steroid

  1. haidut

    Higher doses of vitamin D, other steroids, may be needed in obese people

    The title, at least in regards to vitamin D, is something Ray commented quite a few times when people asked him what the optimal dose for raising vitamin D levels was. His response always cautioned that there is no one-size-fits-all due to the fact that in obese people vitamin D can accumulate...
    • haidut
    • Thread
    • adipose cholecalciferol obesity sequestration steroid visceral vitamin d vitamin d3
    • Replies: 1
    • Forum: Scientific Studies
  2. F

    RPF approved/peaty "PCT" protocol for testosterone base cycle?

    I've decided I want to run testosterone base indefinitely for muscle building and libido purposes, but want to be careful that I have a way to recover my natural hormone production after cycle. I've run a steroid cycle before a few years back, and hoped to use SERMs to recover, as is...
    • feedandseed
    • Thread
    • bodybuilding estrogen antagonist pct pregnenolone progesterone steroid steroidogenesis testosterone
    • Replies: 4
    • Forum: Hormones
  3. haidut

    Molecules dissolved in vitamin E preferentially target brain injuries

    A fascinating study, confirming Ray's work from decades ago. Namely, that various lipophilic molecules (e.g. steroids) dissolved in vitamin E not only significantly bypass the liver, but are also taken up by organs/tissues in much higher amounts than if those molecules were floating around...
    • haidut
    • Thread
    • brain lesion steroid stroke tocopherol uptake vitamin e
    • Replies: 5
    • Forum: Scientific Studies
  4. Yody

    29yo Male Taking 735-840+mg Progesterone/Week

    Providing this anecdotal experience as a male running high dose progesterone, as there doesn't seem to be much out there. Currently 7½ weeks in. Everything topical except the exemestane. Getting blood drawn today. I started 3x a day with: 5 drops Cortinon+ (sfa/ethanol) 2 drops of Progestene...
    • Yody
    • Thread
    • 11-keto androstanolone dhea exemestane osteophyte progesterone stenosis steroid steroid hormones strength tulsi
    • Replies: 8
    • Forum: Supplements, Pharmaceutical Drugs
  5. MetabolicTrash

    Guy on forum claims he can only have sex when on heavy drugs & impulsive -- thoughts? Being honest, hardworking, even good looking guy doesn't cut it?

    I noticed this post and thought I'd share it here to have feedback. Why would a guy ONLY be able to have sex if he's taking three steroid compounds at super-physiological doses? We're not saying roids help his confidence, his sense of self, they literally -- according to him -- EXACERBATE more...
    • MetabolicTrash
    • Thread
    • behavior dht hormones incel male male issues steroid testosterone trenbolone
    • Replies: 25
    • Forum: Male Issues
  6. blackface

    What oil would provide the best absorbtion of transdermal hormones?

    Im planning to make another formula for transdermal application of hormones (DHEA, DHT, test base). I have tried DMSO and other stuff. I want to try just mixing ethanol + oil. The question is if the type of oil matters? Ie, would MCT oil provide better absorbtion than olive oil etc.? Im...
    • blackface
    • Thread
    • dhea mct oil olive oil steroid steroid hormones topical transdermal vitamin e
    • Replies: 30
    • Forum: Thyroid and Hormones
  7. haidut

    Fasting decreases androgens, increases aldosterone (and possibly cortisol/estrogens) in women

    I often get criticized that I rely too much on animal studies, so here is a human one that should give the proponents of caloric restriction / fasting a pause. Even a short fast (24-48 hours) resulted in decreased androgen synthesis in women, while increasing aldosterone. In general, fasting...
    • haidut
    • Thread
    • aldosterone androgen caloric restriction cortisol estrogen fasting steroid
    • Replies: 1
    • Forum: Scientific Studies
  8. haidut

    Sample report for steroid analysis in hair/nails

    I have been getting a lot of requests for posting a sample report on the forum, so here it is below. Please keep in mind that it a work in progress and it will likely change in the future, as we add more analytes/biomarkers for steroids and various steroid ratios that have been established as...
    • haidut
    • Thread
    • bioanalysis hair hormone intracellular nail ratio report steroid tissue
    • Replies: 27
    • Forum: IdeaLabs
  9. haidut

    IdeaLabs Service - Steroid Analysis (hair and/or (toe)nail)

    Note (5/27/2022): This launch is Part I of a two-part service - steroid analysis in hair or nails. While we have confirmed our ability to analyze steroids in both types of samples, nail steroid analysis is still in its scientific infancy and there are very few publications on the topic. As such...
    • haidut
    • Thread
    • analysis biomarker hair hormone idealabs longitudinal nails ratio steroid
    • Replies: 44
    • Forum: IdeaLabs
  10. cupofcoffee

    Growth hormone and thyroid hormones stimulate liver 5 alpha-reductase

    https://pubmed.ncbi.nlm.nih.gov/2172247/ not sure if this study was posted
    • cupofcoffee
    • Thread
    • 5ar cortisol dht dihydrotestosterone growth hormone liver steroid steroid hormones steroid metabolism steroidogenesis
    • Replies: 2
    • Forum: Thyroid and Hormones
  11. Mauritio

    Long term DHEA supplementation doubles androgens and progesterone in males

    I'm not sure if this study has been posted before , at least I haven found anything under the "DHEA" tag. Anyways, it's always good to have more in vivo evidence for peaty substances and what they do in real life. This study gave aging men with partial androgen deficiency (58-69)the "low dose"...
    • Mauritio
    • Thread
    • allopregnanolone androgens dhea dhea-s progesterone steroid steroid hormones testosterone
    • Replies: 28
    • Forum: Scientific Studies
  12. Mauritio

    The skin as a steroidogenic organ

    Here's a collection of studies on the skin as a steroidogenic organ mainly to show that hormones like pregnenolone have a different metabolization topically, compared to orally. "The cutaneous steroidogenic system can also have systemic effects, which are emphasized by significant skin...
    • Mauritio
    • Thread
    • androgen cholesterol lanolin lanosterol pregnenolone skin steroid steroid hormones steroidogenesis
    • Replies: 275
    • Forum: Cholesterol
  13. haidut

    Androgens (e.g. DHT) curative even for treatment-resistant breast cancer

    As many of my readers know, back in the "good ol' days" (when medicine was slightly less evil and berserk) breast cancer in women was treated with androgens, and the results were so impressive that a synthetic DHT-derivative known as Drostanolone / Masteron (2α-Methyl-DHT) was approved by the...
    • haidut
    • Thread
    • androgen antiestrogenic breast cancer cure dht steroid treatment-resistant
    • Replies: 4
    • Forum: Scientific Studies
  14. Mauritio

    5aOHP -Progesterone and DHT mix ? Has anybody heard about this steroid?

    I just came a across this pro hormone/steroid. Has anybody heard about it? It seems phenomenal its anabolic, progestogenic and converts into DHT . It sounds like the perfect combo for males . There seems to be very few research on it. What do you guys think? "5aOHP (chemical name...
  15. haidut

    Ear wax testing as a reliable method for measuring long-term steroid levels

    Many of my readers already know about the unreliability of using steroid blood tests as diagnostic methods, except in cases where the values are so extreme that are unlikely to be temporary fluctuations. Saliva tests for steroids are even less reliable, even though combining both saliva and...
    • haidut
    • Thread
    • average blood chronic cortisol ear wax hair saliva steroid
    • Replies: 3
    • Forum: Scientific Studies
  16. Gohan

    Topical Steroids

    Can you make steroids topically bio available (cream/oil/dmso)? Talking about things like Masteron/EQ/Tren etc? Do they have to be no ester? Whats their bioavailability compared to injectables like this? I know they are unhealthy, just wanna know.
  17. haidut

    Allopregnanolone May Soon Be Approved As A Fast-acting Antidepressant

    The patents on most SSRI drugs have either expired or are close to expiration. Lately, there have also been a number of high profile cases obtaining favorable court outcomes by blaming SSRI drugs for a host of human criminal behaviors or adverse health events. As such, Big Pharma is desperate to...
    • haidut
    • Thread
    • 5a-dhp allopregnanolone antidepressant approval brexanolone fast-acting fda gaba mental health mental illness mood progesterone steroid
    • Replies: 67
    • Forum: Scientific Studies
  18. haidut

    Structural Requirements For An Optimal Anti-Catabolic Steroid

    This post will be a bit long, but I hope it is worth it. I think @Jsaute21 and @dand will find it highly interesting but the information here applies just as much to females wishing to preserve lean tissue and prevent the catabolism that often occurs with aging. Here we go. Lately, I have been...
    • haidut
    • Thread
    • anabolic androgenic androsterone anticatabolic dhea dht glucocorticoid progesterone receptor ru486 steroid testosterone
    • Replies: 226
    • Forum: Scientific Studies
  19. haidut

    All Steroids (not Just Unbound/free Ones) Are Bioavailable

    One of the recurring points of contention in Peat's writings that I have not seen addressed yet is his comment on total vs. free hormones and the relevance this has for common blood tests for thyroid and sex hormones. The mainstream medical claim is that only free hormones are capable of...
    • haidut
    • Thread
    • albumin bioavailable bound cell globulin hormone protein steroid unbound uptake
    • Replies: 5
    • Forum: Scientific Studies
  20. haidut

    Finasteride Causes Physical Damage To Nerves, Depression, ED, Steroid Imbalance

    After a decade of denying that a thing such as PFS exists, mainstream medicine seems to be wisening up to the fact that this poison does a lot more than lower the "bad" DHT. Up until very recently, it was common to simply measure blood steroid levels and then declare that they had rebounded upon...
    • haidut
    • Thread
    • 5a-dhp allopregnanolone damage depression dhea dht edd erectile dysfunction finasteride imbalance mdd nerve nervous system pregnenolone progesterone pudental steroid
    • Replies: 41
    • Forum: Scientific Studies
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