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allopregnanolone

  1. haidut

    Finasteride causes gut inflammation, high serotonin, low dopamine; allopregnanolone may treat

    A great new study, which goes a long way towards explaining the dreaded post-finasteride syndrome (PFS). Currently, medicine does not recognize PFS as a formal disease and in fact attempts to gaslight the patients with PFS into believing they are simply mentally ill and in need of SSRI drugs...
    • haidut
    • Thread
    • allopregnanolone colon dopamine finasteride gut inflammation pfs serotonin
    • Replies: 0
    • Forum: Scientific Studies
  2. TMCMac

    AlloP is helping a lot with anxiety and mood! Can I replicate this without it? Would it be sustainable long term?

    I have struggled with a lot of anxiety and mood lately as I work 70 hours and I got Georgis AlloP and its helped a lot with mood and Ive noticed it increases my wanting to socialize it comes so much more natural. I take 4-8mg allop for the past week. I also pair it with metergoline 4mg. I...
    • TMCMac
    • Thread
    • allopregnanolone caffeine isolation metergoline mood socializing
    • Replies: 0
    • Forum: Testimonials
  3. haidut

    Progesterone, bromocriptine may treat autism

    A great new study, which, while genomic in character, inadvertently points the finger directly at estrogen and/or serotonin as causes of autism. After all progesterone's main role in the human organism is as an estrogen (and cortisol!) antagonist, while bromocriptine is one of the oldest...
    • haidut
    • Thread
    • allopregnanolone autism bromocriptine cortisol dopamine estrogen progesterone serotonin
    • Replies: 0
    • Forum: Scientific Studies
  4. haidut

    Allopregnanolone found safe, may slow brain atrophy from Alzheimer's

    A great new study, which is one of the very few to examine the safety and effectiveness of allopregnanolone in humans. The trial was conducted in patients with Alzheimer Disease (AD) and aimed to establish the safety of various doses of once-weekly allopregnanolone administration, as well as any...
    • haidut
    • Thread
    • allopregnanolone alzheimer atrophy brain cognitive dementia neurogenesis
    • Replies: 5
    • Forum: Scientific Studies
  5. haidut

    Oral allopregnanolone coming soon to a pharmacy near you

    Kidding aside, it looks like pharma companies are starting to develop a very strong interest in oral delivery of steroids, using the technique described by Peat decades ago to bypass the first-pass metabolism in the liver. Namely, as Peat described, mixing a steroid (or another molecule) with...
    • haidut
    • Thread
    • allopregnanolone chylomicron fat first-pass liver lymphatic lyt-300 oral
    • Replies: 28
    • Forum: Scientific Studies
  6. Mauritio

    Long term DHEA supplementation doubles androgens and progesterone in males

    I'm not sure if this study has been posted before , at least I haven found anything under the "DHEA" tag. Anyways, it's always good to have more in vivo evidence for peaty substances and what they do in real life. This study gave aging men with partial androgen deficiency (58-69)the "low dose"...
    • Mauritio
    • Thread
    • allopregnanolone androgens dhea dhea-s progesterone steroid steroid hormones testosterone
    • Replies: 28
    • Forum: Scientific Studies
  7. haidut

    AlloP - Liquid Allopregnanolone For Lab/R&D

    Just a quick announcement that we have replaced the 5α-DHP in our store with allopregnanolone. The main reason for switching over to allopregnanolone is that we always wanted to provide that steroid right from the start, however we could not find a lab willing to synthesize it. Thus, 5α-DHP...
    • haidut
    • Thread
    • 5α-dhp allop allopregnanolone antidepressant anxiety cognition depression dutasteride finasteride gaba memory pfs post finasteride syndrome progesterone
    • Replies: 184
    • Forum: IdeaLabs
  8. haidut

    Endocrine disruptors in cosmetics may cause postpartum depression, premature births

    Hardly a surprising finding, but it will probably come as a shock to most modern women who are the biggest consumers of such products (e.g. nail polish, perfumes, shampoo, etc). One of the reasons for this "controversy" is that doctors continue to insist that using such products during pregnancy...
    • haidut
    • Thread
    • abortion allopregnanolone endocrine disruptor phthalates post-partum depression ppd preterm progesterone
    • Replies: 1
    • Forum: Scientific Studies
  9. youngsinatra

    How To Increase Allopregnenolone?

    I‘ve seen 5a-DHP is a potent way to increase allopregnenolone. How about other things to increase it? Is plain pregnenolone also able to convert into allopregnenolone?
  10. Hans

    PFS: 3a and 3b-HSD theory

    In this Friday's newsletter, I postulated the theory that it might not necessarily be the 5-AR type 1 or 2 enzymes that are defective, but rather 3a and 3b-HSD. I quote from the newsletter: "Most people think that PFS is caused by downregulated 5AR, but a lot of people actually have normal DHT...
    • Hans
    • Thread
    • 3a-hsd 3b-hsd allopregnanolone isopregnanolone pfs
    • Replies: 76
    • Forum: Scientific Studies
  11. Mauritio

    What you can do about quarantine induced social isolation and depression : Allopregnanolone!

    This is just a heads up to everyone strugglin with depression by itself and especially depression caused by social isolation and a hopeless situation, that many people find them selves in . Social isolation does have an effect on the human body and especially brain ! There's a few studies...
    • Mauritio
    • Thread
    • allopregnanolone brain depression pregnenolone progesterone quarantine social isolation stress
    • Replies: 84
    • Forum: Scientific Studies
  12. Mauritio

    Autism caused by low allopregnenolone , chinese herb can treat

    This study shows that the chinese herbal formula Kami-shoyo-san, also known as Jia Wei Xiao Yao Pian, can treat autism / reverse autistic behaviors in mice . First they show that autistic behaviour was caused by a decrease in allopregnenolone. Then they gave mice the herbal formula and...
    • Mauritio
    • Thread
    • allopregnanolone autism dopamine gaba herbs kami shoyo san tcm
    • Replies: 65
    • Forum: Autism
  13. haidut

    Progesterone and allpregnanolone are protective against COVID-19

    I think we will be seeing more studies on this topic, especially in light of the ongoing human studies administering progesterone or (gasp!) estrogen to men in the hopes of improving the course of their COVID-19 disease. The results from the estrogen trials are already - surprise, surprise -...
    • haidut
    • Thread
    • allopregnanolone covid-19 cytokine inflammation pregnancy progesterone sepsis
    • Replies: 20
    • Forum: Scientific Studies
  14. haidut

    Allopregnanolone As A Treatment Of Alzheimer Disease (AD)

    It looks like the recent FDA approval of allopregnanolone (ALLO) for postpartum depression may open the floodgates to ton of new research with this steroid, as well as with its reliable precursors such as pregnenolone and progesterone. I posted several studies in the past demonstrating that...
    • haidut
    • Thread
    • ad allo allopregnanolone alzheimer's endotoxin energy inflammation lps metabolism pregnenolone progesterone tlr tlr4 treatment
    • Replies: 0
    • Forum: Scientific Studies
  15. haidut

    FDA Approves Allopregnanolone As A Fast-acting, Long-lasting Antidepressant

    As many of forum users know, one of the real mechanisms of action of the SSRI drugs is not the increased serotonin but the increase in brain allopregnanolone these drugs cause. As such, there has been (secret) interest from Big Pharma for years in both allpregnanolone and its synthetic...
    • haidut
    • Thread
    • allopregnanolone antidepressant approval brexanolone depression fast-acting fda long-lasting postpartum
    • Replies: 51
    • Forum: Scientific Studies
  16. haidut

    Pregnenolone Is A Potent (functional) Endotoxin (TLR4) Antagonist

    It seems that pregnenolone is finally starting to look exciting to the medical industry. In addition for its intensive studies for a variety of mental issues, now studies are coming out demonstrating its endotoxin (LPS) antagonism effects. As most forum users know, endotoxin exerts its effects...
    • haidut
    • Thread
    • alcoholism allopregnanolone alzheimer's antagonist cvd depression endotoxin epilepsy immune system inflammation lps ms multiple sclerosis pregnenolone ptsd schizophrenia sepsis tlr4 tnf
    • Replies: 10
    • Forum: Scientific Studies
  17. haidut

    Allopregnanolone May Soon Be Approved As A Fast-acting Antidepressant

    The patents on most SSRI drugs have either expired or are close to expiration. Lately, there have also been a number of high profile cases obtaining favorable court outcomes by blaming SSRI drugs for a host of human criminal behaviors or adverse health events. As such, Big Pharma is desperate to...
    • haidut
    • Thread
    • 5a-dhp allopregnanolone antidepressant approval brexanolone fast-acting fda gaba mental health mental illness mood progesterone steroid
    • Replies: 67
    • Forum: Scientific Studies
  18. haidut

    Allopregnanolone Levels Are Low In Both Obese And Anorectic Females

    This new study is one of the few that puts the spotlight on the role of hormones (and thus metabolism) in weight disorders. Most doctors and dieticians believe that being obese or anorectic is simply an issue of eating too much or too little. However, multiple human studies have shown that it is...
    • haidut
    • Thread
    • 5-ar allopregnanolone anorectic anorexia nervosa hypothyroidism levels low metabolism obesity progesterone thyroid
    • Replies: 4
    • Forum: Scientific Studies
  19. haidut

    Low-dose Allopregnanolone Induces Relief From Depression In Just 24 Hours

    I posted a few studies on the powerful mood boosting effects of allopregnanolone in relation to its precursor 5a-DHP. The precursor 5a-DHP converts into allopregnanolone with almost 100% efficiency as it is the the only pathway through which it can be metabolized downstream. All successful...
    • haidut
    • Thread
    • allopregnanolone brexanolone depression low dose postpartum rapid relief sustained
    • Replies: 40
    • Forum: Scientific Studies
  20. haidut

    Finasteride Causes Physical Damage To Nerves, Depression, ED, Steroid Imbalance

    After a decade of denying that a thing such as PFS exists, mainstream medicine seems to be wisening up to the fact that this poison does a lot more than lower the "bad" DHT. Up until very recently, it was common to simply measure blood steroid levels and then declare that they had rebounded upon...
    • haidut
    • Thread
    • 5a-dhp allopregnanolone damage depression dhea dht edd erectile dysfunction finasteride imbalance mdd nerve nervous system pregnenolone progesterone pudental steroid
    • Replies: 41
    • Forum: Scientific Studies
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