As I mentioned in a few threads before, I have always been interested in the so-called "reproductive aging", both in males and females. There is solid evidence that gonadal function declines with age and as such the synthesis and circulating levels of protective steroids like testosterone (T)...
I just posted a thread about androsterone and its potent anti-depressant effects:
Androsterone - An Andidepressant Neurosteroid
Just like allopregannolone (ALLO), androsterone is 5-AR derived neurosteroid, and just like allopreganolone androsterone is a very potent GABA agonist (even more...
The study used the activated form of B6 (pyridoxal-5-phosphate, P5P) and the human equivalent dosage was 500mg-600mg. The mechanism of action was the reduction of brain levels of glutamate via activation of glutamate dehydrogenase (GDH).
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317040/