progesterone

  1. P

    Progesterone Suppresses GAD enzyme MRNA (If progesterone excites you, it may be glutamate)

    Progesterone increases glutamate in the brain via blocking GAD enzyme Progesterone increases glutamate in the brain via blocking GAD enzyme activity, this can lead to overexcitation and depression via glutamate excess. From the start the use of Progesterone felt bad to me and I knew it was...
  2. haidut

    Stress causes/exacerbates allergies, pregnenolone/progesterone therapeutic

    Yet another studies demonstrating the "controversial" link between stress and a condition doctors insist has nothing to do with stress or hormones in general. This time the culprit is CRF/CRH, which is the initial step in the "stress" cascade and is now known to be implicated in conditions such...
  3. haidut

    Endocrine disruptors in cosmetics may cause postpartum depression, premature births

    Hardly a surprising finding, but it will probably come as a shock to most modern women who are the biggest consumers of such products (e.g. nail polish, perfumes, shampoo, etc). One of the reasons for this "controversy" is that doctors continue to insist that using such products during pregnancy...
  4. N

    Progesterone soaking my panties help!

    So started taking progesterone finally . Ordered from ona Naturals and rub 3-4 drops on gums in the am so about 15-20mg. Only been doing this for about 3 days and this is a TMI WARMING but I am so so horny all the time , in fact I have been thinking about sex throughout the day much more often...
  5. Hans

    How to protect yourself against exercise-induced endotoxin absorption

    Endotoxin can significantly negatively affect your health, from chronic low-grade inflammation, joint degeneration, organ inflammation and dysfunction, brain degeneration, insulin resistance, etc. Most people know that gut dysbiosis can increase endotoxin production and absorption into the body...
  6. U

    Maca during early pregnancy?

    I have heard claims that maca boosts progesterone levels and also estrogen (enough progesterone can balance it out) boosts fertility and lowers the rate of pregnancy loss. If a woman is 10 weeks pregnant would this be a thing to try or avoid?
  7. G

    Topicals on Arteries to Maximize Follicle Exposure

    These questions are partially related to my ongoing experiment of applying DHEA and Progesterone to my scalp for hair regrowth. I have an idea about the location of topicals, and I wanted to get some thoughts on it because I am not the most knowledgeable person when it comes to human anatomy...
  8. U

    Progesterone use in pregnancy causes homosexuality?

    I am starting to doubt progesterone supplementing in pregnancy since I know someone who took natural progesterone and it made her spot during early pregnancy. This study claims that adults whose mothers took progesterone in pregnancy are more likely to be gay or bisexual. I was under the...
  9. jzone56

    Progesterone first observations

    27 yr male 185 lbs ~15% bf time of day: 8pm post-workout Method of administration: topical Location: inner wrist Dosage: ~1.7mg Gabaergic effects felt 30-50mins post administration. other observations: 1. testicles retreated closer to the body, sack became tight 2. some sort of tightness...
  10. D

    All These Threads On Hair Loss Go Nowhere Because....

    ....because what we really need is feedback from those who HAVE their hair - a survey or study on their health, habits, diets, fathers/heredity, etc. How we go about doing that I don't know, but I could guess, there wouldn't be found anything markedly different about them then those who've lost...
  11. A

    Progesterone increases libido?

    I would have thought the opposite - sometimes I'm taking it to improve sleep and general health, but I kind of accept that it may reduce testosterone and libido. But actually whenever I take it I have a stronger libido and erections. What could be the mechanism behind this?
  12. maillol

    Progesterone, Progesterone Receptors and Prolactin

    This is an interesting paper I came across from 2019 with new research on progesterone's effects on prolactin. Some highlights: Does progesterone need a certain level of E2 to be beneficial? If you look at the study referenced here (27) it says So it seems this is only an acute effect...
  13. copycat

    Specific advice / a funny predicament.

    Hi! I've made a few posts before but I'd like to keep it short and ask for specific advice. Apologies in advance for my weird English. As you can imagine, it's not my mother tongue, haha. LATER-EDIT: I guess you can ignore the ''keeping it short'' part. I'm a 23 year old male, 1,83cm tall...
  14. egoy

    Brain Cancer stage 4 glioblastoma giant cells. What options are available?

    This is about a family member. She is 56yo. This morning she was diagnosed with head cancer... doctors gave her a short term to live. They want to put her on chemotherapy. What can i do for her ? Is there any way possible to reverse this ? @haidut @mrchibbs @Tarmander
  15. haidut

    Blocking cortisol may treat terminal pancreatic cancer

    Recently, I made a post about some truly amazing results in treating terminal cancer patients with the glucocorticoid/progesterone antagonist Mifepristone (RU486). Some of the cases were stage 4 and possibly terminal. Now, a new case study below reports possibly curative effects on a confirmed...
  16. haidut

    Stress (cortisol) causes pre-term birth by blocking progesterone

    If you ask a gynecologist what causes premature birth, the answer will usually be something along the lines of "insufficient progesterone" often accompanied by mumbling about "genetic predispositions". Yet, how exactly is insufficient progesterone responsible for premature birth has remained a...
  17. haidut

    DHT / Progesterone / aspirin treat, cortisol ineffective, PUFA promotes prostate cancer

    A great study, albeit in-vitro, that once again throws into doubt the entire hypothesis behind prostate cancer. First, it proves the key role of PUFA in the genesis and progression of prostate cancer by demonstrating that inhibitors of the COX enzyme (responsible for synthesizing prostaglandins...
  18. Igorevich

    Strange hormonal profile

    Hi. I recently posted my story here, but I want to be more precise in asking for advice. I'm 27 years old male. My main problems right now are the following: 1) Most of the time I'm fatigued, having malaise, uneasiness, pure concentration, low-grade akathisia, brain fog. but every little...
  19. Drareg

    Progesterone could reduce the severity of their COVID-19

    The headline will put everyone off progesterone in the age of transgender mania, folks will think the ruling class are further trying to feminize males. I’m sure this works in women also, it will turn out that more men are dying "with" covid overall also, this won’t make headlines because we are...
  20. P

    Progesterone receptors and serotonin levels in colon epithelial cells from females with slow transit constipation (P4 lowers SERT)

    Abstract link to study Background: Females with slow transit constipation (STC) exhibit progesterone receptor (P4R) overexpression in colon muscle that impair their contractility. These studies examined whether these patients have an overexpression of P4R in epithelial cells and...
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