mtor

  1. C

    High Protein Is Officially Anti-Peat As Ray Became A Low Protein Advocate In His Final Years (Video Jun 24, 2022)

    I thought this was a big deal and should have been nailed down on the rpf. Dr. Ray Peat denounced a high protein diet in his last 4 or 5 interviews. He switched from recommending at least 80-100 grams (or more) to about 50 grams per 2500 calories and thought his high protein diet was...
    • Clyde
    • Thread
    • aging diet health methionine mtor protein protein restriction ray peat
    • Replies: 0
    • Forum: Diet
  2. haidut

    Aspirin may treat (idiopathic) pulmonary fibrosis (PF)

    I mentioned in several of my latest podcast appearances that Pfizer is running clinical trials with a serotonin antagonist to reverse/treat several lethal conditions, for which medicine claims there is no cure. Those conditions include heart fibrosis / heart failure, pulmonary hypertension...
    • haidut
    • Thread
    • aspirin autophagy fibrosis inflammation lungs mtor pulmonary fibrosis scar
    • Replies: 8
    • Forum: Scientific Studies
  3. Limon9

    MTOR Activates Warburg Effect From Endotoxin

    As Dr. Peat referred to in his newsletters, it's no surprise that a cell-proliferative enzyme activates aerobic glycolysis. Oxidative energy production is halted so the cells may regress to a primitive growth-state. Inhibiting either mTOR or the glycolytic enzyme it upregulated was sufficient to...
    • Limon9
    • Thread
    • endotoxin fibrosis glycolysis lps mtor pfkfb3 rapamycin warburg effect
    • Replies: 17
    • Forum: Scientific Studies
  4. Limon9

    MTOR Increases With Aging/Sarcopenia, (Partial) Inhibition Restores Muscle Mass

    This was a nice experiment which upsets the naive axis of anabolism and catabolism commonly-associated with the mTOR (mammalian target of rapamycin). Its activation is not sufficient to maintain muscle mass, and partially inhibiting it can unexpectedly restore muscle. Common medical advice is...
  5. Limon9

    Cognitive Benefits Of Caloric Restriction Are Due To Reduced Tryptophan/Serotonin/mTOR Signalling

    It seems that consuming pure egg white will indeed make you stupid enough to consume pure egg white. Key Points - Calorie restriction improves mental test performance in mice. - Adding tryptophan into calorie-restricted diet abolished memory benefits. - Giving C.R. mice the serotonergic drug...
    • Limon9
    • Thread
    • caloric restriction cognition mtor rapamycin serotonin study tryptophan
    • Replies: 1
    • Forum: Scientific Studies
  6. Tarmander

    Rapamycin is Fantastic and Worth Trying

    There really has not been much talk of Rapamycin on this forum. When it was brought up in the past, its mTOR inhibition was often talked about as a negative. Many assumed this would lead to muscle wasting and catabolism. Well I am here to tell you, it is worth looking into. Alone it has given...
  7. Lejeboca

    Ray Peat Interview KMUD - February 18, 2022

    https://archive.kmudfm.org/ Yet another packed with information show. This is the first time I've heard Dr. Peat talking about mTOR, mentioning that progesterone is precursor to glucocorticoids, and why he does not in favor of (wisdom) tooth extraction. "The brain is participating...
    • Lejeboca
    • Thread
    • cancer flavonoids glutatione interview mtor progesterone ray peat root canal decay tooth extraction
    • Replies: 5
    • Forum: KMUD Radio-The Herb Doctors
  8. haidut

    Glycine Is Directly Anabolic AND Anticatabolic For The Muscle

    I posted a few interesting studies about glycine in the past. Among the interesting properties are lowering cortisol, increasing DHT synthesis, improving insulin sensitivity, and serving as a biomarker of stress. Glycine Powerfully Lowers Cortisol Glycine Strongly Upregulates 5-alpha Reductase...
    • haidut
    • Thread
    • anabolic anti-catabolic glycine inflammation mtor muscle protein synthesis sarcopenia
    • Replies: 64
    • Forum: Scientific Studies
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