progesterone

  1. md_a

    RENIN-ANGIOTENSIN-ALDOSTERONE SYSYTEM And HAIR LOSS PROCESS

    I think excess cortisol-aldosterone- mineralocorticoid activation trough angiotensin system are main players in balding by cytokine activation and progressing to fibrosis. Focusing on TGF-β₁, which shuts off the anagen phase of the hair cycle, and 11β-HSD₁ expression should fix to the problem...
  2. GorillaHead

    Some SOLID Bro Science On Balding

    Among the raypeat community and in line with Danny Roddys theory on hair-loss. Balding is essentially fibrosis. We know from biopsies that balding scalp has perifollicular fibrosis. www.ncbi.nlm.nih.gov › pubmedPerifollicular fibrosis: pathogenetic role in androgenetic ... - NCBI Essentially...
  3. haidut

    Almost 40% Of Military Women (and Even More Military Males) Are Infertile

    I think this study should dispel some of the myths about what being "fit" really means, and that being truly healthy or "fit" often are quite divergent paths. Infertility is actually one of the most reliable indicators of poor systemic health and predictor of future chronic disease (in both...
  4. Orangeyouglad

    I'm Getting Hairy

    After peating for almost a year now my body hair has increased, everywhere. It's insane and extremely unsightly. Places that it normally shouldn't be, it is. I should note that at 29, I am by far the hairiest guy in my family and I can't figure out why. I've always been a bit furrier, but it's...
  5. haidut

    Progesterone May Treat Diabetes, Obesity, And Metabolic Syndrome

    Interesting new study, which adds more to the already existing mountain of evidence for the benefit of progesterone in a variety of conditions of metabolic origin. While the study does not mention any specific doses, it is known that the receptor (PGRMC2) whose activation the study found to be...
  6. haidut

    Inhibiting Estrogen Synthesis May Treat / Prevent Ectopic Pregnancy

    I just made a post about the role of estrogen in male infertility, which matches perfectly the evidence about estrogen's role as a metabolic inhibitor, and an agent that causes atrophy in both male and female gonads. Male Fertility Depends On Intensity Of (sperm) Metabolism Now, a new study...
  7. haidut

    Male Fertility Depends On Intensity Of (sperm) Metabolism

    Yet another aspect of health that turns out to be directly controlled by quality/speed of metabolism. I made a few posts in the past demonstrating that progesterone and pregnenolone activate a calcium channel (CatSper) specific to progesterone, which greatly increases sperm motility...
  8. haidut

    Estrogen, Not HPV, Causes Cervical Cancer; Progesterone Can Stop / Reverse It

    Yet another one of the carefully crafted, fear mongering myths that modern medicine literally sells to us on a daily basis just got busted. As many of my readers know, there has been huge publicity over the last 10 years in regards to the human papillomavirus (HPV) and the multitude of cancers...
  9. haidut

    Estrogen And Cortisol, Not Androgens, Suppress Immunity

    There is a very famous theory in reproductive biology still considered the dominant one in its field. Namely, males have to accept a trade-off between androgen levels and immunity. It is known as the immunocompetence handicap hypothesis (ICHH). Higher androgen levels, the theory goes, allow the...
  10. haidut

    Humans Have A 'salamander-like' Ability To Regrow Cartilage

    The title says it all, but the study authors make the unfortunate/handicapped conclusion that while we may very well be able to regrow cartilage, we cannot regrow limbs. Well, multiple animal studies I posted in the last beg to disagree and point to both high metabolism and progesterone as...
  11. haidut

    Natural Progesterone (but Not Synthetic Progestins) Has Potent Anti-hypertensive Effects

    As many readers already know, synthetic estrogens and progestins currently dominate the market for female reproductive health. These chemicals are in everything from birth control pills, to drugs for "treating" endometriosis, to drugs for menopausal symptoms, to treating neurodegenerative...
  12. Orangeyouglad

    Hairloss Blood Work: Low T + High DHT + High Progesterone

    I've been going through a lot of tests to try and see if there's something that could be causing my early-onset MPB. I recently received my blood work back and found interesting results. Free T was low but DHT was at the upper limit. My progesterone is high. Double the higher end amount for...
  13. haidut

    Allopregnanolone As A Treatment Of Alzheimer Disease (AD)

    It looks like the recent FDA approval of allopregnanolone (ALLO) for postpartum depression may open the floodgates to ton of new research with this steroid, as well as with its reliable precursors such as pregnenolone and progesterone. I posted several studies in the past demonstrating that...
  14. haidut

    Progesterone May Bind And Deactivate Endotoxin (LPS) Directly

    I made a few posts recently discussing the blocking effects of pregnenolone on TLR4 and TLR family receptors in general, and the reduction of systemic inflammation stemming from this blockade/regulation...
  15. haidut

    Birth Control (BC) Pills With Estrogen Cause Abortion, Not Contraception

    In one of his earlier articles, Ray talks about how the estrogen industry had to publish fake studies and show them to the Catholic Church in order to get their tacit approval for selling BC to the public. The church still maintained that they are opposed to all forms of BC but explained that it...
  16. haidut

    Pregnenolone Is As Potent As Progesterone As An (irreversible) Aromatase Inhibitor

    Progesterone does not need an introduction here and most people are likely aware of its antiestrogenic effects. A few years ago, I posted a thread with an old French study showing that a 500mg daily dose pregnenolone completely blocked estrogen's effects - an effect identical to what...
  17. haidut

    High Metabolism And/Or Progesterone Can Regrow Amputated Limbs

    Another great example of "synchronicity" (Synchronicity - Wikipedia) happened today. Two separate but related studies, with similar organisms, popped up today in my mailbox. One of them (at UCDavis) shows that the redox status in favor of oxidation, and thus high reactive oxygen species (ROS)...
  18. japanesedude

    Progesterone Triggered Erection In Castrated Rats And Restored The Frequency In Noncastrated Rats

    Hormone treatment facilitates penile erection in castrated rats after sleep deprivation and cocaine. - PubMed - NCBI Sleep deprivation is associated with cocaine-enhanced genital reflexes in male rats, and castration of the male rat causes a decline in sexual behaviour, which can be reversed...
  19. haidut

    Allopregnanolone May Soon Be Approved As A Fast-acting Antidepressant

    The patents on most SSRI drugs have either expired or are close to expiration. Lately, there have also been a number of high profile cases obtaining favorable court outcomes by blaming SSRI drugs for a host of human criminal behaviors or adverse health events. As such, Big Pharma is desperate to...
  20. haidut

    Low Progesterone Drives The Conception Of Twin (or More) Babies

    I have always wondered about what causes some people to have twins (e.g. twinning), and why fertility treatments for women often result in much higher chance of twinning or even higher number of babies. While the "unassisted" conception of twins is usually explained away as being genetically...
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