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Gonadin - Liquid Steroid Optimizer For Lab/R&D

Discussion in 'IdeaLabs' started by haidut, Feb 17, 2017.

  1. Wagner83

    Wagner83 Member

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  2. charlie

    charlie The Law & Order Admin

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    There is a hard coded time limit, no way to change it. So after it times out on pulling the title over, it goes ahead and submits the post even if all titles were not pulled. Also I notice Pubmed is very slow to respond at different times. So the way around this is to click edit, then hit "save changes" so that it will go through the process again for the rest of the links that were not done. I went ahead and did it for your OP. It took a few times but it did get them all done.
     
  3. Waynish

    Waynish Member

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    Isn't Squalene the dangerous substance used in vaccines? I'll have to lookup references, but I remember reading that injecting it can basically cause PTSD (tests on soldiers - my memory might not be serving me right, though).
    EDIT: I release this source isn't trustworthy, but reading the cautionary - even if bogus - tales of a substance is probably a good idea before taking it:
    Million TIMES More Squalene In H1N1 Vax Than Caused GWI !!
     
  4. OP
    haidut

    haidut Member

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    Yes, it is similar to vitamin A in that respect. But one of the studies I posted above in the "Skin health" section deals exactly with the presence of squalene in the sebum and concludes that it is there as a protective mechanism. Also, the amount in Gonadin is not that much, and it matches the study in boars. So, I used the minimum amount that was shown to have a highly beneficial effects. Finally, there is sufficient vitamin E in Gonadin to protect from any peroxidation issues with squalene.
     
  5. OP
    haidut

    haidut Member

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    Yes, they are.
     
  6. OP
    haidut

    haidut Member

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    A good number of the studies in the References section are on humans. There were no toxicities as far as I could see.
     
  7. OP
    haidut

    haidut Member

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    Lol, glad to hear it. Yes, please keep everybody posted on experimental results.
     
  8. OP
    haidut

    haidut Member

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    Not sure, the studies showed no effects on pituitary hormones but if it increases progesterone enough that should trigger the negative feedback mechanism and lower FSH.
     
  9. Agent207

    Agent207 Member

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    I'd say its thimerosal -along with formaldehydes- the most dangerous one.
     
  10. OP
    haidut

    haidut Member

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    Not directly. One of them is dopaminergic, anti-serotonin, anti-cortisol, and a powerful HDAC inhibitor (anti-cancer). The dopamine and anti-cortisol effects may lead to improved steroid profile though. The other one is an electron withdrawing agent and it is sold as a drug for improving heart function and metabolism in some countries. It is not related to Mildronate though.
     
  11. OP
    haidut

    haidut Member

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    I think the scrotum application would also work and should be able to achieve the same with much lower dose. But given that many tissues can synthesize steroids, you may want the systemic effects as well.
     
  12. OP
    haidut

    haidut Member

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    It is squalene. The saturated version squalane was not shown to have effects on steroidogenesis.
     
  13. Waynish

    Waynish Member

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    Ah, sorry for the conflation. I'll look into what possible actions it has in the blood. Interesting how one could have (supposedly) such toxic effects, while the saturated not having them.
     
  14. OP
    haidut

    haidut Member

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    OK, I will change that in the original thread. The 30uM concentration was the same they used in the vitamin K study and that study replicated the results in vivo using vitamin K2 in a HED of 1mg/kg. So, for most people 70mg - 100mg vitamin K2 daily should replicate that study. But no all of those 70mg-100mg vitamin K2 is geranylgeraniol. So, to be conservative, I put 100mg phytol just to be sure. To achieve 1uM concentration you need about 3mg phytol. So the 100mg per dose seems to be good.
    Finally, the study in boars used 40mg/kg of diet, not bodyweight. From the study:
    "...Experimental groups of boars were treated with 10, 20 or 40 mg/kg/day squalene in 1 kg basal diet, respectively (Healthy Nature Resource, Inc., Walnut, CA, USA) and then were fed with 1.5 kg basal diet and 0.5–1.0 kg green feed daily."


    The conversion factor from pigs to humans is about 1:1 so this means 40mg/kg of diet in humans as well. Given that humans consume on average about 2.5kg of food daily, you get 100mg of squalene. Btw, the lower dose of 20mg/kg also had an effect and it was not that far off from the 40mg/kg but given that an overall dose of 100mg daily would not be that much and I wanted to keep things simple I went with that amount per dose.
     
  15. OP
    haidut

    haidut Member

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    Great, thanks!
     
  16. OP
    haidut

    haidut Member

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    Possibly, when injected. Squalene is present in (real) olive oil in about 0.5% concentration. So if you eat about 30g of olive oil you'd get that amount of squalene. I am not aware of anybody getting side effects from dietary squalene.
     
  17. OP
    haidut

    haidut Member

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  18. dookie

    dookie Member

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    @haidut

    Have you yourself used this product yet, and if so, what were the effects you noticed?
     
  19. OP
    haidut

    haidut Member

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    Yes, it increased my T levels by about 30%.
     
  20. dookie

    dookie Member

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    What's the argument for taking a synthetic supplement of something that can be consumed naturally in a food? Even Peat recommends against such things - he said its much safer to eat coconut oil than to take the "MCT oils" ..
     
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