1. haidut

    Blocking prostaglandins restores (glucose) metabolism, reverses brain aging

    It is rare to find a study like the one below that combines so many crucial topics into a unified message. Namely, the role of energy in aging and disease, the role of oxidative glucose metabolism in aging and health, the pathological role of PUFA as a negative (glucose) metabolic regulator and...
  2. haidut

    PUFA metabolites (prostaglandins) drive "flu" pathology

    A highly relevant study in light of the recent (and apparently, still ongoing) COVID-19 pandemic, which not only casts doubt on the official story about how infectious disease develops, but also its treatments and public health response. The study below demonstrated that prostaglandins - the...
  3. Sapien


    see Brain Cell Death and Raised Inflammatory mediators after exposure to delta 9 THC. (Role of Endocannabinoid system?)
  4. haidut

    PUFA metabolite (prostaglandin) promotes lipolysis / fibrosis, causes obesity / diabetes

    Just in case there are still doubts out there about just how detrimental PUFA is to our health, here is a study showing that just one of PUFA's "normal" metabolites (i.e. enzymatically derived, instead of through peroxidation) is sufficient to elevate lipolysis, and that effect alone is enough...
  5. haidut

    Pregnenolone/aspirin can block cellular estrogen uptake, PUFA promotes it

    I have posted in the past about the "obscure" estrogen estrone sulfate (E1S) and its role as a biomarker of both onset and progression of breast, colon, prostate, endometrial, and many other cancers. Despite its major role in cancer development, E1S remains known to mainstream medicine as simply...
  6. haidut

    Higher PUFA intake correlated with mental disease

    An epidemiological study, yet still useful IMO since the correlation was maintained across the various levels of PUFA intake - i.e. the higher the PUFA intake the higher the prevalence of a mental disorder such as depression, which suggests a causal link. The link was the strongest in males and...
  7. haidut

    PUFA required for periodontal disease, aspirin may help

    It is common knowledge even among mainstream dentists that periodontal disease is caused by bacteria accumulating under the gums, which over time leads to chronic inflammation and thus destruction of both gum tissue and the alveolar/jaw bone underneath the gums. Another "new" discover is that...
  8. RenaissanceMan

    Omega-3 EPA and DHA may be the solution to "male pattern baldness" / hair loss in men

    Follow up to my previous post on Omega-3s and Peat's flawed perspective on them (they increase dopamine and reduce learned helplessness i.e. high serotonin): Recent research...
  9. haidut

    Aspirin May Help Treat Melanoma

    A few months ago, a study made the rounds on social media and even this forum, claiming that aspirin actually increased risk of melanoma. Peat published a separate newsletter just to address that study. And now, this study below shows that aspirin actually may help treat Stage 2 and 3 melanomas...
  10. haidut

    Low Progesterone Drives The Conception Of Twin (or More) Babies

    I have always wondered about what causes some people to have twins (e.g. twinning), and why fertility treatments for women often result in much higher chance of twinning or even higher number of babies. While the "unassisted" conception of twins is usually explained away as being genetically...
  11. haidut

    Emotional Response To Pain Is Driven By Serotonin And Prostaglandins

    I posted previously on how serotonin is required for the formation of traumatic memories. This process plays a major role in disorders like depression, PTSD, chronic anxiety and even schizophrenia. Serotonin Is Involved In The Formation Of Traumatic Memories This study shows that the activation...
  12. EndAllDisease

    Sea Cucumber Extract Frondoside A Inhibits Prostaglandin Formation

    Sea cucumbers are squishy, boneless saltwater creatures found on the bottom of oceans worldwide, whose bodies are shaped like cucumbers and wrapped in a soft, leather-like casing. A study shows that one of the many anti-cancer substances found in the sea cucumber works by antagonizing the EP2...
  13. Hugh Johnson

    Effects Of Chronic Ethanol Treatment On Lipid Composition And Prostaglandins In Rats Fed Essential F The data are consistent with an increased utilization of EFA during chronic ethanol intoxication leading to a depletion of PG precursor stores in some but not all organs. Time to supplement with some alcohol.
  14. S

    Prostaglandin Could Cause Up To 40% Of Preterm Births

    Tensile strain increased COX-2 expression and PGE2 release leading to weakening of the human amniotic membrane
  15. haidut

    Cyproheptadine - A Wonder Drug?

    Hi all, As you many of you know, Ray Peat has mentioned cyproheptadine as a possible option for correcting certain physiological processes that have been derailed after years of eating PUFA, being exposed to chronic stress, toxins, endotoxin, battling chronic diseases, etc. As I mentioned in...
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