allopregnanolone

I'm not sure if this study has been posted before , at least I haven found anything under the "DHEA" tag. Anyways, it's always good to have more in vivo evidence for peaty substances and what they do in real life. This study gave aging men with partial androgen deficiency (58-69)the "low dose"...

Just a quick announcement that we have replaced the 5α-DHP in our store with allopregnanolone. The main reason for switching over to allopregnanolone is that we always wanted to provide that steroid right from the start, however we could not find a lab willing to synthesize it. Thus, 5α-DHP...

Hardly a surprising finding, but it will probably come as a shock to most modern women who are the biggest consumers of such products (e.g. nail polish, perfumes, shampoo, etc). One of the reasons for this "controversy" is that doctors continue to insist that using such products during pregnancy...

I‘ve seen 5a-DHP is a potent way to increase allopregnenolone. How about other things to increase it? Is plain pregnenolone also able to convert into allopregnenolone?

In this Friday's newsletter, I postulated the theory that it might not necessarily be the 5-AR type 1 or 2 enzymes that are defective, but rather 3a and 3b-HSD. I quote from the newsletter: "Most people think that PFS is caused by downregulated 5AR, but a lot of people actually have normal DHT...

This is just a heads up to everyone strugglin with depression by itself and especially depression caused by social isolation and a hopeless situation, that many people find them selves in . Social isolation does have an effect on the human body and especially brain ! There's a few studies...

This study shows that the chinese herbal formula Kami-shoyo-san, also known as Jia Wei Xiao Yao Pian, can treat autism / reverse autistic behaviors in mice . First they show that autistic behaviour was caused by a decrease in allopregnenolone. Then they gave mice the herbal formula and...

I think we will be seeing more studies on this topic, especially in light of the ongoing human studies administering progesterone or (gasp!) estrogen to men in the hopes of improving the course of their COVID-19 disease. The results from the estrogen trials are already - surprise, surprise -...

It looks like the recent FDA approval of allopregnanolone (ALLO) for postpartum depression may open the floodgates to ton of new research with this steroid, as well as with its reliable precursors such as pregnenolone and progesterone. I posted several studies in the past demonstrating that...

As many of forum users know, one of the real mechanisms of action of the SSRI drugs is not the increased serotonin but the increase in brain allopregnanolone these drugs cause. As such, there has been (secret) interest from Big Pharma for years in both allpregnanolone and its synthetic...

It seems that pregnenolone is finally starting to look exciting to the medical industry. In addition for its intensive studies for a variety of mental issues, now studies are coming out demonstrating its endotoxin (LPS) antagonism effects. As most forum users know, endotoxin exerts its effects...

The patents on most SSRI drugs have either expired or are close to expiration. Lately, there have also been a number of high profile cases obtaining favorable court outcomes by blaming SSRI drugs for a host of human criminal behaviors or adverse health events. As such, Big Pharma is desperate to...

This new study is one of the few that puts the spotlight on the role of hormones (and thus metabolism) in weight disorders. Most doctors and dieticians believe that being obese or anorectic is simply an issue of eating too much or too little. However, multiple human studies have shown that it is...

I posted a few studies on the powerful mood boosting effects of allopregnanolone in relation to its precursor 5a-DHP. The precursor 5a-DHP converts into allopregnanolone with almost 100% efficiency as it is the the only pathway through which it can be metabolized downstream. All successful...

After a decade of denying that a thing such as PFS exists, mainstream medicine seems to be wisening up to the fact that this poison does a lot more than lower the "bad" DHT. Up until very recently, it was common to simply measure blood steroid levels and then declare that they had rebounded upon...

Hey guys- did a short write up for allopreg with a lot of the work from here plus some other in depth studies I came across.

Effects of morphine dependence and withdrawal on levels of neurosteroids in rat brain. - PubMed - NCBI It's a rat study but I think the results are applicable to humans. "The chronic morphine administration (ip) resulted in a marked decrease in the brain concentrations of pregnenolone (PREG)...

I touched upon this idea/topic in some of my other posts, and just like those other posts, I would like to emphasize here that I am not suggesting steroid supplementation as a substitute for social interaction. The purpose of this post if to provide some insight on the biochemical effects of...

****DISCONTINUED****DISCONTINUED****DISCONTINUED**** Replaced by allopregnanolone, which is a direct metabolite of 5α-Dihydroprogesterone (5α-DHP). https://raypeatforum.com/community/threads/allop-liquid-allopregnanolone-for-lab-r-d.41055/...

https://www.ncbi.nlm.nih.gov/pubmed/27871861?dopt=Abstract