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Rapamycin is Fantastic and Worth Trying
Thank you Blossom.@Ania, this link might possibly help with some ideas for sourcing.
Has anyone from Europe (ideally Poland) Gotten Rapamycin From Abroad (India, etc)?
Other than that, prescription from EUDoctor, unfortunately it is probably impossible to get it in EU in other ways.www.rapamycin.news
i contacted the Longevity Center some time ago.
They make assessment, which is quite complex, including genetic testing, and on that basis they propose you a longevity strategy.
They are into things a la David Sinclair like metformin etc.
I told them I will go through the process and pay the absurd amount of money if they guarantee I will receive Rapamacin prescription in the end. They never answered.
So for now I see no possibility to source rapa.
No. I should have been more clear. In a hurry you see. I ordered from India. I'm always surprised to see where things ship from when I order from India.
Thanks for all of this. Yes, pretty amazing what your doc said. Very encouraging for us here! I hope the 3.5 yo has improvement w the bladder.
My report on the first week of 1mg, so far - First night results were that I slept better the night before, but when I awakened I felt stronger overall and more rested..Husband slept "as usual". First day and ev day after my body has felt stronger. Hard to describe. Husband is more motivated. These are not huge changes but in a good direction.
Next dose is tomorrow morning. Plan to keep at 1mg/week but may delay mine because I began to have a return of sciatica yesterday from over gardening.
Next dose is tomorrow morning. Plan to keep at 1mg/week but may delay mine because I began to have a return of sciatica yesterday from over gardening.
Reposting this from yerrag on page 3 of this thread.
Ray Peat Q1, 2022:
An important factor in creating functional and metabolic inertia is a phosphate transfer enzyme that creates a general pattern of activation, the kinase called mTOR
(mechanistic target of rapamycin).
A bacterial fungicidal antibiotic, rapamycin, originally used to treat candidiasis, was found to be immunosuppressive, and is used to prevent rejection of kidney transplants. The mTOR enzyme inhibited by rapamycin has been found to promote growth, inflammation, fibrosis, and cancer growth, and to accelerate aging. Lactate
promotes the activation of mTOR, and mTOR activates aerobic glycolysis, the defining feature of cancer.
Interrupting the vicious circles of cancerization is essential for the survival of the organism. There are many substances that can inhibit the
inflammatory, degenerative processes acting at multiple levels, and these substances tend to be synergistic, so that a great number of substances
can be safely used at the same time. This kind of supportive therapy has nothing in common with the ruling paradigm of cancer treatment—it is reinforcing the organism’s state of health, rather
than attacking the disease of cancer.
Things that favor the production of CO2 rather than lactate include CO2, sodium bicarbonate and acetazolamide, flavonoids such as apigenin and
fisetin (Constantin, et al., 2010; Shan, et al., 2017;
Zhao, et al., 2021), thyroid hormone,
progesterone, and lidocaine (Karniel and Beitner, 2000),
Some of the things that inhibit mTOR include caffeine (Zhou, et al., 2010), aspirin (Din, et al.,2012), lidocaine (Zhang, et al., 2021), vitamin D (Al-Hendy, et al., 2016), and flavonoids.
Things that increase intracellular calcium tend to increase mTOR (Amemiya, et al., 2021). Radiation (ultraviolet and ionizing radiation) increases mTOR, and this effect can be reduced by flavonoids (Bridgeman, et al., 2016). mTOR is
one of the factors in the radiation bystander effect, which is responsible for prolonged damage of other unirradiated cells in the organism (Verma
and Tiku, 2022).
Many of the flavonoids are known as “antioxidants,” but, like ascorbic acid/dehydroascorbate, inside the functioning cell they become beneficial
oxidative catalysts. In excessive doses they might act as reducing agents. Ascorbic acid itself in some situations increases mTOR (Moretti, et al.,4
2014). It’s safest to get the flavonoids from food, rather than supplements.
Ray Peat Q1, 2022:
An important factor in creating functional and metabolic inertia is a phosphate transfer enzyme that creates a general pattern of activation, the kinase called mTOR
(mechanistic target of rapamycin).
A bacterial fungicidal antibiotic, rapamycin, originally used to treat candidiasis, was found to be immunosuppressive, and is used to prevent rejection of kidney transplants. The mTOR enzyme inhibited by rapamycin has been found to promote growth, inflammation, fibrosis, and cancer growth, and to accelerate aging. Lactate
promotes the activation of mTOR, and mTOR activates aerobic glycolysis, the defining feature of cancer.
Interrupting the vicious circles of cancerization is essential for the survival of the organism. There are many substances that can inhibit the
inflammatory, degenerative processes acting at multiple levels, and these substances tend to be synergistic, so that a great number of substances
can be safely used at the same time. This kind of supportive therapy has nothing in common with the ruling paradigm of cancer treatment—it is reinforcing the organism’s state of health, rather
than attacking the disease of cancer.
Things that favor the production of CO2 rather than lactate include CO2, sodium bicarbonate and acetazolamide, flavonoids such as apigenin and
fisetin (Constantin, et al., 2010; Shan, et al., 2017;
Zhao, et al., 2021), thyroid hormone,
progesterone, and lidocaine (Karniel and Beitner, 2000),
Some of the things that inhibit mTOR include caffeine (Zhou, et al., 2010), aspirin (Din, et al.,2012), lidocaine (Zhang, et al., 2021), vitamin D (Al-Hendy, et al., 2016), and flavonoids.
Things that increase intracellular calcium tend to increase mTOR (Amemiya, et al., 2021). Radiation (ultraviolet and ionizing radiation) increases mTOR, and this effect can be reduced by flavonoids (Bridgeman, et al., 2016). mTOR is
one of the factors in the radiation bystander effect, which is responsible for prolonged damage of other unirradiated cells in the organism (Verma
and Tiku, 2022).
Many of the flavonoids are known as “antioxidants,” but, like ascorbic acid/dehydroascorbate, inside the functioning cell they become beneficial
oxidative catalysts. In excessive doses they might act as reducing agents. Ascorbic acid itself in some situations increases mTOR (Moretti, et al.,4
2014). It’s safest to get the flavonoids from food, rather than supplements.
This is great, thank you. You tend to forget what was in the beginning of a long thread.
My sister sent me this from Dr Green's office. I can't remember if anyone put it here. It has a lot of info. At first look, it seems that he has his patients on 6mg per week.
Until I learn more, we'll stick to 1mg a week. I might go back and read experiences on this and other Rapamycin threads on the forum to get a better idea of dosing.
rapamycintherapy.com
Oh, I see @Badger gave us this link back in December of 22. Thank you Badger.
Until I learn more, we'll stick to 1mg a week. I might go back and read experiences on this and other Rapamycin threads on the forum to get a better idea of dosing.
Rapamycin Treatment for Age Related Diseases
44-01 Westmoreland Street, Little Neck, New York 11363 Make a new appointment by emailing us at [email protected]
rapamycintherapy.com
Oh, I see @Badger gave us this link back in December of 22. Thank you Badger.
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@ecstatichamster I wonder if you kept trying rapa and if you noticed any benefit.
Is this holding steady or do you not notice any tiredness by now? And @Blossom could you give us an update?
Sure, I was holding off for my blood work results but I’ve had to put that off for now. My blood glucose is great and generally 76-86 when I wake up so no interference there as some people report. I’m really curious about my lipids though so I might just get a spot check from the drug store for now. My fitness/ body composition is improving but I think that probably has more to do with overall feeling better and more motivated to walk in my weighted vest and lift weights consistently. I’m eating better in general because my gut is less sensitive. My hair, skin and nails have improved. It seems like month 8 was when the improvements started to really show up for both myself and my husband. Husband has lost about 10 pounds without any diet changes and says his strength at the gym has improved. My dog had rapid improvements initially of course and seems to be staying about the same day to day with possibly a 10% improvement from his rapid and spectacular early results. He never limps anymore so apparently the CCL ligament tear has healed and he runs, plays, jumps on the couch and seems to be really enjoying life. I don’t think I look dramatically different but that’s never been my goal. I just hope to remain strong and functional for as long as possible. :) Here’s my biometric scale reading from last Wednesday fwiw so my muscle and bone mass estimate is excellent for my age so hopefully there’s no frailty in my immediate future. I think the scale underestimates fat mass a little though. The navy method estimates about 17.6% which seems more realistic. I can’t afford nor do I want a dexa scan so I’m okay with just the estimates.
I seem well adjusted to rapa at this point and don’t notice much of anything when I take it tbh. I settled on 3mg/week. Sometimes it’s all in one dose and sometimes 1mg every M-W-F. I still haven’t decided which dosing schedule I prefer tbh. That’s about all I have to report until I get my labs done hopefully next month. Oh, I almost forgot that I no longer wake up feeling like I’m rapidly aging but more like I’m holding steady.
This is so fantastic. Did you ever have any hair issues like thinning, and if so, any improvement in that respect?
VitoScaletta
Member
Interesting.
When my prolactin was elevated 15 years ago due to a prolactinoma I had diffuse thinning. I’ve never felt like my hair completely returned to it’s previous thickness although many things I learned from Peat’s work seemed to help. Thankfully I had really thick hair prior to that so if you saw me on the street you’d never think I had any issues with hair thinning. By hair improvements the best I can describe it is that it lays better and is smoother. The quality and strength of the hair growing in now seems better. I don’t need to style it much at all for it to look presentable. This is a picture of my hair from last month. I’m generally fine with it for an ordinary woman about to turn 54.
Great hair!
@Regina, thank you ma’am. I just like to brush and go! Hahaha
That's all it needs.
OP
Tarmander
Member
- Joined
- Apr 30, 2015
- Messages
- 3,775
I have been doing 20mg once a month lately. The next day is rough, and then I feel meh for a week before getting back to normal. I think at some point I will go back to doing 5-7mg once per week. I have tried all the different dosages, and they all have different benefits and costs. The high dosages get "deep," but can be pretty debilitating and tiring. The lower dosages are easier to handle, but don't give that bounce back of feeling just great. I think its useful to try the higher dosages at least a few times, but after that, I don't know if it matter much as long as you stay on it in some capacity. It seems like most of the benefits you get are right at the beginning, and everything else is incremental.
Edit: I realize this contradicts what @Blossom said about 8 months, which I find really interesting. Maybe I did get better with time and didn't notice it? My experience is that I got the energy when I first started taking it, and then I used that energy to start working out more, and getting healthier in other ways. So its hard to differentiate.
@Tarmander, Don’t forget I’m pretty old in comparison to you so that might make a difference!
@sunny, I thought you might like this paper on the topic of hair and mTOR.
www.ncbi.nlm.nih.gov
mTOR signaling in hair follicle and hair diseases: recent progress
Mammalian target of rapamycin (mTOR) signaling pathway is a major regulator of cell proliferation and metabolism, playing significant roles in proliferation, apoptosis, inflammation, and illness. More and more evidences showed that the mTOR signaling ...
www.ncbi.nlm.nih.gov
Thank you. I had put rapa on the back burner for awhile- I had not had the time to obtain it. This paper makes me think I need to try some.@sunny, I thought you might like this paper on the topic of hair and mTOR.
mTOR signaling in hair follicle and hair diseases: recent progress
Mammalian target of rapamycin (mTOR) signaling pathway is a major regulator of cell proliferation and metabolism, playing significant roles in proliferation, apoptosis, inflammation, and illness. More and more evidences showed that the mTOR signaling ...
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