steroid

  1. Mauritio

    The skin as a steroidogenic organ

    Here's a collection of studies on the skin as a steroidogenic organ mainly to show that hormones like pregnenolone have a different metabolization topically, compared to orally. "The cutaneous steroidogenic system can also have systemic effects, which are emphasized by significant skin...
  2. haidut

    Androgens (e.g. DHT) curative even for treatment-resistant breast cancer

    As many of my readers know, back in the "good ol' days" (when medicine was slightly less evil and berserk) breast cancer in women was treated with androgens, and the results were so impressive that a synthetic DHT-derivative known as Drostanolone / Masteron (2α-Methyl-DHT) was approved by the...
  3. Mauritio

    5aOHP -Progesterone and DHT mix ? Has anybody heard about this steroid?

    I just came a across this pro hormone/steroid. Has anybody heard about it? It seems phenomenal its anabolic, progestogenic and converts into DHT . It sounds like the perfect combo for males . There seems to be very few research on it. What do you guys think? "5aOHP (chemical name...
  4. haidut

    Ear wax testing as a reliable method for measuring long-term steroid levels

    Many of my readers already know about the unreliability of using steroid blood tests as diagnostic methods, except in cases where the values are so extreme that are unlikely to be temporary fluctuations. Saliva tests for steroids are even less reliable, even though combining both saliva and...
  5. Gohan

    Topical Steroids

    Can you make steroids topically bio available (cream/oil/dmso)? Talking about things like Masteron/EQ/Tren etc? Do they have to be no ester? Whats their bioavailability compared to injectables like this? I know they are unhealthy, just wanna know.
  6. haidut

    Allopregnanolone May Soon Be Approved As A Fast-acting Antidepressant

    The patents on most SSRI drugs have either expired or are close to expiration. Lately, there have also been a number of high profile cases obtaining favorable court outcomes by blaming SSRI drugs for a host of human criminal behaviors or adverse health events. As such, Big Pharma is desperate to...
  7. haidut

    Structural Requirements For An Optimal Anti-Catabolic Steroid

    This post will be a bit long, but I hope it is worth it. I think @Jsaute21 and @dand will find it highly interesting but the information here applies just as much to females wishing to preserve lean tissue and prevent the catabolism that often occurs with aging. Here we go. Lately, I have been...
  8. haidut

    All Steroids (not Just Unbound/free Ones) Are Bioavailable

    One of the recurring points of contention in Peat's writings that I have not seen addressed yet is his comment on total vs. free hormones and the relevance this has for common blood tests for thyroid and sex hormones. The mainstream medical claim is that only free hormones are capable of...
  9. haidut

    Finasteride Causes Physical Damage To Nerves, Depression, ED, Steroid Imbalance

    After a decade of denying that a thing such as PFS exists, mainstream medicine seems to be wisening up to the fact that this poison does a lot more than lower the "bad" DHT. Up until very recently, it was common to simply measure blood steroid levels and then declare that they had rebounded upon...
  10. haidut

    DMSO Potentiates The Effects Of Steroids Inside The Cell

    This claims has been made many times, and is even listed on the Wikipedia page. However, I have not been able to find the actual reference to back this up even though I have been looking for a long time. Now, thanks to @Wagner83 and his link to the "Cornell Vet" book, I found that study and I am...
  11. haidut

    Gonadin - Liquid Steroid Optimizer For Lab/R&D

    As I mentioned in a few threads before, I have always been interested in the so-called "reproductive aging", both in males and females. There is solid evidence that gonadal function declines with age and as such the synthesis and circulating levels of protective steroids like testosterone (T)...
  12. haidut

    Acetylcholine Has Negative Effects On Gonadal Steroidogenesis

    Choline and acetylcholine are another topic that often pops up online. Cholinergic drugs are still the main "treatment" for Alzheimer, even though all of them are abject failure clinically. Ray has written about the excititoxic properties of acetylcholine, and how estrogen manifests its effects...
  13. haidut

    Pineal Gland Chemicals Inhibit Androgen Synthesis

    There is great interest in the blogosophere in writing about and supplementing with the pineal hormone melatonin. Ray has written about the dangers of melatonin, but there is enough contradictory research to confuse people. This study shows that another pineal hormone, which ALWAYS rises...
  14. haidut

    Unsaturation = Estrogenic, Saturation = Androgenic

    Most people on the forum have read Peat's articles on PUFA and its great synergism with the estrogenic hormones. Peat has written that saturated fats have effects opposite to those of PUFA and there are studies showing feeding saturated fat increases androgen synthesis. I have been researching...
  15. haidut

    11-keto DHT - Adrenosterone Derivative For Lab/R&D Use

    As promised, I am releasing a steroid that may be of interest to some people on the forum. It is a variation of the well-known steroid DHT that Peat has written about and I have also posted quite a few studies on. The steroid belongs to the group of the so-called keto-steroids and AFAIK this is...
  16. S

    TRT Beard Experiences

    Does anyone have experience with this? I saw someone claim his beard "didn't fill in until" he reached 1500mg (a month?)
  17. P

    Dietary lipids modify redox homeostasis and steroidogenic status in rat testis.

    http://www.ncbi.nlm.nih.gov/pubmed/18549927 OBJECTIVE: The present study explored the effect of dietary oils on lipid composition, antioxidant status, and the activity of the main steroidogenic enzymes in the testis. METHODS: Forty Wistar rats were randomly assigned to one of four groups (n =...
  18. haidut

    Effects Of Thyroid Hormone On Steroid Metabolism

    Very good study for those who want to know how taking thyroid affects their steroid metabolism. Below is my summary of the relevant point, but I still strongly recommend everyone reads the entire study, as it is very accessible. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1807335/ 1...
  19. Tarmander

    Anabolic Steroids

    I have recently started experimenting a bit with Pregnenolone, and have been reading quite a bit from Haidut about DHEA in low amounts being very androgenic. My question though is what separates some of these substances and supplements that we talk about that have androgenic and anabolic...
  20. haidut

    DMSO Makes Transdermal Steroid Absorption Close To 100%

    For those asking about my steroid supplements, and why use DMSO as a carrier (questions mostly coming from the Facebook RP groups). The studies below show that transdermal application of steroids (including progesterone, estrogen, and testosterone) dissolved in DMSO achieved the same...
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