-high caffeine diet(SHC) for 5 weeks. Thirty male...

https://www.medrxiv.org/content/10.1101/2020.03.27.20045427v1.full.pdf While lymphocytopenia is a common characteristic of patients infected by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the mechanisms responsible for this depletion are unclear. Through careful...

Interesting study with chickens where Thiamine HCL (at reasonable dosages) increased muscle mass more than clenbuterol. (chickens have been known to be insensitive to beta-agonists though, so that part makes sense.) Breast muscle weight increased while total body weight went slightly down.

Article in Chinese; Abstract available in Chinese from the publisher] Fan L1, Xiong YP1, Liu HT1, Min X1, Tang YQ1, Zhang ZY1. Author information 1 Department of Otolaryngology Head and Neck Surgery，First Affiliated Hospital of Nanchang University，Nanchang，330006，China. Abstract in English...

I seems that every week more physicians are expressing their doubts publicly. The following is from the website of a Swiss hospital specialized in infectiology. Pioneering work barely noticed by the media It is therefore not surprising that the publication by Li et al. passed us almost...

A few years ago, I posted a thread on the possibility of using pregnenolone as a treatment for loneliness in humans. Pregnenolone As A Treatment For Loneliness At the time, the studies were mostly based on animal models and a small pilot human study. It seems that the results were promising...

As I was getting this post ready, I saw that haidut beat me to the punch by 3 years or so - but maybe the 2018 article that spurred this will answer @Giraffe 's question ("what's the mechanism?") in that thread Niacinamide May Be Able To Treat Both HIV And Tuberculosis Pulling from instagram...

This is one of the very few official studies from the US government that directly acknowledges the carcinogenicity of cellphone radiation. The study only found increased incidence in male animals, but the findings in females were inconclusive which is not the same as a finding of safety...

Fructan, Rather Than Gluten, Induces Symptoms in Patients With Self-reported Non-celiac Gluten Sensitivity. - PubMed - NCBI “Foods with gluten often contain fructans, a type of fermentable oligo-, di-, monosaccharides and polyols.” “In a randomized, double-blind, placebo-controlled crossover...

The effect of niacinamide on osteoarthritis: A pilot study In the 1940's and 50's William Kaufman treated several hundred patients with both osteo and rheumatoid arthritis with large doses of niacinamide. The researchers here are following Kaufman's approach. They conducted a three month...

Not sure if this is a positive or negative for magnesium, would be nice for more knowledgeable posters to explain this. Asian Pac J Cancer Prev. 2016;17(S3):131-4. Comparison of in Vitro Cytotoxicity and Apoptogenic Activity of Magnesium Chlorideand Cisplatin as Conventional Chemotherapeutic...

Please delete if the study has been posted before. dos Santos et al. (2017) Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells MB-PDT: Methylene blue photodynamic therapy Ps: Photosensitizer A few excerpts from the Discussion section: In...

A new study (h/t Mike Lustgarten) on methylene blue for skin health: Anti-Aging Potentials of Methylene Blue for Human Skin Longevity

I recently had a great experience with thiamine with regards to mental energy, and got curious as to why and how. Found some cool studies on the thiamine-serotonin connection; Thiamine deficiency: selective impairment of the cerebellar serotonergic system. - PubMed - NCBI According to this...

Metabolism can be roughly viewed as a set of timed processes, with many dimensions between the degrees of timing. This is a fairly mechanistic view of what is happening, but will allow us to think about how disruptions in the timing can lead to changes in the system. Many different biological...

My own observations have found that chronic cigarette smoking alters the function of the kidneys, at the local and nervous level. This disruption in the quantitative and qualitative efficiency in the kidneys sets the entire body up for a state of deranged metabolism. The kidneys are critical for...