allopregnanolone

  1. haidut

    Progesterone and allpregnanolone are protective against COVID-19

    I think we will be seeing more studies on this topic, especially in light of the ongoing human studies administering progesterone or (gasp!) estrogen to men in the hopes of improving the course of their COVID-19 disease. The results from the estrogen trials are already - surprise, surprise -...
  2. haidut

    Allopregnanolone As A Treatment Of Alzheimer Disease (AD)

    It looks like the recent FDA approval of allopregnanolone (ALLO) for postpartum depression may open the floodgates to ton of new research with this steroid, as well as with its reliable precursors such as pregnenolone and progesterone. I posted several studies in the past demonstrating that...
  3. haidut

    FDA Approves Allopregnanolone As A Fast-acting, Long-lasting Antidepressant

    As many of forum users know, one of the real mechanisms of action of the SSRI drugs is not the increased serotonin but the increase in brain allopregnanolone these drugs cause. As such, there has been (secret) interest from Big Pharma for years in both allpregnanolone and its synthetic...
  4. haidut

    Pregnenolone Is A Potent (functional) Endotoxin (TLR4) Antagonist

    It seems that pregnenolone is finally starting to look exciting to the medical industry. In addition for its intensive studies for a variety of mental issues, now studies are coming out demonstrating its endotoxin (LPS) antagonism effects. As most forum users know, endotoxin exerts its effects...
  5. haidut

    Allopregnanolone May Soon Be Approved As A Fast-acting Antidepressant

    The patents on most SSRI drugs have either expired or are close to expiration. Lately, there have also been a number of high profile cases obtaining favorable court outcomes by blaming SSRI drugs for a host of human criminal behaviors or adverse health events. As such, Big Pharma is desperate to...
  6. haidut

    Allopregnanolone Levels Are Low In Both Obese And Anorectic Females

    This new study is one of the few that puts the spotlight on the role of hormones (and thus metabolism) in weight disorders. Most doctors and dieticians believe that being obese or anorectic is simply an issue of eating too much or too little. However, multiple human studies have shown that it is...
  7. haidut

    Low-dose Allopregnanolone Induces Relief From Depression In Just 24 Hours

    I posted a few studies on the powerful mood boosting effects of allopregnanolone in relation to its precursor 5a-DHP. The precursor 5a-DHP converts into allopregnanolone with almost 100% efficiency as it is the the only pathway through which it can be metabolized downstream. All successful...
  8. haidut

    Finasteride Causes Physical Damage To Nerves, Depression, ED, Steroid Imbalance

    After a decade of denying that a thing such as PFS exists, mainstream medicine seems to be wisening up to the fact that this poison does a lot more than lower the "bad" DHT. Up until very recently, it was common to simply measure blood steroid levels and then declare that they had rebounded upon...
  9. TubZy

    Allopreg {write Up}

    Hey guys- did a short write up for allopreg with a lot of the work from here plus some other in depth studies I came across.
  10. BigYellowLemon

    Effects Of Morphine Dependence And Withdrawal On Levels Of Neurosteroids In Rat Brain

    Effects of morphine dependence and withdrawal on levels of neurosteroids in rat brain. - PubMed - NCBI It's a rat study but I think the results are applicable to humans. "The chronic morphine administration (ip) resulted in a marked decrease in the brain concentrations of pregnenolone (PREG)...
  11. haidut

    Pregnenolone As A Treatment For Loneliness

    I touched upon this idea/topic in some of my other posts, and just like those other posts, I would like to emphasize here that I am not suggesting steroid supplementation as a substitute for social interaction. The purpose of this post if to provide some insight on the biochemical effects of...
  12. haidut

    5α-DHP - Liquid 5α-Dihydroprogesterone For Lab/R&D

    As many of you know by now, I have acquired an interest lately to research the connection between the process of saturation of various nutrients and steroids and the effects of this saturation on the properties of these substances. After doing some work on androgens such as androsterone and...
  13. Koveras

    The Role Of Steroids In The Prediction Of Affective Disorders In Adult Men

    https://www.ncbi.nlm.nih.gov/pubmed/27871861?dopt=Abstract
  14. haidut

    Pregnenolone Is The Most Potent Inhibitor Of The Stress Signal (CRH)

    I think this study should finally put to rest the arguments and debates of whether pregnenolone raises or lowers cortisol, and how it affects the stress response overall. I posted a similar study, which showed that the pregnenolone metabolites progesterone and allopregannolone potently inhibited...
  15. haidut

    Progesterone, Testosterone, Allopregnanolone Are Serotonin Antagonists

    This study shows that some of the gonadal steroids act in a manner similar to the drug ondansetron - i.e. antagonize the 5-HT3 "receptor". While pregnenolone sulfate was not antagonistic to 5-HT3, taking pregnenolone metabolizes mostly into progesterone and allopregnanolone. So, it seems like a...
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