haidut

Member
Joined
Mar 18, 2013
Messages
17,979
Location
USA / Europe
****DISCONTINUED****DISCONTINUED****DISCONTINUED****

Replaced by allopregnanolone, which is a direct metabolite of 5α-Dihydroprogesterone (5α-DHP).
************************************************************************
As many of you know by now, I have acquired an interest lately to research the connection between the process of saturation of various nutrients and steroids and the effects of this saturation on the properties of these substances. After doing some work on androgens such as androsterone and 11-keto DHT, I started researching the effects of various progestins / progestogens, especially metabolites of progesterone. As most people familiar with this forum know, progesterone occupies a rather prominent role in metabolic therapy due to its multitude of systemic beneficial effects such as opposition to estrogen, PUFA, aging, degeneration, infections, serotonin, prolactin, NO, etc. After reviewing the metabolic pathways of progesterone, especially in the brain, one metabolite immediately caught my eye. That metabolite was 5α-Dihydroprogesterone (5α-DHP).
5α-Dihydroprogesterone - Wikipedia

5α-DHP is formed from progesterone by the activity of the enzyme 5α-reductase (5-AR) - the same enzyme that converts T into DHT. I noticed that 5α-DHP levels rise sharply during pregnancy in most mammals (including humans) and in some species are the only progestogen as that species (horses) produces almost no regular progesterone. 5α-DHP is also the direct precursor to the neurosteroid allopregnanolone.
Allopregnanolone - Wikipedia

Allopregnanolone is the current darling of the pharma industry (since everything else failed) and is in clinical trials for almost every conceivable brain or mood condition including epilepsy, Alzheimer, Parkinson, TBI, MS, ALS, depression, schizophrenia, bipolar disorder, PTSD, suicidal tendencies, etc. Those trials are being conducted with both bioidentical allopregnanolone and its bastardized synthetic cousin Ganaxolone.
Ganaxolone - Wikipedia

Early animal studies and subsequent human ones showed that it is progesterone metabolites formed by the activity of the enzyme 5-AR that are primarily responsible for the beneficial effects of progesterone in the brain and in so many conditions. Administration of a 5-AR inhibitor like finasteride reliably lowers levels of not only DHT but also of 5α-DHP and allopregnanolone. The administratios of a 5-AR inhibitor abolished almost all positive effects of progesterone in the brain. This suggests that it is the 5-AR metabolites of progesterone such as 5α-DHP and allopregnanolone that are primarily responsible for the benefits of progesterone in all these conditions. Reductions in brain allopregnanolone are widely recognized as the single most important factor in mental health (especially depression, suicide, and the infamous "brain fog"). Virtually all SSRI drugs that have shown some effectiveness raise levels of allopregannolone in the brain. However, in people who are under stress, have neurological damage, have endured treatment with finsateride, or are simply loaded with PUFA the enzyme 5-AR is downregulated both in levels and in activity. As such, simply supplementing with progesterone may not have the desired effects of raising allopregnanolone. This may be one of the reasons why progesterone seems to lose effectiveness as an anti-depressant in older people - i.e. they have much lower expression and activity of 5-AR compared to younger people. However, with the widespread PUFA assault even young people are showing signs of diminished neurological responsiveness to progesterone when administered as a supplement. One option would be to supplement allopregnanolone. However, allopregnanolone is not available OTC or by prescription in any country. In addition, due to the recent successful trials with both bioidentical and synthetic allopregnanolone derivatives, the future of allopregnanolone as a freely available chemical looks rather bleak. In all likelihood, one the FDA approved allopregnanolone or Ganaxolone for any condition, the company behind the trial will petition FDA to start regulating allopregnanolone as a drug. In addition, while allopregnanolone has a great track record as neurosteroid, it has no progesterone effect - i.e. it is not an agonist of the progesterone receptor. Agonism of the progesterone receptor has a multitude of other benefits including opposition to estrogen, prolactin, serotonin, NO and variety of other mediators tat serve to inhibit metabolism. Thus, ideally the substance to be supplemented with should have the properties of allopregnanolone (or easily convert into it) while also having the properties of progesterone through the progesterone receptor. The steroid 5α-DHP is exactly such substance, and for now it seems to not be subject to any clinical trials or legal threats. It is a direct precursor of allopregnanolone and as such should elevate allopregnanolone levels even in people with strongly downregulated 5-AR - i.e. sufferers of the so-called post-finasteride syndrome (PFS), older people or people under severe stress or PUFA loads. Just like progesterone 5α-DHP is capable of reducing estrogen receptor levels inside the cells and knock the estrogen out of the cells. It also inhibits prolactin release, just like progesterone. More importantly, it achieve these benefits in doses 2-3 times lower than progesterone. And last but not least, 5α-DHP is not a metabolic precursor to estrogen, cortisol, and aldosterone like regular progesterone is.
Furthermore, 5α-DHP (like other 5-AR derived steroids) can serve as raw material for synthesis of potent androgens such DHT, androstanedione, and androsterone. And unlilke other precursors such as DHEA, 5α-DHP does not seem to activate the same negative feedback mechanisms upon its conversion to DHT or other androgens.
Finally, to top it all off, 5α-DHP does not seem to possess anti-androgenic effects like regular progesterone. This should make it a bit more convenient for supplementation in males who are wary of using progesterone supplements. I think the saturation of the steroid is what removes some if its anti-androgenic effects while preserving the activation of the progesterone receptor.

Disclaimer: The fact that this post and product description contain quotes from Ray Peat does not mean he endorses/approves of this product. His opinions on a chemical may change when new evidence becomes available in the future, so future inquiries about a chemical, solvent, ingredients, etc contained in this product may elicit a different response than his quotes included in this post. Please seek his opinion independently on any chemical, solvent, ingredient, etc that you may have concerns/questions about.

The units listed on the label are just for measurement purposes. They do not indicate or suggest optimal dose. Please note that similar to the products sold by companies like BlueSky, this product if for lab/research use only. The product can be ordered from the link below:
http://www.idealabsdc.com/lab

*******************************************************************************
5α-Dihydroprogesterone (5α-DHP) is a metabolite of progesterone through the action of the enzyme 5α-reductase (5-AR). It is an agonist of the progesterone receptor with similar potency to progesterone, and just like progesterone it is an agonist of the GABA receptor. As a result, 5α-DHP has been shown to possess a number of properties ascribed to progesterone, including anti-estrogenic, anti-prolactin, sedative, anxyolitic, anti-depressant, neuprotective, anti-aging, pro-metabolic, pro-thyroid, and anti-proliferative. Unlike progesterone, 5α-DHP is not a metabolic precursor to cortisol, estrogen and androsterone. However, due to its 5-AR derived nature 5α-Dihydroprogesterone (5α-DHP) can serve as a pro-hormone to potent androgens such as DHT, androstanedione, and androsterone through a recently discovered alternative pathway. 5α-DHP is also a direct precursor to allopregnanolone and can elevate its levels even in cases of severely downregulated 5-AR activity due to stress, PUFA overload, or administration of 5-AR like finasteride or dutasteride. Finally, unlike progesterone, 5α-DHP seems to have little or no anti-androgenic effects.

Drops per container: about 240
Each drop contains the following ingredients:

5α-Dihydroprogesterone (5α-DHP): 1 mg

Other ingredients: add product to shopping cart to see info
*******************************************************************************

References:

1. Po-hormone for DHT / androgen agonist / progesterone agonist
5α-Dihydroprogesterone (5α-DHP) Is Androgen/Progesterone Agonist And Pro-hormone For DHT

2. Anti-estrogen effects
5α-Dihydroprogesterone (5α-DHP) Is More Effective Than Progesterone As Estrogen Antagonist

3. Anti-prolactin effects
5α-Dihydroprogesterone (5α-DHP) Is More Effective Than Progesterone In Lowering Prolactin

4. GABA agonist and neurosteroid
5α-Dihydroprogesterone (5α-DHP) - The Primary Progestogen Neurosteroid

5. Effects on neurodegenerative conditions
5α-Dihydroprogesterone (5α-DHP) - Potent Role In Neurodegenerative Conditions
 

Attachments

  • dht_precursors.jpg
    dht_precursors.jpg
    38.4 KB · Views: 326
  • dht_backdoor.png
    dht_backdoor.png
    190.2 KB · Views: 322
Last edited:

Dhair

Member
Joined
Jul 29, 2015
Messages
878
What kind of effects have you noticed after experimenting with it, @haidut ?
Also, could this be used with 11-keto-DHT?
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,979
Location
USA / Europe
for male.....rats ?

or female rats ?

Both, it seems to work equally well. The HED doses for lowering estrogen and prolactin are rather low - 10mg - 15mg in a single dose should lower estrogen receptor levels by up to 75% and prolactin release by up to 70%.
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,979
Location
USA / Europe
What kind of effects have you noticed after experimenting with it, @haidut ?
Also, could this be used with 11-keto-DHT?

Just like androsterone - potent anti-depressant. The saturated steroids are really where it seems to be at for improving mood. Also, unlike androsterone which gave me a bit of unrestful sleep, 5α-DHP seems to be great to improve sleep. In higher doses (20mg - 30mg daily) I also noticed androgenic effects like harder muscles and leaner body. It also seems to be rather good for memory and cognition. It is not as sedative as progesterone, so it should be useful for studying but I think that effect is individual as one potent human anesthetic agent (pregnanolone) is a metabolite of 5α-DHP.
I think it can also be used for flu protection, given the posts about progesterone being protective from both lethality and infectiveness of viruses.
Is the "Man Flu" a real thing? Science says yes - Cantech Letter

All in all, quite a versatile steroid.
 

X3CyO

Member
Joined
Sep 19, 2016
Messages
513
Any idea when cypro will be coming out? Wanna order both.
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,979
Location
USA / Europe
Any idea when cypro will be coming out? Wanna order both.

We should have it next week, probably by Wednesday.
 

X3CyO

Member
Joined
Sep 19, 2016
Messages
513

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,979
Location
USA / Europe
EXTRA SATURATED

Lol, exactly my friend. I thought of you when I stumbled upon 5α-DHP.
A bottle is on its way to Peat, so hopefully he will give some feedback on how he likes this fully saturated liquid.
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,979
Location
USA / Europe
Last edited:

Blossom

Moderator
Joined
Nov 23, 2013
Messages
8,894
Would this replace progesterone for female rats or should they stay on their normal progesterone dose and use this as well?
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,979
Location
USA / Europe
Would this replace progesterone for female rats or should they stay on their normal progesterone dose and use this as well?

.
 
Last edited:

X3CyO

Member
Joined
Sep 19, 2016
Messages
513
So whats the catch? Just more calories and nutrients needed? And if so, how much faster is metabolism gonna be?
 

Blossom

Moderator
Joined
Nov 23, 2013
Messages
8,894
So yes, I think it should be able to replace regular progesterone for both women and men who use it.
Of course, just my 2c and YMMV.
Awesome. Thank you.
 

TubZy

Member
Joined
Sep 30, 2016
Messages
1,649
Location
USA
This is right down my alley...ordering now, thank you for no dmso
 

Laurence

Member
Joined
Aug 9, 2016
Messages
16

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,979
Location
USA / Europe
Similar threads
Thread starter Title Forum Replies Date
haidut 5α-Dihydroprogesterone (5α-DHP) Is Androgen/Progesterone Agonist And Pro-hormone For DHT Scientific Studies 25
haidut 5α-Dihydroprogesterone (5α-DHP) - Potent Role In Neurodegenerative Conditions Scientific Studies 13
haidut 5α-Dihydroprogesterone (5α-DHP) - The Primary Progestogen Neurosteroid Scientific Studies 25
haidut 5α-Dihydroprogesterone (5α-DHP) Is More Effective Than Progesterone In Lowering Prolactin Scientific Studies 29
haidut 5α-Dihydroprogesterone (5α-DHP) Is More Effective Than Progesterone As Estrogen Antagonist Scientific Studies 5
Drareg 5α-reductase type 2 (SRD5α2) Scientific Studies 9
H Apigenin inhibits rat neurosteroidogenic 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase Scientific Studies 3
Diokine 5α-reductase is important for corticoid modulation and HPA axis feedback Stress 16
haidut Estrogen Lowers T, DHT, And Fertility; Inhibits 5α-Reductase (5-AR) Scientific Studies 13
Lokzo 5α-reductase 2 Deficiency Leads To Reduced Dominance-related And Impulse-control Behaviors Scientific Studies 2
Repas du soir Should Natural Aromatase-inhibitors That Reduce 5α-Reductase Be Avoided? Diet 2
Razvan Advice for Haidut with 5a-dhp. Supplements, Pharmaceutical Drugs 21
F 5a-dhp, Potentially Posionous? IdeaLabs 2
M Pregnenolone Vs Progesterone Vs 5-dhp For Reducing Stress Hormones 10
M Would Supplementing 5a-DHP Increase DHT Levels To The Extent That It Offsets Finasteride’s Effects? Hormones 1
W Supplementing 5a-DHP While On Finasteride? Supplements, Pharmaceutical Drugs 4
johnwester130 Help me in making liquid acetazolamide Pharmaceutical Drugs 3
Vileplume Those with high liquid diets -- How much salt? Sodium 74
haidut AlloP - Liquid Allopregnanolone For Lab/R&D IdeaLabs 107
T Thorne Research vitamin K2 liquid topically does nothing to me Ask For Help or Advice 6
T Will Thorne research liquid vitamin K2 absorb through the skin? Ask For Help or Advice 8
T How to mix StressNon with liquid to consume orally IdeaLabs 4
M Liquid minerals for people who don’t absorb them well? Ask For Help or Advice 6
Momado965 Liquid tcopherol source E 2
S Liquid Alternatives Water 11
Frankdee20 Anyone Try Examastane Liquid From Blue Sky ? Ask For Help or Advice 8
B Starch Makes Extremities Warm But Lowers Underarm Temp; Liquid Sugar Does The Opposite Metabolism 6
C Benadryl (generic) Liquid Adult Ingredients Pharmaceutical Drugs 3
SuperStressed Boiling Meat: Does It Leach The Muscle Protein Into The Liquid? Diet, Recipes 1
A Constipation, Liquid Stools. At The Same Time Ask For Help or Advice 2
ecstatichamster The Thread For People Making Their Own Liquid Supplements (progest-e Etc.) Supplements, Pharmaceutical Drugs 9
YamnayaMommy Instapot CARAMEL From Liquid Whey Leftover From Cottage Cheese Cheese 0
haidut CamphoSal - Liquid Camphoric Acid + Salol IdeaLabs 380
YamnayaMommy Nutritional Value Of Whey Liquid Discarded From Making Cottage Cheese? Diet 5
methylenewhite I'm Scared, Bad Luck Accident, Wild Bat Physiological Liquid Contact Ask For Help or Advice 20
K What's The Deal With Liquid Coconut Oil? Coconut Oil 10
S How To Make Liquid DHEA? DHEA 6
Viiiiyu Dont Drink Water Nor Much Liquid Food.Normal? Diet 0
jzeno Thoughts On Liquid Magnesium? Supplements, Pharmaceutical Drugs 20
haidut Pyrucet - Liquid (ethyl) Pyruvate/Aceatoacetate Mix IdeaLabs 496
yerrag What Is Transfat-Free PUFA Oils That Are Still Liquid At Room Temp? Polyunsaturated Fats, Seed Oils 41
L Thorne Research - Vitamin K2 Liquid (1 Mg/drop) - 30 Ml (Dosage, Expiration, Storage) K 7
haidut 6-keto P4 - Liquid 6-ketoprogesterone For Lab/R&D IdeaLabs 393
denise Easy Scalp Application Of Liquid Supplements Hair & Nails 6
haidut Magnoil - Liquid Magnesium IdeaLabs 412
Captain_Coconut Help, What Is The Stability Of Pregnenolone In Liquid? Pregnenolone 3
R Dietary Liquid Advice/Tips Diet 0
haidut Cardenosine - Liquid Product For R&D IdeaLabs 375
haidut Calcirol - Liquid Vitamin D3 IdeaLabs 340
haidut CortiNon - Liquid Progesterone/DHEA Mix IdeaLabs 341

Similar threads

Top