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  1. Ras

    Anti-Aging Breakthrough: Detoxing Body of Harmful Fat By-Products To Extend Lifespan

    The study discussed here presents evidence that clearing the body of the fat byproducts glycerol and glyceraldehyde could lead to an increased lifespan. In light of those data, a supplement that comes to mind is dihydromyricetin, which causes the body to produce more alcohol dehydrogenase and...
  2. C

    Aging Of A 53 YO Male After 25yrs of Dutasteride 35yrs Oral Steroids + No Testosterone Or DHT

    On top of suppressing his natural testosterone production to nothing until age 51 by taking oral steroids, he suppressed his dht to about zero by taking a full dose of dutasteride. He added 125mg of testosterone at age 51 and used to take aromatase inhibitors when he was taking growth hormone...
  3. Tarmander

    Rapamycin is Fantastic and Worth Trying

    There really has not been much talk of Rapamycin on this forum. When it was brought up in the past, its mTOR inhibition was often talked about as a negative. Many assumed this would lead to muscle wasting and catabolism. Well I am here to tell you, it is worth looking into. Alone it has given...
  4. haidut

    No evidence for rate-of-living theory of aging

    Just a quick post, since this topic dominates anti-aging research - i.e. despite lack of concrete evidence for it, mainstream research (and finding agencies) continue to claim that longevity is tied to metabolism, but in an inverse relationship. The study below is on turtles - one of the longest...
  5. NewACC

    (-) Benzofuranylpropylaminopropan is unknown peaty chemical?

    I had recently dug into the "depths" of pubmed and found two notable and rather unknown substances that could potentially become very peaty. In short, this is one of the most powerful neurotrophic substances I have seen. But it also is anticancer and anti-cortisol drug. The only negative can be...
  6. haidut

    Eating meat extends human life expectancy

    Another study challenging the vegan dogma relentlessly promoted by mainstream media under the aegis of World Economic Forum (WEF) members and other similarly microcephalic goons. As the study says, other studies that found benefits in eating vegan diets have failed to account for the so-called...
  7. Hans

    The best exercise and longevity booster supplement

    This is by far one of my favorite supps. https://men-elite.com/2022/03/25/the-best-exercise-and-longevity-booster-supplement/
  8. A

    Low levels of methionine, cystathionine, choline, succinate, malate and high levels of non-polar amino acids, carnitine are associated with longevity

    Methionine metabolism arises as a key target to elucidate the molecular adaptations underlying animal longevity due to the negative association between longevity and methionine content. The present study follows a comparative approach to analyse plasma methionine metabolic profile using a...
  9. Peatful

    Living to 120. Pregnancies at 65. See what they eat and how they live.

    View: https://youtu.be/QW_713n3D0o Fascinating.
  10. B

    NIH Longevity Testing Program - Interventions that extend lifespan in mice

    Came across the NIH Interventions Testing Program. Pretty interesting info. Interventions Testing Program (ITP) Interventions shown to extend lifespan in UM-HET3 mice include; Aspirin – Increased lifespan in males but not females (Strong et al., 2008). Rapamycin – Increased mean and...
  11. A

    Hypercapnia-inducible factor: a hypothesis | Aging and longevity

    Abstract Cells and tissues sense and respond to hypercapnia by global activation or down-regulation of hundreds of genes and switching on/off a number of signaling and metabolic pathways. We hypothesize for the first time that such complex rearrangements are hardly possible without subtle...
  12. A

    Aspirin was the most potent life-extension agent when data for all model organisms was combined, more so than rapamycin or metformin

    Research on aging and lifespan-extending compounds has been carried out using diverse model organisms, including yeast, worms, flies and mice. Many studies reported the identification of novel lifespan‐extending compounds in different species, some of which may have the potential to translate to...
  13. Apple

    World's oldest person - Kane Tanaka (118yo)

    Just stumbled on this peaty centenarian - Kane Tanaka. She likes eating chocolate and drinking Coke. Secret to her longevity, Tanaka replied, “Eating delicious food and studying.”...
  14. haidut

    Metabolically, children are different species compared to adults

    A great study, which once again puts metabolism in the spotlight. Many studies have tried to discover the main biological differences between children and adults and so far none of them have discovered a "smoking gun". At the same time, multiple studies have demonstrated that children are much...
  15. haidut

    Inflammation (from PUFA), not telomeres, determines lifespan / healthspan

    The idea of lifespan being entirely determined by limits on cellular division has ruled biology for more than a century and is perhaps best exemplified by the (in)famous (and false) Hayflick limit. Reaching the said limit is postulated to be controlled by telomere length, and as such the...
  16. Mauritio

    Why PUFA is bad: how high membrane polyunsaturation decreases longevity

    Why PUFA is bad: how high membrane polyunsaturation decreases longevity: This is probably one of the most interesting papers I've read in a long time . It goes into depth about the danger of PUFA and conncects the dots between PUFA ,membranes ,rate of living theory, life expectancy, and...
  17. youngsinatra

    Rate My Anti-Aging Stack

    Hello everyone, I am personally very interested in longevity and extending healthy lifespan. I am curious if some of you are also into this field of interest and could give me some advice for what you would change/add/remove. My supplement stack: 1. Fat-solubles: (All dissolved in MCT-oil...
  18. P

    55 year-old looks like 25

    Interesting video about a 55 year-old photographer who looks like an elite 25 year-old fitness model. He's 55 Years Old But Looks 25... Reacting To Chuando Tan Reveal His Secrets Summary: He looks the same as he did in the late 1980s, in his 20s. He doesn't drink or smoke, doesn't drink coffee...
  19. M

    Metabolic Rate & Longevity

    Peat's central premise is that a high metabolic rate will improve chances of longevity. This is in direct contrast to the mainstream premise. (Just look up "metabolic rate longevity") to get an idea of this. I'm trying to gather up evidence for the idea that a higher metabolic rate gives us a...
  20. haidut

    Sexual activity and stress levels (HPA activity) may determine longevity

    The study below tried to tease out the main factors affecting the longevity of the legendary naked mole rat - the animal with longest lifespan in its genus, and the sole mammal known to be virtually immune to developing cancer. Most of the biological/biochemical findings in regards to naked mole...