What's the argument for taking a synthetic supplement of something that can be consumed naturally in a food? Even Peat recommends against such things - he said its much safer to eat coconut oil than to take the "MCT oils" ..
Yes, it is similar to vitamin A in that respect. But one of the studies I posted above in the "Skin health" section deals exactly with the presence of squalene in the sebum and concludes that it is there as a protective mechanism. Also, the amount in Gonadin is not that much, and it matches the study in boars. So, I used the minimum amount that was shown to have a highly beneficial effects. Finally, there is sufficient vitamin E in Gonadin to protect from any peroxidation issues with squalene.
OK, so it changed a number on a paper, but were there any signs and symptoms that improved, physical or mental changes?
and any side-effects?
Possibly, when injected. Squalene is present in (real) olive oil in about 0.5% concentration. So if you eat about 30g of olive oil you'd get that amount of squalene. I am not aware of anybody getting side effects from dietary squalene.
Im not sure of that interpretation about the dose being based on kg. of food. I would say it is per kg of body weight. If it were as you say, then why to specify "/day"?. If it were based in the kgs of food, the "/day" would have no sense, it would add no info to the calculated amount.Finally, the study in boars used 40mg/kg of diet, not bodyweight. From the study:
"...Experimental groups of boars were treated with 10, 20 or 40 mg/kg/day squalene in 1 kg basal diet, respectively (Healthy Nature Resource, Inc., Walnut, CA, USA) and then were fed with 1.5 kg basal diet and 0.5–1.0 kg green feed daily."
This study discusses possible squalene-mediated virgin olive oil beneficial effects,
"Squalene, first isolated from shark liver oil and named by Tsujimoto in 1916 , is a polyunsaturated triterpene containing six isoprene units and a biochemical precursor of cholesterol and other steroids . Squalene content in extra virgin olive oil is especially high, up to 0.7% (7 g/kg), compared to other oils and human dietary fats , . In vitro, it is a highly effective oxygen scavenging agent "
Dietary Squalene Increases High Density Lipoprotein-Cholesterol and Paraoxonase 1 and Decreases Oxidative Stress in Mice
So a single tbsp of olive oil contains up to 100mg squalene woww, I've been taking evoo almost all my life and so squalene without knowking. I always swore by olive oil, god knows what pile of other countless unknown substances it contains.
I think for pushing those properties as a supplement, the ideal should be going on higher doses than obtained normally through food, to see if there is an increased effect. Or give a try to its saturated version,
"Squalane is a saturated form of squalene in which the double bonds have been eliminated by hydrogenation. Squalane is less susceptible to oxidation than squalene" - Squalene - Wikipedia
which in Peat land it could be suggested to be superior for being fully saturated, under the principle: "saturated is always better, polyunsaturated tends to be the opposite".
Im not sure of that interpretation about the dose being based on kg. of food. I would say it is per kg of body weight. If it were as you say, why specify the "/day". If it were based in the kgs of food, the "/day" would have no sense, it would add no info to the calculated amount.
Squalene. The miraculous essential omega 2 oil. Secrets from the sea
"The biochemical structure of squalene is C30 H50 (C30:6n-omega2) all trans isoprenoid"
"Squalene an omega 2 fatty acid has unlike omega 3 fish oils more complete and effective chemic groups."
"As an omega 2 fatty acid squalene has a redox function which releases oxygen from water, resulting in this above mentioned increased oxygen level in the cells."
Lol you're promoting and omega supplement!! can't wait to know what Peat thinks of this compound... my guess is that he will be skeptical because its pufa structure.
Yeah, it was just a joke :) Btw, why you didn't put GGOH in it too, to make it more "complete". Did you considerate it and discarded the idea for some reason?
How much GGOH is in mk4, and how much would be the dose of mk4 to achieve 30μM of GGOH?
Going from 980 to 1250 should probably have some very significant effects. How much did your lifts go up?No side effects. It improved weight lifting capacity and mood. I am not sure if this is due to the T boost or the dopaminergic effects squalene showed in one study.
Going from 980 to 1250 should probably have some very significant effects. How much did your lifts go up?
Does this supplement increase anabolic to androgenic ratio or keep it the same because of t>dht conversion?
dude, I love you, no homo:)...but seriously I'm extremely excited! I respond very well to K2 (it shoots my libido up big time) so this is very interesting to me and not only that but it can increase the function of the gonads and provide skin and hair benefits? No brainer...ordered.
I'll log it when I get it.
And no DMSO
Cant find where to order. Am I blind?
Trimetazidine maybe?Not directly. One of them is dopaminergic, anti-serotonin, anti-cortisol, and a powerful HDAC inhibitor (anti-cancer). The dopamine and anti-cortisol effects may lead to improved steroid profile though. The other one is an electron withdrawing agent and it is sold as a drug for improving heart function and metabolism in some countries. It is not related to Mildronate though.