1. Limon9

    MTOR Activates Warburg Effect From Endotoxin

    As Dr. Peat referred to in his newsletters, it's no surprise that a cell-proliferative enzyme activates aerobic glycolysis. Oxidative energy production is halted so the cells may regress to a primitive growth-state. Inhibiting either mTOR or the glycolytic enzyme it upregulated was sufficient to...
  2. Limon9

    MTOR Increases With Aging/Sarcopenia, (Partial) Inhibition Restores Muscle Mass

    This was a nice experiment which upsets the naive axis of anabolism and catabolism commonly-associated with the mTOR (mammalian target of rapamycin). Its activation is not sufficient to maintain muscle mass, and partially inhibiting it can unexpectedly restore muscle. Common medical advice is...
  3. Limon9

    Cognitive Benefits Of Caloric Restriction Are Due To Reduced Tryptophan/Serotonin/mTOR Signalling

    It seems that consuming pure egg white will indeed make you stupid enough to consume pure egg white. Key Points - Calorie restriction improves mental test performance in mice. - Adding tryptophan into calorie-restricted diet abolished memory benefits. - Giving C.R. mice the serotonergic drug...
  4. Tarmander

    Rapamycin is Fantastic and Worth Trying

    There really has not been much talk of Rapamycin on this forum. When it was brought up in the past, its mTOR inhibition was often talked about as a negative. Many assumed this would lead to muscle wasting and catabolism. Well I am here to tell you, it is worth looking into. Alone it has given...
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